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Protein

Toxic protein SymE

Gene

symE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Toxic component of a type I toxin-antitoxin (TA) system. Involved in the degradation and recycling of damaged RNA. It is itself a target for degradation by the ATP-dependent protease Lon.

Miscellaneous

Overexpression of this protein is toxic for the cell, affecting colony-forming ability and protein synthesis.

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • mRNA catabolic process Source: EcoCyc
  • SOS response Source: EcoCyc

Keywordsi

Molecular functionDNA-binding, Endonuclease, Hydrolase, Nuclease, RNA-binding
Biological processToxin-antitoxin system

Enzyme and pathway databases

BioCyciEcoCyc:G7940-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Toxic protein SymE
Alternative name(s):
Putative endoribonuclease SymE (EC:3.1.-.-)
Gene namesi
Name:symE
Synonyms:dinL, sosC, yjiW
Ordered Locus Names:b4347, JW4310
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12584 symE

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001697991 – 113Toxic protein SymEAdd BLAST113

Proteomic databases

PaxDbiP39394
PRIDEiP39394

Expressioni

Inductioni

During the SOS response (at protein level when expressed as a fusion protein). In normal growth conditions, it is repressed by LexA. The mRNA stability and translation is controlled by the small regulatory RNA symR, which probably blocks ribosome binding. Expression of the proteinaceous toxin (putative endonuclease) is controlled by antisense sRNA SymR.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi4262766, 164 interactors
STRINGi316407.85677087

Structurei

3D structure databases

ProteinModelPortaliP39394
SMRiP39394
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 74SpoVT-AbrBPROSITE-ProRule annotationAdd BLAST46

Sequence similaritiesi

Belongs to the SymE family.Curated

Phylogenomic databases

eggNOGiENOG4105FU6 Bacteria
ENOG4111QQF LUCA
HOGENOMiHOG000266483
KOiK19048
OMAiMRQHTRT

Family and domain databases

HAMAPiMF_01193 Endoribonucl_SymE, 1 hit
InterProiView protein in InterPro
IPR007159 SpoVT-AbrB_dom
IPR014944 Toxin_SymE-like
IPR020883 TypeI_TA_SymE
PfamiView protein in Pfam
PF08845 SymE_toxin, 1 hit
PROSITEiView protein in PROSITE
PS51740 SPOVT_ABRB, 1 hit

Sequencei

Sequence statusi: Complete.

P39394-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDTHSIAQP FEAEVSPANN RHVTVGYASR YPDYSRIPAI TLKGQWLEAA
60 70 80 90 100
GFATGTAVDV KVMEGCIVLT AQPPAAEESE LMQSLRQVCK LSARKQKQVQ
110
AFIGVIAGKQ KVA
Length:113
Mass (Da):12,203
Last modified:July 10, 2007 - v2
Checksum:i4C3C0CE696CE7D9D
GO

Sequence cautioni

The sequence AAA97244 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAE78337 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97244.1 Different initiation.
U00096 Genomic DNA Translation: AAC77303.2
AP009048 Genomic DNA Translation: BAE78337.1 Different initiation.
PIRiS56573
RefSeqiNP_418767.4, NC_000913.3
WP_000132601.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77303; AAC77303; b4347
BAE78337; BAE78337; BAE78337
GeneIDi949088
KEGGiecj:JW4310
eco:b4347
PATRICifig|1411691.4.peg.2339

Similar proteinsi

Entry informationi

Entry nameiSYME_ECOLI
AccessioniPrimary (citable) accession number: P39394
Secondary accession number(s): Q2M5W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 10, 2007
Last modified: March 28, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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