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Protein

Multidrug resistance protein MdtM

Gene

mdtM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Confers resistance to acriflavine, chloramphenicol, norfloxacin, ethidium bromide and TPP.1 Publication

GO - Molecular functioni

  • drug:proton antiporter activity Source: EcoCyc
  • drug transmembrane transporter activity Source: EcoCyc
  • potassium:proton antiporter activity Source: EcoCyc
  • sodium:proton antiporter activity Source: EcoCyc

GO - Biological processi

  • drug transmembrane transport Source: EcoCyc
  • regulation of cellular pH Source: EcoCyc
  • response to antibiotic Source: EcoCyc

Keywordsi

Biological processAntibiotic resistance, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YJIO-MONOMER
MetaCyc:YJIO-MONOMER

Protein family/group databases

TCDBi2.A.1.2.52 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtM
Gene namesi
Name:mdtM
Synonyms:yjiO
Ordered Locus Names:b4337, JW4300
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12576 mdtM

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 48PeriplasmicSequence analysisAdd BLAST16
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 78CytoplasmicSequence analysis9
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 103PeriplasmicSequence analysis4
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 140CytoplasmicSequence analysisAdd BLAST16
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 167PeriplasmicSequence analysis6
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 216CytoplasmicSequence analysisAdd BLAST28
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 251PeriplasmicSequence analysisAdd BLAST14
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Topological domaini273 – 282CytoplasmicSequence analysis10
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Topological domaini304 – 307PeriplasmicSequence analysis4
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 348CytoplasmicSequence analysisAdd BLAST20
Transmembranei349 – 369HelicalSequence analysisAdd BLAST21
Topological domaini370 – 373PeriplasmicSequence analysis4
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 410CytoplasmicSequence analysisAdd BLAST16

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000848391 – 410Multidrug resistance protein MdtMAdd BLAST410

Proteomic databases

PaxDbiP39386
PRIDEiP39386

Interactioni

Protein-protein interaction databases

BioGridi4261450, 183 interactors
DIPiDIP-12641N
STRINGi316407.85677080

Structurei

3D structure databases

ProteinModelPortaliP39386
SMRiP39386
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41083G8 Bacteria
ENOG410XT98 LUCA
HOGENOMiHOG000118215
InParanoidiP39386
OMAiSYIPLMS
PhylomeDBiP39386

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P39386-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRFFTRHAA TLFFPMALIL YDFAAYLSTD LIQPGIINVV RDFNADVSLA
60 70 80 90 100
PAAVSLYLAG GMALQWLLGP LSDRIGRRPV LITGALIFTL ACAATMFTTS
110 120 130 140 150
MTQFLIARAI QGTSICFIAT VGYVTVQEAF GQTKGIKLMA IITSIVLIAP
160 170 180 190 200
IIGPLSGAAL MHFMHWKVLF AIIAVMGFIS FVGLLLAMPE TVKRGAVPFS
210 220 230 240 250
AKSVLRDFRN VFCNRLFLFG AATISLSYIP MMSWVAVSPV ILIDAGSLTT
260 270 280 290 300
SQFAWTQVPV FGAVIVANAI VARFVKDPTE PRFIWRAVPI QLVGLSLLIV
310 320 330 340 350
GNLLSPHVWL WSVLGTSLYA FGIGLIFPTL FRFTLFSNKL PKGTVSASLN
360 370 380 390 400
MVILMVMSVS VEIGRWLWFN GGRLPFHLLA VVAGVIVVFT LAGLLNRVRQ
410
HQAAELVEEQ
Length:410
Mass (Da):44,688
Last modified:February 1, 1995 - v1
Checksum:i17C909971AD788B7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti128E → K in strain: B. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY283773 Genomic DNA Translation: AAP43530.1
U14003 Genomic DNA Translation: AAA97233.1
U00096 Genomic DNA Translation: AAC77293.1
AP009048 Genomic DNA Translation: BAE78330.1
PIRiS56562
RefSeqiNP_418757.1, NC_000913.3
WP_001137036.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77293; AAC77293; b4337
BAE78330; BAE78330; BAE78330
GeneIDi948861
KEGGiecj:JW4300
eco:b4337
PATRICifig|1411691.4.peg.2350

Similar proteinsi

Entry informationi

Entry nameiMDTM_ECOLI
AccessioniPrimary (citable) accession number: P39386
Secondary accession number(s): Q2M5X6, Q7X4V2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 25, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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