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Protein

Multidrug resistance protein MdtM

Gene

mdtM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Confers resistance to acriflavine, chloramphenicol, norfloxacin, ethidium bromide and TPP.1 Publication

GO - Molecular functioni

  • drug:proton antiporter activity Source: EcoCyc
  • drug transmembrane transporter activity Source: EcoCyc
  • potassium:proton antiporter activity Source: EcoCyc
  • sodium:proton antiporter activity Source: EcoCyc

GO - Biological processi

  • drug transmembrane transport Source: EcoCyc
  • regulation of cellular pH Source: EcoCyc
  • response to antibiotic Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YJIO-MONOMER.
ECOL316407:JW4300-MONOMER.
MetaCyc:YJIO-MONOMER.

Protein family/group databases

TCDBi2.A.1.2.52. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtM
Gene namesi
Name:mdtM
Synonyms:yjiO
Ordered Locus Names:b4337, JW4300
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12576. mdtM.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 48PeriplasmicSequence analysisAdd BLAST16
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 78CytoplasmicSequence analysis9
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 103PeriplasmicSequence analysis4
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 140CytoplasmicSequence analysisAdd BLAST16
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 167PeriplasmicSequence analysis6
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 216CytoplasmicSequence analysisAdd BLAST28
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 251PeriplasmicSequence analysisAdd BLAST14
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Topological domaini273 – 282CytoplasmicSequence analysis10
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Topological domaini304 – 307PeriplasmicSequence analysis4
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 348CytoplasmicSequence analysisAdd BLAST20
Transmembranei349 – 369HelicalSequence analysisAdd BLAST21
Topological domaini370 – 373PeriplasmicSequence analysis4
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 410CytoplasmicSequence analysisAdd BLAST16

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000848391 – 410Multidrug resistance protein MdtMAdd BLAST410

Proteomic databases

PaxDbiP39386.
PRIDEiP39386.

Interactioni

Protein-protein interaction databases

BioGridi4261450. 183 interactors.
DIPiDIP-12641N.
STRINGi511145.b4337.

Structurei

3D structure databases

ProteinModelPortaliP39386.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41083G8. Bacteria.
ENOG410XT98. LUCA.
HOGENOMiHOG000118215.
InParanoidiP39386.
OMAiAPCILIP.
PhylomeDBiP39386.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39386-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRFFTRHAA TLFFPMALIL YDFAAYLSTD LIQPGIINVV RDFNADVSLA
60 70 80 90 100
PAAVSLYLAG GMALQWLLGP LSDRIGRRPV LITGALIFTL ACAATMFTTS
110 120 130 140 150
MTQFLIARAI QGTSICFIAT VGYVTVQEAF GQTKGIKLMA IITSIVLIAP
160 170 180 190 200
IIGPLSGAAL MHFMHWKVLF AIIAVMGFIS FVGLLLAMPE TVKRGAVPFS
210 220 230 240 250
AKSVLRDFRN VFCNRLFLFG AATISLSYIP MMSWVAVSPV ILIDAGSLTT
260 270 280 290 300
SQFAWTQVPV FGAVIVANAI VARFVKDPTE PRFIWRAVPI QLVGLSLLIV
310 320 330 340 350
GNLLSPHVWL WSVLGTSLYA FGIGLIFPTL FRFTLFSNKL PKGTVSASLN
360 370 380 390 400
MVILMVMSVS VEIGRWLWFN GGRLPFHLLA VVAGVIVVFT LAGLLNRVRQ
410
HQAAELVEEQ
Length:410
Mass (Da):44,688
Last modified:February 1, 1995 - v1
Checksum:i17C909971AD788B7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti128E → K in strain: B. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY283773 Genomic DNA. Translation: AAP43530.1.
U14003 Genomic DNA. Translation: AAA97233.1.
U00096 Genomic DNA. Translation: AAC77293.1.
AP009048 Genomic DNA. Translation: BAE78330.1.
PIRiS56562.
RefSeqiNP_418757.1. NC_000913.3.
WP_001137036.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77293; AAC77293; b4337.
BAE78330; BAE78330; BAE78330.
GeneIDi948861.
KEGGiecj:JW4300.
eco:b4337.
PATRICi32124280. VBIEscCol129921_4483.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY283773 Genomic DNA. Translation: AAP43530.1.
U14003 Genomic DNA. Translation: AAA97233.1.
U00096 Genomic DNA. Translation: AAC77293.1.
AP009048 Genomic DNA. Translation: BAE78330.1.
PIRiS56562.
RefSeqiNP_418757.1. NC_000913.3.
WP_001137036.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP39386.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261450. 183 interactors.
DIPiDIP-12641N.
STRINGi511145.b4337.

Protein family/group databases

TCDBi2.A.1.2.52. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP39386.
PRIDEiP39386.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77293; AAC77293; b4337.
BAE78330; BAE78330; BAE78330.
GeneIDi948861.
KEGGiecj:JW4300.
eco:b4337.
PATRICi32124280. VBIEscCol129921_4483.

Organism-specific databases

EchoBASEiEB2464.
EcoGeneiEG12576. mdtM.

Phylogenomic databases

eggNOGiENOG41083G8. Bacteria.
ENOG410XT98. LUCA.
HOGENOMiHOG000118215.
InParanoidiP39386.
OMAiAPCILIP.
PhylomeDBiP39386.

Enzyme and pathway databases

BioCyciEcoCyc:YJIO-MONOMER.
ECOL316407:JW4300-MONOMER.
MetaCyc:YJIO-MONOMER.

Miscellaneous databases

PROiP39386.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMDTM_ECOLI
AccessioniPrimary (citable) accession number: P39386
Secondary accession number(s): Q2M5X6, Q7X4V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.