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Protein

RNA 2'-phosphotransferase

Gene

kptA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
LigandNAD

Enzyme and pathway databases

BioCyciEcoCyc:G7928-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
RNA 2'-phosphotransferase (EC:2.7.1.-)
Gene namesi
Name:kptA
Synonyms:yjiI
Ordered Locus Names:b4331, JW5784
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12570 kptA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001574761 – 184RNA 2'-phosphotransferaseAdd BLAST184

Proteomic databases

PaxDbiP39380
PRIDEiP39380

Interactioni

Protein-protein interaction databases

BioGridi4259662, 111 interactors
IntActiP39380, 3 interactors
STRINGi316407.85677074

Structurei

3D structure databases

ProteinModelPortaliP39380
SMRiP39380
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KptA/TPT1 family.Curated

Phylogenomic databases

eggNOGiENOG4108UMS Bacteria
COG1859 LUCA
HOGENOMiHOG000229875
InParanoidiP39380
KOiK07559
OMAiLVHGTFW
PhylomeDBiP39380

Family and domain databases

HAMAPiMF_00299 KptA, 1 hit
InterProiView protein in InterPro
IPR002745 Ptrans_KptA/Tpt1
IPR022928 RNA_2'-PTrans_KptA
PANTHERiPTHR12684 PTHR12684, 1 hit
PfamiView protein in Pfam
PF01885 PTS_2-RNA, 1 hit

Sequencei

Sequence statusi: Complete.

P39380-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKYNEKELA DTSKFLSFVL RHKPEAIGIV LDREGWADID KLILCAQKAG
60 70 80 90 100
KRLTRALLDT VVATSDKKRF SYSSDGRCIR AVQGHSTSQV AISFAEKTPP
110 120 130 140 150
QFLYHGTASR FLDEIKKQGL IAGERHYVHL SADEATARKV GARHGSPVIL
160 170 180
TVKAQEMAKR GLPFWQAENG VWLTSTVAVE FLEW
Length:184
Mass (Da):20,530
Last modified:January 11, 2001 - v2
Checksum:i2C654B7C762E7494
GO

Sequence cautioni

The sequence AAA97227 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97227.1 Different initiation.
U00096 Genomic DNA Translation: AAC77287.2
AP009048 Genomic DNA Translation: BAE78324.1
PIRiS56556
RefSeqiNP_418751.4, NC_000913.3
WP_001151855.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77287; AAC77287; b4331
BAE78324; BAE78324; BAE78324
GeneIDi948858
KEGGiecj:JW5784
eco:b4331
PATRICifig|1411691.4.peg.2357

Similar proteinsi

Entry informationi

Entry nameiKPTA_ECOLI
AccessioniPrimary (citable) accession number: P39380
Secondary accession number(s): Q2M5Y2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 11, 2001
Last modified: March 28, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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