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Protein

RNA 2'-phosphotransferase

Gene

kptA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciEcoCyc:G7928-MONOMER.
ECOL316407:JW5784-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA 2'-phosphotransferase (EC:2.7.1.-)
Gene namesi
Name:kptA
Synonyms:yjiI
Ordered Locus Names:b4331, JW5784
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12570. kptA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 184184RNA 2'-phosphotransferasePRO_0000157476Add
BLAST

Proteomic databases

PaxDbiP39380.

Interactioni

Protein-protein interaction databases

BioGridi4259662. 102 interactions.
IntActiP39380. 3 interactions.
STRINGi511145.b4331.

Structurei

3D structure databases

ProteinModelPortaliP39380.
SMRiP39380. Positions 13-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KptA/TPT1 family.Curated

Phylogenomic databases

eggNOGiENOG4108UMS. Bacteria.
COG1859. LUCA.
HOGENOMiHOG000229875.
InParanoidiP39380.
KOiK07559.
OMAiSANGVWL.
PhylomeDBiP39380.

Family and domain databases

HAMAPiMF_00299. KptA. 1 hit.
InterProiIPR002745. Ptrans_KptA/Tpt1.
IPR022928. RNA_2'-PTrans_KptA.
[Graphical view]
PfamiPF01885. PTS_2-RNA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39380-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKYNEKELA DTSKFLSFVL RHKPEAIGIV LDREGWADID KLILCAQKAG
60 70 80 90 100
KRLTRALLDT VVATSDKKRF SYSSDGRCIR AVQGHSTSQV AISFAEKTPP
110 120 130 140 150
QFLYHGTASR FLDEIKKQGL IAGERHYVHL SADEATARKV GARHGSPVIL
160 170 180
TVKAQEMAKR GLPFWQAENG VWLTSTVAVE FLEW
Length:184
Mass (Da):20,530
Last modified:January 11, 2001 - v2
Checksum:i2C654B7C762E7494
GO

Sequence cautioni

The sequence AAA97227 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97227.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77287.2.
AP009048 Genomic DNA. Translation: BAE78324.1.
PIRiS56556.
RefSeqiNP_418751.4. NC_000913.3.
WP_001151855.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77287; AAC77287; b4331.
BAE78324; BAE78324; BAE78324.
GeneIDi948858.
KEGGiecj:JW5784.
eco:b4331.
PATRICi32124266. VBIEscCol129921_4476.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97227.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77287.2.
AP009048 Genomic DNA. Translation: BAE78324.1.
PIRiS56556.
RefSeqiNP_418751.4. NC_000913.3.
WP_001151855.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP39380.
SMRiP39380. Positions 13-180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259662. 102 interactions.
IntActiP39380. 3 interactions.
STRINGi511145.b4331.

Proteomic databases

PaxDbiP39380.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77287; AAC77287; b4331.
BAE78324; BAE78324; BAE78324.
GeneIDi948858.
KEGGiecj:JW5784.
eco:b4331.
PATRICi32124266. VBIEscCol129921_4476.

Organism-specific databases

EchoBASEiEB2458.
EcoGeneiEG12570. kptA.

Phylogenomic databases

eggNOGiENOG4108UMS. Bacteria.
COG1859. LUCA.
HOGENOMiHOG000229875.
InParanoidiP39380.
KOiK07559.
OMAiSANGVWL.
PhylomeDBiP39380.

Enzyme and pathway databases

BioCyciEcoCyc:G7928-MONOMER.
ECOL316407:JW5784-MONOMER.

Miscellaneous databases

PROiP39380.

Family and domain databases

HAMAPiMF_00299. KptA. 1 hit.
InterProiIPR002745. Ptrans_KptA/Tpt1.
IPR022928. RNA_2'-PTrans_KptA.
[Graphical view]
PfamiPF01885. PTS_2-RNA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKPTA_ECOLI
AccessioniPrimary (citable) accession number: P39380
Secondary accession number(s): Q2M5Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 11, 2001
Last modified: September 7, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.