Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Anti-adapter protein IraD

Gene

iraD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.1 Publication

GO - Molecular functioni

  • anti-sigma factor antagonist activity Source: EcoCyc

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoCyc
  • negative regulation of protein catabolic process Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciEcoCyc:G7923-MONOMER.
ECOL316407:JW5782-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-adapter protein IraD
Gene namesi
Name:iraD
Synonyms:yjiD
Ordered Locus Names:b4326, JW5782
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12565. yjiD.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 130130Anti-adapter protein IraDPRO_0000169787Add
BLAST

Proteomic databases

PaxDbiP39375.
PRIDEiP39375.

Expressioni

Inductioni

By oxidative stress.1 Publication

Interactioni

Subunit structurei

Interacts with RssB.1 Publication

Protein-protein interaction databases

BioGridi4261002. 127 interactions.
IntActiP39375. 1 interaction.
STRINGi511145.b4326.

Structurei

3D structure databases

ProteinModelPortaliP39375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GpW/Gp25 family. IraD subfamily.Curated

Phylogenomic databases

eggNOGiENOG4106PZD. Bacteria.
ENOG410YG2Q. LUCA.
HOGENOMiHOG000050876.
OMAiFKEAYCH.

Family and domain databases

HAMAPiMF_02010. IraD. 1 hit.
InterProiIPR023776. Anti-adapt_IraD.
IPR007048. GpW/Gp25/IraD.
[Graphical view]
PfamiPF04965. GPW_gp25. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39375-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRQSLQAVL PEISGNKTSS LRKSVCSDLL TLFNSPHSAL PSLLVSGMPE
60 70 80 90 100
WQVHNPSDKH LQSWYCRQLR SALLFHEPRI AALQVNLKEA YCHTLAISLE
110 120 130
IMLYHDDEPL TFDLVWDNGG WRSATLENVS
Length:130
Mass (Da):14,747
Last modified:December 1, 2000 - v2
Checksum:iAA07645C39525D90
GO

Sequence cautioni

The sequence AAA97222 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97222.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77282.2.
AP009048 Genomic DNA. Translation: BAE78319.1.
PIRiS56551.
RefSeqiNP_418746.4. NC_000913.3.
WP_001309187.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77282; AAC77282; b4326.
BAE78319; BAE78319; BAE78319.
GeneIDi948851.
KEGGiecj:JW5782.
eco:b4326.
PATRICi32124254. VBIEscCol129921_4470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97222.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77282.2.
AP009048 Genomic DNA. Translation: BAE78319.1.
PIRiS56551.
RefSeqiNP_418746.4. NC_000913.3.
WP_001309187.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP39375.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261002. 127 interactions.
IntActiP39375. 1 interaction.
STRINGi511145.b4326.

Proteomic databases

PaxDbiP39375.
PRIDEiP39375.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77282; AAC77282; b4326.
BAE78319; BAE78319; BAE78319.
GeneIDi948851.
KEGGiecj:JW5782.
eco:b4326.
PATRICi32124254. VBIEscCol129921_4470.

Organism-specific databases

EchoBASEiEB2453.
EcoGeneiEG12565. yjiD.

Phylogenomic databases

eggNOGiENOG4106PZD. Bacteria.
ENOG410YG2Q. LUCA.
HOGENOMiHOG000050876.
OMAiFKEAYCH.

Enzyme and pathway databases

BioCyciEcoCyc:G7923-MONOMER.
ECOL316407:JW5782-MONOMER.

Miscellaneous databases

PROiP39375.

Family and domain databases

HAMAPiMF_02010. IraD. 1 hit.
InterProiIPR023776. Anti-adapt_IraD.
IPR007048. GpW/Gp25/IraD.
[Graphical view]
PfamiPF04965. GPW_gp25. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIRAD_ECOLI
AccessioniPrimary (citable) accession number: P39375
Secondary accession number(s): Q2M5Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 1, 2000
Last modified: September 7, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.