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Protein

Anti-adapter protein IraD

Gene

iraD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.1 Publication

GO - Molecular functioni

  • anti-sigma factor antagonist activity Source: EcoCyc

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoCyc
  • negative regulation of protein catabolic process Source: EcoCyc

Keywordsi

Biological processStress response

Enzyme and pathway databases

BioCyciEcoCyc:G7923-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-adapter protein IraD
Gene namesi
Name:iraD
Synonyms:yjiD
Ordered Locus Names:b4326, JW5782
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12565 yjiD

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001697871 – 130Anti-adapter protein IraDAdd BLAST130

Proteomic databases

PaxDbiP39375
PRIDEiP39375

Expressioni

Inductioni

By oxidative stress (PubMed:11443091). Low expression in exponential phase, rises in stationary phase, translation is repressed by CsrA via translational coupling to the upstream open reading frame IdlP (at protein level) (PubMed:28851853).2 Publications

Interactioni

Subunit structurei

Interacts with RssB.1 Publication

Protein-protein interaction databases

BioGridi4261002, 127 interactors
IntActiP39375, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliP39375
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GpW/Gp25 family. IraD subfamily.Curated

Phylogenomic databases

eggNOGiENOG4106PZD Bacteria
ENOG410YG2Q LUCA
HOGENOMiHOG000050876
KOiK21637
OMAiFKEAYCH

Family and domain databases

HAMAPiMF_02010 IraD, 1 hit
InterProiView protein in InterPro
IPR023776 Anti-adapt_IraD
IPR007048 GpW/Gp25/IraD
PfamiView protein in Pfam
PF04965 GPW_gp25, 1 hit

Sequencei

Sequence statusi: Complete.

P39375-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRQSLQAVL PEISGNKTSS LRKSVCSDLL TLFNSPHSAL PSLLVSGMPE
60 70 80 90 100
WQVHNPSDKH LQSWYCRQLR SALLFHEPRI AALQVNLKEA YCHTLAISLE
110 120 130
IMLYHDDEPL TFDLVWDNGG WRSATLENVS
Length:130
Mass (Da):14,747
Last modified:December 1, 2000 - v2
Checksum:iAA07645C39525D90
GO

Sequence cautioni

The sequence AAA97222 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97222.1 Different initiation.
U00096 Genomic DNA Translation: AAC77282.2
AP009048 Genomic DNA Translation: BAE78319.1
PIRiS56551
RefSeqiNP_418746.4, NC_000913.3
WP_001309187.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77282; AAC77282; b4326
BAE78319; BAE78319; BAE78319
GeneIDi948851
KEGGiecj:JW5782
eco:b4326
PATRICifig|1411691.4.peg.2363

Similar proteinsi

Entry informationi

Entry nameiIRAD_ECOLI
AccessioniPrimary (citable) accession number: P39375
Secondary accession number(s): Q2M5Y7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 1, 2000
Last modified: March 28, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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