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Protein

Putative aminopeptidase SgcX

Gene

sgcX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi67Divalent metal cation 1By similarity1
Metal bindingi180Divalent metal cation 1By similarity1
Metal bindingi180Divalent metal cation 2By similarity1
Active sitei212Proton acceptorBy similarity1
Metal bindingi213Divalent metal cation 2By similarity1
Metal bindingi235Divalent metal cation 1By similarity1
Metal bindingi329Divalent metal cation 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding

Enzyme and pathway databases

BioCyciEcoCyc:SGCB-MONOMER

Protein family/group databases

MEROPSiM42.A01

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aminopeptidase SgcX (EC:3.4.11.-)
Gene namesi
Name:sgcX
Synonyms:yjhO
Ordered Locus Names:b4305, JW5776
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12557 sgcX

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000716561 – 373Putative aminopeptidase SgcXAdd BLAST373

Proteomic databases

PaxDbiP39366
PRIDEiP39366

Interactioni

Protein-protein interaction databases

BioGridi4262743, 3 interactors
DIPiDIP-10881N
STRINGi316385.ECDH10B_4507

Structurei

3D structure databases

ProteinModelPortaliP39366
SMRiP39366
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M42 family.Curated

Phylogenomic databases

eggNOGiENOG4105CN9 Bacteria
COG1363 LUCA
HOGENOMiHOG000291972
InParanoidiP39366
KOiK20609
OMAiGGFMIAE
PhylomeDBiP39366

Family and domain databases

Gene3Di2.40.30.40, 1 hit
InterProiView protein in InterPro
IPR008007 Peptidase_M42
IPR023367 Peptidase_M42_dom2
PfamiView protein in Pfam
PF05343 Peptidase_M42, 1 hit
PIRSFiPIRSF001123 PepA_GA, 1 hit

Sequencei

Sequence statusi: Complete.

P39366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSVQETLF SLLQHNAISG HENAVADVML CEFRRQAKEV WRDRLGNVVA
60 70 80 90 100
RYGSDKPDAL RLMIFAHMDE VGFMVRKIEP SGFLRFERVG GPAQVTMAGS
110 120 130 140 150
IVTLTGDKGP VMGCIGIKSY HFAKGDERTQ SPSVDKLWID IGAKDKDDAI
160 170 180 190 200
RMGIQVGTPV TLYNPPQLLA NDLVCSKALD DRLGCTALLG VADAISTMEL
210 220 230 240 250
DIAVYLVASV QEEFNIRGIV PVLRRVKPDL AIGIDITPSC DTPDLHDYSE
260 270 280 290 300
VRINQGVGIT CLNYHGRGTL AGLITPPRLI RMLEQTALEH NIPVQREVAP
310 320 330 340 350
GVITETGYIQ VEQDGIPCAS LSIPCRYTHS PAEVASLRDL TDCIRLLTAL
360 370
AGMSAAHFPV EPDSGTTQEA HPL
Length:373
Mass (Da):40,615
Last modified:January 23, 2002 - v3
Checksum:iCAC872934C3A017A
GO

Sequence cautioni

The sequence AAA97201 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125G → A in AAA97201 (PubMed:7610040).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97201.1 Different initiation.
U00096 Genomic DNA Translation: AAC77261.2
AP009048 Genomic DNA Translation: BAE78297.1
PIRiC65244
RefSeqiNP_418725.4, NC_000913.3
WP_000010829.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77261; AAC77261; b4305
BAE78297; BAE78297; BAE78297
GeneIDi948840
KEGGiecj:JW5776
eco:b4305
PATRICifig|1411691.4.peg.2391

Similar proteinsi

Entry informationi

Entry nameiSGCX_ECOLI
AccessioniPrimary (citable) accession number: P39366
Secondary accession number(s): Q2M609
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2002
Last modified: March 28, 2018
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health