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Protein

Putative aminopeptidase SgcX

Gene

sgcX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi67Divalent metal cation 1By similarity1
Metal bindingi180Divalent metal cation 1By similarity1
Metal bindingi180Divalent metal cation 2By similarity1
Active sitei212Proton acceptorBy similarity1
Metal bindingi213Divalent metal cation 2By similarity1
Metal bindingi235Divalent metal cation 1By similarity1
Metal bindingi329Divalent metal cation 2By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:SGCB-MONOMER.
ECOL316407:JW5776-MONOMER.

Protein family/group databases

MEROPSiM42.A01.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aminopeptidase SgcX (EC:3.4.11.-)
Gene namesi
Name:sgcX
Synonyms:yjhO
Ordered Locus Names:b4305, JW5776
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12557. sgcX.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000716561 – 373Putative aminopeptidase SgcXAdd BLAST373

Proteomic databases

PaxDbiP39366.
PRIDEiP39366.

Interactioni

Protein-protein interaction databases

BioGridi4262743. 3 interactors.
DIPiDIP-10881N.
STRINGi511145.b4305.

Structurei

3D structure databases

ProteinModelPortaliP39366.
SMRiP39366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M42 family.Curated

Phylogenomic databases

eggNOGiENOG4105CN9. Bacteria.
COG1363. LUCA.
HOGENOMiHOG000291972.
InParanoidiP39366.
KOiK20609.
OMAiICHPTIV.
PhylomeDBiP39366.

Family and domain databases

Gene3Di2.40.30.40. 1 hit.
InterProiIPR008007. Peptidase_M42.
IPR023367. Peptidase_M42_dom2.
[Graphical view]
PfamiPF05343. Peptidase_M42. 1 hit.
[Graphical view]
PIRSFiPIRSF001123. PepA_GA. 1 hit.

Sequencei

Sequence statusi: Complete.

P39366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSVQETLF SLLQHNAISG HENAVADVML CEFRRQAKEV WRDRLGNVVA
60 70 80 90 100
RYGSDKPDAL RLMIFAHMDE VGFMVRKIEP SGFLRFERVG GPAQVTMAGS
110 120 130 140 150
IVTLTGDKGP VMGCIGIKSY HFAKGDERTQ SPSVDKLWID IGAKDKDDAI
160 170 180 190 200
RMGIQVGTPV TLYNPPQLLA NDLVCSKALD DRLGCTALLG VADAISTMEL
210 220 230 240 250
DIAVYLVASV QEEFNIRGIV PVLRRVKPDL AIGIDITPSC DTPDLHDYSE
260 270 280 290 300
VRINQGVGIT CLNYHGRGTL AGLITPPRLI RMLEQTALEH NIPVQREVAP
310 320 330 340 350
GVITETGYIQ VEQDGIPCAS LSIPCRYTHS PAEVASLRDL TDCIRLLTAL
360 370
AGMSAAHFPV EPDSGTTQEA HPL
Length:373
Mass (Da):40,615
Last modified:January 23, 2002 - v3
Checksum:iCAC872934C3A017A
GO

Sequence cautioni

The sequence AAA97201 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125G → A in AAA97201 (PubMed:7610040).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97201.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77261.2.
AP009048 Genomic DNA. Translation: BAE78297.1.
PIRiC65244.
RefSeqiNP_418725.4. NC_000913.3.
WP_000010829.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77261; AAC77261; b4305.
BAE78297; BAE78297; BAE78297.
GeneIDi948840.
KEGGiecj:JW5776.
eco:b4305.
PATRICi32124198. VBIEscCol129921_4442.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97201.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77261.2.
AP009048 Genomic DNA. Translation: BAE78297.1.
PIRiC65244.
RefSeqiNP_418725.4. NC_000913.3.
WP_000010829.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP39366.
SMRiP39366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262743. 3 interactors.
DIPiDIP-10881N.
STRINGi511145.b4305.

Protein family/group databases

MEROPSiM42.A01.

Proteomic databases

PaxDbiP39366.
PRIDEiP39366.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77261; AAC77261; b4305.
BAE78297; BAE78297; BAE78297.
GeneIDi948840.
KEGGiecj:JW5776.
eco:b4305.
PATRICi32124198. VBIEscCol129921_4442.

Organism-specific databases

EchoBASEiEB2445.
EcoGeneiEG12557. sgcX.

Phylogenomic databases

eggNOGiENOG4105CN9. Bacteria.
COG1363. LUCA.
HOGENOMiHOG000291972.
InParanoidiP39366.
KOiK20609.
OMAiICHPTIV.
PhylomeDBiP39366.

Enzyme and pathway databases

BioCyciEcoCyc:SGCB-MONOMER.
ECOL316407:JW5776-MONOMER.

Miscellaneous databases

PROiP39366.

Family and domain databases

Gene3Di2.40.30.40. 1 hit.
InterProiIPR008007. Peptidase_M42.
IPR023367. Peptidase_M42_dom2.
[Graphical view]
PfamiPF05343. Peptidase_M42. 1 hit.
[Graphical view]
PIRSFiPIRSF001123. PepA_GA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSGCX_ECOLI
AccessioniPrimary (citable) accession number: P39366
Secondary accession number(s): Q2M609
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2002
Last modified: November 2, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.