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Protein

Putative permease IIC component

Gene

sgcC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Phosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:SGCC-MONOMER.
ECOL316407:JW4266-MONOMER.

Protein family/group databases

TCDBi4.A.5.1.3. the pts galactitol (gat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative permease IIC component
Alternative name(s):
Putative PTS system EIIC component
Gene namesi
Name:sgcC
Synonyms:yjhN
Ordered Locus Names:b4304, JW4266
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12556. sgcC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei35 – 5521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei88 – 10821HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei134 – 15421HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei173 – 19321HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei215 – 23521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei236 – 25621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei302 – 32221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei325 – 34521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei354 – 37421HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei385 – 40521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei410 – 43021HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Putative permease IIC componentPRO_0000186691Add
BLAST

Proteomic databases

PaxDbiP39365.
PRIDEiP39365.

Interactioni

Protein-protein interaction databases

BioGridi4262751. 6 interactions.
STRINGi511145.b4304.

Structurei

3D structure databases

ProteinModelPortaliP39365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 437436PTS EIIC type-2PROSITE-ProRule annotationAdd
BLAST

Domaini

The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.

Sequence similaritiesi

Contains 1 PTS EIIC type-2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DT3. Bacteria.
COG3775. LUCA.
HOGENOMiHOG000053574.
InParanoidiP39365.
KOiK02775.
OMAiMQALSPI.
OrthoDBiEOG6G4VV9.
PhylomeDBiP39365.

Family and domain databases

InterProiIPR013853. GatC.
IPR013014. PTS_EIIC_2.
IPR004703. PTS_sugar-sp_permease.
[Graphical view]
PfamiPF03611. EIIC-GAT. 1 hit.
[Graphical view]
PIRSFiPIRSF006304. GatC. 1 hit.
TIGRFAMsiTIGR00827. EIIC-GAT. 1 hit.
PROSITEiPS51104. PTS_EIIC_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39365-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDYILSLGG TVFVPIIMIV IGLIFRIPWL QAIKAGVTVG IGFVGMGLVI
60 70 80 90 100
VMAIDSLSPP IKVMIERFGL ALHVFDVGAG PASGVGYATA IGAMIIPVIF
110 120 130 140 150
LLNVAMLVTR LTKTMNVDIY NYWHYAITGT VVQLMTGSLI YGVLGAICHA
160 170 180 190 200
ALSLKMADWT AKRVQNIVGL EGISIPQGYG SSSVPLFVLL DAIYEKIPFM
210 220 230 240 250
KGRNIDAQEI QKRYGMVGDP VIIGVVLGLI FGLAAGEGFK GCASLMITVA
260 270 280 290 300
AIMVLFPRMI RLIVEGLLPI SDGARKFFQK YFKGREVYIG LDTAVTLGHP
310 320 330 340 350
TTIAVGLLLI PIMLILASIL PGNKVLPLAD LPVAPFFICM ATVIHRGDLV
360 370 380 390 400
RTLISGVIVM ITVLLIATQF APYFTEMALK GGFSFAGESA QISALSVGNM
410 420 430
FGWSISELMS LGIIGVVVAV GIVASVVLFL RKRELSE
Length:437
Mass (Da):46,684
Last modified:February 1, 1995 - v1
Checksum:i5FE8C034BD925F21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97200.1.
U00096 Genomic DNA. Translation: AAC77260.1.
AP009048 Genomic DNA. Translation: BAE78295.1.
PIRiS56529.
RefSeqiNP_418724.1. NC_000913.3.
WP_000460843.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77260; AAC77260; b4304.
BAE78295; BAE78295; BAE78295.
GeneIDi946849.
KEGGiecj:JW4266.
eco:b4304.
PATRICi32124194. VBIEscCol129921_4440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97200.1.
U00096 Genomic DNA. Translation: AAC77260.1.
AP009048 Genomic DNA. Translation: BAE78295.1.
PIRiS56529.
RefSeqiNP_418724.1. NC_000913.3.
WP_000460843.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP39365.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262751. 6 interactions.
STRINGi511145.b4304.

Protein family/group databases

TCDBi4.A.5.1.3. the pts galactitol (gat) family.

Proteomic databases

PaxDbiP39365.
PRIDEiP39365.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77260; AAC77260; b4304.
BAE78295; BAE78295; BAE78295.
GeneIDi946849.
KEGGiecj:JW4266.
eco:b4304.
PATRICi32124194. VBIEscCol129921_4440.

Organism-specific databases

EchoBASEiEB2444.
EcoGeneiEG12556. sgcC.

Phylogenomic databases

eggNOGiENOG4105DT3. Bacteria.
COG3775. LUCA.
HOGENOMiHOG000053574.
InParanoidiP39365.
KOiK02775.
OMAiMQALSPI.
OrthoDBiEOG6G4VV9.
PhylomeDBiP39365.

Enzyme and pathway databases

BioCyciEcoCyc:SGCC-MONOMER.
ECOL316407:JW4266-MONOMER.

Miscellaneous databases

PROiP39365.

Family and domain databases

InterProiIPR013853. GatC.
IPR013014. PTS_EIIC_2.
IPR004703. PTS_sugar-sp_permease.
[Graphical view]
PfamiPF03611. EIIC-GAT. 1 hit.
[Graphical view]
PIRSFiPIRSF006304. GatC. 1 hit.
TIGRFAMsiTIGR00827. EIIC-GAT. 1 hit.
PROSITEiPS51104. PTS_EIIC_TYPE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes."
    Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.
    Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Novel phosphotransferases system genes revealed by bacterial genome analysis: operons encoding homologues of sugar-specific permease domains of the phosphotransferase system and pentose catabolic enzymes."
    Reizer J., Charbit A., Reizer A., Saier M.H. Jr.
    Genome Sci. Technol. 1:53-75(1996)
    Cited for: DISCUSSION OF SEQUENCE.
  5. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiSGCC_ECOLI
AccessioniPrimary (citable) accession number: P39365
Secondary accession number(s): Q2M611
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 6, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.