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Protein

Putative permease IIC component

Gene

sgcC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processPhosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:SGCC-MONOMER
MetaCyc:SGCC-MONOMER

Protein family/group databases

TCDBi4.A.5.1.3 the pts galactitol (gat) family

Names & Taxonomyi

Protein namesi
Recommended name:
Putative permease IIC component
Alternative name(s):
Putative PTS system EIIC component
Gene namesi
Name:sgcC
Synonyms:yjhN
Ordered Locus Names:b4304, JW4266
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12556 sgcC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei35 – 55HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei88 – 108HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei134 – 154HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei173 – 193HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei215 – 235HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei236 – 256HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei302 – 322HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei325 – 345HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei354 – 374HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei385 – 405HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei410 – 430HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001866911 – 437Putative permease IIC componentAdd BLAST437

Proteomic databases

PaxDbiP39365
PRIDEiP39365

Interactioni

Protein-protein interaction databases

BioGridi4262751, 8 interactors
STRINGi316385.ECDH10B_4505

Structurei

3D structure databases

ProteinModelPortaliP39365
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 437PTS EIIC type-2PROSITE-ProRule annotationAdd BLAST436

Domaini

The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DT3 Bacteria
COG3775 LUCA
HOGENOMiHOG000053574
InParanoidiP39365
KOiK02775
OMAiFGFMIWG
PhylomeDBiP39365

Family and domain databases

InterProiView protein in InterPro
IPR013853 GatC
IPR013014 PTS_EIIC_2
IPR004703 PTS_sugar-sp_permease
PANTHERiPTHR37324 PTHR37324, 1 hit
PfamiView protein in Pfam
PF03611 EIIC-GAT, 1 hit
PIRSFiPIRSF006304 GatC, 1 hit
TIGRFAMsiTIGR00827 EIIC-GAT, 1 hit
PROSITEiView protein in PROSITE
PS51104 PTS_EIIC_TYPE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P39365-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDYILSLGG TVFVPIIMIV IGLIFRIPWL QAIKAGVTVG IGFVGMGLVI
60 70 80 90 100
VMAIDSLSPP IKVMIERFGL ALHVFDVGAG PASGVGYATA IGAMIIPVIF
110 120 130 140 150
LLNVAMLVTR LTKTMNVDIY NYWHYAITGT VVQLMTGSLI YGVLGAICHA
160 170 180 190 200
ALSLKMADWT AKRVQNIVGL EGISIPQGYG SSSVPLFVLL DAIYEKIPFM
210 220 230 240 250
KGRNIDAQEI QKRYGMVGDP VIIGVVLGLI FGLAAGEGFK GCASLMITVA
260 270 280 290 300
AIMVLFPRMI RLIVEGLLPI SDGARKFFQK YFKGREVYIG LDTAVTLGHP
310 320 330 340 350
TTIAVGLLLI PIMLILASIL PGNKVLPLAD LPVAPFFICM ATVIHRGDLV
360 370 380 390 400
RTLISGVIVM ITVLLIATQF APYFTEMALK GGFSFAGESA QISALSVGNM
410 420 430
FGWSISELMS LGIIGVVVAV GIVASVVLFL RKRELSE
Length:437
Mass (Da):46,684
Last modified:February 1, 1995 - v1
Checksum:i5FE8C034BD925F21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97200.1
U00096 Genomic DNA Translation: AAC77260.1
AP009048 Genomic DNA Translation: BAE78295.1
PIRiS56529
RefSeqiNP_418724.1, NC_000913.3
WP_000460843.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77260; AAC77260; b4304
BAE78295; BAE78295; BAE78295
GeneIDi946849
KEGGiecj:JW4266
eco:b4304
PATRICifig|1411691.4.peg.2393

Similar proteinsi

Entry informationi

Entry nameiSGCC_ECOLI
AccessioniPrimary (citable) accession number: P39365
Secondary accession number(s): Q2M611
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health