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Protein

Putative phosphotransferase IIA component SgcA

Gene

sgcA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.By similarity

Catalytic activityi

Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei63 – 631Tele-phosphohistidine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Phosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:SGCA-MONOMER.
ECOL316407:JW4264-MONOMER.

Protein family/group databases

TCDBi4.A.5.1.3. the pts galactitol (gat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative phosphotransferase IIA component SgcA (EC:2.7.1.-)
Alternative name(s):
Putative PTS system EIIA component
Gene namesi
Name:sgcA
Synonyms:yjhL
Ordered Locus Names:b4302, JW4264
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12554. sgcA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 143143Putative phosphotransferase IIA component SgcAPRO_0000186689Add
BLAST

Proteomic databases

PaxDbiP39363.

Interactioni

Protein-protein interaction databases

BioGridi4261489. 8 interactions.
IntActiP39363. 7 interactions.
STRINGi511145.b4302.

Structurei

3D structure databases

ProteinModelPortaliP39363.
SMRiP39363. Positions 8-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 143143PTS EIIA type-2PROSITE-ProRule annotationAdd
BLAST

Domaini

The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.

Sequence similaritiesi

Contains 1 PTS EIIA type-2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108XBJ. Bacteria.
ENOG4111P54. LUCA.
HOGENOMiHOG000227560.
KOiK02773.
OMAiTHIRTIQ.
OrthoDBiEOG68DCVK.
PhylomeDBiP39363.

Family and domain databases

Gene3Di3.40.930.10. 1 hit.
InterProiIPR016152. PTrfase/Anion_transptr.
IPR002178. PTS_EIIA_type-2_dom.
[Graphical view]
PfamiPF00359. PTS_EIIA_2. 1 hit.
[Graphical view]
SUPFAMiSSF55804. SSF55804. 1 hit.
PROSITEiPS51094. PTS_EIIA_TYPE_2. 1 hit.
PS00372. PTS_EIIA_TYPE_2_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39363-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINDIKWVQA QRKATDWRQA VEIATRPLVA YGAAQPCYVN GIIENTLNWG
60 70 80 90 100
PYYLIAPGIA LPHARPEQGA NYNQVSITTL RTPVAFGNEE CDPVWLLLCV
110 120 130 140
SATDANAHIL TIQRISQFID SPQRLTAVGN ASTDDALFAL VSG
Length:143
Mass (Da):15,638
Last modified:February 1, 1995 - v1
Checksum:i24F59C5C4C3BC56A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97198.1.
U00096 Genomic DNA. Translation: AAC77258.1.
AP009048 Genomic DNA. Translation: BAE78293.1.
PIRiH65243.
RefSeqiNP_418722.1. NC_000913.3.
WP_000606406.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77258; AAC77258; b4302.
BAE78293; BAE78293; BAE78293.
GeneIDi948831.
KEGGiecj:JW4264.
eco:b4302.
PATRICi32124190. VBIEscCol129921_4438.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97198.1.
U00096 Genomic DNA. Translation: AAC77258.1.
AP009048 Genomic DNA. Translation: BAE78293.1.
PIRiH65243.
RefSeqiNP_418722.1. NC_000913.3.
WP_000606406.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP39363.
SMRiP39363. Positions 8-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261489. 8 interactions.
IntActiP39363. 7 interactions.
STRINGi511145.b4302.

Protein family/group databases

TCDBi4.A.5.1.3. the pts galactitol (gat) family.

Proteomic databases

PaxDbiP39363.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77258; AAC77258; b4302.
BAE78293; BAE78293; BAE78293.
GeneIDi948831.
KEGGiecj:JW4264.
eco:b4302.
PATRICi32124190. VBIEscCol129921_4438.

Organism-specific databases

EchoBASEiEB2442.
EcoGeneiEG12554. sgcA.

Phylogenomic databases

eggNOGiENOG4108XBJ. Bacteria.
ENOG4111P54. LUCA.
HOGENOMiHOG000227560.
KOiK02773.
OMAiTHIRTIQ.
OrthoDBiEOG68DCVK.
PhylomeDBiP39363.

Enzyme and pathway databases

BioCyciEcoCyc:SGCA-MONOMER.
ECOL316407:JW4264-MONOMER.

Miscellaneous databases

PROiP39363.

Family and domain databases

Gene3Di3.40.930.10. 1 hit.
InterProiIPR016152. PTrfase/Anion_transptr.
IPR002178. PTS_EIIA_type-2_dom.
[Graphical view]
PfamiPF00359. PTS_EIIA_2. 1 hit.
[Graphical view]
SUPFAMiSSF55804. SSF55804. 1 hit.
PROSITEiPS51094. PTS_EIIA_TYPE_2. 1 hit.
PS00372. PTS_EIIA_TYPE_2_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes."
    Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.
    Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Novel phosphotransferases system genes revealed by bacterial genome analysis: operons encoding homologues of sugar-specific permease domains of the phosphotransferase system and pentose catabolic enzymes."
    Reizer J., Charbit A., Reizer A., Saier M.H. Jr.
    Genome Sci. Technol. 1:53-75(1996)
    Cited for: DISCUSSION OF SEQUENCE.

Entry informationi

Entry nameiSGCA_ECOLI
AccessioniPrimary (citable) accession number: P39363
Secondary accession number(s): Q2M613
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 20, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.