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Protein

Putative phosphotransferase IIA component SgcA

Gene

sgcA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei63Tele-phosphohistidine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processPhosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:SGCA-MONOMER
MetaCyc:SGCA-MONOMER

Protein family/group databases

TCDBi4.A.5.1.3 the pts galactitol (gat) family

Names & Taxonomyi

Protein namesi
Recommended name:
Putative phosphotransferase IIA component SgcA
Alternative name(s):
Putative PTS system EIIA component
Gene namesi
Name:sgcA
Synonyms:yjhL
Ordered Locus Names:b4302, JW4264
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12554 sgcA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001866891 – 143Putative phosphotransferase IIA component SgcAAdd BLAST143

Proteomic databases

PaxDbiP39363
PRIDEiP39363

Interactioni

Protein-protein interaction databases

BioGridi4261489, 8 interactors
IntActiP39363, 7 interactors
STRINGi316385.ECDH10B_4503

Structurei

3D structure databases

ProteinModelPortaliP39363
SMRiP39363
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 143PTS EIIA type-2PROSITE-ProRule annotationAdd BLAST143

Domaini

The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.

Phylogenomic databases

eggNOGiENOG4108XBJ Bacteria
ENOG4111P54 LUCA
HOGENOMiHOG000227560
KOiK02773
OMAiMPHALAT
PhylomeDBiP39363

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR016152 PTrfase/Anion_transptr
IPR002178 PTS_EIIA_type-2_dom
PfamiView protein in Pfam
PF00359 PTS_EIIA_2, 1 hit
SUPFAMiSSF55804 SSF55804, 1 hit
PROSITEiView protein in PROSITE
PS51094 PTS_EIIA_TYPE_2, 1 hit
PS00372 PTS_EIIA_TYPE_2_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

P39363-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINDIKWVQA QRKATDWRQA VEIATRPLVA YGAAQPCYVN GIIENTLNWG
60 70 80 90 100
PYYLIAPGIA LPHARPEQGA NYNQVSITTL RTPVAFGNEE CDPVWLLLCV
110 120 130 140
SATDANAHIL TIQRISQFID SPQRLTAVGN ASTDDALFAL VSG
Length:143
Mass (Da):15,638
Last modified:February 1, 1995 - v1
Checksum:i24F59C5C4C3BC56A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97198.1
U00096 Genomic DNA Translation: AAC77258.1
AP009048 Genomic DNA Translation: BAE78293.1
PIRiH65243
RefSeqiNP_418722.1, NC_000913.3
WP_000606406.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77258; AAC77258; b4302
BAE78293; BAE78293; BAE78293
GeneIDi948831
KEGGiecj:JW4264
eco:b4302
PATRICifig|1411691.4.peg.2395

Similar proteinsi

Entry informationi

Entry nameiSGCA_ECOLI
AccessioniPrimary (citable) accession number: P39363
Secondary accession number(s): Q2M613
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health