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Protein

Protein SgcE

Gene

sgcE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable pentose-5-phosphate 3-epimerase.

Cofactori

Co2+By similarity, Fe2+By similarity, Mn2+By similarity, Zn2+By similarityNote: Binds 1 divalent metal cation per subunit. Active with Co2+, Fe2+, Mn2+ and Zn2+.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei6 – 61SubstrateBy similarity
Metal bindingi31 – 311Divalent metal cationBy similarity
Active sitei33 – 331Proton acceptorBy similarity
Metal bindingi33 – 331Divalent metal cationBy similarity
Metal bindingi64 – 641Divalent metal cationBy similarity
Binding sitei64 – 641SubstrateBy similarity
Active sitei169 – 1691Proton donorBy similarity
Metal bindingi169 – 1691Divalent metal cationBy similarity
Binding sitei171 – 1711Substrate; via amide nitrogenBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Cobalt, Iron, Manganese, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:G7914-MONOMER.
ECOL316407:JW4263-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SgcE (EC:5.1.3.-)
Gene namesi
Name:sgcE
Synonyms:yjhK
Ordered Locus Names:b4301, JW4263
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12553. sgcE.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Protein SgcEPRO_0000171586Add
BLAST

Proteomic databases

PaxDbiP39362.

Interactioni

Protein-protein interaction databases

BioGridi4260976. 6 interactions.
DIPiDIP-10878N.
IntActiP39362. 5 interactions.
STRINGi511145.b4301.

Structurei

3D structure databases

ProteinModelPortaliP39362.
SMRiP39362. Positions 30-204.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni140 – 1434Substrate bindingBy similarity
Regioni191 – 1922Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108RK0. Bacteria.
COG0036. LUCA.
HOGENOMiHOG000259347.
InParanoidiP39362.
KOiK14587.
OMAiPYLNDVE.
PhylomeDBiP39362.

Family and domain databases

CDDicd00429. RPE. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000056. Ribul_P_3_epim-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PANTHERiPTHR11749. PTHR11749. 1 hit.
PfamiPF00834. Ribul_P_3_epim. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
PROSITEiPS01085. RIBUL_P_3_EPIMER_1. 1 hit.
PS01086. RIBUL_P_3_EPIMER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39362-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILHPSLASA NPLHYGRELT ALDNLDFGSL HLDIEDSSFI NNITFGMKTV
60 70 80 90 100
QAVARQTPHP LSFHFMLARP QRWFNALAEI RPAWIFVHAE TLDYPSETLT
110 120 130 140 150
EIRHTGARAG LVFNPATPID AWRYLASELD GVMVMTSEPD GQGQRFIPSM
160 170 180 190 200
CEKIQKVRTA FPQTECWADG GITLAAAQQL AAAGAQHMVI GRALFSSSDY
210
RATLAQFATL
Length:210
Mass (Da):23,214
Last modified:February 1, 1995 - v1
Checksum:i5DDC3C0B09DAFB50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97197.1.
U00096 Genomic DNA. Translation: AAC77257.1.
AP009048 Genomic DNA. Translation: BAE78292.1.
PIRiS56526.
RefSeqiNP_418721.1. NC_000913.3.
WP_000600622.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77257; AAC77257; b4301.
BAE78292; BAE78292; BAE78292.
GeneIDi948829.
KEGGiecj:JW4263.
eco:b4301.
PATRICi32124188. VBIEscCol129921_4437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97197.1.
U00096 Genomic DNA. Translation: AAC77257.1.
AP009048 Genomic DNA. Translation: BAE78292.1.
PIRiS56526.
RefSeqiNP_418721.1. NC_000913.3.
WP_000600622.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP39362.
SMRiP39362. Positions 30-204.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260976. 6 interactions.
DIPiDIP-10878N.
IntActiP39362. 5 interactions.
STRINGi511145.b4301.

Proteomic databases

PaxDbiP39362.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77257; AAC77257; b4301.
BAE78292; BAE78292; BAE78292.
GeneIDi948829.
KEGGiecj:JW4263.
eco:b4301.
PATRICi32124188. VBIEscCol129921_4437.

Organism-specific databases

EchoBASEiEB2441.
EcoGeneiEG12553. sgcE.

Phylogenomic databases

eggNOGiENOG4108RK0. Bacteria.
COG0036. LUCA.
HOGENOMiHOG000259347.
InParanoidiP39362.
KOiK14587.
OMAiPYLNDVE.
PhylomeDBiP39362.

Enzyme and pathway databases

BioCyciEcoCyc:G7914-MONOMER.
ECOL316407:JW4263-MONOMER.

Miscellaneous databases

PROiP39362.

Family and domain databases

CDDicd00429. RPE. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000056. Ribul_P_3_epim-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PANTHERiPTHR11749. PTHR11749. 1 hit.
PfamiPF00834. Ribul_P_3_epim. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
PROSITEiPS01085. RIBUL_P_3_EPIMER_1. 1 hit.
PS01086. RIBUL_P_3_EPIMER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSGCE_ECOLI
AccessioniPrimary (citable) accession number: P39362
Secondary accession number(s): Q2M614
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.