Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable 2-dehydro-3-deoxy-D-pentonate aldolase YjhH

Gene

yjhH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a 2-dehydro-3-deoxy-D-pentonate aldolase.1 Publication

Catalytic activityi

2-dehydro-3-deoxy-D-pentonate = pyruvate + glycolaldehyde.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei46Charge relay systemBy similarity1
Active sitei109Charge relay systemBy similarity1
Active sitei135Proton donorBy similarity1
Active sitei164Schiff-base intermediate with substrateBy similarity1

GO - Molecular functioni

  • 2-dehydro-3-deoxy-D-pentonate aldolase activity Source: EcoCyc

GO - Biological processi

  • aldonic acid catabolic process Source: EcoCyc

Keywordsi

Molecular functionLyase
LigandSchiff base

Enzyme and pathway databases

BioCyciEcoCyc:G7911-MONOMER
MetaCyc:G7911-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-dehydro-3-deoxy-D-pentonate aldolase YjhHCurated (EC:4.1.2.281 Publication)
Gene namesi
Name:yjhH
Ordered Locus Names:b4298, JW5775
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12550 yjhH

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Disruption mutant has reduced ability to catabolize D-xylonic acid. YjhH-yagE double mutant cannot use D-xylonate as the sole source of carbon.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001032451 – 301Probable 2-dehydro-3-deoxy-D-pentonate aldolase YjhHAdd BLAST301

Proteomic databases

PaxDbiP39359
PRIDEiP39359

Interactioni

Protein-protein interaction databases

BioGridi4260972, 5 interactors
DIPiDIP-12622N
IntActiP39359, 1 interactor
STRINGi316385.ECDH10B_4499

Structurei

3D structure databases

ProteinModelPortaliP39359
SMRiP39359
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DapA family.Curated

Phylogenomic databases

eggNOGiENOG4105CDP Bacteria
COG0329 LUCA
HOGENOMiHOG000173604
InParanoidiP39359
KOiK22397
OMAiEIPYRTR
PhylomeDBiP39359

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR002220 DapA-like
IPR020625 Schiff_base-form_aldolases_AS
IPR020624 Schiff_base-form_aldolases_CS
PANTHERiPTHR12128 PTHR12128, 1 hit
PfamiView protein in Pfam
PF00701 DHDPS, 1 hit
PIRSFiPIRSF001365 DHDPS, 1 hit
PRINTSiPR00146 DHPICSNTHASE
SMARTiView protein in SMART
SM01130 DHDPS, 1 hit
PROSITEiView protein in PROSITE
PS00665 DHDPS_1, 1 hit
PS00666 DHDPS_2, 1 hit

Sequencei

Sequence statusi: Complete.

P39359-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKFSGIIPP VSSTFHRDGT LDKKAMREVA DFLINKGVDG LFYLGTGGEF
60 70 80 90 100
SQMNTAQRMA LAEEAVTIVD GRVPVLIGVG SPSTDEAVKL AQHAQAYGAD
110 120 130 140 150
GIVAINPYYW KVAPRNLDDY YQQIARSVTL PVILYNFPDL TGQDLTPETV
160 170 180 190 200
TRLALQNENI VGIKDTIDSV GHLRTMINTV KSVRPSFSVF CGYDDHLLNT
210 220 230 240 250
MLLGGDGAIT ASANFAPELS VGIYRAWREG DLATAATLNK KLLQLPAIYA
260 270 280 290 300
LETPFVSLIK YSMQCVGLPV ETYCLPPILE ASEEAKDKVH VLLTAQGILP

V
Length:301
Mass (Da):32,722
Last modified:May 30, 2000 - v2
Checksum:iA83BE11A0B134E46
GO

Sequence cautioni

The sequence AAA97194 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97194.1 Different initiation.
U00096 Genomic DNA Translation: AAC77254.2
AP009048 Genomic DNA Translation: BAE78289.1
PIRiS56523
RefSeqiNP_418718.4, NC_000913.3
WP_000714563.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77254; AAC77254; b4298
BAE78289; BAE78289; BAE78289
GeneIDi948825
KEGGiecj:JW5775
eco:b4298
PATRICifig|511145.12.peg.4434

Entry informationi

Entry nameiYJHH_ECOLI
AccessioniPrimary (citable) accession number: P39359
Secondary accession number(s): Q2M617
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 30, 2000
Last modified: March 28, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health