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Protein

Putative protein IntB

Gene

intB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei353O-(3'-phospho-DNA)-tyrosine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA integration, DNA recombination, Viral genome integration, Virus entry into host cell

Enzyme and pathway databases

BioCyciEcoCyc:EG12364-MONOMER.
ECOL316407:JW4227-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative protein IntBCurated
Alternative name(s):
Int(P4)
Putative prophage P4 integrase
Gene namesi
Name:intB
Ordered Locus Names:b4271, JW4227
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12364. intB.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001975121 – 396Putative protein IntBAdd BLAST396

Proteomic databases

PRIDEiP39347.

Interactioni

Protein-protein interaction databases

BioGridi4262732. 18 interactors.
DIPiDIP-10035N.
IntActiP39347. 15 interactors.
STRINGi316407.85677017.

Structurei

3D structure databases

ProteinModelPortaliP39347.
SMRiP39347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 'phage' integrase family.Curated

Phylogenomic databases

eggNOGiCOG0582. LUCA.
HOGENOMiHOG000263105.
InParanoidiP39347.
OMAiWSEEHAN.
PhylomeDBiP39347.

Family and domain databases

Gene3Di1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
InterProiIPR011010. DNA_brk_join_enz.
IPR025166. DUF4102.
IPR013762. Integrase-like_cat.
IPR002104. Integrase_catalytic.
IPR023109. Integrase_recombinase_N.
[Graphical view]
PfamiPF13356. DUF4102. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 1 hit.

Sequencei

Sequence statusi: Complete.

P39347-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLLVHPNGS KYWRLQYRYE GKQKMLALGV YPEITLADAR VRRDEARKLL
60 70 80 90 100
ANGVDPGDKK KNDKVEQSKA RTFKEVAIEW HGTNKKWSED HAHRVLKSLE
110 120 130 140 150
DNLFAALGER NIAELKTRDL LAPIKAVEMS GRLEVAARLQ QRTTAIMRYA
160 170 180 190 200
VQSGLIDYNP AQEMAGAVAS CNRQHRPALE LKRIPELLTK IDSYTGRPLT
210 220 230 240 250
RWAIELTLLI FIRSSELRFA RWSEIDFEAS IWTIPPEREP IPGVKHSHRG
260 270 280 290 300
SKMRTTHLVP LSTQALAILK QIKQFYGAHD LIFIGDHDSH KPMSENTVNS
310 320 330 340 350
ALRVMGYDTK VEVCGHGFRT MACSSLVESG LWSRDAVERQ MSHMARNSVR
360 370 380 390
AAYIHKAEHL EERRLMLQWW ADFLDVNRER FISPFEYAKI NNPLKQ
Length:396
Mass (Da):45,582
Last modified:February 1, 1995 - v1
Checksum:iDE3762C1EFC8BFCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97167.1.
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAE78267.1.
M96355 Genomic DNA. No translation available.
PIRiS56496.
RefSeqiWP_000550469.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiBAE78267; BAE78267; BAE78267.
KEGGiecj:JW4227.
PATRICi48668107. VBIEscCol107702_4305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97167.1.
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAE78267.1.
M96355 Genomic DNA. No translation available.
PIRiS56496.
RefSeqiWP_000550469.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP39347.
SMRiP39347.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262732. 18 interactors.
DIPiDIP-10035N.
IntActiP39347. 15 interactors.
STRINGi316407.85677017.

Proteomic databases

PRIDEiP39347.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE78267; BAE78267; BAE78267.
KEGGiecj:JW4227.
PATRICi48668107. VBIEscCol107702_4305.

Organism-specific databases

EchoBASEiEB2267.
EcoGeneiEG12364. intB.

Phylogenomic databases

eggNOGiCOG0582. LUCA.
HOGENOMiHOG000263105.
InParanoidiP39347.
OMAiWSEEHAN.
PhylomeDBiP39347.

Enzyme and pathway databases

BioCyciEcoCyc:EG12364-MONOMER.
ECOL316407:JW4227-MONOMER.

Family and domain databases

Gene3Di1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
InterProiIPR011010. DNA_brk_join_enz.
IPR025166. DUF4102.
IPR013762. Integrase-like_cat.
IPR002104. Integrase_catalytic.
IPR023109. Integrase_recombinase_N.
[Graphical view]
PfamiPF13356. DUF4102. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiINTB_ECOLI
AccessioniPrimary (citable) accession number: P39347
Secondary accession number(s): Q2M639
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Additional homology to the integrase family exists upstream of the current start codon.Curated
Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.