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Protein

L-idonate 5-dehydrogenase (NAD(P)(+))

Gene

idnD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the NADH/NADPH-dependent oxidation of L-idonate to 5-ketogluconate (5KG).1 Publication

Catalytic activityi

L-idonate + NAD(P)+ = 5-dehydrogluconate + NAD(P)H.1 Publication

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Pathwayi: L-idonate degradation

This protein is involved in the pathway L-idonate degradation, which is part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the pathway L-idonate degradation and in Carbohydrate acid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40Zinc 1; catalyticBy similarity1
Metal bindingi65Zinc 1; catalyticBy similarity1
Metal bindingi93Zinc 2By similarity1
Metal bindingi96Zinc 2By similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi107Zinc 2By similarity1
Metal bindingi153Zinc 1; catalyticBy similarity1

GO - Molecular functioni

  • L-idonate 5-dehydrogenase activity Source: EcoCyc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • D-gluconate metabolic process Source: UniProtKB-KW
  • L-idonate catabolic process Source: EcoCyc

Keywordsi

Molecular functionOxidoreductase
Biological processGluconate utilization
LigandMetal-binding, NADP, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:IDONDEHYD-MONOMER
MetaCyc:IDONDEHYD-MONOMER
BRENDAi1.1.1.264 2026
UniPathwayiUPA00793

Names & Taxonomyi

Protein namesi
Recommended name:
L-idonate 5-dehydrogenase (NAD(P)(+)) (EC:1.1.1.264)
Gene namesi
Name:idnD
Synonyms:yjgV
Ordered Locus Names:b4267, JW4224
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12541 idnD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001608811 – 343L-idonate 5-dehydrogenase (NAD(P)(+))Add BLAST343

Proteomic databases

PaxDbiP39346
PRIDEiP39346

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
lpdAP0A9P02EBI-552913,EBI-542856

Protein-protein interaction databases

BioGridi4259666, 722 interactors
DIPiDIP-10010N
IntActiP39346, 5 interactors
STRINGi316385.ECDH10B_4460

Structurei

3D structure databases

ProteinModelPortaliP39346
SMRiP39346
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CPQ Bacteria
COG1063 LUCA
HOGENOMiHOG000294670
InParanoidiP39346
KOiK00098
OMAiFILGHEC
PhylomeDBiP39346

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

P39346-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVKTQSCVV AGKKTVAVTE QTIDWNNNGT LVQITRGGIC GSDLHYYQEG
60 70 80 90 100
KVGNFMIKAP MVLGHEVIGK VIHSDSSELH EGQTVAINPS KPCGHCKYCI
110 120 130 140 150
EHNENQCTDM RFFGSAMYFP HVDGGFTRYK MVETSQCVPY PAKADEKVMA
160 170 180 190 200
FAEPLAVAIH AAHQAGELQG KRVFISGVGP IGCLIVSAVK TLGAAEIVCA
210 220 230 240 250
DVSPRSLSLG KEMGADVLVN PQNDDMDHWK AEKGYFDVSF EVSGHPSSVN
260 270 280 290 300
TCLEVTRARG VMVQVGMGGA MAEFPMMTLI GKEISLRGSF RFTSEFNTAV
310 320 330 340
SWLANGVINP LPLLSAEYPF TDLEEALRFA GDKTQAAKVQ LVF
Length:343
Mass (Da):37,147
Last modified:February 1, 1995 - v1
Checksum:i7A3C6E6C0CED6F09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97164.1
U00096 Genomic DNA Translation: AAC77224.1
AP009048 Genomic DNA Translation: BAE78264.1
PIRiS56493
RefSeqiNP_418688.1, NC_000913.3
WP_001197411.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77224; AAC77224; b4267
BAE78264; BAE78264; BAE78264
GeneIDi944769
KEGGiecj:JW4224
eco:b4267
PATRICifig|1411691.4.peg.2436

Entry informationi

Entry nameiIDND_ECOLI
AccessioniPrimary (citable) accession number: P39346
Secondary accession number(s): Q2M642
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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