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Protein

Gnt-II system L-idonate transporter

Gene

idnT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transports L-idonate, D-gluconate and 5-keto-D-gluconate, from the periplasm across the inner membrane.2 Publications

Pathwayi: L-idonate degradation

This protein is involved in the pathway L-idonate degradation, which is part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the pathway L-idonate degradation and in Carbohydrate acid metabolism.

GO - Molecular functioni

  • gluconate transmembrane transporter activity Source: EcoCyc
  • L-idonate transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • carbohydrate transport Source: EcoCyc
  • D-gluconate metabolic process Source: UniProtKB-KW
  • L-idonate catabolic process Source: UniProtKB-UniPathway
  • L-idonate transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Gluconate utilization, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YJGT-MONOMER.
ECOL316407:JW4222-MONOMER.
MetaCyc:YJGT-MONOMER.
UniPathwayiUPA00793.

Protein family/group databases

TCDBi2.A.8.1.2. the gluconate:h(+) symporter (gntp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Gnt-II system L-idonate transporter
Short name:
L-Ido transporter
Alternative name(s):
5-keto-D-gluconate transporter
Gene namesi
Name:idnT
Synonyms:gntW, yjgT
Ordered Locus Names:b4265, JW4222
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12539. idnT.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 11PeriplasmicSequence analysis
Transmembranei2 – 2221HelicalSequence analysisAdd
BLAST
Topological domaini23 – 242CytoplasmicSequence analysis
Transmembranei25 – 4521HelicalSequence analysisAdd
BLAST
Topological domaini46 – 516PeriplasmicSequence analysis
Transmembranei52 – 7221HelicalSequence analysisAdd
BLAST
Topological domaini73 – 10533CytoplasmicSequence analysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence analysisAdd
BLAST
Transmembranei127 – 14721HelicalSequence analysisAdd
BLAST
Topological domaini148 – 1514CytoplasmicSequence analysis
Transmembranei152 – 17221HelicalSequence analysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence analysisAdd
BLAST
Topological domaini194 – 22532CytoplasmicSequence analysisAdd
BLAST
Transmembranei226 – 24621HelicalSequence analysisAdd
BLAST
Topological domaini247 – 2548PeriplasmicSequence analysis
Transmembranei255 – 27521HelicalSequence analysisAdd
BLAST
Topological domaini276 – 29015CytoplasmicSequence analysisAdd
BLAST
Transmembranei291 – 31121HelicalSequence analysisAdd
BLAST
Topological domaini312 – 32615PeriplasmicSequence analysisAdd
BLAST
Transmembranei327 – 34721HelicalSequence analysisAdd
BLAST
Topological domaini348 – 3481CytoplasmicSequence analysis
Transmembranei349 – 36921HelicalSequence analysisAdd
BLAST
Topological domaini370 – 3701PeriplasmicSequence analysis
Transmembranei371 – 39121HelicalSequence analysisAdd
BLAST
Topological domaini392 – 41726CytoplasmicSequence analysisAdd
BLAST
Transmembranei418 – 43821HelicalSequence analysisAdd
BLAST
Topological domaini439 – 4391PeriplasmicSequence analysis

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Reduced growth rate when grown on 5-keto-D-gluconate as sole carbon source.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439Gnt-II system L-idonate transporterPRO_0000061940Add
BLAST

Proteomic databases

PaxDbiP39344.

Expressioni

Inductioni

Up-regulated by 5-keto-D-gluconate.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262729. 5 interactions.
DIPiDIP-10014N.
IntActiP39344. 1 interaction.
MINTiMINT-1218744.
STRINGi511145.b4265.

Structurei

3D structure databases

ProteinModelPortaliP39344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GntP permease family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C6Z. Bacteria.
COG2610. LUCA.
HOGENOMiHOG000237115.
InParanoidiP39344.
KOiK06157.
OMAiERVHWAM.
PhylomeDBiP39344.

Family and domain databases

InterProiIPR003474. Glcn_transporter.
[Graphical view]
PfamiPF02447. GntP_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF002746. Gluconate_transporter. 1 hit.
TIGRFAMsiTIGR00791. gntP. 1 hit.

Sequencei

Sequence statusi: Complete.

P39344-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLIIIAAGV ALLLILMIGF KVNGFIALVL VAAVVGFAEG MDAQAVLHSI
60 70 80 90 100
QNGIGSTLGG LAMILGFGAM LGKLISDTGA AQRIATTLIA TFGKKRVQWA
110 120 130 140 150
LVITGLVVGL AMFFEVGFVL LLPLVFTIVA SSGLPLLYVG VPMVAALSVT
160 170 180 190 200
HCFLPPHPGP TAIATIFEAN LGTTLLYGFI ITIPTVIVAG PLFSKLLTRF
210 220 230 240 250
EKAPPEGLFN PHLFSEEEMP SFWNSIFAAV IPVILMAIAA VCEITLPKTN
260 270 280 290 300
TVRLFFEFVG NPAVALFIAI VIAIFTLGRR NGRTIEQIMD IIGDSIGAIA
310 320 330 340 350
MIVFIIAGGG AFKQVLVDSG VGHYISHLMT GTTLSPLLMC WTVAALLRIA
360 370 380 390 400
LGSATVAAIT TAGVVLPIIN VTHADPALMV LATGAGSVIA SHVNDPGFWL
410 420 430
FKGYFNLTVG ETLRTWTVME TLISIMGLLG VLAINAVLH
Length:439
Mass (Da):46,041
Last modified:February 1, 1995 - v1
Checksum:iEA6CBCA88D6C042C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97162.1.
U00096 Genomic DNA. Translation: AAC77222.1.
AP009048 Genomic DNA. Translation: BAE78262.1.
PIRiS56491.
RefSeqiNP_418686.1. NC_000913.3.
WP_001128335.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77222; AAC77222; b4265.
BAE78262; BAE78262; BAE78262.
GeneIDi948798.
KEGGiecj:JW4222.
eco:b4265.
PATRICi32124103. VBIEscCol129921_4396.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97162.1.
U00096 Genomic DNA. Translation: AAC77222.1.
AP009048 Genomic DNA. Translation: BAE78262.1.
PIRiS56491.
RefSeqiNP_418686.1. NC_000913.3.
WP_001128335.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP39344.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262729. 5 interactions.
DIPiDIP-10014N.
IntActiP39344. 1 interaction.
MINTiMINT-1218744.
STRINGi511145.b4265.

Protein family/group databases

TCDBi2.A.8.1.2. the gluconate:h(+) symporter (gntp) family.

Proteomic databases

PaxDbiP39344.

Protocols and materials databases

DNASUi948798.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77222; AAC77222; b4265.
BAE78262; BAE78262; BAE78262.
GeneIDi948798.
KEGGiecj:JW4222.
eco:b4265.
PATRICi32124103. VBIEscCol129921_4396.

Organism-specific databases

EchoBASEiEB2428.
EcoGeneiEG12539. idnT.

Phylogenomic databases

eggNOGiENOG4105C6Z. Bacteria.
COG2610. LUCA.
HOGENOMiHOG000237115.
InParanoidiP39344.
KOiK06157.
OMAiERVHWAM.
PhylomeDBiP39344.

Enzyme and pathway databases

UniPathwayiUPA00793.
BioCyciEcoCyc:YJGT-MONOMER.
ECOL316407:JW4222-MONOMER.
MetaCyc:YJGT-MONOMER.

Miscellaneous databases

PROiP39344.

Family and domain databases

InterProiIPR003474. Glcn_transporter.
[Graphical view]
PfamiPF02447. GntP_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF002746. Gluconate_transporter. 1 hit.
TIGRFAMsiTIGR00791. gntP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIDNT_ECOLI
AccessioniPrimary (citable) accession number: P39344
Secondary accession number(s): Q2M644
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.