P39343 (IDNR_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HTH-type transcriptional regulator IdnR

Alternative name(s):
L-idonate regulatory protein

Gene names

Name:	idnR
Synonyms:	yjgS
Ordered Locus Names:	b4264, JW4221

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	Idn operon regulator. May repress gntKU and gntT genes when growing on L-idonate. Ref.4
Sequence similarities	Contains 1 HTH lacI-type DNA-binding domain.

Ontologies

Keywords
Biological process	Gluconate utilization Transcription Transcription regulation
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	D-gluconate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	HTH-type transcriptional regulator IdnR		PRO_0000107960
Regions
	Domain	6 – 60	55	HTH lacI-type
	DNA binding	8 – 27	20	H-T-H motif Potential

Sequences

	Sequence		Length	Mass (Da)
	P39343 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 9F18972E86DAFBF7	FASTA	332	37,567
	10 20 30 40 50 60 MRNHRISLQD IATLAGVTKM TVSRYIRSPK KVAKETGERI AKIMEEINYI PNRAPGMLLN 70 80 90 100 110 120 AQSYTLGILI PSFQNQLFAD ILAGIESVTS EHNYQTLIAN YNYDRDSEEE SVINLLSYNI 130 140 150 160 170 180 DGIILSEKYH TIRTVKFLRS ATIPVVELMD VQGERLDMEV GFDNRQAAFD MVCTMLEKRV 190 200 210 220 230 240 RHKILYLGSK DDTRDEQRYQ GYCDAMMLHN LSPLRMNPRA ISSIHLGMQL MRDALSANPD 250 260 270 280 290 300 LDGVFCTNDD IAMGALLLCR ERNLAVPEQI SIAGFHGLEI GRQMIPSLAS VITPRFDIGR 310 320 330 MAAQMLLSKI KNNDHNHNTV DLGYQIYHGN TL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes." Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R. Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	"Sequence analysis of the GntII (subsidiary) system for gluconate metabolism reveals a novel pathway for L-idonic acid catabolism in Escherichia coli." Bausch C., Peekhaus N., Utz C., Blais T., Murray E., Lowary T., Conway T. J. Bacteriol. 180:3704-3710(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U14003 Genomic DNA. Translation: AAA97161.1. U00096 Genomic DNA. Translation: AAC77221.1. AP009048 Genomic DNA. Translation: BAE78261.1.
PIR	S56490.
RefSeq	NP_418685.1. NC_000913.2. YP_492402.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P39343.
SMR	P39343. Positions 6-332.
ModBase	Search...
Protein-protein interaction databases
IntAct	P39343. 3 interactions.
STRING	511145.b4264.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC77221; AAC77221; b4264. BAE78261; BAE78261; BAE78261.
GeneID	12933728. 949058.
KEGG	ecj:Y75_p4147. eco:b4264.
PATRIC	32124101. VBIEscCol129921_4395.
Organism-specific databases
EchoBASE	EB2427.
EcoGene	EG12538. idnR.
Phylogenomic databases
eggNOG	COG1609.
HOGENOM	HOG000220181.
KO	K06146.
OMA	HNYQTII.
ProtClustDB	CLSK891824.
Enzyme and pathway databases
BioCyc	EcoCyc:G7891-MONOMER. ECOL316407:JW4221-MONOMER.
Gene expression databases
Genevestigator	P39343.
Family and domain databases
Gene3D	1.10.260.40. 1 hit.
InterPro	IPR010982. Lambda_DNA-bd_dom. IPR000843. Tscrpt_reg_HTH_LacI. [Graphical view]
Pfam	PF00356. LacI. 1 hit. [Graphical view]
SMART	SM00354. HTH_LACI. 1 hit. [Graphical view]
SUPFAM	SSF47413. Lambda_like_DNA. 1 hit.
PROSITE	PS00356. HTH_LACI_1. 1 hit. PS50932. HTH_LACI_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IDNR_ECOLI

Accession

Primary (citable) accession number: P39343
Secondary accession number(s): Q2M645

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program