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Protein

HTH-type transcriptional repressor BdcR

Gene

bdcR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates expression of bdcA.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi38 – 5720H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7882-MONOMER.
ECOL316407:JW4208-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor BdcR
Gene namesi
Name:bdcR
Synonyms:yjgJ
Ordered Locus Names:b4251, JW4208
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12529. bdcR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197HTH-type transcriptional repressor BdcRPRO_0000070647Add
BLAST

Proteomic databases

PaxDbiP39334.

Interactioni

Protein-protein interaction databases

BioGridi4259559. 174 interactions.
IntActiP39334. 1 interaction.
STRINGi511145.b4251.

Structurei

3D structure databases

ProteinModelPortaliP39334.
SMRiP39334. Positions 21-191.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 7561HTH tetR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108XFH. Bacteria.
ENOG4111MNX. LUCA.
HOGENOMiHOG000161265.
InParanoidiP39334.
KOiK19335.
OMAiDRYAQTG.
OrthoDBiEOG689HRC.
PhylomeDBiP39334.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.357.10. 1 hit.
InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTKKQSRVP GRPRRFAPEQ AISAAKVLFH QKGFDAVSVA EVTDYLGINP
60 70 80 90 100
PSLYAAFGSK AGLFSRVLNE YVGTEAIPLA DILRDDRPVG ECLVEVLKEA
110 120 130 140 150
ARRYSQNGGC AGCMVLEGIH SHDPQARDIA VQYYHAAETT IYDYIARRHP
160 170 180 190
QRAQCVTDFM STVMSGLSAK AREGHSIEQL CATAAMAGEA IKTILEE
Length:197
Mass (Da):21,502
Last modified:July 15, 1998 - v2
Checksum:iC1E81B87A27435BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97147.1. Frameshift.
U00096 Genomic DNA. Translation: AAC77208.2.
AP009048 Genomic DNA. Translation: BAE78248.1.
PIRiS56476.
RefSeqiNP_418672.4. NC_000913.3.
WP_000256658.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77208; AAC77208; b4251.
BAE78248; BAE78248; BAE78248.
GeneIDi948775.
KEGGiecj:JW4208.
eco:b4251.
PATRICi32124073. VBIEscCol129921_4381.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97147.1. Frameshift.
U00096 Genomic DNA. Translation: AAC77208.2.
AP009048 Genomic DNA. Translation: BAE78248.1.
PIRiS56476.
RefSeqiNP_418672.4. NC_000913.3.
WP_000256658.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP39334.
SMRiP39334. Positions 21-191.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259559. 174 interactions.
IntActiP39334. 1 interaction.
STRINGi511145.b4251.

Proteomic databases

PaxDbiP39334.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77208; AAC77208; b4251.
BAE78248; BAE78248; BAE78248.
GeneIDi948775.
KEGGiecj:JW4208.
eco:b4251.
PATRICi32124073. VBIEscCol129921_4381.

Organism-specific databases

EchoBASEiEB2419.
EcoGeneiEG12529. bdcR.

Phylogenomic databases

eggNOGiENOG4108XFH. Bacteria.
ENOG4111MNX. LUCA.
HOGENOMiHOG000161265.
InParanoidiP39334.
KOiK19335.
OMAiDRYAQTG.
OrthoDBiEOG689HRC.
PhylomeDBiP39334.

Enzyme and pathway databases

BioCyciEcoCyc:G7882-MONOMER.
ECOL316407:JW4208-MONOMER.

Miscellaneous databases

PROiP39334.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.357.10. 1 hit.
InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes."
    Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.
    Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: SEQUENCE REVISION.
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Engineering a novel c-di-GMP-binding protein for biofilm dispersal."
    Ma Q., Yang Z., Pu M., Peti W., Wood T.K.
    Environ. Microbiol. 13:631-642(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A REGULATOR, GENE NAME.
    Strain: K12 / BW25113.

Entry informationi

Entry nameiBDCR_ECOLI
AccessioniPrimary (citable) accession number: P39334
Secondary accession number(s): P76809, Q2M658
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 15, 1998
Last modified: February 17, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.