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Protein

L-ribulose-5-phosphate 3-epimerase UlaE

Gene

ulaE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate. Is involved in the anaerobic L-ascorbate utilization.UniRule annotation1 Publication

Catalytic activityi

L-ribulose 5-phosphate = L-xylulose 5-phosphate.UniRule annotation

Pathwayi: L-ascorbate degradation

This protein is involved in step 3 of the subpathway that synthesizes D-xylulose 5-phosphate from L-ascorbate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Probable L-ascorbate-6-phosphate lactonase UlaG (ulaG)
  2. 3-keto-L-gulonate-6-phosphate decarboxylase UlaD (ulaD)
  3. L-ribulose-5-phosphate 3-epimerase UlaE (ulaE)
  4. L-ribulose-5-phosphate 4-epimerase UlaF (ulaF)
This subpathway is part of the pathway L-ascorbate degradation, which is itself part of Cofactor degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-xylulose 5-phosphate from L-ascorbate, the pathway L-ascorbate degradation and in Cofactor degradation.

GO - Molecular functioni

GO - Biological processi

  • L-ascorbic acid catabolic process Source: UniProtKB-UniPathway
  • L-ascorbic acid metabolic process Source: EcoCyc

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

BioCyciEcoCyc:G7859-MONOMER
MetaCyc:G7859-MONOMER
UniPathwayiUPA00263; UER00379

Names & Taxonomyi

Protein namesi
Recommended name:
L-ribulose-5-phosphate 3-epimerase UlaEUniRule annotation (EC:5.1.3.22UniRule annotation)
Alternative name(s):
L-ascorbate utilization protein EUniRule annotation
L-xylulose-5-phosphate 3-epimeraseUniRule annotation
Gene namesi
Name:ulaEUniRule annotation
Synonyms:sgaU, yjfW
Ordered Locus Names:b4197, JW4155
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12497 ulaE

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000977161 – 284L-ribulose-5-phosphate 3-epimerase UlaEAdd BLAST284

Proteomic databases

PaxDbiP39305
PRIDEiP39305

Expressioni

Inductioni

Induced by L-ascorbate. Repressed by UlaR.UniRule annotation2 Publications

Interactioni

Protein-protein interaction databases

BioGridi4262715, 7 interactors
IntActiP39305, 1 interactor
STRINGi316385.ECDH10B_4392

Structurei

3D structure databases

ProteinModelPortaliP39305
SMRiP39305
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-ribulose-5-phosphate 3-epimerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41064BZ Bacteria
COG3623 LUCA
HOGENOMiHOG000126090
InParanoidiP39305
KOiK03079
OMAiQAGMGHI
PhylomeDBiP39305

Family and domain databases

HAMAPiMF_01951 UlaE, 1 hit
InterProiView protein in InterPro
IPR004560 L-Ru-5P_3-Epase
IPR023492 L-Ru-5P_3-Epase_Enterobacteria
IPR036237 Xyl_isomerase-like_sf
IPR013022 Xyl_isomerase-like_TIM-brl
PfamiView protein in Pfam
PF01261 AP_endonuc_2, 1 hit
SUPFAMiSSF51658 SSF51658, 1 hit
TIGRFAMsiTIGR00542 hxl6Piso_put, 1 hit

Sequencei

Sequence statusi: Complete.

P39305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKQIPLGI YEKALPAGEC WLERLQLAKT LGFDFVEMSV DETDDRLSRL
60 70 80 90 100
NWSREQRLAL VNAIVETGVR VPSMCLSAHR RFPLGSEDDA VRAQGLEIMR
110 120 130 140 150
KAIQFAQDVG IRVIQLAGYD VYYQEANNET RRRFRDGLKE SVEMASRAQV
160 170 180 190 200
TLAMEIMDYP LMSSISKALG YAHYLNNPWF QLYPDIGNLS AWDNDVQMEL
210 220 230 240 250
QAGIGHIVAV HVKDTKPGVF KNVPFGEGVV DFERCFETLK QSGYCGPYLI
260 270 280
EMWSETAEDP AAEVAKARDW VKARMAKAGM VEAA
Length:284
Mass (Da):32,007
Last modified:February 1, 1995 - v1
Checksum:iAAA9F000B9D94A08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97093.1
U00096 Genomic DNA Translation: AAC77154.1
AP009048 Genomic DNA Translation: BAE78198.1
PIRiS56422
RefSeqiNP_418618.1, NC_000913.3
WP_000949502.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77154; AAC77154; b4197
BAE78198; BAE78198; BAE78198
GeneIDi948712
KEGGiecj:JW4155
eco:b4197
PATRICifig|1411691.4.peg.2504

Similar proteinsi

Entry informationi

Entry nameiULAE_ECOLI
AccessioniPrimary (citable) accession number: P39305
Secondary accession number(s): Q2M6A8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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