Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dipeptide and tripeptide permease C

Gene

dtpC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proton-dependent permease that transports di- and tripeptides. Shows significantly higher specificity towards dipeptides than tripeptides. Has a preference for dipeptides with a C-terminal Lys residue. Can bind Ala-Lys, Lys-Ala, Ala-Ala. Can also transport alanine and trialanine.4 Publications

Kineticsi

  1. KM=0.07 mM for Ala-Lys1 Publication
  2. KM=0.51 mM for Lys-Ala1 Publication

    pH dependencei

    Optimum pH is around 6.5.1 Publication

    GO - Molecular functioni

    • dipeptide transmembrane transporter activity Source: EcoCyc
    • peptide:proton symporter activity Source: EcoCyc
    • proton transmembrane transporter activity Source: EcoCyc
    • tripeptide transporter activity Source: EcoCyc

    GO - Biological processi

    • dipeptide transmembrane transport Source: EcoCyc
    • protein transport Source: UniProtKB-KW
    • proton transmembrane transport Source: EcoCyc
    • tripeptide transmembrane transport Source: EcoCyc

    Keywordsi

    Biological processPeptide transport, Protein transport, Symport, Transport

    Enzyme and pathway databases

    BioCyciEcoCyc:YJDL-MONOMER
    MetaCyc:YJDL-MONOMER
    BRENDAi3.6.3.43 2026

    Protein family/group databases

    TCDBi2.A.17.1.5 the proton-dependent oligopeptide transporter (pot/ptr) family

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dipeptide and tripeptide permease CCurated
    Alternative name(s):
    Dipeptide/tripeptide:H(+) symporter DtpCCurated
    Gene namesi
    Name:dtpC1 Publication
    Synonyms:yjdL
    Ordered Locus Names:b4130, JW4091
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    Proteomesi
    • UP000000318 Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    Organism-specific databases

    EcoGeneiEG12469 dtpC

    Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
    Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
    Topological domaini34 – 46PeriplasmicSequence analysisAdd BLAST13
    Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
    Topological domaini68 – 70CytoplasmicSequence analysis3
    Transmembranei71 – 93HelicalSequence analysisAdd BLAST23
    Topological domaini94 – 102PeriplasmicSequence analysis9
    Transmembranei103 – 125HelicalSequence analysisAdd BLAST23
    Topological domaini126 – 140CytoplasmicSequence analysisAdd BLAST15
    Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
    Topological domaini162 – 164PeriplasmicSequence analysis3
    Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
    Topological domaini186 – 208CytoplasmicSequence analysisAdd BLAST23
    Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
    Topological domaini230 – 234PeriplasmicSequence analysis5
    Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
    Topological domaini256 – 262CytoplasmicSequence analysis7
    Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
    Topological domaini284 – 307PeriplasmicSequence analysisAdd BLAST24
    Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
    Topological domaini329 – 340CytoplasmicSequence analysisAdd BLAST12
    Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
    Topological domaini362 – 375PeriplasmicSequence analysisAdd BLAST14
    Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
    Topological domaini397 – 406CytoplasmicSequence analysis10
    Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
    Topological domaini428 – 446PeriplasmicSequence analysisAdd BLAST19
    Transmembranei447 – 467HelicalSequence analysisAdd BLAST21
    Topological domaini468 – 485Cytoplasmic1 PublicationAdd BLAST18

    GO - Cellular componenti

    • integral component of membrane Source: UniProtKB-KW
    • plasma membrane Source: EcoCyc

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi20E → A: Lack of activity. 1 Publication1
    Mutagenesisi20E → D: Decrease in activity. 1 Publication1
    Mutagenesisi20E → Q: Decrease in activity. Abolishes the pH dependency. 1 Publication1
    Mutagenesisi388E → A: Lack of activity. 1 Publication1
    Mutagenesisi388E → D: Decrease in activity. 1 Publication1
    Mutagenesisi388E → Q: Decrease in activity. Does not bind Ala-Lys dipeptide. 2 Publications1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000643301 – 485Dipeptide and tripeptide permease CAdd BLAST485

    Proteomic databases

    PaxDbiP39276
    PRIDEiP39276

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Protein-protein interaction databases

    BioGridi4261129, 143 interactors
    STRINGi316385.ECDH10B_4323

    Structurei

    3D structure databases

    ProteinModelPortaliP39276
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiENOG4105DUX Bacteria
    COG3104 LUCA
    HOGENOMiHOG000243450
    InParanoidiP39276
    KOiK03305
    OMAiVGQMYDN
    PhylomeDBiP39276

    Family and domain databases

    CDDicd06174 MFS, 1 hit
    InterProiView protein in InterPro
    IPR005279 Dipep/tripep_permease
    IPR020846 MFS_dom
    IPR036259 MFS_trans_sf
    IPR000109 POT_fam
    IPR018456 PTR2_symporter_CS
    PANTHERiPTHR11654 PTHR11654, 1 hit
    PfamiView protein in Pfam
    PF00854 PTR2, 1 hit
    SUPFAMiSSF103473 SSF103473, 2 hits
    TIGRFAMsiTIGR00924 yjdL_sub1_fam, 1 hit
    PROSITEiView protein in PROSITE
    PS50850 MFS, 1 hit
    PS01022 PTR2_1, 1 hit
    PS01023 PTR2_2, 1 hit

    Sequencei

    Sequence statusi: Complete.

    P39276-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MKTPSQPRAI YYIVAIQIWE YFSFYGMRAL LILYLTHQLG FDDNHAISLF
    60 70 80 90 100
    SAYASLVYVT PILGGWLADR LLGNRTAVIA GALLMTLGHV VLGIDTNSTF
    110 120 130 140 150
    SLYLALAIII CGYGLFKSNI SCLLGELYDE NDHRRDGGFS LLYAAGNIGS
    160 170 180 190 200
    IAAPIACGLA AQWYGWHVGF ALAGGGMFIG LLIFLSGHRH FQSTRSMDKK
    210 220 230 240 250
    ALTSVKFALP VWSWLVVMLC LAPVFFTLLL ENDWSGYLLA IVCLIAAQII
    260 270 280 290 300
    ARMMIKFPEH RRALWQIVLL MFVGTLFWVL AQQGGSTISL FIDRFVNRQA
    310 320 330 340 350
    FNIEVPTALF QSVNAIAVML AGVVLAWLAS PESRGNSTLR VWLKFAFGLL
    360 370 380 390 400
    LMACGFMLLA FDARHAAADG QASMGVMISG LALMGFAELF IDPVAIAQIT
    410 420 430 440 450
    RLKMSGVLTG IYMLATGAVA NWLAGVVAQQ TTESQISGMA IAAYQRFFSQ
    460 470 480
    MGEWTLACVA IIVVLAFATR FLFSTPTNMI QESND
    Length:485
    Mass (Da):53,055
    Last modified:February 1, 1995 - v1
    Checksum:iACBE0B947DE0CB61
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U14003 Genomic DNA Translation: AAA97030.1
    U00096 Genomic DNA Translation: AAC77091.1
    AP009048 Genomic DNA Translation: BAE78133.1
    PIRiS56359
    RefSeqiNP_418554.1, NC_000913.3
    WP_000856829.1, NZ_LN832404.1

    Genome annotation databases

    EnsemblBacteriaiAAC77091; AAC77091; b4130
    BAE78133; BAE78133; BAE78133
    GeneIDi948644
    KEGGiecj:JW4091
    eco:b4130
    PATRICifig|511145.12.peg.4262

    Similar proteinsi

    Entry informationi

    Entry nameiDTPC_ECOLI
    AccessioniPrimary (citable) accession number: P39276
    Secondary accession number(s): Q2M6H3
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: April 25, 2018
    This is version 136 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health