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Protein

Putative basic amino acid antiporter YfcC

Gene

yfcC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Metabolomic profiling of different yfcC over-expression and deletion strains suggests that it may affect the glyoxylate shunt.1 Publication

GO - Molecular functioni

Keywordsi

Biological processAntiport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7190-MONOMER

Protein family/group databases

TCDBi2.A.118.1.8 the basic amino acid antiporter (arcd) family

Names & Taxonomyi

Protein namesi
Recommended name:
Putative basic amino acid antiporter YfcC
Gene namesi
Name:yfcC
Ordered Locus Names:b2298, JW2295
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12607 yfcC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Transmembranei419 – 439HelicalSequence analysisAdd BLAST21
Transmembranei442 – 462HelicalSequence analysisAdd BLAST21
Transmembranei485 – 505HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001691911 – 506Putative basic amino acid antiporter YfcCAdd BLAST506

Proteomic databases

PaxDbiP39263
PRIDEiP39263

Interactioni

Protein-protein interaction databases

BioGridi4261493, 212 interactors
DIPiDIP-11977N
IntActiP39263, 2 interactors
STRINGi316385.ECDH10B_2460

Structurei

3D structure databases

ProteinModelPortaliP39263
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

To H.influenzae HI_0594.Curated
To B.subtilis YcgA.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CSX Bacteria
COG1288 LUCA
HOGENOMiHOG000277481
InParanoidiP39263
OMAiGTRELKW
PhylomeDBiP39263

Family and domain databases

InterProiView protein in InterPro
IPR018385 C4_dicarb_anaerob_car-like
PfamiView protein in Pfam
PF03606 DcuC, 1 hit

Sequencei

Sequence statusi: Complete.

P39263-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAITESKPT RRWAMPDTLV IIFFVAILTS LATWVVPVGM FDSQEVQYQV
60 70 80 90 100
DGQTKTRKVV DPHSFRILTN EAGEPEYHRV QLFTTGDERP GLMNFPFEGL
110 120 130 140 150
TSGSKYGTAV GIIMFMLVIG GAFGIVMRTG TIDNGILALI RHTRGNEILF
160 170 180 190 200
IPALFILFSL GGAVFGMGEE AVAFAIIIAP LMVRLGYDSI TTVLVTYIAT
210 220 230 240 250
QIGFASSWMN PFCVVVAQGI AGVPVLSGSG LRIVVWVIAT LIGLIFTMVY
260 270 280 290 300
ASRVKKNPLL SRVHESDRFF REKQADVEQR PFTFGDWLVL IVLTAVMVWV
310 320 330 340 350
IWGVIVNAWF IPEIASQFFT MGLVIGIIGV VFRLNGMTVN TMASSFTEGA
360 370 380 390 400
RMMIAPALLV GFAKGILLLV GNGEAGDASV LNTILNSIAN AISGLDNAVA
410 420 430 440 450
AWFMLLFQAV FNFFVTSGSG QAALTMPLLA PLGDLVGVNR QVTVLAFQFG
460 470 480 490 500
DGFSHIIYPT SASLMATLGV CRVDFRNWLK VGATLLGLLF IMSSVVVIGA

QLMGYH
Length:506
Mass (Da):54,797
Last modified:November 1, 1997 - v2
Checksum:iFA9D2244C19971D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 34MSAIT…SLATW → MLFNQPCHL in D17576 (PubMed:7883769).CuratedAdd BLAST34
Sequence conflicti86 – 90GDERP → AMNAR in D17576 (PubMed:7883769).Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC75358.2
AP009048 Genomic DNA Translation: BAA16137.1
D17576 Genomic DNA No translation available.
PIRiH65001
RefSeqiNP_416801.2, NC_000913.3
WP_001274493.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75358; AAC75358; b2298
BAA16137; BAA16137; BAA16137
GeneIDi946780
KEGGiecj:JW2295
eco:b2298
PATRICifig|511145.12.peg.2393

Similar proteinsi

Entry informationi

Entry nameiYFCC_ECOLI
AccessioniPrimary (citable) accession number: P39263
Secondary accession number(s): P76493, P77678
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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