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Protein

Endonuclease IV

Gene

denB

Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cleaves single-stranded DNA in a dC-specific manner. The cleavage occurs exclusively at the 5'-proximal position (dC1) within a dCs tract having a minimal size of 6 bases. These specific cleavages may have a detrimental effect on the replication of host dC-containing DNA.2 Publications

Catalytic activityi

Endonucleolytic cleavage of the 5' phosphodiester bond of deoxycytidine in single-stranded DNA.1 Publication

GO - Molecular functioni

  • endonuclease activity Source: UniProtKB

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease IV1 Publication (EC:3.1.21.91 Publication)
Alternative name(s):
Deoxyribonuclease IV
Gene namesi
Name:denB
ORF Names:T4147_276Imported, T4Tp278Imported, T4wild_276Imported
OrganismiEnterobacteria phage T4 (Bacteriophage T4)
Taxonomic identifieri10665 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000009087 Componenti: Genome
  • UP000001092 Componenti: Genome
  • UP000185270 Componenti: Genome
  • UP000185271 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001649331 – 185Endonuclease IVAdd BLAST185

Family & Domainsi

Phylogenomic databases

KOiK20842.
OrthoDBiVOG090000S5.

Sequencei

Sequence statusi: Complete.

P39250-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKTNPGLQR LFQIPTFTLS NSDLTCEMKV KIADTARYSL KQNPNQDKAE
60 70 80 90 100
VIERCRIAVY AEFFVADWLS GYVNKGQEDV DDPYTYAWDV LAHPKYCGLR
110 120 130 140 150
VEVKTHQTDS RWISVTTGCS GEYPYGSGIN LGPILNHQVA DCIIIFNTKE
160 170 180
IHPGVIQYTP KFIGDREDLR KVVRKSNYNG WYLSI
Length:185
Mass (Da):21,161
Last modified:February 1, 1995 - v1
Checksum:i65CBAD51F019058F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF158101 Genomic DNA. Translation: AAD42559.1.
HM137666 Genomic DNA. Translation: ADJ39995.1.
KJ477684 Genomic DNA. Translation: AHY83560.1.
KJ477685 Genomic DNA. Translation: AHY83756.1.
RefSeqiNP_049887.1. NC_000866.4.

Genome annotation databases

GeneIDi1258726.
KEGGivg:1258726.

Similar proteinsi

Entry informationi

Entry nameiEND4_BPT4
AccessioniPrimary (citable) accession number: P39250
Secondary accession number(s): D9IEV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 15, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome