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Protein

Antitoxin Dmd

Gene

dmd

Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Antitoxin component of a potential type II toxin-antitoxin (TA) module. Acts as an antitoxin against host toxins RnlA and LsoA, preventing them from degrading T4 bacteriophage-derived mRNA and thus permitting successful virus infection. Stabilizes middle (8-10 minutes) and late (18 to 28 minutes) T4 gene transcripts.1 Publication

GO - Biological processi

Keywordsi

Biological processEvasion of bacteria-mediated translation shutoff by virus, Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Antitoxin Dmd
Gene namesi
Name:dmd
Synonyms:61.5, y02B
OrganismiEnterobacteria phage T4 (Bacteriophage T4)
Taxonomic identifieri10665 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000009087 Componenti: Genome

Pathology & Biotechi

Disruption phenotypei

Phage grows very poorly in wild-type E.coli K12 or in cells expressing plasmid-derived toxin-antitoxin module LsoA-LsoB; if the host has a deletion in rnlA-rnlB no effect is seen. Absence of full-length transcripts of late (18 to 28 minutes) T4 genes, and thus loss of synthesis of late proteins. Partially suppressed by overexpression of host IscR.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001650951 – 60Antitoxin DmdAdd BLAST60

Interactioni

Subunit structurei

Can form a complex with non-cognate host toxins LsoA and RnlA.2 Publications

Structurei

Secondary structure

160
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 11Combined sources8
Beta strandi17 – 24Combined sources8
Helixi26 – 28Combined sources3
Helixi29 – 40Combined sources12
Beta strandi43 – 48Combined sources6
Beta strandi51 – 57Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HY3X-ray3.10B1-60[»]
SMRiP39232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

OrthoDBiVOG090001VS.

Family and domain databases

InterProiView protein in InterPro
IPR035137. Dmd.
PfamiView protein in Pfam
PF17587. Dmd. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD052738. PD052738. 1 hit.

Sequencei

Sequence statusi: Complete.

P39232-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELVKVVFMG WFKNESMFTK EITMMKDDVQ WATTQYAEVN KALVKAFIDD
60
KKVCEVDCRG
Length:60
Mass (Da):7,027
Last modified:February 1, 1995 - v1
Checksum:iA726546EE9AC74B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S57514 Genomic DNA. Translation: AAB25708.1.
AF158101 Genomic DNA. Translation: AAD42512.1.
PIRiA45681.
RefSeqiNP_049653.1. NC_000866.4.

Genome annotation databases

GeneIDi1258668.
KEGGivg:1258668.

Similar proteinsi

Entry informationi

Entry nameiDMD_BPT4
AccessioniPrimary (citable) accession number: P39232
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: August 30, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Caution

Enterobacteria phage T4 probably has no corresponding toxin gene.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references