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P39217

- TLPB_BACSU

UniProt

P39217 - TLPB_BACSU

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Protein
Methyl-accepting chemotaxis protein TlpB
Gene
tlpB, BSU31230
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. All amino acids serve as attractants in B.subtilis, they appear to cause an increase in the turnover methyl groups, leading to methylation of an unidentified acceptor, while repellents have been shown to cause a decrease in methyl group turnover. The methyl groups are added by a methyltransferase and removed by a methylesterase.

GO - Molecular functioni

  1. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. chemotaxis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

BioCyciBSUB:BSU31230-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-accepting chemotaxis protein TlpB
Gene namesi
Name:tlpB
Ordered Locus Names:BSU31230
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU31230. [Micado]

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei17 – 3721Helical; Reviewed prediction
Add
BLAST
Topological domaini38 – 281244Extracellular Reviewed prediction
Add
BLAST
Transmembranei282 – 30221Helical; Reviewed prediction
Add
BLAST
Topological domaini303 – 662360Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 662662Methyl-accepting chemotaxis protein TlpB
PRO_0000110560Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei370 – 3701Glutamate methyl ester (Glu) By similarity
Modified residuei594 – 5941Glutamate methyl ester (Gln) By similarity
Modified residuei629 – 6291Glutamate methyl ester (Glu) By similarity
Modified residuei636 – 6361Glutamate methyl ester (Glu) By similarity

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiP39217.

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU31230.

Structurei

3D structure databases

ProteinModelPortaliP39217.
SMRiP39217. Positions 303-355, 380-661.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini153 – 22876Cache
Add
BLAST
Domaini303 – 35553HAMP
Add
BLAST
Domaini374 – 610237Methyl-accepting transducer
Add
BLAST

Sequence similaritiesi

Contains 1 cache domain.
Contains 1 HAMP domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0840.
HOGENOMiHOG000083278.
KOiK03406.
OMAiGRHMAAS.
OrthoDBiEOG6MM1H2.
PhylomeDBiP39217.

Family and domain databases

InterProiIPR004010. Cache_domain.
IPR003122. Chemotax_Me-accpt_rcpt_lig-bd.
IPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
IPR029151. Sensor-like.
[Graphical view]
PfamiPF02743. Cache_1. 1 hit.
PF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
PF02203. TarH. 1 hit.
[Graphical view]
SMARTiSM00304. HAMP. 1 hit.
SM00283. MA. 1 hit.
SM00319. TarH. 1 hit.
[Graphical view]
SUPFAMiSSF103190. SSF103190. 1 hit.
PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39217-1 [UniParc]FASTAAdd to Basket

« Hide

MGKFIQWIKQ PSISKPLIAA FLAVLILPVG VLAYFSYQSA WNALDRELIS    50
SAKGNVEELN STLQNKLEDK VKAIDYYSET VDKDILLGKN KTLLKEKFKQ 100
YTTLNDDVGA IYAASEDKKL YKYPDSGVPK GFDPTGRDWY KQAVAEKGQA 150
VFSEPYTDEA TGDIVVTISK QLKDGSGVIA LDLNLDEVLT ASKRIKIGKE 200
GFAFITTGNK KYIAHPTIKP GTTGSGDWTN QVYSKKEGSF EYTFEGKEKK 250
MAFTTNKLTG WKIAGTYFVS ELQDASSPVL NTAVIILCVS IVIGGILILY 300
IIRAITKPLR KLVSTSAKIS SGDLTEVIDI HSKNEFGQLG ESFNEMSASL 350
RSVIGVIQTS VENVASSSEE LTASAAQTSK ATEHITLAIE QFSDGNEAQS 400
EKLETSSNHL SQMNEGISKV AQASSTITKS SIQSSEAAGS GEKLVEHTVG 450
QMKTIDQSVQ KAEAVVKGLE TKSQDITSIL NVINGIADQT NLLALNAAIE 500
AARAGEYGRG FSVVAEEVRK LAVQSADSAK EIEGLIQEIV REISTSLSMF 550
QSVNHEVKEG LQITDQTAES FKQIYEMTTQ ISGELQNLNA TVEQLSAGSQ 600
EVSSAVEDIS AVAKESSAGI QDIAASAEEQ LASMEEISSS AETLANMAEE 650
LQDITKKFKI ES 662
Length:662
Mass (Da):71,536
Last modified:February 1, 1995 - v1
Checksum:i91215F86293D7425
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L29189 Genomic DNA. Translation: AAA20557.1.
AL009126 Genomic DNA. Translation: CAB15101.1.
PIRiD54078.
RefSeqiNP_391001.1. NC_000964.3.
WP_003243983.1. NZ_CM000487.1.

Genome annotation databases

EnsemblBacteriaiCAB15101; CAB15101; BSU31230.
GeneIDi937152.
KEGGibsu:BSU31230.
PATRICi18978204. VBIBacSub10457_3265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L29189 Genomic DNA. Translation: AAA20557.1 .
AL009126 Genomic DNA. Translation: CAB15101.1 .
PIRi D54078.
RefSeqi NP_391001.1. NC_000964.3.
WP_003243983.1. NZ_CM000487.1.

3D structure databases

ProteinModelPortali P39217.
SMRi P39217. Positions 303-355, 380-661.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU31230.

Proteomic databases

PaxDbi P39217.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB15101 ; CAB15101 ; BSU31230 .
GeneIDi 937152.
KEGGi bsu:BSU31230.
PATRICi 18978204. VBIBacSub10457_3265.

Organism-specific databases

GenoListi BSU31230. [Micado ]

Phylogenomic databases

eggNOGi COG0840.
HOGENOMi HOG000083278.
KOi K03406.
OMAi GRHMAAS.
OrthoDBi EOG6MM1H2.
PhylomeDBi P39217.

Enzyme and pathway databases

BioCyci BSUB:BSU31230-MONOMER.

Family and domain databases

InterProi IPR004010. Cache_domain.
IPR003122. Chemotax_Me-accpt_rcpt_lig-bd.
IPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
IPR029151. Sensor-like.
[Graphical view ]
Pfami PF02743. Cache_1. 1 hit.
PF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
PF02203. TarH. 1 hit.
[Graphical view ]
SMARTi SM00304. HAMP. 1 hit.
SM00283. MA. 1 hit.
SM00319. TarH. 1 hit.
[Graphical view ]
SUPFAMi SSF103190. SSF103190. 1 hit.
PROSITEi PS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of genes encoding methyl-accepting chemotaxis proteins in Bacillus subtilis."
    Hanlon D.W., Ordal G.W.
    J. Biol. Chem. 269:14038-14046(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168 / OI1085.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.

Entry informationi

Entry nameiTLPB_BACSU
AccessioniPrimary (citable) accession number: P39217
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 3, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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