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P39216 (TLPA_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Methyl-accepting chemotaxis protein TlpA
Gene names
Name:tlpA
Ordered Locus Names:BSU31250
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length662 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. All amino acids serve as attractants in B.subtilis, they appear to cause an increase in the turnover methyl groups, leading to methylation of an unidentified acceptor, while repellents have been shown to cause a decrease in methyl group turnover. The methyl groups are added by a methyltransferase and removed by a methylesterase.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Contains 1 cache domain.

Contains 1 HAMP domain.

Contains 1 methyl-accepting transducer domain.

Ontologies

Keywords
   Biological processChemotaxis
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionTransducer
   PTMMethylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processchemotaxis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontransmembrane signaling receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 662662Methyl-accepting chemotaxis protein TlpA
PRO_0000110559

Regions

Topological domain1 – 1616Cytoplasmic Potential
Transmembrane17 – 3721Helical; Potential
Topological domain38 – 281244Extracellular Potential
Transmembrane282 – 30221Helical; Potential
Topological domain303 – 662360Cytoplasmic Potential
Domain152 – 22877Cache
Domain303 – 35553HAMP
Domain374 – 610237Methyl-accepting transducer

Amino acid modifications

Modified residue3701Glutamate methyl ester (Glu) By similarity
Modified residue5941Glutamate methyl ester (Glu) By similarity
Modified residue6291Glutamate methyl ester (Glu) By similarity
Modified residue6361Glutamate methyl ester (Glu) By similarity

Sequences

Sequence LengthMass (Da)Tools
P39216 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 7335B27992D07FF6

FASTA66272,278
        10         20         30         40         50         60 
MKKTLTTIRR SSIARRLIIS FLLILIVPIT ALSVSAYQSA VASLDVQMTQ SAKENVQILD 

        70         80         90        100        110        120 
HIIDDKISTT EKSLAYFSDW ATAEKFQDKK KTELKQEFKQ FIQMNDNVAA VFSSGKDGDF 

       130        140        150        160        170        180 
TRYPYADMPS DFNALERDWY KEAMANKGKT IVTEPYESIS SGKMVVTIAR QTVDGSGVVA 

       190        200        210        220        230        240 
IDMKIDDLVT TAKGINIGKE GYAFILSQNK KVIAYSGEKA GTELKGDWVD KLYKDKSGDF 

       250        260        270        280        290        300 
EYTYKGKKKK MAFATSQTTG WKISGTMYAN EIHDAASRVL IMASIVLAIA IGAGMTAIYF 

       310        320        330        340        350        360 
VIRSITKPLR RIVASAEKIS EGDLTETIEI NSKDELGVLS ESFNHMAHSL RSLIHGIKDS 

       370        380        390        400        410        420 
VEHVASSSEE LTASADQTSR ATEHITMAIE QFSNGSESQS EKIETTTEQI NEMNDGLAEL 

       430        440        450        460        470        480 
ARAAAVITET SADSTEVSSK GETLVQKTAG QMNTIDHSVK AAEQVVKGLE IKSKDITNIL 

       490        500        510        520        530        540 
RVINGIADQT NLLALNAAIE AARAGEYGRG FSVVAEEVRK LAVQSADSAK EIESLISEIV 

       550        560        570        580        590        600 
KEIHTSLNVL QSVNKEVETG LVMTDETKQS FKHISQMTNQ IASELQNMNA TVEELSAGAQ 

       610        620        630        640        650        660 
EISAASNDIT AISKESSDGI QDIAASAEEQ LASMEEISSS ALTLERMSEE LRDLTKQFKV 


DK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of genes encoding methyl-accepting chemotaxis proteins in Bacillus subtilis."
Hanlon D.W., Ordal G.W.
J. Biol. Chem. 269:14038-14046(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168 / OI1085.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L29189 Genomic DNA. Translation: AAA20555.1.
AL009126 Genomic DNA. Translation: CAB15103.1.
PIRC54078.
RefSeqNP_391003.1. NC_000964.3.

3D structure databases

ProteinModelPortalP39216.
SMRP39216. Positions 302-355, 379-659.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP39216. 17 interactions.
STRING224308.BSU31250.

Proteomic databases

PaxDbP39216.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB15103; CAB15103; BSU31250.
GeneID938840.
KEGGbsu:BSU31250.
PATRIC18978208. VBIBacSub10457_3267.

Organism-specific databases

GenoListBSU31250. [Micado]

Phylogenomic databases

eggNOGCOG0840.
HOGENOMHOG000083278.
KOK03406.
OMALERDWYK.
OrthoDBEOG67HJTT.
PhylomeDBP39216.

Enzyme and pathway databases

BioCycBSUB:BSU31250-MONOMER.

Family and domain databases

InterProIPR004010. Cache_domain.
IPR003122. Chemotax_Me-accpt_rcpt_lig-bd.
IPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
IPR029151. Sensor-like.
[Graphical view]
PfamPF02743. Cache_1. 1 hit.
PF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
PF02203. TarH. 1 hit.
[Graphical view]
SMARTSM00304. HAMP. 1 hit.
SM00283. MA. 1 hit.
SM00319. TarH. 1 hit.
[Graphical view]
SUPFAMSSF103190. SSF103190. 1 hit.
PROSITEPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTLPA_BACSU
AccessionPrimary (citable) accession number: P39216
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList