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P39216

- TLPA_BACSU

UniProt

P39216 - TLPA_BACSU

Protein

Methyl-accepting chemotaxis protein TlpA

Gene

tlpA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. All amino acids serve as attractants in B.subtilis, they appear to cause an increase in the turnover methyl groups, leading to methylation of an unidentified acceptor, while repellents have been shown to cause a decrease in methyl group turnover. The methyl groups are added by a methyltransferase and removed by a methylesterase.

    GO - Molecular functioni

    1. transmembrane signaling receptor activity Source: InterPro

    GO - Biological processi

    1. chemotaxis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transducer

    Keywords - Biological processi

    Chemotaxis

    Enzyme and pathway databases

    BioCyciBSUB:BSU31250-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methyl-accepting chemotaxis protein TlpA
    Gene namesi
    Name:tlpA
    Ordered Locus Names:BSU31250
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU31250. [Micado]

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 662662Methyl-accepting chemotaxis protein TlpAPRO_0000110559Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei370 – 3701Glutamate methyl ester (Glu)By similarity
    Modified residuei594 – 5941Glutamate methyl ester (Glu)By similarity
    Modified residuei629 – 6291Glutamate methyl ester (Glu)By similarity
    Modified residuei636 – 6361Glutamate methyl ester (Glu)By similarity

    Keywords - PTMi

    Methylation

    Proteomic databases

    PaxDbiP39216.

    Interactioni

    Protein-protein interaction databases

    IntActiP39216. 17 interactions.
    STRINGi224308.BSU31250.

    Structurei

    3D structure databases

    ProteinModelPortaliP39216.
    SMRiP39216. Positions 302-355, 379-659.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini38 – 281244ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini303 – 662360CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei282 – 30221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini152 – 22877CacheAdd
    BLAST
    Domaini303 – 35553HAMPPROSITE-ProRule annotationAdd
    BLAST
    Domaini374 – 610237Methyl-accepting transducerPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 cache domain.Curated
    Contains 1 HAMP domain.PROSITE-ProRule annotation
    Contains 1 methyl-accepting transducer domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0840.
    HOGENOMiHOG000083278.
    KOiK03406.
    OMAiLERDWYK.
    OrthoDBiEOG67HJTT.
    PhylomeDBiP39216.

    Family and domain databases

    InterProiIPR004010. Cache_domain.
    IPR003122. Chemotax_Me-accpt_rcpt_lig-bd.
    IPR003660. HAMP_linker_domain.
    IPR004089. MCPsignal_dom.
    IPR029151. Sensor-like.
    [Graphical view]
    PfamiPF02743. Cache_1. 1 hit.
    PF00672. HAMP. 1 hit.
    PF00015. MCPsignal. 1 hit.
    PF02203. TarH. 1 hit.
    [Graphical view]
    SMARTiSM00304. HAMP. 1 hit.
    SM00283. MA. 1 hit.
    SM00319. TarH. 1 hit.
    [Graphical view]
    SUPFAMiSSF103190. SSF103190. 1 hit.
    PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
    PS50885. HAMP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39216-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKTLTTIRR SSIARRLIIS FLLILIVPIT ALSVSAYQSA VASLDVQMTQ    50
    SAKENVQILD HIIDDKISTT EKSLAYFSDW ATAEKFQDKK KTELKQEFKQ 100
    FIQMNDNVAA VFSSGKDGDF TRYPYADMPS DFNALERDWY KEAMANKGKT 150
    IVTEPYESIS SGKMVVTIAR QTVDGSGVVA IDMKIDDLVT TAKGINIGKE 200
    GYAFILSQNK KVIAYSGEKA GTELKGDWVD KLYKDKSGDF EYTYKGKKKK 250
    MAFATSQTTG WKISGTMYAN EIHDAASRVL IMASIVLAIA IGAGMTAIYF 300
    VIRSITKPLR RIVASAEKIS EGDLTETIEI NSKDELGVLS ESFNHMAHSL 350
    RSLIHGIKDS VEHVASSSEE LTASADQTSR ATEHITMAIE QFSNGSESQS 400
    EKIETTTEQI NEMNDGLAEL ARAAAVITET SADSTEVSSK GETLVQKTAG 450
    QMNTIDHSVK AAEQVVKGLE IKSKDITNIL RVINGIADQT NLLALNAAIE 500
    AARAGEYGRG FSVVAEEVRK LAVQSADSAK EIESLISEIV KEIHTSLNVL 550
    QSVNKEVETG LVMTDETKQS FKHISQMTNQ IASELQNMNA TVEELSAGAQ 600
    EISAASNDIT AISKESSDGI QDIAASAEEQ LASMEEISSS ALTLERMSEE 650
    LRDLTKQFKV DK 662
    Length:662
    Mass (Da):72,278
    Last modified:February 1, 1995 - v1
    Checksum:i7335B27992D07FF6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L29189 Genomic DNA. Translation: AAA20555.1.
    AL009126 Genomic DNA. Translation: CAB15103.1.
    PIRiC54078.
    RefSeqiNP_391003.1. NC_000964.3.
    WP_003243846.1. NZ_CM000487.1.

    Genome annotation databases

    EnsemblBacteriaiCAB15103; CAB15103; BSU31250.
    GeneIDi938840.
    KEGGibsu:BSU31250.
    PATRICi18978208. VBIBacSub10457_3267.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L29189 Genomic DNA. Translation: AAA20555.1 .
    AL009126 Genomic DNA. Translation: CAB15103.1 .
    PIRi C54078.
    RefSeqi NP_391003.1. NC_000964.3.
    WP_003243846.1. NZ_CM000487.1.

    3D structure databases

    ProteinModelPortali P39216.
    SMRi P39216. Positions 302-355, 379-659.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P39216. 17 interactions.
    STRINGi 224308.BSU31250.

    Proteomic databases

    PaxDbi P39216.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB15103 ; CAB15103 ; BSU31250 .
    GeneIDi 938840.
    KEGGi bsu:BSU31250.
    PATRICi 18978208. VBIBacSub10457_3267.

    Organism-specific databases

    GenoListi BSU31250. [Micado ]

    Phylogenomic databases

    eggNOGi COG0840.
    HOGENOMi HOG000083278.
    KOi K03406.
    OMAi LERDWYK.
    OrthoDBi EOG67HJTT.
    PhylomeDBi P39216.

    Enzyme and pathway databases

    BioCyci BSUB:BSU31250-MONOMER.

    Family and domain databases

    InterProi IPR004010. Cache_domain.
    IPR003122. Chemotax_Me-accpt_rcpt_lig-bd.
    IPR003660. HAMP_linker_domain.
    IPR004089. MCPsignal_dom.
    IPR029151. Sensor-like.
    [Graphical view ]
    Pfami PF02743. Cache_1. 1 hit.
    PF00672. HAMP. 1 hit.
    PF00015. MCPsignal. 1 hit.
    PF02203. TarH. 1 hit.
    [Graphical view ]
    SMARTi SM00304. HAMP. 1 hit.
    SM00283. MA. 1 hit.
    SM00319. TarH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103190. SSF103190. 1 hit.
    PROSITEi PS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
    PS50885. HAMP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of genes encoding methyl-accepting chemotaxis proteins in Bacillus subtilis."
      Hanlon D.W., Ordal G.W.
      J. Biol. Chem. 269:14038-14046(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168 / OI1085.
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.

    Entry informationi

    Entry nameiTLPA_BACSU
    AccessioniPrimary (citable) accession number: P39216
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3