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Protein

Methyl-accepting chemotaxis protein TlpC

Gene

tlpC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. chemotaxis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

BioCyciBSUB:BSU03440-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-accepting chemotaxis protein TlpC
Gene namesi
Name:tlpC
Ordered Locus Names:BSU03440
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570 Componenti: Chromosome

Organism-specific databases

GenoListiBSU03440. [Micado]

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei14 – 3421HelicalSequence AnalysisAdd
BLAST
Topological domaini35 – 188154ExtracellularSequence AnalysisAdd
BLAST
Transmembranei189 – 20719HelicalSequence AnalysisAdd
BLAST
Topological domaini208 – 573366CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573Methyl-accepting chemotaxis protein TlpCPRO_0000110561Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei276 – 2761Glutamate methyl ester (Gln)By similarity
Modified residuei535 – 5351Glutamate methyl ester (Glu)By similarity
Modified residuei542 – 5421Glutamate methyl ester (Glu)By similarity

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiP39209.

Interactioni

Protein-protein interaction databases

IntActiP39209. 2 interactions.
STRINGi224308.BSU03440.

Structurei

3D structure databases

ProteinModelPortaliP39209.
SMRiP39209. Positions 307-568.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 26153HAMPPROSITE-ProRule annotationAdd
BLAST
Domaini280 – 544265Methyl-accepting transducerPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HAMP domain.PROSITE-ProRule annotation
Contains 1 methyl-accepting transducer domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0840.
HOGENOMiHOG000148080.
InParanoidiP39209.
KOiK03406.
OMAiQHIANTS.
OrthoDBiEOG62NX2Z.
PhylomeDBiP39209.

Family and domain databases

InterProiIPR004090. Chemotax_Me-accpt_rcpt.
IPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
IPR029151. Sensor-like.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]
PRINTSiPR00260. CHEMTRNSDUCR.
SMARTiSM00304. HAMP. 1 hit.
SM00283. MA. 1 hit.
[Graphical view]
SUPFAMiSSF103190. SSF103190. 1 hit.
PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39209-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIKRFKMKL GTKILCLVFV VILLFSASVG TVMLKEITES MKQMATEKAK
60 70 80 90 100
GDLALSSTYI DDVMSGDWQV KNNKLYKGQT QINGNEDIVD LLGEKTGDTI
110 120 130 140 150
TIFQGDTRVA TNVMKNGERA VGTQASSEVI AAVLKKGKRF YGQADVAGSS
160 170 180 190 200
YQTAYMPLKD QNGNIIGMLY TGANQSILAS LTQSLFTQFA IVLVIVIMVS
210 220 230 240 250
VILVLVFTRK INKRLNALKS AFESAGNGDM TIEVSDKTGD ELSELSVYYN
260 270 280 290 300
KMRMKLNDTI QTVQQSALQL ASASQQLSAG AEETNQASEK ITEAVQQIAN
310 320 330 340 350
GAQDQITRIE NSESSLKQAS ADIRDISANT AAIADKGQLA QSKADIGQKE
360 370 380 390 400
IANVQAQMDA IHQSIQKSGE IIHQLDGRSK QIEQILSVIT QIADQTNLLA
410 420 430 440 450
LNAAIEAARA GEQGKGFAVV ADEVRKLAEE SQQSAGQISK LIIEIQKDMN
460 470 480 490 500
RSARSVEHVK TEAAEGVTMI QRTRDAFKEI AAATGEISAE ISDLSASVTN
510 520 530 540 550
ISASAHQIND SFAANTADIK ESTKNTRQAA ALTEEQFAAM EEITAASETL
560 570
SQLAEELTGI ISQFKMINQA ENG
Length:573
Mass (Da):61,784
Last modified:June 16, 2009 - v3
Checksum:i80E3A90EE35E5CDF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti216 – 2161N → T in BAA06432 (PubMed:7704255).Curated
Sequence conflicti216 – 2161N → T in BAA08978 (PubMed:8969502).Curated
Sequence conflicti332 – 3321A → P in BAA06432 (PubMed:7704255).Curated
Sequence conflicti332 – 3321A → P in BAA08978 (PubMed:8969502).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34005 Genomic DNA. Translation: CAA83970.1.
D30762 Genomic DNA. Translation: BAA06432.1.
D50453 Genomic DNA. Translation: BAA08978.1.
AL009126 Genomic DNA. Translation: CAB12138.2.
PIRiI40496.
RefSeqiNP_388226.2. NC_000964.3.
WP_003246498.1. NZ_JNCM01000030.1.

Genome annotation databases

EnsemblBacteriaiCAB12138; CAB12138; BSU03440.
GeneIDi938316.
KEGGibsu:BSU03440.
PATRICi18972251. VBIBacSub10457_0354.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34005 Genomic DNA. Translation: CAA83970.1.
D30762 Genomic DNA. Translation: BAA06432.1.
D50453 Genomic DNA. Translation: BAA08978.1.
AL009126 Genomic DNA. Translation: CAB12138.2.
PIRiI40496.
RefSeqiNP_388226.2. NC_000964.3.
WP_003246498.1. NZ_JNCM01000030.1.

3D structure databases

ProteinModelPortaliP39209.
SMRiP39209. Positions 307-568.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP39209. 2 interactions.
STRINGi224308.BSU03440.

Proteomic databases

PaxDbiP39209.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12138; CAB12138; BSU03440.
GeneIDi938316.
KEGGibsu:BSU03440.
PATRICi18972251. VBIBacSub10457_0354.

Organism-specific databases

GenoListiBSU03440. [Micado]

Phylogenomic databases

eggNOGiCOG0840.
HOGENOMiHOG000148080.
InParanoidiP39209.
KOiK03406.
OMAiQHIANTS.
OrthoDBiEOG62NX2Z.
PhylomeDBiP39209.

Enzyme and pathway databases

BioCyciBSUB:BSU03440-MONOMER.

Family and domain databases

InterProiIPR004090. Chemotax_Me-accpt_rcpt.
IPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
IPR029151. Sensor-like.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]
PRINTSiPR00260. CHEMTRNSDUCR.
SMARTiSM00304. HAMP. 1 hit.
SM00283. MA. 1 hit.
[Graphical view]
SUPFAMiSSF103190. SSF103190. 1 hit.
PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of TlpC, a novel 62 kDa MCP-like protein from Bacillus subtilis."
    Hanlon D.W., Rosario M.M.L., Ordal G.W., Venema G., van Sinderen D.
    Microbiology 140:1847-1854(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168 / OI1085.
  2. "A 10 kb nucleotide sequence at the 5' flanking region (32 degrees) of srfAA of the Bacillus subtilis chromosome."
    Fujishima Y., Yamane K.
    Microbiology 141:277-279(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  3. "The 25 degrees-36 degrees region of the Bacillus subtilis chromosome: determination of the sequence of a 146 kb segment and identification of 113 genes."
    Yamane K., Kumano M., Kurita K.
    Microbiology 142:3047-3056(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  4. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  5. "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
    Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
    Microbiology 155:1758-1775(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 216 AND 332.

Entry informationi

Entry nameiTLPC_BACSU
AccessioniPrimary (citable) accession number: P39209
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 16, 2009
Last modified: January 7, 2015
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.