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P39209 (TLPC_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Methyl-accepting chemotaxis protein TlpC
Gene names
Name:tlpC
Ordered Locus Names:BSU03440
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus ›

Protein attributes

Sequence length573 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Contains 1 HAMP domain.

Contains 1 methyl-accepting transducer domain.

Ontologies

Keywords
   Biological processChemotaxis
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionTransducer
   PTMMethylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processchemotaxis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsignal transducer activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 573573Methyl-accepting chemotaxis protein TlpC
PRO_0000110561

Regions

Topological domain1 – 1313Cytoplasmic Potential
Transmembrane14 – 3421Helical; Potential
Topological domain35 – 188154Extracellular Potential
Transmembrane189 – 20719Helical; Potential
Topological domain208 – 573366Cytoplasmic Potential
Domain209 – 26153HAMP
Domain280 – 544265Methyl-accepting transducer

Amino acid modifications

Modified residue2761Glutamate methyl ester (Gln) By similarity
Modified residue5351Glutamate methyl ester (Glu) By similarity
Modified residue5421Glutamate methyl ester (Glu) By similarity

Experimental info

Sequence conflict2161N → T in BAA06432. Ref.2
Sequence conflict2161N → T in BAA08978. Ref.3
Sequence conflict3321A → P in BAA06432. Ref.2
Sequence conflict3321A → P in BAA08978. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P39209 [UniParc].

Last modified June 16, 2009. Version 3.
Checksum: 80E3A90EE35E5CDF

FASTA57361,784
        10         20         30         40         50         60 
MLIKRFKMKL GTKILCLVFV VILLFSASVG TVMLKEITES MKQMATEKAK GDLALSSTYI 

        70         80         90        100        110        120 
DDVMSGDWQV KNNKLYKGQT QINGNEDIVD LLGEKTGDTI TIFQGDTRVA TNVMKNGERA 

       130        140        150        160        170        180 
VGTQASSEVI AAVLKKGKRF YGQADVAGSS YQTAYMPLKD QNGNIIGMLY TGANQSILAS 

       190        200        210        220        230        240 
LTQSLFTQFA IVLVIVIMVS VILVLVFTRK INKRLNALKS AFESAGNGDM TIEVSDKTGD 

       250        260        270        280        290        300 
ELSELSVYYN KMRMKLNDTI QTVQQSALQL ASASQQLSAG AEETNQASEK ITEAVQQIAN 

       310        320        330        340        350        360 
GAQDQITRIE NSESSLKQAS ADIRDISANT AAIADKGQLA QSKADIGQKE IANVQAQMDA 

       370        380        390        400        410        420 
IHQSIQKSGE IIHQLDGRSK QIEQILSVIT QIADQTNLLA LNAAIEAARA GEQGKGFAVV 

       430        440        450        460        470        480 
ADEVRKLAEE SQQSAGQISK LIIEIQKDMN RSARSVEHVK TEAAEGVTMI QRTRDAFKEI 

       490        500        510        520        530        540 
AAATGEISAE ISDLSASVTN ISASAHQIND SFAANTADIK ESTKNTRQAA ALTEEQFAAM 

       550        560        570 
EEITAASETL SQLAEELTGI ISQFKMINQA ENG

« Hide

References

« Hide 'large scale' references
[1]"Identification of TlpC, a novel 62 kDa MCP-like protein from Bacillus subtilis."
Hanlon D.W., Rosario M.M.L., Ordal G.W., Venema G., van Sinderen D.
Microbiology 140:1847-1854(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168 / OI1085.
[2]"A 10 kb nucleotide sequence at the 5' flanking region (32 degrees) of srfAA of the Bacillus subtilis chromosome."
Fujishima Y., Yamane K.
Microbiology 141:277-279(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[3]"The 25 degrees-36 degrees region of the Bacillus subtilis chromosome: determination of the sequence of a 146 kb segment and identification of 113 genes."
Yamane K., Kumano M., Kurita K.
Microbiology 142:3047-3056(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[4]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[5]"From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION TO 216 AND 332.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z34005 Genomic DNA. Translation: CAA83970.1.
D30762 Genomic DNA. Translation: BAA06432.1.
D50453 Genomic DNA. Translation: BAA08978.1.
AL009126 Genomic DNA. Translation: CAB12138.2.
PIRI40496.
RefSeqNP_388226.2. NC_000964.3.

3D structure databases

ProteinModelPortalP39209.
SMRP39209. Positions 307-568.
ModBaseSearch...

Protein-protein interaction databases

IntActP39209. 2 interactions.
STRING224308.BSU03440.

Proteomic databases

PaxDbP39209.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB12138; CAB12138; BSU03440.
GeneID938316.
KEGGbsu:BSU03440.
PATRIC18972251. VBIBacSub10457_0354.

Organism-specific databases

GenoListBSU03440. [Micado]

Phylogenomic databases

eggNOGCOG0840.
HOGENOMHOG000148080.
KOK03406.
ProtClustDBCLSK886673.

Enzyme and pathway databases

BioCycBSUB:BSU03440-MONOMER.

Family and domain databases

InterProIPR004090. Chemotax_Me-accpt_rcpt.
IPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
[Graphical view]
PfamPF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]
PRINTSPR00260. CHEMTRNSDUCR.
SMARTSM00304. HAMP. 1 hit.
SM00283. MA. 1 hit.
[Graphical view]
PROSITEPS00538. CHEMOTAXIS_TRANSDUC_1. False negative.
PS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTLPC_BACSU
AccessionPrimary (citable) accession number: P39209
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 16, 2009
Last modified: May 1, 2013
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents