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P39209

- TLPC_BACSU

UniProt

P39209 - TLPC_BACSU

Protein

Methyl-accepting chemotaxis protein TlpC

Gene

tlpC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 3 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. chemotaxis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transducer

    Keywords - Biological processi

    Chemotaxis

    Enzyme and pathway databases

    BioCyciBSUB:BSU03440-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methyl-accepting chemotaxis protein TlpC
    Gene namesi
    Name:tlpC
    Ordered Locus Names:BSU03440
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU03440. [Micado]

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 573573Methyl-accepting chemotaxis protein TlpCPRO_0000110561Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei276 – 2761Glutamate methyl ester (Gln)By similarity
    Modified residuei535 – 5351Glutamate methyl ester (Glu)By similarity
    Modified residuei542 – 5421Glutamate methyl ester (Glu)By similarity

    Keywords - PTMi

    Methylation

    Proteomic databases

    PaxDbiP39209.

    Interactioni

    Protein-protein interaction databases

    IntActiP39209. 2 interactions.
    STRINGi224308.BSU03440.

    Structurei

    3D structure databases

    ProteinModelPortaliP39209.
    SMRiP39209. Positions 307-568.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1313CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini35 – 188154ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini208 – 573366CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei189 – 20719HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini209 – 26153HAMPPROSITE-ProRule annotationAdd
    BLAST
    Domaini280 – 544265Methyl-accepting transducerPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HAMP domain.PROSITE-ProRule annotation
    Contains 1 methyl-accepting transducer domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0840.
    HOGENOMiHOG000148080.
    KOiK03406.
    OrthoDBiEOG62NX2Z.
    PhylomeDBiP39209.

    Family and domain databases

    InterProiIPR004090. Chemotax_Me-accpt_rcpt.
    IPR003660. HAMP_linker_domain.
    IPR004089. MCPsignal_dom.
    IPR029151. Sensor-like.
    [Graphical view]
    PfamiPF00672. HAMP. 1 hit.
    PF00015. MCPsignal. 1 hit.
    [Graphical view]
    PRINTSiPR00260. CHEMTRNSDUCR.
    SMARTiSM00304. HAMP. 1 hit.
    SM00283. MA. 1 hit.
    [Graphical view]
    SUPFAMiSSF103190. SSF103190. 1 hit.
    PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
    PS50885. HAMP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39209-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLIKRFKMKL GTKILCLVFV VILLFSASVG TVMLKEITES MKQMATEKAK    50
    GDLALSSTYI DDVMSGDWQV KNNKLYKGQT QINGNEDIVD LLGEKTGDTI 100
    TIFQGDTRVA TNVMKNGERA VGTQASSEVI AAVLKKGKRF YGQADVAGSS 150
    YQTAYMPLKD QNGNIIGMLY TGANQSILAS LTQSLFTQFA IVLVIVIMVS 200
    VILVLVFTRK INKRLNALKS AFESAGNGDM TIEVSDKTGD ELSELSVYYN 250
    KMRMKLNDTI QTVQQSALQL ASASQQLSAG AEETNQASEK ITEAVQQIAN 300
    GAQDQITRIE NSESSLKQAS ADIRDISANT AAIADKGQLA QSKADIGQKE 350
    IANVQAQMDA IHQSIQKSGE IIHQLDGRSK QIEQILSVIT QIADQTNLLA 400
    LNAAIEAARA GEQGKGFAVV ADEVRKLAEE SQQSAGQISK LIIEIQKDMN 450
    RSARSVEHVK TEAAEGVTMI QRTRDAFKEI AAATGEISAE ISDLSASVTN 500
    ISASAHQIND SFAANTADIK ESTKNTRQAA ALTEEQFAAM EEITAASETL 550
    SQLAEELTGI ISQFKMINQA ENG 573
    Length:573
    Mass (Da):61,784
    Last modified:June 16, 2009 - v3
    Checksum:i80E3A90EE35E5CDF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti216 – 2161N → T in BAA06432. (PubMed:7704255)Curated
    Sequence conflicti216 – 2161N → T in BAA08978. (PubMed:8969502)Curated
    Sequence conflicti332 – 3321A → P in BAA06432. (PubMed:7704255)Curated
    Sequence conflicti332 – 3321A → P in BAA08978. (PubMed:8969502)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z34005 Genomic DNA. Translation: CAA83970.1.
    D30762 Genomic DNA. Translation: BAA06432.1.
    D50453 Genomic DNA. Translation: BAA08978.1.
    AL009126 Genomic DNA. Translation: CAB12138.2.
    PIRiI40496.
    RefSeqiNP_388226.2. NC_000964.3.
    WP_003246498.1. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB12138; CAB12138; BSU03440.
    GeneIDi938316.
    KEGGibsu:BSU03440.
    PATRICi18972251. VBIBacSub10457_0354.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z34005 Genomic DNA. Translation: CAA83970.1 .
    D30762 Genomic DNA. Translation: BAA06432.1 .
    D50453 Genomic DNA. Translation: BAA08978.1 .
    AL009126 Genomic DNA. Translation: CAB12138.2 .
    PIRi I40496.
    RefSeqi NP_388226.2. NC_000964.3.
    WP_003246498.1. NC_000964.3.

    3D structure databases

    ProteinModelPortali P39209.
    SMRi P39209. Positions 307-568.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P39209. 2 interactions.
    STRINGi 224308.BSU03440.

    Proteomic databases

    PaxDbi P39209.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB12138 ; CAB12138 ; BSU03440 .
    GeneIDi 938316.
    KEGGi bsu:BSU03440.
    PATRICi 18972251. VBIBacSub10457_0354.

    Organism-specific databases

    GenoListi BSU03440. [Micado ]

    Phylogenomic databases

    eggNOGi COG0840.
    HOGENOMi HOG000148080.
    KOi K03406.
    OrthoDBi EOG62NX2Z.
    PhylomeDBi P39209.

    Enzyme and pathway databases

    BioCyci BSUB:BSU03440-MONOMER.

    Family and domain databases

    InterProi IPR004090. Chemotax_Me-accpt_rcpt.
    IPR003660. HAMP_linker_domain.
    IPR004089. MCPsignal_dom.
    IPR029151. Sensor-like.
    [Graphical view ]
    Pfami PF00672. HAMP. 1 hit.
    PF00015. MCPsignal. 1 hit.
    [Graphical view ]
    PRINTSi PR00260. CHEMTRNSDUCR.
    SMARTi SM00304. HAMP. 1 hit.
    SM00283. MA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103190. SSF103190. 1 hit.
    PROSITEi PS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
    PS50885. HAMP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of TlpC, a novel 62 kDa MCP-like protein from Bacillus subtilis."
      Hanlon D.W., Rosario M.M.L., Ordal G.W., Venema G., van Sinderen D.
      Microbiology 140:1847-1854(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168 / OI1085.
    2. "A 10 kb nucleotide sequence at the 5' flanking region (32 degrees) of srfAA of the Bacillus subtilis chromosome."
      Fujishima Y., Yamane K.
      Microbiology 141:277-279(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    3. "The 25 degrees-36 degrees region of the Bacillus subtilis chromosome: determination of the sequence of a 146 kb segment and identification of 113 genes."
      Yamane K., Kumano M., Kurita K.
      Microbiology 142:3047-3056(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    4. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    5. "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
      Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
      Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION TO 216 AND 332.

    Entry informationi

    Entry nameiTLPC_BACSU
    AccessioniPrimary (citable) accession number: P39209
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 104 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3