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Protein

Thermosensitive gluconokinase

Gene

idnK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-gluconate = ADP + 6-phospho-D-gluconate.

Pathwayi: L-idonate degradation

This protein is involved in the pathway L-idonate degradation, which is part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the pathway L-idonate degradation and in Carbohydrate acid metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178ATPSequence analysis

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • gluconokinase activity Source: EcoCyc

GO - Biological processi

  • D-gluconate metabolic process Source: EcoCyc
  • L-idonate catabolic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Gluconate utilization

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:GLUCONOKINI-MONOMER.
ECOL316407:JW4225-MONOMER.
MetaCyc:GLUCONOKINI-MONOMER.
RETL1328306-WGS:GSTH-6755-MONOMER.
RETL1328306-WGS:GSTH-753-MONOMER.
UniPathwayiUPA00793.

Names & Taxonomyi

Protein namesi
Recommended name:
Thermosensitive gluconokinase (EC:2.7.1.12)
Alternative name(s):
Gluconate kinase 1
Gene namesi
Name:idnK
Synonyms:gntV
Ordered Locus Names:b4268, JW4225
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12152. idnK.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 187187Thermosensitive gluconokinasePRO_0000084151Add
BLAST

Proteomic databases

PaxDbiP39208.

Interactioni

Protein-protein interaction databases

BioGridi4261380. 10 interactions.
IntActiP39208. 8 interactions.
STRINGi511145.b4268.

Structurei

3D structure databases

ProteinModelPortaliP39208.
SMRiP39208. Positions 6-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gluconokinase GntK/GntV family.Curated

Phylogenomic databases

eggNOGiENOG4108Z67. Bacteria.
COG3265. LUCA.
HOGENOMiHOG000032567.
InParanoidiP39208.
KOiK00851.
OMAiMGVCASG.
OrthoDBiEOG6XHC8K.
PhylomeDBiP39208.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR031322. Shikimate/glucono_kinase.
IPR006001. Therm_gnt_kin.
[Graphical view]
PfamiPF01202. SKI. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01313. therm_gnt_kin. 1 hit.

Sequencei

Sequence statusi: Complete.

P39208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGESFILMG VSGSGKTLIG SKVAALLSAK FIDGDDLHPA KNIDKMSQGI
60 70 80 90 100
PLSDEDRLPW LERLNDASYS LYKKNETGFI VCSSLKKQYR DILRKGSPHV
110 120 130 140 150
HFLWLDGDYE TILARMQRRA GHFMPVALLK SQFEALERPQ ADEQDIVRID
160 170 180
INHDIANVTE QCRQAVLAIR QNRICAKEGS ASDQRCE
Length:187
Mass (Da):21,004
Last modified:February 1, 1995 - v1
Checksum:iDA85C86951037ECC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97165.1.
U00096 Genomic DNA. Translation: AAC77225.1.
AP009048 Genomic DNA. Translation: BAE78265.1.
M96355 Genomic DNA. No translation available.
PIRiS56494.
RefSeqiNP_418689.1. NC_000913.3.
WP_000896738.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77225; AAC77225; b4268.
BAE78265; BAE78265; BAE78265.
GeneIDi946066.
KEGGiecj:JW4225.
eco:b4268.
PATRICi32124109. VBIEscCol129921_4399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97165.1.
U00096 Genomic DNA. Translation: AAC77225.1.
AP009048 Genomic DNA. Translation: BAE78265.1.
M96355 Genomic DNA. No translation available.
PIRiS56494.
RefSeqiNP_418689.1. NC_000913.3.
WP_000896738.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP39208.
SMRiP39208. Positions 6-158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261380. 10 interactions.
IntActiP39208. 8 interactions.
STRINGi511145.b4268.

Proteomic databases

PaxDbiP39208.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77225; AAC77225; b4268.
BAE78265; BAE78265; BAE78265.
GeneIDi946066.
KEGGiecj:JW4225.
eco:b4268.
PATRICi32124109. VBIEscCol129921_4399.

Organism-specific databases

EchoBASEiEB2072.
EcoGeneiEG12152. idnK.

Phylogenomic databases

eggNOGiENOG4108Z67. Bacteria.
COG3265. LUCA.
HOGENOMiHOG000032567.
InParanoidiP39208.
KOiK00851.
OMAiMGVCASG.
OrthoDBiEOG6XHC8K.
PhylomeDBiP39208.

Enzyme and pathway databases

UniPathwayiUPA00793.
BioCyciEcoCyc:GLUCONOKINI-MONOMER.
ECOL316407:JW4225-MONOMER.
MetaCyc:GLUCONOKINI-MONOMER.
RETL1328306-WGS:GSTH-6755-MONOMER.
RETL1328306-WGS:GSTH-753-MONOMER.

Miscellaneous databases

PROiP39208.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR031322. Shikimate/glucono_kinase.
IPR006001. Therm_gnt_kin.
[Graphical view]
PfamiPF01202. SKI. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01313. therm_gnt_kin. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes."
    Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.
    Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. Pucci M.J., Discotto L.F., Dougherty T.J.
    Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-187.
    Strain: B.
  5. "Sequence analysis of the GntII (subsidiary) system for gluconate metabolism reveals a novel pathway for L-idonic acid catabolism in Escherichia coli."
    Bausch C., Peekhaus N., Utz C., Blais T., Murray E., Lowary T., Conway T.
    J. Bacteriol. 180:3704-3710(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiIDNK_ECOLI
AccessioniPrimary (citable) accession number: P39208
Secondary accession number(s): Q2M641
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 20, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.