P39206 (CAIE_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Carnitine operon protein CaiE

Gene names

Name:	caiE
Ordered Locus Names:	b0035, JW5004

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Overproduction of CaiE stimulates the activity of CaiB and CaiD. Ref.1
Pathway	Amine and polyamine metabolism; carnitine metabolism. HAMAP MF_01525
Sequence similarities	Belongs to the transferase hexapeptide repeat family.
Sequence caution	The sequence CAA52115.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Domain	Repeat
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	carnitine metabolic process Inferred from experiment Ref.1. Source: EcoliWiki
Molecular function	carnitine dehydratase activity Inferred from experiment Ref.1. Source: EcoliWiki transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 196	196	Carnitine operon protein CaiE HAMAP MF_01525		PRO_0000068719
Natural variations
	Natural variant	54	1	A → T in strain: O44:K74.
	Natural variant	90	1	L → V in strain: O44:K74.
	Natural variant	126	1	R → H in strain: O44:K74.
	Natural variant	143	1	N → S in strain: O44:K74.
	Natural variant	153	1	R → Q in strain: O44:K74.
	Natural variant	168	1	V → A in strain: O44:K74.

Sequences

	Sequence		Length	Mass (Da)
	P39206 [UniParc]. Last modified December 1, 2000. Version 2. Checksum: BF47443CA7850770	FASTA	196	21,244
	10 20 30 40 50 60 MSYYAFEGLI PVVHPTAFVH PSAVLIGDVI VGAGVYIGPL ASLRGDYGRL IVQAGANIQD 70 80 90 100 110 120 GCIMHGYCDT DTIVGENGHI GHGAILHGCL IGRDALVGMN SVIMDGAVIG EESIVAAMSF 130 140 150 160 170 180 VKAGFRGEKR QLLMGTPARA VRNVSDDELH WKRLNTKEYQ DLVGRCHVSL HETQPLRQME 190 ENRPRLQGTT DVTPKR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of the cai operon necessary for carnitine metabolism in Escherichia coli." Eichler K., Bourgis F., Buchet A., Kleber H.-P., Mandrand-Berthelot M.-A. Mol. Microbiol. 13:775-786(1994) [PubMed: 7815937] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION. Strain: O44:K74.
[2]	"Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region." Yura T., Mori H., Nagai H., Nagata T., Ishihama A., Fujita N., Isono K., Mizobuchi K., Nakata A. Nucleic Acids Res. 20:3305-3308(1992) [PubMed: 1630901] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X73904 Genomic DNA. Translation: CAA52115.1. Different initiation. U00096 Genomic DNA. Translation: AAC73146.2. AP009048 Genomic DNA. Translation: BAB96604.2.
PIR	C64724.
RefSeq	NP_414577.2. NC_000913.2.
3D structure databases
ProteinModelPortal	P39206.
SMR	P39206. Positions 3-167.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000000137; EBESCP00000000137; EBESCG00000000107. EBESCT00000014835; EBESCP00000014126; EBESCG00000013895.
GeneID	948999.
GenomeReviews	Gene locus JW5004 in contig AP009048_GR. Gene locus b0035 in contig U00096_GR.
KEGG	ecj:JW5004. eco:b0035.
PATRIC	32115165. VBIEscCol129921_0034.
Organism-specific databases
EchoBASE	EB2492.
EcoGene	EG12608. caiE.
Phylogenomic databases
eggNOG	COG0663.
GeneTree	EBGT00050000010015.
HOGENOM	HBG621238.
OMA	HIGHGAV.
PhylomeDB	P39206.
ProtClustDB	PRK13627.
Enzyme and pathway databases
BioCyc	EcoCyc:CAIE-MONOMER. MetaCyc:CAIE-MONOMER.
Gene expression databases
Genevestigator	P39206.
Family and domain databases
HAMAP	MF_01525. CaiE. [Tree]
InterPro	IPR023446. CaiE. IPR001451. Hexapep_transf. IPR011004. Trimer_LpxA-like. [Graphical view]
KO	K08279.
Pfam	PF00132. Hexapep. 3 hits. [Graphical view]
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAIE_ECOLI

Accession

Primary (citable) accession number: P39206
Secondary accession number(s): Q8KMY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	December 1, 2000
Last modified:	January 25, 2012
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program