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P39205 (CIN_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Molybdenum cofactor synthesis protein cinnamon

Including the following 2 domains:

  1. Molybdopterin adenylyltransferase
    Short name=MPT adenylyltransferase
    EC=2.7.7.75
    Alternative name(s):
    Domain G
  2. Molybdopterin molybdenumtransferase
    Short name=MPT Mo-transferase
    EC=2.10.1.1
    Alternative name(s):
    Domain E
Gene names
Name:cin
ORF Names:CG2945
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length601 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. Ref.3

Catalytic activity

ATP + molybdopterin = diphosphate + adenylyl-molybdopterin.

Adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP.

Cofactor

Magnesium By similarity.

Pathway

Cofactor biosynthesis; molybdopterin biosynthesis.

Developmental stage

Detected primarily in the epidermal cells of the segmental grooves during germ-band retraction (7-9 hours after egg laying). Ref.3

Sequence similarities

In the N-terminal section; belongs to the MoaB/Mog family.

In the C-terminal section; belongs to the MoeA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 601601Molybdenum cofactor synthesis protein cinnamon
PRO_0000170962

Regions

Region3 – 153151MPT adenylyltransferase
Region184 – 596413MPT Mo-transferase

Amino acid modifications

Modified residue3761Phosphoserine Ref.7

Experimental info

Sequence conflict4141S → T in AAA65877. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P39205 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: DFA6926E955BF287

FASTA60165,733
        10         20         30         40         50         60 
MESITFGVLT ISDTCWQEPE KDTSGPILRQ LIGETFANTQ VIGNIVPDEK DIIQQELRKW 

        70         80         90        100        110        120 
IDREELRVIL TTGGTGFAPR DVTPEATRQL LEKECPQLSM YITLESIKQT QYAALSRGLC 

       130        140        150        160        170        180 
GIAGNTLILN LPGSEKAVKE CFQTISALLP HAVHLIGDDV SLVRKTHAEV QGSAQKSHIC 

       190        200        210        220        230        240 
PHKTGTGTDS DRNSPYPMLP VQEVLSIIFN TVQKTANLNK ILLEMNAPVN IPPFRASIKD 

       250        260        270        280        290        300 
GYAMKSTGFS GTKRVLGCIA AGDSPNSLPL AEDECYKINT GAPLPLEADC VVQVEDTKLL 

       310        320        330        340        350        360 
QLDKNGQESL VDILVEPQAG LDVRPVGYDL STNDRIFPAL DPSPVVVKSL LASVGNRLIL 

       370        380        390        400        410        420 
SKPKVAIVST GSELCSPRNQ LTPGKIFDSN TTMLTELLVY FGFNCMHTCV LSDSFQRTKE 

       430        440        450        460        470        480 
SLLELFEVVD FVICSGGVSM GDKDFVKSVL EDLQFRIHCG RVNIKPGKPM TFASRKDKYF 

       490        500        510        520        530        540 
FGLPGNPVSA FVTFHLFALP AIRFAAGWDR CKCSLSVLNV KLLNDFSLDS RPEFVRASVI 

       550        560        570        580        590        600 
SKSGELYASV NGNQISSRLQ SIVGADVLIN LPARTSDRPL AKAGEIFPAS VLRFDFISKY 


E 

« Hide

References

« Hide 'large scale' references
[1]"The Drosophila molybdenum cofactor gene cinnamon is homologous to three Escherichia coli cofactor proteins and to the rat protein gephyrin."
Kamdar K.P., Shelton M.E., Finnerty V.
Genetics 137:791-801(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"The Drosophila cinnamon gene is functionally homologous to Arabidopsis cnx1 and has a similar expression pattern to the mammalian gephyrin gene."
Wittle A.E., Kamdar K.P., Finnerty V.
Mol. Gen. Genet. 261:672-680(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DEVELOPMENTAL STAGE.
Strain: Canton-S.
[4]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[5]"From sequence to chromosome: the tip of the X chromosome of D. melanogaster."
Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G., Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Borkova D., Minana B. expand/collapse author list , Kafatos F.C., Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L., Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P., Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H., Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S., McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C., Glover D.M.
Science 287:2220-2222(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Oregon-R.
[6]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Head.
[7]"An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells."
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A.
Mol. Biosyst. 3:275-286(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-376, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L19876 mRNA. Translation: AAA65877.1.
AE014298 Genomic DNA. Translation: AAN09010.1.
AL050231 Genomic DNA. Translation: CAB65851.1. Sequence problems.
AL050231 Genomic DNA. Translation: CAB65852.1.
AY069078 mRNA. Translation: AAL39223.1.
PIRS47896.
RefSeqNP_477030.1. NM_057682.3.
NP_726659.1. NM_166835.3.
UniGeneDm.2294.

3D structure databases

ProteinModelPortalP39205.
SMRP39205. Positions 7-156, 193-594.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP39205.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0070064; FBpp0070063; FBgn0000316.
FBtr0070065; FBpp0070064; FBgn0000316.
GeneID30973.
KEGGdme:Dmel_CG2945.
UCSCCG2945-RA. d. melanogaster.

Organism-specific databases

CTD30973.
FlyBaseFBgn0000316. cin.

Phylogenomic databases

eggNOGCOG0303.
GeneTreeENSGT00390000016577.
HOGENOMHOG000218563.
InParanoidP39205.
KOK15376.
OMANIPPFRA.
OrthoDBEOG70087N.
PhylomeDBP39205.

Enzyme and pathway databases

UniPathwayUPA00344.

Family and domain databases

Gene3D2.40.340.10. 1 hit.
3.40.980.10. 2 hits.
InterProIPR020817. Mo_cofactor_synthesis.
IPR008284. MoCF_biosynth_CS.
IPR005111. MoeA_C_domain_IV.
IPR005110. MoeA_linker/N.
IPR001453. Mopterin-bd_dom.
[Graphical view]
PfamPF00994. MoCF_biosynth. 2 hits.
PF03454. MoeA_C. 1 hit.
PF03453. MoeA_N. 1 hit.
[Graphical view]
SMARTSM00852. MoCF_biosynth. 2 hits.
[Graphical view]
SUPFAMSSF53218. SSF53218. 2 hits.
SSF63867. SSF63867. 1 hit.
SSF63882. SSF63882. 1 hit.
TIGRFAMsTIGR00177. molyb_syn. 2 hits.
PROSITEPS01078. MOCF_BIOSYNTHESIS_1. 1 hit.
PS01079. MOCF_BIOSYNTHESIS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi30973.
NextBio771251.
PROP39205.

Entry information

Entry nameCIN_DROME
AccessionPrimary (citable) accession number: P39205
Secondary accession number(s): Q0KHX9, Q9U1M0, Q9V3E2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase