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Protein

Lysophospholipid transporter LplT

Gene

lplT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell.1 Publication

GO - Molecular functioni

  • lysophospholipid transporter activity Source: EcoCyc

GO - Biological processi

  • lysophospholipid transport Source: EcoCyc
  • transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG12455-MONOMER.
ECOL316407:JW2803-MONOMER.
MetaCyc:EG12455-MONOMER.

Protein family/group databases

TCDBi2.A.1.42.1. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipid transporter LplT
Gene namesi
Name:lplT
Synonyms:ygeD
Ordered Locus Names:b2835, JW2803
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12455. lplT.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17PeriplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 52CytoplasmicSequence analysisAdd BLAST14
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 90PeriplasmicSequence analysisAdd BLAST17
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 144CytoplasmicSequence analysisAdd BLAST33
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166PeriplasmicSequence analysis1
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 226CytoplasmicSequence analysisAdd BLAST39
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 256PeriplasmicSequence analysis9
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Topological domaini278 – 280CytoplasmicSequence analysis3
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Topological domaini302 – 304PeriplasmicSequence analysis3
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Topological domaini326 – 343CytoplasmicSequence analysisAdd BLAST18
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 366PeriplasmicSequence analysis2
Transmembranei367 – 387HelicalSequence analysisAdd BLAST21
Topological domaini388 – 397CytoplasmicSequence analysis10

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001693381 – 397Lysophospholipid transporter LplTAdd BLAST397

Proteomic databases

PaxDbiP39196.
PRIDEiP39196.

Interactioni

Protein-protein interaction databases

BioGridi4263140. 265 interactors.
STRINGi511145.b2835.

Structurei

3D structure databases

ProteinModelPortaliP39196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107S74. Bacteria.
ENOG410XQW5. LUCA.
HOGENOMiHOG000261823.
InParanoidiP39196.
KOiK08227.
OMAiLMAFYTK.
PhylomeDBiP39196.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01585. MFS_LplT. 1 hit.
InterProiIPR023727. LysoPLipid__transptr_LplT.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

P39196-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESVHTNTS LWSKGMKAVI VAQFLSAFGD NALLFATLAL LKAQFYPEWS
60 70 80 90 100
QPILQMVFVG AYILFAPFVG QVADSFAKGR VMMFANGLKL LGAASICFGI
110 120 130 140 150
NPFLGYTLVG VGAAAYSPAK YGILGELTTG SKLVKANGLM EASTIAAILL
160 170 180 190 200
GSVAGGVLAD WHVLVALAAC ALAYGGAVVA NIYIPKLAAA RPGQSWNLIN
210 220 230 240 250
MTRSFLNACT SLWRNGETRF SLVGTSLFWG AGVTLRFLLV LWVPVALGIT
260 270 280 290 300
DNATPTYLNA MVAIGIVVGA GAAAKLVTLE TVSRCMPAGI LIGVVVLIFS
310 320 330 340 350
LQHELLPAYA LLMLIGVMGG FFVVPLNALL QERGKKSVGA GNAIAVQNLG
360 370 380 390
ENSAMLLMLG IYSLAVMIGI PVVPIGIGFG ALFALAITAL WIWQRRH
Length:397
Mass (Da):41,656
Last modified:November 1, 1997 - v2
Checksum:i0BB3B0DEA7FF534C
GO

Sequence cautioni

The sequence L14681 differs from that shown. Reason: Frameshift at positions 75 and 89.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29581 Genomic DNA. Translation: AAB40482.1.
U00096 Genomic DNA. Translation: AAC75874.1.
AP009048 Genomic DNA. Translation: BAE76904.1.
L14681 Unassigned DNA. No translation available.
PIRiD65066.
RefSeqiNP_417312.1. NC_000913.3.
WP_000004616.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75874; AAC75874; b2835.
BAE76904; BAE76904; BAE76904.
GeneIDi947317.
KEGGiecj:JW2803.
eco:b2835.
PATRICi32121088. VBIEscCol129921_2933.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29581 Genomic DNA. Translation: AAB40482.1.
U00096 Genomic DNA. Translation: AAC75874.1.
AP009048 Genomic DNA. Translation: BAE76904.1.
L14681 Unassigned DNA. No translation available.
PIRiD65066.
RefSeqiNP_417312.1. NC_000913.3.
WP_000004616.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP39196.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263140. 265 interactors.
STRINGi511145.b2835.

Protein family/group databases

TCDBi2.A.1.42.1. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP39196.
PRIDEiP39196.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75874; AAC75874; b2835.
BAE76904; BAE76904; BAE76904.
GeneIDi947317.
KEGGiecj:JW2803.
eco:b2835.
PATRICi32121088. VBIEscCol129921_2933.

Organism-specific databases

EchoBASEiEB2349.
EcoGeneiEG12455. lplT.

Phylogenomic databases

eggNOGiENOG4107S74. Bacteria.
ENOG410XQW5. LUCA.
HOGENOMiHOG000261823.
InParanoidiP39196.
KOiK08227.
OMAiLMAFYTK.
PhylomeDBiP39196.

Enzyme and pathway databases

BioCyciEcoCyc:EG12455-MONOMER.
ECOL316407:JW2803-MONOMER.
MetaCyc:EG12455-MONOMER.

Miscellaneous databases

PROiP39196.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01585. MFS_LplT. 1 hit.
InterProiIPR023727. LysoPLipid__transptr_LplT.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLPLT_ECOLI
AccessioniPrimary (citable) accession number: P39196
Secondary accession number(s): Q2MA02, Q46934
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.