P39177 (USPG_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Universal stress protein G

Gene names

Name:	uspG
Synonyms:	ybdQ, yzzU
Ordered Locus Names:	b0607, JW0600

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with GroEL. Ref.9
Induction	By starvation, heat shock and in response to some toxic agents. Ref.9
Sequence similarities	Belongs to the universal stress protein A family.

Ontologies

Keywords
Biological process	Stress response
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	protein adenylylation Inferred from direct assay PubMed 16460009. Source: EcoliWiki protein autophosphorylation Inferred from direct assay PubMed 16460009. Source: EcoliWiki regulation of cell motility Inferred from mutant phenotype PubMed 16159758. Source: EcoCyc response to stress Inferred from expression pattern Ref.9. Source: EcoCyc
Cellular_component	cytoplasm Inferred from direct assay PubMed 16460009. Source: EcoliWiki
Molecular_function	adenylate kinase activity Inferred from direct assay PubMed 16460009. Source: EcoliWiki
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
groL	P0A6F5	4	EBI-561722,EBI-543750

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 142	142	Universal stress protein G		PRO_0000147432

Sequences

	Sequence		Length	Mass (Da)
	P39177 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 9BF5F7E7BBD51467	FASTA	142	15,935
	10 20 30 40 50 60 MYKTIIMPVD VFEMELSDKA VRHAEFLAQD DGVIHLLHVL PGSASLSLHR FAADVRRFEE 70 80 90 100 110 120 HLQHEAQERL QTMVSHFTID PSRIKQHVRF GSVRDEVNEL AEELGADVVV IGSRNPSIST 130 140 HLLGSNASSV IRHANLPVLV VR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K. , Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T. DNA Res. 3:137-155(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]	"Sequence of minutes 4-25 of Escherichia coli." Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12." Link A.J., Robison K., Church G.M. Electrophoresis 18:1259-1313(1997) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-12. Strain: K12 / EMG2.
[6]	Pasquali C., Sanchez J.-C., Ravier F., Golaz O., Hughes G.J., Frutiger S., Paquet N., Wilkins M., Appel R.D., Bairoch A., Hochstrasser D.F. Submitted (AUG-1995) to UniProtKB Cited for: PROTEIN SEQUENCE OF 1-11. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[7]	"Protein identification with N and C-terminal sequence tags in proteome projects." Wilkins M.R., Gasteiger E., Tonella L., Ou K., Tyler M., Sanchez J.-C., Gooley A.A., Walsh B.J., Bairoch A., Appel R.D., Williams K.L., Hochstrasser D.F. J. Mol. Biol. 278:599-608(1998) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-4. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[8]	"The universal stress protein paralogues of Escherichia coli are co-ordinately regulated and co-operate in the defence against DNA damage." Gustavsson N., Diez A., Nystroem T. Mol. Microbiol. 43:107-117(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENE NAME. Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.
[9]	"Identification and characterization of the Escherichia coli stress protein UP12, a putative in vivo substrate of GroEL." Bochkareva E.S., Girshovich A.S., Bibi E. Eur. J. Biochem. 269:3032-3040(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION, INTERACTION WITH GROEL. Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U82598 Genomic DNA. Translation: AAB40808.1. U00096 Genomic DNA. Translation: AAC73708.1. AP009048 Genomic DNA. Translation: BAA35237.1.
PIR	E64794.
RefSeq	NP_415140.1. NC_000913.2. YP_488897.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P39177.
SMR	P39177. Positions 5-142.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-11354N.
IntAct	P39177. 77 interactions.
STRING	511145.b0607.
PTM databases
PhosSite	P0810449.
2D gel databases
SWISS-2DPAGE	P39177.
Proteomic databases
PaxDb	P39177.
PRIDE	P39177.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC73708; AAC73708; b0607. BAA35237; BAA35237; BAA35237.
GeneID	12930900. 945229.
KEGG	ecj:Y75_p0597. eco:b0607.
PATRIC	32116394. VBIEscCol129921_0637.
Organism-specific databases
EchoBASE	EB2547.
EcoGene	EG12683. uspG.
Phylogenomic databases
eggNOG	COG0589.
HOGENOM	HOG000238897.
KO	K11932.
OMA	IIHLLHV.
ProtClustDB	PRK15456.
Enzyme and pathway databases
BioCyc	EcoCyc:G6334-MONOMER. ECOL316407:JW0600-MONOMER.
Gene expression databases
Genevestigator	P39177.
Family and domain databases
Gene3D	3.40.50.620. 1 hit.
InterPro	IPR014729. Rossmann-like_a/b/a_fold. IPR006015. Universal_stress_UspA. IPR006016. UspA. [Graphical view]
Pfam	PF00582. Usp. 1 hit. [Graphical view]
PRINTS	PR01438. UNVRSLSTRESS.
ProtoNet	Search...

Entry information

Entry name

USPG_ECOLI

Accession

Primary (citable) accession number: P39177
Secondary accession number(s): P77720

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program