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Protein

Universal stress protein UP12

Gene

uspG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has intrinsic autoadenylation and autophosphorylation activities, probably on Ser or Thr residues.1 Publication

GO - Molecular functioni

  • adenylate kinase activity Source: EcoliWiki

GO - Biological processi

  • protein adenylylation Source: EcoliWiki
  • protein autophosphorylation Source: EcoliWiki
  • regulation of cell motility Source: EcoCyc
  • response to stress Source: InterPro

Keywordsi

Biological processStress response

Enzyme and pathway databases

BioCyciEcoCyc:G6334-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Universal stress protein UP121 Publication
Alternative name(s):
Universal stress protein G1 Publication
Gene namesi
Name:uspG1 Publication
Synonyms:ybdQ, yzzU
Ordered Locus Names:b0607, JW0600
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12683. uspG.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: EcoliWiki

Pathology & Biotechi

Disruption phenotypei

Recovers slowly from late stationary phase growth, increased sensitivity to carbonyl cyanide m-chlorophenyl hydrazone, a proton ionophore and respiratory chain uncoupler.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001474321 – 142Universal stress protein UP12Add BLAST142

Post-translational modificationi

Upon overproduction 2 forms are seen in exponential phase and 3 in stationary phase. Isoform 1 is the most abundant form in exponential phase, isoforms 1 and 2 are equivalent in stationary phase and greater than isoform 3. Isoform 3 is stationary-phase specific and autophosphorylated. Isoforms 2 and 3 are more acidic than isoform 1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP39177.
PRIDEiP39177.

2D gel databases

SWISS-2DPAGEiP39177.

Expressioni

Inductioni

By starvation, heat shock and in response to some toxic agents.1 Publication

Interactioni

Subunit structurei

Interacts with GroEL (PubMed:12071968). Forms homodimers, mediated by the C-terminus of the protein (PubMed:16460009).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
groLP0A6F54EBI-561722,EBI-543750

Protein-protein interaction databases

BioGridi4259894. 9 interactors.
DIPiDIP-11354N.
IntActiP39177. 78 interactors.
STRINGi316385.ECDH10B_0676.

Structurei

3D structure databases

ProteinModelPortaliP39177.
SMRiP39177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the universal stress protein A family.Curated

Phylogenomic databases

eggNOGiENOG4108U51. Bacteria.
COG0589. LUCA.
HOGENOMiHOG000238897.
InParanoidiP39177.
KOiK11932.
PhylomeDBiP39177.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiView protein in InterPro
IPR014729. Rossmann-like_a/b/a_fold.
IPR006015. Universal_stress_UspA.
IPR006016. UspA.
PfamiView protein in Pfam
PF00582. Usp. 1 hit.
PRINTSiPR01438. UNVRSLSTRESS.

Sequencei

Sequence statusi: Complete.

P39177-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKTIIMPVD VFEMELSDKA VRHAEFLAQD DGVIHLLHVL PGSASLSLHR
60 70 80 90 100
FAADVRRFEE HLQHEAQERL QTMVSHFTID PSRIKQHVRF GSVRDEVNEL
110 120 130 140
AEELGADVVV IGSRNPSIST HLLGSNASSV IRHANLPVLV VR
Length:142
Mass (Da):15,935
Last modified:November 1, 1997 - v2
Checksum:i9BF5F7E7BBD51467
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40808.1.
U00096 Genomic DNA. Translation: AAC73708.1.
AP009048 Genomic DNA. Translation: BAA35237.1.
PIRiE64794.
RefSeqiNP_415140.1. NC_000913.3.
WP_000278509.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73708; AAC73708; b0607.
BAA35237; BAA35237; BAA35237.
GeneIDi945229.
KEGGiecj:JW0600.
eco:b0607.
PATRICifig|1411691.4.peg.1661.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiUSPG_ECOLI
AccessioniPrimary (citable) accession number: P39177
Secondary accession number(s): P77720
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1997
Last modified: July 5, 2017
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families