P39173 (YEAD_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative glucose-6-phosphate 1-epimerase
EC=5.1.3.15

Alternative name(s):
Putative D-hexose-6-phosphate mutarotase
Unknown protein from 2D-page spots T26/PR37

Gene names

Name:	yeaD
Synonyms:	yzzQ
Ordered Locus Names:	b1780, JW1769

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate.
Sequence similarities	Belongs to the Glucose-6-phosphate 1-epimerase family.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	carbohydrate binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate 1-epimerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Putative glucose-6-phosphate 1-epimerase		PRO_0000213036
Sites
	Active site	164	1	By similarity
	Active site	267	1	By similarity
	Binding site	74	1	Substrate By similarity
	Binding site	99	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P39173 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: ADACFE6D46F20957	FASTA	294	32,666
	10 20 30 40 50 60 MIKKIFALPV IEQISPVLSR RKLDELDLIV VDHPQVKASF ALQGAHLLSW KPAGEEEVLW 70 80 90 100 110 120 LSNNTPFKNG VAIRGGVPVC WPWFGPAAQQ GLPAHGFARN LPWTLKSHHE DADGVALTFE 130 140 150 160 170 180 LTQSEETKKF WPHDFTLLAH FRVGKTCEID LESHGEFETT SALHTYFNVG DIAKVSVSGL 190 200 210 220 230 240 GDRFIDKVND AKENVLTDGI QTFPDRTDRV YLNPQDCSVI NDEALNRIIA VGHQHHLNVV 250 260 270 280 290 GWNPGPALSI SMGDMPDDGY KTFVCVETAY ASETQKVTKE KPAHLAQSIR VAKR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map." Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S. , Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y., Horiuchi T. DNA Res. 3:379-392(1996) [PubMed: 9097040] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	"Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12." Link A.J., Robison K., Church G.M. Electrophoresis 18:1259-1313(1997) [PubMed: 9298646] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-12. Strain: K12 / EMG2.
[5]	"Enrichment of low abundance proteins of Escherichia coli by hydroxyapatite chromatography." Fountoulakis M., Takacs M.-F., Berndt P., Langen H., Takacs B. Electrophoresis 20:2181-2195(1999) [PubMed: 10493123] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY. Strain: B / BL21.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00096 Genomic DNA. Translation: AAC74850.2. AP009048 Genomic DNA. Translation: BAA15577.1.
PIR	D64938.
RefSeq	NP_416294.4. NC_000913.2.
3D structure databases
ProteinModelPortal	P39173.
SMR	P39173. Positions 1-294.
ModBase	Search...
Protein-protein interaction databases
IntAct	P39173. 2 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000002311; EBESCP00000002311; EBESCG00000001886. EBESCT00000017817; EBESCP00000017108; EBESCG00000016873.
GeneID	946572.
GenomeReviews	Gene locus JW1769 in contig AP009048_GR. Gene locus b1780 in contig U00096_GR.
KEGG	ecj:JW1769. eco:b1780.
PATRIC	32118871. VBIEscCol129921_1853.
Organism-specific databases
EchoBASE	EB2544.
EcoGene	EG12679. yeaD.
Phylogenomic databases
eggNOG	COG0676.
GeneTree	EBGT00050000010830.
HOGENOM	HBG737737.
OMA	MVCLEAA.
PhylomeDB	P39173.
ProtClustDB	CLSK880197.
Enzyme and pathway databases
BioCyc	EcoCyc:G6966-MONOMER.
Gene expression databases
Genevestigator	P39173.
Family and domain databases
InterPro	IPR008183. Aldose_1-epimerase. IPR011013. Glyco_hydro-type_carb-bd. IPR014718. Glyco_hydro-type_carb-bd_sub. [Graphical view]
Gene3D	G3DSA:2.70.98.10. Glyco_hydro_42_D5. 1 hit.
KO	K01792.
Pfam	PF01263. Aldose_epim. 1 hit. [Graphical view]
SUPFAM	SSF74650. Gal_mut_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

YEAD_ECOLI

Accession

Primary (citable) accession number: P39173
Secondary accession number(s): P76233, P76913

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program