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Protein

Putative glucose-6-phosphate 1-epimerase

Gene

yeaD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei74 – 741SubstrateBy similarity
Binding sitei99 – 991SubstrateBy similarity
Active sitei164 – 1641By similarity
Binding sitei208 – 2081SubstrateBy similarity
Active sitei267 – 2671By similarity

GO - Molecular functioni

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • cellular response to DNA damage stimulus Source: EcoliWiki
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciEcoCyc:G6966-MONOMER.
ECOL316407:JW1769-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glucose-6-phosphate 1-epimeraseBy similarity (EC:5.1.3.15By similarity)
Alternative name(s):
Putative D-hexose-6-phosphate mutarotaseBy similarity
Unknown protein from 2D-page spots T26/PR37
Gene namesi
Name:yeaD
Synonyms:yzzQ
Ordered Locus Names:b1780, JW1769
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12679. yeaD.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Putative glucose-6-phosphate 1-epimerasePRO_0000213036Add
BLAST

Proteomic databases

EPDiP39173.
PaxDbiP39173.
PRIDEiP39173.

Interactioni

Subunit structurei

Monomer in solution.1 Publication

Protein-protein interaction databases

BioGridi4260309. 22 interactions.
IntActiP39173. 2 interactions.
STRINGi511145.b1780.

Structurei

3D structure databases

ProteinModelPortaliP39173.
SMRiP39173. Positions 1-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DSB. Bacteria.
COG0676. LUCA.
HOGENOMiHOG000283048.
InParanoidiP39173.
KOiK01792.
OMAiICFPWFG.
PhylomeDBiP39173.

Family and domain databases

CDDicd09020. D-hex-6-P-epi_like. 1 hit.
Gene3Di2.70.98.10. 1 hit.
InterProiIPR008183. Aldose_1/G6P_1-epimerase.
IPR025532. G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. GH-type_carb-bd.
[Graphical view]
PfamiPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF016020. PHexose_mutarotase. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.

Sequencei

Sequence statusi: Complete.

P39173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKKIFALPV IEQISPVLSR RKLDELDLIV VDHPQVKASF ALQGAHLLSW
60 70 80 90 100
KPAGEEEVLW LSNNTPFKNG VAIRGGVPVC WPWFGPAAQQ GLPAHGFARN
110 120 130 140 150
LPWTLKSHHE DADGVALTFE LTQSEETKKF WPHDFTLLAH FRVGKTCEID
160 170 180 190 200
LESHGEFETT SALHTYFNVG DIAKVSVSGL GDRFIDKVND AKENVLTDGI
210 220 230 240 250
QTFPDRTDRV YLNPQDCSVI NDEALNRIIA VGHQHHLNVV GWNPGPALSI
260 270 280 290
SMGDMPDDGY KTFVCVETAY ASETQKVTKE KPAHLAQSIR VAKR
Length:294
Mass (Da):32,666
Last modified:November 1, 1997 - v2
Checksum:iADACFE6D46F20957
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74850.2.
AP009048 Genomic DNA. Translation: BAA15577.1.
PIRiD64938.
RefSeqiNP_416294.4. NC_000913.3.
WP_001335909.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74850; AAC74850; b1780.
BAA15577; BAA15577; BAA15577.
GeneIDi946572.
KEGGiecj:JW1769.
eco:b1780.
PATRICi32118871. VBIEscCol129921_1853.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74850.2.
AP009048 Genomic DNA. Translation: BAA15577.1.
PIRiD64938.
RefSeqiNP_416294.4. NC_000913.3.
WP_001335909.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP39173.
SMRiP39173. Positions 1-294.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260309. 22 interactions.
IntActiP39173. 2 interactions.
STRINGi511145.b1780.

Proteomic databases

EPDiP39173.
PaxDbiP39173.
PRIDEiP39173.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74850; AAC74850; b1780.
BAA15577; BAA15577; BAA15577.
GeneIDi946572.
KEGGiecj:JW1769.
eco:b1780.
PATRICi32118871. VBIEscCol129921_1853.

Organism-specific databases

EchoBASEiEB2544.
EcoGeneiEG12679. yeaD.

Phylogenomic databases

eggNOGiENOG4105DSB. Bacteria.
COG0676. LUCA.
HOGENOMiHOG000283048.
InParanoidiP39173.
KOiK01792.
OMAiICFPWFG.
PhylomeDBiP39173.

Enzyme and pathway databases

BioCyciEcoCyc:G6966-MONOMER.
ECOL316407:JW1769-MONOMER.

Miscellaneous databases

PROiP39173.

Family and domain databases

CDDicd09020. D-hex-6-P-epi_like. 1 hit.
Gene3Di2.70.98.10. 1 hit.
InterProiIPR008183. Aldose_1/G6P_1-epimerase.
IPR025532. G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. GH-type_carb-bd.
[Graphical view]
PfamiPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF016020. PHexose_mutarotase. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYEAD_ECOLI
AccessioniPrimary (citable) accession number: P39173
Secondary accession number(s): P76233, P76913
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.