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Protein

High-affinity zinc uptake system protein ZnuA

Gene

znuA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the high-affinity zinc uptake transport system.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60ZincBy similarity1
Metal bindingi143ZincBy similarity1
Metal bindingi207ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:ZNUA-MONOMER.
ECOL316407:JW5831-MONOMER.
MetaCyc:ZNUA-MONOMER.

Protein family/group databases

TCDBi3.A.1.15.5. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity zinc uptake system protein ZnuA
Gene namesi
Name:znuA
Synonyms:yebL, yzzP
Ordered Locus Names:b1857, JW5831
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12678. znuA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 263 PublicationsAdd BLAST26
ChainiPRO_000003187527 – 310High-affinity zinc uptake system protein ZnuAAdd BLAST284

Proteomic databases

EPDiP39172.
PaxDbiP39172.
PRIDEiP39172.

2D gel databases

SWISS-2DPAGEP39172.

Expressioni

Inductioni

Maximally induced 30 minutes under zinc-limiting conditions, still induced in stationary phase.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260353. 6 interactors.
DIPiDIP-12949N.
STRINGi511145.b1857.

Structurei

Secondary structure

1310
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi28 – 32Combined sources5
Helixi33 – 43Combined sources11
Turni44 – 46Combined sources3
Beta strandi49 – 53Combined sources5
Turni59 – 61Combined sources3
Helixi68 – 74Combined sources7
Beta strandi76 – 80Combined sources5
Turni83 – 85Combined sources3
Helixi87 – 89Combined sources3
Helixi90 – 94Combined sources5
Helixi98 – 100Combined sources3
Beta strandi101 – 103Combined sources3
Helixi104 – 106Combined sources3
Turni108 – 110Combined sources3
Helixi111 – 113Combined sources3
Helixi144 – 146Combined sources3
Helixi148 – 165Combined sources18
Helixi167 – 169Combined sources3
Helixi170 – 195Combined sources26
Helixi196 – 198Combined sources3
Beta strandi203 – 208Combined sources6
Helixi211 – 217Combined sources7
Beta strandi223 – 228Combined sources6
Beta strandi229 – 231Combined sources3
Helixi235 – 247Combined sources13
Beta strandi252 – 255Combined sources4
Helixi262 – 267Combined sources6
Turni268 – 270Combined sources3
Beta strandi274 – 277Combined sources4
Helixi291 – 307Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OGWX-ray1.83A/B1-310[»]
2OSVX-ray1.75A/B27-310[»]
2PRSX-ray1.70A/B27-310[»]
2PS0X-ray2.00A/B27-310[»]
2PS3X-ray2.47A/B27-310[»]
2PS9X-ray2.15A/B27-310[»]
ProteinModelPortaliP39172.
SMRiP39172.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP39172.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi119 – 137His-richAdd BLAST19

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105NXV. Bacteria.
COG4531. LUCA.
HOGENOMiHOG000180311.
InParanoidiP39172.
KOiK09815.
OMAiRHFGEDS.
PhylomeDBiP39172.

Family and domain databases

InterProiIPR006128. Lipoprotein_4.
IPR006127. ZnuA-like.
[Graphical view]
PfamiPF01297. ZnuA. 1 hit.
[Graphical view]
PRINTSiPR00690. ADHESNFAMILY.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39172-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHKKTLLFA ALSAALWGGA TQAADAAVVA SLKPVGFIAS AIADGVTETE
60 70 80 90 100
VLLPDGASEH DYSLRPSDVK RLQNADLVVW VGPEMEAFMQ KPVSKLPGAK
110 120 130 140 150
QVTIAQLEDV KPLLMKSIHG DDDDHDHAEK SDEDHHHGDF NMHLWLSPEI
160 170 180 190 200
ARATAVAIHG KLVELMPQSR AKLDANLKDF EAQLASTETQ VGNELAPLKG
210 220 230 240 250
KGYFVFHDAY GYFEKQFGLT PLGHFTVNPE IQPGAQRLHE IRTQLVEQKA
260 270 280 290 300
TCVFAEPQFR PAVVESVARG TSVRMGTLDP LGTNIKLGKT SYSEFLSQLA
310
NQYASCLKGD
Length:310
Mass (Da):33,777
Last modified:June 1, 2001 - v4
Checksum:i99500F04C6C3DBF0
GO

Sequence cautioni

The sequence AAA81030 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195L → V in AAA81030 (Ref. 1) Curated1
Sequence conflicti262A → P in AAA81030 (Ref. 1) Curated1
Sequence conflicti289K → E in AAA81030 (Ref. 1) Curated1
Sequence conflicti306C → S in AAA81030 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38702 Genomic DNA. Translation: AAA81030.1. Different initiation.
U00096 Genomic DNA. Translation: AAC74927.2.
AP009048 Genomic DNA. Translation: BAA15665.2.
PIRiA64948.
RefSeqiNP_416371.4. NC_000913.3.
WP_001300644.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74927; AAC74927; b1857.
BAA15665; BAA15665; BAA15665.
GeneIDi946375.
KEGGiecj:JW5831.
eco:b1857.
PATRICi32119037. VBIEscCol129921_1936.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38702 Genomic DNA. Translation: AAA81030.1. Different initiation.
U00096 Genomic DNA. Translation: AAC74927.2.
AP009048 Genomic DNA. Translation: BAA15665.2.
PIRiA64948.
RefSeqiNP_416371.4. NC_000913.3.
WP_001300644.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OGWX-ray1.83A/B1-310[»]
2OSVX-ray1.75A/B27-310[»]
2PRSX-ray1.70A/B27-310[»]
2PS0X-ray2.00A/B27-310[»]
2PS3X-ray2.47A/B27-310[»]
2PS9X-ray2.15A/B27-310[»]
ProteinModelPortaliP39172.
SMRiP39172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260353. 6 interactors.
DIPiDIP-12949N.
STRINGi511145.b1857.

Protein family/group databases

TCDBi3.A.1.15.5. the atp-binding cassette (abc) superfamily.

2D gel databases

SWISS-2DPAGEP39172.

Proteomic databases

EPDiP39172.
PaxDbiP39172.
PRIDEiP39172.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74927; AAC74927; b1857.
BAA15665; BAA15665; BAA15665.
GeneIDi946375.
KEGGiecj:JW5831.
eco:b1857.
PATRICi32119037. VBIEscCol129921_1936.

Organism-specific databases

EchoBASEiEB2543.
EcoGeneiEG12678. znuA.

Phylogenomic databases

eggNOGiENOG4105NXV. Bacteria.
COG4531. LUCA.
HOGENOMiHOG000180311.
InParanoidiP39172.
KOiK09815.
OMAiRHFGEDS.
PhylomeDBiP39172.

Enzyme and pathway databases

BioCyciEcoCyc:ZNUA-MONOMER.
ECOL316407:JW5831-MONOMER.
MetaCyc:ZNUA-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP39172.
PROiP39172.

Family and domain databases

InterProiIPR006128. Lipoprotein_4.
IPR006127. ZnuA-like.
[Graphical view]
PfamiPF01297. ZnuA. 1 hit.
[Graphical view]
PRINTSiPR00690. ADHESNFAMILY.
ProtoNetiSearch...

Entry informationi

Entry nameiZNUA_ECOLI
AccessioniPrimary (citable) accession number: P39172
Secondary accession number(s): P76284
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 133 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.