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Protein

Uxu operon transcriptional regulator

Gene

uxuR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Repressor for the uxuRBA operon.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi36 – 5520H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • transcription, DNA-templated Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG20249-MONOMER.
ECOL316407:JW4287-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uxu operon transcriptional regulator
Gene namesi
Name:uxuR
Ordered Locus Names:b4324, JW4287
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG20249. uxuR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Uxu operon transcriptional regulatorPRO_0000050670Add
BLAST

Proteomic databases

PaxDbiP39161.

Interactioni

Protein-protein interaction databases

BioGridi4261007. 10 interactions.
DIPiDIP-11110N.
IntActiP39161. 2 interactions.
STRINGi511145.b4324.

Structurei

3D structure databases

ProteinModelPortaliP39161.
SMRiP39161. Positions 30-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7669HTH gntR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH gntR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105C6F. Bacteria.
COG2186. LUCA.
HOGENOMiHOG000273991.
InParanoidiP39161.
KOiK13637.
OMAiNSESGDM.
OrthoDBiEOG6S52JF.
PhylomeDBiP39161.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.20.120.530. 1 hit.
InterProiIPR011711. GntR_C.
IPR008920. TF_FadR/GntR_C.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF07729. FCD. 1 hit.
PF00392. GntR. 1 hit.
[Graphical view]
PRINTSiPR00035. HTHGNTR.
SMARTiSM00895. FCD. 1 hit.
SM00345. HTH_GNTR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48008. SSF48008. 1 hit.
PROSITEiPS50949. HTH_GNTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39161-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSATSAQRP YQEVGAMIRD LIIKTPYNPG ERLPPEREIA EMLDVTRTVV
60 70 80 90 100
REALIMLEIK GLVEVRRGAG IYVLDNSGSQ NTDSPDANVC NDAGPFELLQ
110 120 130 140 150
ARQLLESNIA EFAALQATRE DIVKMRQALQ LEERELASSA PGSSESGDMQ
160 170 180 190 200
FHLAIAEATH NSMLVELFRQ SWQWRENNPM WIQLHSHLDD SLYRKEWLGD
210 220 230 240 250
HKQILAALIK KDARAAKLAM WQHLENVKQR LLEFSNVDDI YFDGYLFDSW

PLDKVDA
Length:257
Mass (Da):29,308
Last modified:February 1, 1995 - v1
Checksum:iFA9A64922E5F5F5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13329 Genomic DNA. Translation: BAA02592.1.
U14003 Genomic DNA. Translation: AAA97220.1.
U00096 Genomic DNA. Translation: AAC77280.1.
AP009048 Genomic DNA. Translation: BAE78317.1.
PIRiS56549.
RefSeqiNP_418744.1. NC_000913.3.
WP_000833679.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77280; AAC77280; b4324.
BAE78317; BAE78317; BAE78317.
GeneIDi948849.
KEGGiecj:JW4287.
eco:b4324.
PATRICi32124246. VBIEscCol129921_4466.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13329 Genomic DNA. Translation: BAA02592.1.
U14003 Genomic DNA. Translation: AAA97220.1.
U00096 Genomic DNA. Translation: AAC77280.1.
AP009048 Genomic DNA. Translation: BAE78317.1.
PIRiS56549.
RefSeqiNP_418744.1. NC_000913.3.
WP_000833679.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP39161.
SMRiP39161. Positions 30-225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261007. 10 interactions.
DIPiDIP-11110N.
IntActiP39161. 2 interactions.
STRINGi511145.b4324.

Proteomic databases

PaxDbiP39161.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77280; AAC77280; b4324.
BAE78317; BAE78317; BAE78317.
GeneIDi948849.
KEGGiecj:JW4287.
eco:b4324.
PATRICi32124246. VBIEscCol129921_4466.

Organism-specific databases

EchoBASEiEB4151.
EcoGeneiEG20249. uxuR.

Phylogenomic databases

eggNOGiENOG4105C6F. Bacteria.
COG2186. LUCA.
HOGENOMiHOG000273991.
InParanoidiP39161.
KOiK13637.
OMAiNSESGDM.
OrthoDBiEOG6S52JF.
PhylomeDBiP39161.

Enzyme and pathway databases

BioCyciEcoCyc:EG20249-MONOMER.
ECOL316407:JW4287-MONOMER.

Miscellaneous databases

PROiP39161.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.20.120.530. 1 hit.
InterProiIPR011711. GntR_C.
IPR008920. TF_FadR/GntR_C.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF07729. FCD. 1 hit.
PF00392. GntR. 1 hit.
[Graphical view]
PRINTSiPR00035. HTHGNTR.
SMARTiSM00895. FCD. 1 hit.
SM00345. HTH_GNTR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48008. SSF48008. 1 hit.
PROSITEiPS50949. HTH_GNTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Mizobuchi K.
    Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes."
    Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.
    Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiUXUR_ECOLI
AccessioniPrimary (citable) accession number: P39161
Secondary accession number(s): Q2M5Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 20, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.