P39161 (UXUR_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uxu operon transcriptional regulator

Gene names

Name:	uxuR
Ordered Locus Names:	b4324, JW4287

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	Repressor for the uxuRBA operon.
Sequence similarities	Contains 1 HTH gntR-type DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Uxu operon transcriptional regulator		PRO_0000050670
Regions
	Domain	8 – 76	69	HTH gntR-type
	DNA binding	36 – 55	20	H-T-H motif Potential

Sequences

	Sequence		Length	Mass (Da)
	P39161 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: FA9A64922E5F5F5A	FASTA	257	29,308
	10 20 30 40 50 60 MKSATSAQRP YQEVGAMIRD LIIKTPYNPG ERLPPEREIA EMLDVTRTVV REALIMLEIK 70 80 90 100 110 120 GLVEVRRGAG IYVLDNSGSQ NTDSPDANVC NDAGPFELLQ ARQLLESNIA EFAALQATRE 130 140 150 160 170 180 DIVKMRQALQ LEERELASSA PGSSESGDMQ FHLAIAEATH NSMLVELFRQ SWQWRENNPM 190 200 210 220 230 240 WIQLHSHLDD SLYRKEWLGD HKQILAALIK KDARAAKLAM WQHLENVKQR LLEFSNVDDI 250 YFDGYLFDSW PLDKVDA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Mizobuchi K. Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]	"Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes." Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R. Nucleic Acids Res. 23:2105-2119(1995) [PubMed: 7610040] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D13329 Genomic DNA. Translation: BAA02592.1. U14003 Genomic DNA. Translation: AAA97220.1. U00096 Genomic DNA. Translation: AAC77280.1. AP009048 Genomic DNA. Translation: BAE78317.1.
PIR	S56549.
RefSeq	NP_418744.1. NC_000913.2.
3D structure databases
ProteinModelPortal	P39161.
SMR	P39161. Positions 9-234.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-11110N.
IntAct	P39161. 2 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000003129; EBESCP00000003129; EBESCG00000002565. EBESCT00000017457; EBESCP00000016748; EBESCG00000016513.
GeneID	948849.
GenomeReviews	Gene locus JW4287 in contig AP009048_GR. Gene locus b4324 in contig U00096_GR.
KEGG	ecj:JW4287. eco:b4324.
PATRIC	32124246. VBIEscCol129921_4466.
Organism-specific databases
EchoBASE	EB4151.
EcoGene	EG20249. uxuR.
Phylogenomic databases
eggNOG	COG2186.
GeneTree	EBGT00050000009602.
HOGENOM	HBG700007.
OMA	ENIVNRT.
PhylomeDB	P39161.
ProtClustDB	PRK10225.
Enzyme and pathway databases
BioCyc	EcoCyc:EG20249-MONOMER.
Gene expression databases
Genevestigator	P39161.
Family and domain databases
InterPro	IPR011711. GntR_C. IPR000524. Tscrpt_reg_HTH_GntR. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
KO	K13637.
Pfam	PF07729. FCD. 1 hit. PF00392. GntR. 1 hit. [Graphical view]
PRINTS	PR00035. HTHGNTR.
SMART	SM00895. FCD. 1 hit. SM00345. HTH_GNTR. 1 hit. [Graphical view]
PROSITE	PS50949. HTH_GNTR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UXUR_ECOLI

Accession

Primary (citable) accession number: P39161
Secondary accession number(s): Q2M5Y9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	January 25, 2012
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program