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P39160

- UXUB_ECOLI

UniProt

P39160 - UXUB_ECOLI

Protein

D-mannonate oxidoreductase

Gene

uxuB

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-mannonate + NAD+ = D-fructuronate + NADH.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi25 – 3612NADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. coenzyme binding Source: InterPro
    2. fructuronate reductase activity Source: CACAO

    GO - Biological processi

    1. D-glucuronate catabolic process Source: EcoCyc
    2. mannitol metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciEcoCyc:MANNONOXIDOREDUCT-MONOMER.
    ECOL316407:JW4286-MONOMER.
    MetaCyc:MANNONOXIDOREDUCT-MONOMER.
    UniPathwayiUPA00246.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D-mannonate oxidoreductase (EC:1.1.1.57)
    Alternative name(s):
    Fructuronate reductase
    Gene namesi
    Name:uxuB
    Ordered Locus Names:b4323, JW4286
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG20248. uxuB.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 486486D-mannonate oxidoreductasePRO_0000170747Add
    BLAST

    Proteomic databases

    PaxDbiP39160.
    PRIDEiP39160.

    Expressioni

    Gene expression databases

    GenevestigatoriP39160.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-11109N.
    IntActiP39160. 3 interactions.
    STRINGi511145.b4323.

    Structurei

    3D structure databases

    ProteinModelPortaliP39160.
    SMRiP39160. Positions 14-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0246.
    HOGENOMiHOG000202982.
    KOiK00040.
    OMAiWLHFVRR.
    OrthoDBiEOG6X9MNH.
    PhylomeDBiP39160.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR000669. Mannitol_DH.
    IPR013118. Mannitol_DH_C.
    IPR023027. Mannitol_DH_CS.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view]
    PRINTSiPR00084. MTLDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    PROSITEiPS00974. MANNITOL_DHGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39160-1 [UniParc]FASTAAdd to Basket

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    MTTIVDSNLP VARPSWDHSR LESRIVHLGC GAFHRAHQAL YTHHLLESTD    50
    SDWGICEVNL MPGNDRVLIE NLKKQQLLYT VAEKGAESTE LKIIGSMKEA 100
    LHPEIDGCEG ILNAMARPQT AIVSLTVTEK GYCADAASGQ LDLNNPLIKH 150
    DLENPTAPKS AIGYIVEALR LRREKGLKAF TVMSCDNVRE NGHVAKVAVL 200
    GLAQARDPQL AAWIEENVTF PCTMVDRIVP AATPETLQEI ADQLGVYDPC 250
    AIACEPFRQW VIEDNFVNGR PDWDKVGAQF VADVVPFEMM KLRMLNGSHS 300
    FLAYLGYLGG YETIADTVTN PAYRKAAFAL MMQEQAPTLS MPEGTDLNAY 350
    ATLLIERFSN PSLRHRTWQI AMDGSQKLPQ RLLDPVRLHL QNGGSWRHLA 400
    LGVAGWMRYT QGVDEQGNAI DVVDPMLAEF QKINAQYQGA DRVKALLGLS 450
    GIFADDLPQN ADFVGAVTAA YQQLCERGAR ECVAAL 486
    Length:486
    Mass (Da):53,580
    Last modified:February 1, 1995 - v1
    Checksum:i7835638682AF7B87
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13329 Genomic DNA. Translation: BAA02591.1.
    U14003 Genomic DNA. Translation: AAA97219.1.
    U00096 Genomic DNA. Translation: AAC77279.1.
    AP009048 Genomic DNA. Translation: BAE78316.1.
    PIRiS56548.
    RefSeqiNP_418743.1. NC_000913.3.
    YP_492457.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC77279; AAC77279; b4323.
    BAE78316; BAE78316; BAE78316.
    GeneIDi12932005.
    946795.
    KEGGiecj:Y75_p4209.
    eco:b4323.
    PATRICi32124242. VBIEscCol129921_4464.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13329 Genomic DNA. Translation: BAA02591.1 .
    U14003 Genomic DNA. Translation: AAA97219.1 .
    U00096 Genomic DNA. Translation: AAC77279.1 .
    AP009048 Genomic DNA. Translation: BAE78316.1 .
    PIRi S56548.
    RefSeqi NP_418743.1. NC_000913.3.
    YP_492457.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P39160.
    SMRi P39160. Positions 14-484.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-11109N.
    IntActi P39160. 3 interactions.
    STRINGi 511145.b4323.

    Proteomic databases

    PaxDbi P39160.
    PRIDEi P39160.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC77279 ; AAC77279 ; b4323 .
    BAE78316 ; BAE78316 ; BAE78316 .
    GeneIDi 12932005.
    946795.
    KEGGi ecj:Y75_p4209.
    eco:b4323.
    PATRICi 32124242. VBIEscCol129921_4464.

    Organism-specific databases

    EchoBASEi EB4150.
    EcoGenei EG20248. uxuB.

    Phylogenomic databases

    eggNOGi COG0246.
    HOGENOMi HOG000202982.
    KOi K00040.
    OMAi WLHFVRR.
    OrthoDBi EOG6X9MNH.
    PhylomeDBi P39160.

    Enzyme and pathway databases

    UniPathwayi UPA00246 .
    BioCyci EcoCyc:MANNONOXIDOREDUCT-MONOMER.
    ECOL316407:JW4286-MONOMER.
    MetaCyc:MANNONOXIDOREDUCT-MONOMER.

    Miscellaneous databases

    PROi P39160.

    Gene expression databases

    Genevestigatori P39160.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR000669. Mannitol_DH.
    IPR013118. Mannitol_DH_C.
    IPR023027. Mannitol_DH_CS.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00084. MTLDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    PROSITEi PS00974. MANNITOL_DHGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Mizobuchi K.
      Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    2. "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes."
      Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.
      Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

    Entry informationi

    Entry nameiUXUB_ECOLI
    AccessioniPrimary (citable) accession number: P39160
    Secondary accession number(s): Q2M5Z0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3