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P39160 (UXUB_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-mannonate oxidoreductase

EC=1.1.1.57
Alternative name(s):
Fructuronate reductase
Gene names
Name:uxuB
Ordered Locus Names:b4323, JW4286
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-mannonate + NAD+ = D-fructuronate + NADH.

Pathway

Carbohydrate metabolism; pentose and glucuronate interconversion.

Sequence similarities

Belongs to the mannitol dehydrogenase family. UxuB subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486D-mannonate oxidoreductase
PRO_0000170747

Regions

Nucleotide binding25 – 3612NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
P39160 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 7835638682AF7B87

FASTA48653,580
        10         20         30         40         50         60 
MTTIVDSNLP VARPSWDHSR LESRIVHLGC GAFHRAHQAL YTHHLLESTD SDWGICEVNL 

        70         80         90        100        110        120 
MPGNDRVLIE NLKKQQLLYT VAEKGAESTE LKIIGSMKEA LHPEIDGCEG ILNAMARPQT 

       130        140        150        160        170        180 
AIVSLTVTEK GYCADAASGQ LDLNNPLIKH DLENPTAPKS AIGYIVEALR LRREKGLKAF 

       190        200        210        220        230        240 
TVMSCDNVRE NGHVAKVAVL GLAQARDPQL AAWIEENVTF PCTMVDRIVP AATPETLQEI 

       250        260        270        280        290        300 
ADQLGVYDPC AIACEPFRQW VIEDNFVNGR PDWDKVGAQF VADVVPFEMM KLRMLNGSHS 

       310        320        330        340        350        360 
FLAYLGYLGG YETIADTVTN PAYRKAAFAL MMQEQAPTLS MPEGTDLNAY ATLLIERFSN 

       370        380        390        400        410        420 
PSLRHRTWQI AMDGSQKLPQ RLLDPVRLHL QNGGSWRHLA LGVAGWMRYT QGVDEQGNAI 

       430        440        450        460        470        480 
DVVDPMLAEF QKINAQYQGA DRVKALLGLS GIFADDLPQN ADFVGAVTAA YQQLCERGAR 


ECVAAL 

« Hide

References

« Hide 'large scale' references
[1]Mizobuchi K.
Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]"Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes."
Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.
Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D13329 Genomic DNA. Translation: BAA02591.1.
U14003 Genomic DNA. Translation: AAA97219.1.
U00096 Genomic DNA. Translation: AAC77279.1.
AP009048 Genomic DNA. Translation: BAE78316.1.
PIRS56548.
RefSeqNP_418743.1. NC_000913.3.
YP_492457.1. NC_007779.1.

3D structure databases

ProteinModelPortalP39160.
SMRP39160. Positions 14-484.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-11109N.
IntActP39160. 3 interactions.
STRING511145.b4323.

Proteomic databases

PaxDbP39160.
PRIDEP39160.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC77279; AAC77279; b4323.
BAE78316; BAE78316; BAE78316.
GeneID12932005.
946795.
KEGGecj:Y75_p4209.
eco:b4323.
PATRIC32124242. VBIEscCol129921_4464.

Organism-specific databases

EchoBASEEB4150.
EcoGeneEG20248. uxuB.

Phylogenomic databases

eggNOGCOG0246.
HOGENOMHOG000202982.
KOK00040.
OMAFEKVGVQ.
OrthoDBEOG6X9MNH.
PhylomeDBP39160.
ProtClustDBPRK15037.

Enzyme and pathway databases

BioCycEcoCyc:MANNONOXIDOREDUCT-MONOMER.
ECOL316407:JW4286-MONOMER.
MetaCyc:MANNONOXIDOREDUCT-MONOMER.
UniPathwayUPA00246.

Gene expression databases

GenevestigatorP39160.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. SSF48179. 1 hit.
PROSITEPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP39160.

Entry information

Entry nameUXUB_ECOLI
AccessionPrimary (citable) accession number: P39160
Secondary accession number(s): Q2M5Z0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene