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Protein

D-mannonate oxidoreductase

Gene

uxuB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-mannonate + NAD+ = D-fructuronate + NADH.

Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi25 – 36NADBy similarityAdd BLAST12

GO - Molecular functioni

  • coenzyme binding Source: InterPro
  • fructuronate reductase activity Source: CACAO

GO - Biological processi

  • D-glucuronate catabolic process Source: EcoCyc
  • mannitol metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciEcoCyc:MANNONOXIDOREDUCT-MONOMER.
ECOL316407:JW4286-MONOMER.
MetaCyc:MANNONOXIDOREDUCT-MONOMER.
UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
D-mannonate oxidoreductase (EC:1.1.1.57)
Alternative name(s):
Fructuronate reductase
Gene namesi
Name:uxuB
Ordered Locus Names:b4323, JW4286
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG20248. uxuB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001707471 – 486D-mannonate oxidoreductaseAdd BLAST486

Proteomic databases

EPDiP39160.
PaxDbiP39160.
PRIDEiP39160.

Interactioni

Protein-protein interaction databases

BioGridi4260999. 6 interactors.
DIPiDIP-11109N.
IntActiP39160. 3 interactors.
STRINGi511145.b4323.

Structurei

3D structure databases

ProteinModelPortaliP39160.
SMRiP39160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DEI. Bacteria.
COG0246. LUCA.
HOGENOMiHOG000202982.
InParanoidiP39160.
KOiK00040.
OMAiCHNPATG.
PhylomeDBiP39160.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSiPR00084. MTLDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39160-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTIVDSNLP VARPSWDHSR LESRIVHLGC GAFHRAHQAL YTHHLLESTD
60 70 80 90 100
SDWGICEVNL MPGNDRVLIE NLKKQQLLYT VAEKGAESTE LKIIGSMKEA
110 120 130 140 150
LHPEIDGCEG ILNAMARPQT AIVSLTVTEK GYCADAASGQ LDLNNPLIKH
160 170 180 190 200
DLENPTAPKS AIGYIVEALR LRREKGLKAF TVMSCDNVRE NGHVAKVAVL
210 220 230 240 250
GLAQARDPQL AAWIEENVTF PCTMVDRIVP AATPETLQEI ADQLGVYDPC
260 270 280 290 300
AIACEPFRQW VIEDNFVNGR PDWDKVGAQF VADVVPFEMM KLRMLNGSHS
310 320 330 340 350
FLAYLGYLGG YETIADTVTN PAYRKAAFAL MMQEQAPTLS MPEGTDLNAY
360 370 380 390 400
ATLLIERFSN PSLRHRTWQI AMDGSQKLPQ RLLDPVRLHL QNGGSWRHLA
410 420 430 440 450
LGVAGWMRYT QGVDEQGNAI DVVDPMLAEF QKINAQYQGA DRVKALLGLS
460 470 480
GIFADDLPQN ADFVGAVTAA YQQLCERGAR ECVAAL
Length:486
Mass (Da):53,580
Last modified:February 1, 1995 - v1
Checksum:i7835638682AF7B87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13329 Genomic DNA. Translation: BAA02591.1.
U14003 Genomic DNA. Translation: AAA97219.1.
U00096 Genomic DNA. Translation: AAC77279.1.
AP009048 Genomic DNA. Translation: BAE78316.1.
PIRiS56548.
RefSeqiNP_418743.1. NC_000913.3.
WP_000208205.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77279; AAC77279; b4323.
BAE78316; BAE78316; BAE78316.
GeneIDi946795.
KEGGiecj:JW4286.
eco:b4323.
PATRICi32124242. VBIEscCol129921_4464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13329 Genomic DNA. Translation: BAA02591.1.
U14003 Genomic DNA. Translation: AAA97219.1.
U00096 Genomic DNA. Translation: AAC77279.1.
AP009048 Genomic DNA. Translation: BAE78316.1.
PIRiS56548.
RefSeqiNP_418743.1. NC_000913.3.
WP_000208205.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP39160.
SMRiP39160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260999. 6 interactors.
DIPiDIP-11109N.
IntActiP39160. 3 interactors.
STRINGi511145.b4323.

Proteomic databases

EPDiP39160.
PaxDbiP39160.
PRIDEiP39160.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77279; AAC77279; b4323.
BAE78316; BAE78316; BAE78316.
GeneIDi946795.
KEGGiecj:JW4286.
eco:b4323.
PATRICi32124242. VBIEscCol129921_4464.

Organism-specific databases

EchoBASEiEB4150.
EcoGeneiEG20248. uxuB.

Phylogenomic databases

eggNOGiENOG4105DEI. Bacteria.
COG0246. LUCA.
HOGENOMiHOG000202982.
InParanoidiP39160.
KOiK00040.
OMAiCHNPATG.
PhylomeDBiP39160.

Enzyme and pathway databases

UniPathwayiUPA00246.
BioCyciEcoCyc:MANNONOXIDOREDUCT-MONOMER.
ECOL316407:JW4286-MONOMER.
MetaCyc:MANNONOXIDOREDUCT-MONOMER.

Miscellaneous databases

PROiP39160.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSiPR00084. MTLDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUXUB_ECOLI
AccessioniPrimary (citable) accession number: P39160
Secondary accession number(s): Q2M5Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.