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Reviewed, UniProtKB/Swiss-Prot P39113 (CAT8_YEAST)

Last modified January 19, 2010. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Regulatory protein CAT8
Gene names
Name: CAT8
Synonyms: MSP8
Ordered Locus Names: YMR280C
ORF Names: YM8021.06C
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length1433 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Activator of the gluconeogenic enzymes FBP1 and PCK1 genes.

Subcellular location

Nucleus.

Post-translational modification

Could be the target of the SNF1/CAT1 - SNF4/CAT3 kinase complex.

Sequence similarities

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

STD1Q027941EBI-4052,EBI-18344

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14331433Regulatory protein CAT8
PRO_0000114940

Regions

DNA binding70 – 9728Zn(2)-C6 fungal-type
Compositional bias208 – 2125Poly-Pro
Compositional bias972 – 9765Poly-Asn

Amino acid modifications

Modified residue1731Phosphoserine Ref.4
Modified residue1751Phosphothreonine Ref.4
Modified residue11701Phosphoserine Ref.4

Experimental info

Sequence conflict3031S → A in CAA63906. Ref.3
Sequence conflict7471K → L in CAA55139. Ref.1
Sequence conflict7681T → A in CAA63906. Ref.3
Sequence conflict999 – 10024Missing in CAA63906. Ref.3
Sequence conflict10081G → S in CAA63906. Ref.3
Sequence conflict10161H → Q in CAA63906. Ref.3
Sequence conflict10191Q → P in CAA63906. Ref.3
Sequence conflict10611V → M in CAA63906. Ref.3
Sequence conflict1072 – 10743TDA → ADS in CAA63906. Ref.3
Sequence conflict10921N → S in CAA63906. Ref.3
Sequence conflict11001I → V in CAA63906. Ref.3
Sequence conflict11201M → L in CAA63906. Ref.3
Sequence conflict11621S → A in CAA63906. Ref.3

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Sequences

Sequence LengthMass (Da)Tools
P39113-1 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: 5ED790BEFB47B632

FASTA1,433160,485
        10         20         30         40         50         60 
MANNNSDRQG LEPRVIRTLG SQALSGPSIS NRTSSSEANP HFSKNVKEAM IKTASPTPLS 

        70         80         90        100        110        120 
TPIYRIAQAC DRCRSKKTRC DGKRPQCSQC AAVGFECRIS DKLLRKAYPK GYTESLEERV 

       130        140        150        160        170        180 
RELEAENKRL LALCDIKEQQ ISLVSQSRPQ TSTDNTINGN FKHDLKDAPL NLSSTNIYLL 

       190        200        210        220        230        240 
NQTVNKQLQN GKMDGDNSGS AMSPLGAPPP PPHKDHLCDG VSCTNHLHVK PTSTSLNDPT 

       250        260        270        280        290        300 
AISFEQDEAP GLPAVKALKS MTTHQRSTQL ATLVSLSIPR STEEILFIPQ LLTRIRQIFG 

       310        320        330        340        350        360 
FNSKQCLYTV SLLSSLKNRL PAPRLLAPST STKLKEKDED KKLDDDSAFV KRFQSTNLSE 

       370        380        390        400        410        420 
FVDLKKFLIS LKFNINSFSK QSEKPANDQD DELLSLTEIK ELLHLFFKFW SNQVPILNND 

       430        440        450        460        470        480 
HFLIYFNNFV EVVKHLSTEN LETNNTTKST VTTNHEIFAL KLLMMLQMGL LVKIKMEKIK 

       490        500        510        520        530        540 
YTVPKNPKAK YARLMAYYHQ LSLIIPKNPY FLNMSTTSLP SLQLLSLASF YYLNVGDISA 

       550        560        570        580        590        600 
IYGVRGRIVS MAQQLRLHRC PSAVLSVHSN PVLQKFEQSE RRLLFWAIYY VDVFASLQLG 

       610        620        630        640        650        660 
VPRLLKDFDI ECALPISDVE YKDQLSMENE KADKKAKKIQ LQGQVSSFSL QIIRFAKILG 

       670        680        690        700        710        720 
NILDSIFKRG MMDERITSEV ALVHENALDN WRNQLPEMYY FQITVNGTVN LDEIRATNQR 

       730        740        750        760        770        780 
NTETKFDKKD IILFEKKILL LFYFLAKSMI HLPVIATKPL PKNVDNATKK KQSMFNNDSK 

       790        800        810        820        830        840 
GATNQDHMIL DVDMTSPAIR TSSSYIILQQ ATNATLTIFQ AINSMYLPLP LNVSRTLIRF 

       850        860        870        880        890        900 
SLLCARGSLE YTKGGALFLD NKNLLLDTIK DIENDRLLDL PGIASWHTLK LFDMSINLLL 

       910        920        930        940        950        960 
KAPNVKVERL DKFLEKKLNY YNRLMGLPPA TTTSLKPLFG SQSKNSLENR QRTPNVKREN 

       970        980        990       1000       1010       1020 
PEHEYLYGND SNNNNNSEAG HSPMTNTTNG NKRLKYEKDA KRNAKDGGIS KGENAHNFQN 

      1030       1040       1050       1060       1070       1080 
DTKKNMSTSN LFPFSFSNTD LTALFTHPEG PNCTNTNNGN VDVCNRASTD ATDANIENLS 

      1090       1100       1110       1120       1130       1140 
FLNMAPFLQT GNSNIGQNTI ENKPMHMDAI FSLPSNLDLM KDNMDSKPEQ LEPVIKQNPE 

      1150       1160       1170       1180       1190       1200 
NSKNNQFHQK GKSTNMEKNN LSFNNKSNYS LTKLMRLLNN DNSFSNISIN NFLYQNDQNS 

      1210       1220       1230       1240       1250       1260 
ASADPGTNKK AVTNAGANFK PPSTGSNTSQ GSILGSTKHG MDNCDFNDLG NFNNFMTNVN 

      1270       1280       1290       1300       1310       1320 
YSGVDYDYIV DASLGLAPLL VDTPDISNTN TTSTTSNRSK NSIILDTTFN DDLDRSRMNA 

      1330       1340       1350       1360       1370       1380 
REVLNPTDSI LSQGMVSSVS TRNTSNQRSL SSGNDSKGDS SSQENSKSAT GNQLDTPSTL 

      1390       1400       1410       1420       1430 
FQMRRTSSGP SASHRGPRRP QKNRYNTDRS KSSGGGSSNT DNVSDLFQWQ NAK

« Hide

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References

« Hide 'large scale' references
[1]"CAT8, a new zinc cluster-encoding gene necessary for derepression of gluconeogenic enzymes in the yeast Saccharomyces cerevisiae."
Hedges D., Proft M., Entian K.-D.
Mol. Cell. Biol. 15:1915-1922(1995) [PubMed: 7891685] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed: 9169872] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[3]Boles E., Hettmann C., Zimmermann F.K.
Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ENY.WA-1A.
[4]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-173; THR-175 AND SER-1170, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X78344 Genomic DNA. Translation: CAA55139.1.
Z49704 Genomic DNA. Translation: CAA89778.1.
X94215 Genomic DNA. Translation: CAA63906.1.
PIRS54587.
RefSeqNP_014007.1.

3D structure databases

SMRP39113. Positions 66-133.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-4397N.
IntActP39113. 1 interaction.
STRINGP39113.

Proteomic databases

PeptideAtlasP39113.
PRIDEP39113.

Genome annotation databases

EnsemblYMR280C; YMR280C; YMR280C; Saccharomyces cerevisiae. [Genome view]
GeneID855323.
KEGGsce:YMR280C.
NMPDRfig|4932.3.peg.5065.

Organism-specific databases

CYGDYMR280c.
SGDS000004893. CAT8.

Phylogenomic databases

eggNOGfuNOG05586.
HOGENOMHBG203520.
OMAERRLLFW.
OrthoDBEOG98963H.
PhylomeDBP39113.

Gene expression databases

ArrayExpressP39113.
GenevestigatorP39113.
GermOnlineYMR280C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR007219. Fungal_trans.
IPR001138. Fungi_Trscrp_N.
[Graphical view]
PfamPF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTSM00066. GAL4. 1 hit.
[Graphical view]
PROSITEPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio979032.

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Entry information

Entry nameCAT8_YEAST
AccessionPrimary (citable) accession number: P39113
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: January 19, 2010
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents