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P39113

- CAT8_YEAST

UniProt

P39113 - CAT8_YEAST

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Protein
Regulatory protein CAT8
Gene
CAT8, MSP8, YMR280C, YM8021.06C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Activator of the gluconeogenic enzymes FBP1 and PCK1 genes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi70 – 9728Zn(2)-C6 fungal-type
Add
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: SGD
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: SGD
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB-KW
  2. positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  3. positive regulation of glyoxylate cycle by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  4. positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Carbohydrate metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-32951-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein CAT8
Gene namesi
Name:CAT8
Synonyms:MSP8
Ordered Locus Names:YMR280C
ORF Names:YM8021.06C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR280c.
SGDiS000004893. CAT8.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14331433Regulatory protein CAT8
PRO_0000114940Add
BLAST

Post-translational modificationi

Could be the target of the SNF1/CAT1 - SNF4/CAT3 kinase complex.

Proteomic databases

MaxQBiP39113.
PaxDbiP39113.
PeptideAtlasiP39113.

Expressioni

Gene expression databases

GenevestigatoriP39113.

Interactioni

Protein-protein interaction databases

BioGridi35459. 26 interactions.
DIPiDIP-4397N.
IntActiP39113. 1 interaction.
MINTiMINT-489548.
STRINGi4932.YMR280C.

Structurei

3D structure databases

ProteinModelPortaliP39113.
SMRiP39113. Positions 68-124.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi208 – 2125Poly-Pro
Compositional biasi972 – 9765Poly-Asn

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG76428.
GeneTreeiENSGT00530000068569.
HOGENOMiHOG000111315.
KOiK09240.
OMAiLFWAIYY.
OrthoDBiEOG7GTTDC.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00906. Fungal_trans. 1 hit.
SM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39113-1 [UniParc]FASTAAdd to Basket

« Hide

MANNNSDRQG LEPRVIRTLG SQALSGPSIS NRTSSSEANP HFSKNVKEAM     50
IKTASPTPLS TPIYRIAQAC DRCRSKKTRC DGKRPQCSQC AAVGFECRIS 100
DKLLRKAYPK GYTESLEERV RELEAENKRL LALCDIKEQQ ISLVSQSRPQ 150
TSTDNTINGN FKHDLKDAPL NLSSTNIYLL NQTVNKQLQN GKMDGDNSGS 200
AMSPLGAPPP PPHKDHLCDG VSCTNHLHVK PTSTSLNDPT AISFEQDEAP 250
GLPAVKALKS MTTHQRSTQL ATLVSLSIPR STEEILFIPQ LLTRIRQIFG 300
FNSKQCLYTV SLLSSLKNRL PAPRLLAPST STKLKEKDED KKLDDDSAFV 350
KRFQSTNLSE FVDLKKFLIS LKFNINSFSK QSEKPANDQD DELLSLTEIK 400
ELLHLFFKFW SNQVPILNND HFLIYFNNFV EVVKHLSTEN LETNNTTKST 450
VTTNHEIFAL KLLMMLQMGL LVKIKMEKIK YTVPKNPKAK YARLMAYYHQ 500
LSLIIPKNPY FLNMSTTSLP SLQLLSLASF YYLNVGDISA IYGVRGRIVS 550
MAQQLRLHRC PSAVLSVHSN PVLQKFEQSE RRLLFWAIYY VDVFASLQLG 600
VPRLLKDFDI ECALPISDVE YKDQLSMENE KADKKAKKIQ LQGQVSSFSL 650
QIIRFAKILG NILDSIFKRG MMDERITSEV ALVHENALDN WRNQLPEMYY 700
FQITVNGTVN LDEIRATNQR NTETKFDKKD IILFEKKILL LFYFLAKSMI 750
HLPVIATKPL PKNVDNATKK KQSMFNNDSK GATNQDHMIL DVDMTSPAIR 800
TSSSYIILQQ ATNATLTIFQ AINSMYLPLP LNVSRTLIRF SLLCARGSLE 850
YTKGGALFLD NKNLLLDTIK DIENDRLLDL PGIASWHTLK LFDMSINLLL 900
KAPNVKVERL DKFLEKKLNY YNRLMGLPPA TTTSLKPLFG SQSKNSLENR 950
QRTPNVKREN PEHEYLYGND SNNNNNSEAG HSPMTNTTNG NKRLKYEKDA 1000
KRNAKDGGIS KGENAHNFQN DTKKNMSTSN LFPFSFSNTD LTALFTHPEG 1050
PNCTNTNNGN VDVCNRASTD ATDANIENLS FLNMAPFLQT GNSNIGQNTI 1100
ENKPMHMDAI FSLPSNLDLM KDNMDSKPEQ LEPVIKQNPE NSKNNQFHQK 1150
GKSTNMEKNN LSFNNKSNYS LTKLMRLLNN DNSFSNISIN NFLYQNDQNS 1200
ASADPGTNKK AVTNAGANFK PPSTGSNTSQ GSILGSTKHG MDNCDFNDLG 1250
NFNNFMTNVN YSGVDYDYIV DASLGLAPLL VDTPDISNTN TTSTTSNRSK 1300
NSIILDTTFN DDLDRSRMNA REVLNPTDSI LSQGMVSSVS TRNTSNQRSL 1350
SSGNDSKGDS SSQENSKSAT GNQLDTPSTL FQMRRTSSGP SASHRGPRRP 1400
QKNRYNTDRS KSSGGGSSNT DNVSDLFQWQ NAK 1433
Length:1,433
Mass (Da):160,485
Last modified:October 1, 1996 - v2
Checksum:i5ED790BEFB47B632
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti303 – 3031S → A in CAA63906. 1 Publication
Sequence conflicti747 – 7471K → L in CAA55139. 1 Publication
Sequence conflicti768 – 7681T → A in CAA63906. 1 Publication
Sequence conflicti999 – 10024Missing in CAA63906. 1 Publication
Sequence conflicti1008 – 10081G → S in CAA63906. 1 Publication
Sequence conflicti1016 – 10161H → Q in CAA63906. 1 Publication
Sequence conflicti1019 – 10191Q → P in CAA63906. 1 Publication
Sequence conflicti1061 – 10611V → M in CAA63906. 1 Publication
Sequence conflicti1072 – 10743TDA → ADS in CAA63906. 1 Publication
Sequence conflicti1092 – 10921N → S in CAA63906. 1 Publication
Sequence conflicti1100 – 11001I → V in CAA63906. 1 Publication
Sequence conflicti1120 – 11201M → L in CAA63906. 1 Publication
Sequence conflicti1162 – 11621S → A in CAA63906. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78344 Genomic DNA. Translation: CAA55139.1.
Z49704 Genomic DNA. Translation: CAA89778.1.
X94215 Genomic DNA. Translation: CAA63906.1.
BK006946 Genomic DNA. Translation: DAA10181.1.
PIRiS54587.
RefSeqiNP_014007.1. NM_001182787.1.

Genome annotation databases

EnsemblFungiiYMR280C; YMR280C; YMR280C.
GeneIDi855323.
KEGGisce:YMR280C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78344 Genomic DNA. Translation: CAA55139.1 .
Z49704 Genomic DNA. Translation: CAA89778.1 .
X94215 Genomic DNA. Translation: CAA63906.1 .
BK006946 Genomic DNA. Translation: DAA10181.1 .
PIRi S54587.
RefSeqi NP_014007.1. NM_001182787.1.

3D structure databases

ProteinModelPortali P39113.
SMRi P39113. Positions 68-124.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35459. 26 interactions.
DIPi DIP-4397N.
IntActi P39113. 1 interaction.
MINTi MINT-489548.
STRINGi 4932.YMR280C.

Proteomic databases

MaxQBi P39113.
PaxDbi P39113.
PeptideAtlasi P39113.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR280C ; YMR280C ; YMR280C .
GeneIDi 855323.
KEGGi sce:YMR280C.

Organism-specific databases

CYGDi YMR280c.
SGDi S000004893. CAT8.

Phylogenomic databases

eggNOGi NOG76428.
GeneTreei ENSGT00530000068569.
HOGENOMi HOG000111315.
KOi K09240.
OMAi LFWAIYY.
OrthoDBi EOG7GTTDC.

Enzyme and pathway databases

BioCyci YEAST:G3O-32951-MONOMER.

Miscellaneous databases

NextBioi 979032.

Gene expression databases

Genevestigatori P39113.

Family and domain databases

Gene3Di 4.10.240.10. 1 hit.
InterProi IPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view ]
Pfami PF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view ]
SMARTi SM00906. Fungal_trans. 1 hit.
SM00066. GAL4. 1 hit.
[Graphical view ]
SUPFAMi SSF57701. SSF57701. 1 hit.
PROSITEi PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CAT8, a new zinc cluster-encoding gene necessary for derepression of gluconeogenic enzymes in the yeast Saccharomyces cerevisiae."
    Hedges D., Proft M., Entian K.-D.
    Mol. Cell. Biol. 15:1915-1922(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Boles E., Hettmann C., Zimmermann F.K.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ENY.WA-1A.
  5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCAT8_YEAST
AccessioniPrimary (citable) accession number: P39113
Secondary accession number(s): D6W0A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

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