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Protein

Regulatory protein CAT8

Gene

CAT8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Activator of the gluconeogenic enzymes FBP1 and PCK1 genes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi70 – 97Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processCarbohydrate metabolism, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-32951-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein CAT8
Gene namesi
Name:CAT8
Synonyms:MSP8
Ordered Locus Names:YMR280C
ORF Names:YM8021.06C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR280C.
SGDiS000004893. CAT8.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001149401 – 1433Regulatory protein CAT8Add BLAST1433

Post-translational modificationi

Could be the target of the SNF1/CAT1 - SNF4/CAT3 kinase complex.

Proteomic databases

MaxQBiP39113.
PRIDEiP39113.

PTM databases

iPTMnetiP39113.

Interactioni

Protein-protein interaction databases

BioGridi35459. 94 interactors.
DIPiDIP-4397N.
IntActiP39113. 1 interactor.
MINTiMINT-489548.
STRINGi4932.YMR280C.

Structurei

3D structure databases

ProteinModelPortaliP39113.
SMRiP39113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi208 – 212Poly-Pro5
Compositional biasi972 – 976Poly-Asn5

Phylogenomic databases

GeneTreeiENSGT00530000068569.
HOGENOMiHOG000111315.
InParanoidiP39113.
KOiK09240.
OMAiHRCPSAV.
OrthoDBiEOG092C2SG5.

Family and domain databases

CDDicd00067. GAL4. 1 hit.
Gene3Di4.10.240.10. 1 hit.
InterProiView protein in InterPro
IPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
PfamiView protein in Pfam
PF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
SMARTiView protein in SMART
SM00906. Fungal_trans. 1 hit.
SM00066. GAL4. 1 hit.
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiView protein in PROSITE
PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P39113-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANNNSDRQG LEPRVIRTLG SQALSGPSIS NRTSSSEANP HFSKNVKEAM
60 70 80 90 100
IKTASPTPLS TPIYRIAQAC DRCRSKKTRC DGKRPQCSQC AAVGFECRIS
110 120 130 140 150
DKLLRKAYPK GYTESLEERV RELEAENKRL LALCDIKEQQ ISLVSQSRPQ
160 170 180 190 200
TSTDNTINGN FKHDLKDAPL NLSSTNIYLL NQTVNKQLQN GKMDGDNSGS
210 220 230 240 250
AMSPLGAPPP PPHKDHLCDG VSCTNHLHVK PTSTSLNDPT AISFEQDEAP
260 270 280 290 300
GLPAVKALKS MTTHQRSTQL ATLVSLSIPR STEEILFIPQ LLTRIRQIFG
310 320 330 340 350
FNSKQCLYTV SLLSSLKNRL PAPRLLAPST STKLKEKDED KKLDDDSAFV
360 370 380 390 400
KRFQSTNLSE FVDLKKFLIS LKFNINSFSK QSEKPANDQD DELLSLTEIK
410 420 430 440 450
ELLHLFFKFW SNQVPILNND HFLIYFNNFV EVVKHLSTEN LETNNTTKST
460 470 480 490 500
VTTNHEIFAL KLLMMLQMGL LVKIKMEKIK YTVPKNPKAK YARLMAYYHQ
510 520 530 540 550
LSLIIPKNPY FLNMSTTSLP SLQLLSLASF YYLNVGDISA IYGVRGRIVS
560 570 580 590 600
MAQQLRLHRC PSAVLSVHSN PVLQKFEQSE RRLLFWAIYY VDVFASLQLG
610 620 630 640 650
VPRLLKDFDI ECALPISDVE YKDQLSMENE KADKKAKKIQ LQGQVSSFSL
660 670 680 690 700
QIIRFAKILG NILDSIFKRG MMDERITSEV ALVHENALDN WRNQLPEMYY
710 720 730 740 750
FQITVNGTVN LDEIRATNQR NTETKFDKKD IILFEKKILL LFYFLAKSMI
760 770 780 790 800
HLPVIATKPL PKNVDNATKK KQSMFNNDSK GATNQDHMIL DVDMTSPAIR
810 820 830 840 850
TSSSYIILQQ ATNATLTIFQ AINSMYLPLP LNVSRTLIRF SLLCARGSLE
860 870 880 890 900
YTKGGALFLD NKNLLLDTIK DIENDRLLDL PGIASWHTLK LFDMSINLLL
910 920 930 940 950
KAPNVKVERL DKFLEKKLNY YNRLMGLPPA TTTSLKPLFG SQSKNSLENR
960 970 980 990 1000
QRTPNVKREN PEHEYLYGND SNNNNNSEAG HSPMTNTTNG NKRLKYEKDA
1010 1020 1030 1040 1050
KRNAKDGGIS KGENAHNFQN DTKKNMSTSN LFPFSFSNTD LTALFTHPEG
1060 1070 1080 1090 1100
PNCTNTNNGN VDVCNRASTD ATDANIENLS FLNMAPFLQT GNSNIGQNTI
1110 1120 1130 1140 1150
ENKPMHMDAI FSLPSNLDLM KDNMDSKPEQ LEPVIKQNPE NSKNNQFHQK
1160 1170 1180 1190 1200
GKSTNMEKNN LSFNNKSNYS LTKLMRLLNN DNSFSNISIN NFLYQNDQNS
1210 1220 1230 1240 1250
ASADPGTNKK AVTNAGANFK PPSTGSNTSQ GSILGSTKHG MDNCDFNDLG
1260 1270 1280 1290 1300
NFNNFMTNVN YSGVDYDYIV DASLGLAPLL VDTPDISNTN TTSTTSNRSK
1310 1320 1330 1340 1350
NSIILDTTFN DDLDRSRMNA REVLNPTDSI LSQGMVSSVS TRNTSNQRSL
1360 1370 1380 1390 1400
SSGNDSKGDS SSQENSKSAT GNQLDTPSTL FQMRRTSSGP SASHRGPRRP
1410 1420 1430
QKNRYNTDRS KSSGGGSSNT DNVSDLFQWQ NAK
Length:1,433
Mass (Da):160,485
Last modified:October 1, 1996 - v2
Checksum:i5ED790BEFB47B632
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti303S → A in CAA63906 (Ref. 4) Curated1
Sequence conflicti747K → L in CAA55139 (PubMed:7891685).Curated1
Sequence conflicti768T → A in CAA63906 (Ref. 4) Curated1
Sequence conflicti999 – 1002Missing in CAA63906 (Ref. 4) Curated4
Sequence conflicti1008G → S in CAA63906 (Ref. 4) Curated1
Sequence conflicti1016H → Q in CAA63906 (Ref. 4) Curated1
Sequence conflicti1019Q → P in CAA63906 (Ref. 4) Curated1
Sequence conflicti1061V → M in CAA63906 (Ref. 4) Curated1
Sequence conflicti1072 – 1074TDA → ADS in CAA63906 (Ref. 4) Curated3
Sequence conflicti1092N → S in CAA63906 (Ref. 4) Curated1
Sequence conflicti1100I → V in CAA63906 (Ref. 4) Curated1
Sequence conflicti1120M → L in CAA63906 (Ref. 4) Curated1
Sequence conflicti1162S → A in CAA63906 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78344 Genomic DNA. Translation: CAA55139.1.
Z49704 Genomic DNA. Translation: CAA89778.1.
X94215 Genomic DNA. Translation: CAA63906.1.
BK006946 Genomic DNA. Translation: DAA10181.1.
PIRiS54587.
RefSeqiNP_014007.1. NM_001182787.1.

Genome annotation databases

EnsemblFungiiYMR280C; YMR280C; YMR280C.
GeneIDi855323.
KEGGisce:YMR280C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCAT8_YEAST
AccessioniPrimary (citable) accession number: P39113
Secondary accession number(s): D6W0A7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: July 5, 2017
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names