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Protein

V-type proton ATPase subunit F

Gene

VMA7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Miscellaneous

Present with 4050 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • proton-transporting ATPase activity, rotational mechanism Source: SGD

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: InterPro
  • vacuolar acidification Source: SGD

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30746-MONOMER.
ReactomeiR-SCE-1222556. ROS, RNS production in phagocytes.
R-SCE-77387. Insulin receptor recycling.
R-SCE-917977. Transferrin endocytosis and recycling.

Protein family/group databases

TCDBi3.A.2.2.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit F
Short name:
V-ATPase subunit F
Alternative name(s):
V-ATPase 14 kDa subunit
Vacuolar proton pump subunit F
Gene namesi
Name:VMA7
Ordered Locus Names:YGR020C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR020C.
SGDiS000003252. VMA7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448121 – 118V-type proton ATPase subunit FAdd BLAST118

Proteomic databases

MaxQBiP39111.
PRIDEiP39111.
TopDownProteomicsiP39111.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d and e).

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33262. 56 interactors.
DIPiDIP-2077N.
IntActiP39111. 22 interactors.
MINTiMINT-507949.
STRINGi4932.YGR020C.

Structurei

Secondary structure

1118
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 4Combined sources3
Beta strandi7 – 13Combined sources7
Helixi14 – 22Combined sources9
Turni23 – 26Combined sources4
Turni30 – 32Combined sources3
Beta strandi37 – 40Combined sources4
Turni42 – 44Combined sources3
Helixi47 – 59Combined sources13
Beta strandi62 – 69Combined sources8
Helixi71 – 76Combined sources6
Helixi78 – 82Combined sources5
Beta strandi86 – 93Combined sources8
Helixi108 – 115Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Telectron microscopy6.90N1-118[»]
3J9Uelectron microscopy7.60N1-118[»]
3J9Velectron microscopy8.30N1-118[»]
4IX9X-ray2.33A/B/C/D1-94[»]
4RNDX-ray3.18B/D1-118[»]
5D80X-ray6.20O/o1-118[»]
5VOXelectron microscopy6.80N1-118[»]
5VOYelectron microscopy7.90N1-118[»]
5VOZelectron microscopy7.60N1-118[»]
ProteinModelPortaliP39111.
SMRiP39111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase F subunit family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000013208.
HOGENOMiHOG000056545.
InParanoidiP39111.
KOiK02151.
OMAiQNVAEMI.
OrthoDBiEOG092C5L7Q.

Family and domain databases

Gene3Di3.40.50.10580. 1 hit.
InterProiView protein in InterPro
IPR008218. ATPase_V1-cplx_f_g_su.
IPR005772. ATPase_V1-cplx_fsu_euk.
IPR036906. ATPase_V1_fsu_sf.
PfamiView protein in Pfam
PF01990. ATP-synt_F. 1 hit.
PIRSFiPIRSF015945. ATPase_V1_F_euk. 1 hit.
SUPFAMiSSF159468. SSF159468. 1 hit.
TIGRFAMsiTIGR01101. V_ATP_synt_F. 1 hit.

Sequencei

Sequence statusi: Complete.

P39111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKRTLIAV IADEDTTTGL LLAGIGQITP ETQEKNFFVY QEGKTTKEEI
60 70 80 90 100
TDKFNHFTEE RDDIAILLIN QHIAENIRAR VDSFTNAFPA ILEIPSKDHP
110
YDPEKDSVLK RVRKLFGE
Length:118
Mass (Da):13,461
Last modified:February 1, 1995 - v1
Checksum:iD21EC0980EB99DFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10073 Genomic DNA. Translation: AAA50753.1.
U12786 Genomic DNA. Translation: AAA53208.1.
Z72805 Genomic DNA. Translation: CAA97003.1.
BK006941 Genomic DNA. Translation: DAA08116.1.
PIRiA55118.
RefSeqiNP_011534.1. NM_001181149.1.

Genome annotation databases

EnsemblFungiiYGR020C; YGR020C; YGR020C.
GeneIDi852903.
KEGGisce:YGR020C.

Similar proteinsi

Entry informationi

Entry nameiVATF_YEAST
AccessioniPrimary (citable) accession number: P39111
Secondary accession number(s): D6VUF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 22, 2017
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names