P39111 (VATF_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
V-type proton ATPase subunit F
Short name=V-ATPase subunit F

Alternative name(s):
V-ATPase 14 kDa subunit
Vacuolar proton pump subunit F

Gene names

Name:	VMA7
Ordered Locus Names:	YGR020C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	118 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Subunit structure	V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d and e).
Miscellaneous	Present with 4050 molecules/cell in log phase SD medium. Ref.6
Sequence similarities	Belongs to the V-ATPase F subunit family.

Ontologies

Keywords
Biological process	Hydrogen ion transport Ion transport Transport
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP hydrolysis coupled proton transport Inferred from electronic annotation. Source: InterPro vacuolar acidification Traceable author statement. Source: SGD
Cellular component	fungal-type vacuole membrane Traceable author statement. Source: SGD vacuolar proton-transporting V-type ATPase, V1 domain Traceable author statement. Source: SGD
Molecular function	hydrogen ion transporting ATP synthase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct proton-transporting ATPase activity, rotational mechanism Traceable author statement. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
VMA13	P41807	4	EBI-20272,EBI-20281
VMA6	P32366	5	EBI-20272,EBI-20201
VMA8	P32610	5	EBI-20272,EBI-20264
VPH1	P32563	5	EBI-20272,EBI-20455

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 118	118	V-type proton ATPase subunit F		PRO_0000144812

Sequences

	Sequence		Length	Mass (Da)
	P39111 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: D21EC0980EB99DFF	FASTA	118	13,461
	10 20 30 40 50 60 MAEKRTLIAV IADEDTTTGL LLAGIGQITP ETQEKNFFVY QEGKTTKEEI TDKFNHFTEE 70 80 90 100 110 RDDIAILLIN QHIAENIRAR VDSFTNAFPA ILEIPSKDHP YDPEKDSVLK RVRKLFGE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Saccharomyces cerevisiae VMA7 gene encodes a 14-kDa subunit of the vacuolar H(+)-ATPase catalytic sector." Nelson H., Mandiyan S., Nelson N. J. Biol. Chem. 269:24150-24155(1994) [PubMed: 7929071] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 200060 / W303.
[2]	"VMA7 encodes a novel 14-kDa subunit of the Saccharomyces cerevisiae vacuolar H(+)-ATPase complex." Graham L.A., Hill K.J., Stevens T.H. J. Biol. Chem. 269:25974-25977(1994) [PubMed: 7929308] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Sigma 1278B.
[3]	"Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII." Rieger M., Brueckner M., Schaefer M., Mueller-Auer S. Yeast 13:1077-1090(1997) [PubMed: 9290212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[5]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U10073 Genomic DNA. Translation: AAA50753.1. U12786 Genomic DNA. Translation: AAA53208.1. Z72805 Genomic DNA. Translation: CAA97003.1. BK006941 Genomic DNA. Translation: DAA08116.1.
PIR	A55118.
RefSeq	NP_011534.1. NM_001181149.1.
3D structure databases
ProteinModelPortal	P39111.
SMR	P39111. Positions 7-117.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2077N.
IntAct	P39111. 32 interactions.
MINT	MINT-507949.
STRING	P39111.
Protein family/group databases
TCDB	3.A.2.2.3. H+- or Na+-translocating F-type, V-type and A-type ATPase (F-ATPase) superfamily.
Proteomic databases
PeptideAtlas	P39111.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGR020C; YGR020C; YGR020C.
GeneID	852903.
KEGG	sce:YGR020C.
NMPDR	fig|4932.3.peg.2644.
Organism-specific databases
CYGD	YGR020c.
SGD	S000003252. VMA7.
Phylogenomic databases
eggNOG	fuNOG10598.
GeneTree	EFGT00050000004374.
HOGENOM	HBG402579.
OMA	HPYDPEK.
OrthoDB	EOG44F9KR.
Gene expression databases
ArrayExpress	P39111.
Genevestigator	P39111.
GermOnline	YGR020C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR005772. ATPase_V1-cplx_fsu_euk. IPR008218. ATPase_V1/A1-cplx_fsu. [Graphical view]
KO	K02151.
PANTHER	PTHR13861. ATPase_V1_F_euk. 1 hit.
Pfam	PF01990. ATP-synt_F. 1 hit. [Graphical view]
PIRSF	PIRSF015945. ATPase_V1_F_euk. 1 hit.
TIGRFAMs	TIGR01101. V_ATP_synt_F. 1 hit.
ProtoNet	Search...
Other
NextBio	972586.

Entry information

Entry name

VATF_YEAST

Accession

Primary (citable) accession number: P39111
Secondary accession number(s): D6VUF5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	December 14, 2011
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program