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P39110

- CIN4_YEAST

UniProt

P39110 - CIN4_YEAST

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Protein

GTP-binding protein CIN4

Gene
CIN4, GTP1, UGX1, YMR138W, YM9375.07
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Implicated in yeast microtubule function.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 308GTP By similarity
Nucleotide bindingi69 – 735GTP By similarity
Nucleotide bindingi131 – 1344GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: SGD

GO - Biological processi

  1. protein folding Source: SGD
  2. small GTPase mediated signal transduction Source: InterPro
  3. tubulin complex assembly Source: SGD
  4. tubulin complex biogenesis Source: SGD
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32831-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein CIN4
Alternative name(s):
Chromosome instability protein 4
Gene namesi
Name:CIN4
Synonyms:GTP1, UGX1
Ordered Locus Names:YMR138W
ORF Names:YM9375.07
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR138w.
SGDiS000004746. CIN4.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 191191GTP-binding protein CIN4PRO_0000122464Add
BLAST

Proteomic databases

MaxQBiP39110.
PaxDbiP39110.
PRIDEiP39110.

Expressioni

Gene expression databases

GenevestigatoriP39110.

Interactioni

Protein-protein interaction databases

BioGridi35315. 67 interactions.
DIPiDIP-1256N.
IntActiP39110. 4 interactions.
MINTiMINT-404656.
STRINGi4932.YMR138W.

Structurei

3D structure databases

ProteinModelPortaliP39110.
SMRiP39110. Positions 2-178.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00750000118672.
HOGENOMiHOG000163691.
KOiK07943.
OMAiEIRCLIL.
OrthoDBiEOG7FNCKB.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39110-1 [UniParc]FASTAAdd to Basket

« Hide

MGLLSIIRKQ KLRDKEIRCL ILGLDNSGKS TIVNKLLPKD EQNNDGIMPT    50
VGFQIHSLMI KDVTISLWDI GGQRTLRPFW DNYFDKTQAM IWCIDVSLSM 100
RFDETLQELK ELINRDENRI GYECAVIVVL NKIDLVEDKS ELHRRCLLVE 150
SELKCLFKPD IRIELVKCSG VTGEGIDNLR DRLVESCHFT Q 191
Length:191
Mass (Da):22,067
Last modified:February 1, 1995 - v1
Checksum:iCF30AF932A2D2566
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36669 Genomic DNA. Translation: AAA50350.1.
X77086 Genomic DNA. Translation: CAA54358.1.
Z47071 Genomic DNA. Translation: CAA87352.1.
AY558409 Genomic DNA. Translation: AAS56735.1.
BK006946 Genomic DNA. Translation: DAA10035.1.
PIRiS51496.
RefSeqiNP_013858.1. NM_001182640.1.

Genome annotation databases

EnsemblFungiiYMR138W; YMR138W; YMR138W.
GeneIDi855169.
KEGGisce:YMR138W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36669 Genomic DNA. Translation: AAA50350.1 .
X77086 Genomic DNA. Translation: CAA54358.1 .
Z47071 Genomic DNA. Translation: CAA87352.1 .
AY558409 Genomic DNA. Translation: AAS56735.1 .
BK006946 Genomic DNA. Translation: DAA10035.1 .
PIRi S51496.
RefSeqi NP_013858.1. NM_001182640.1.

3D structure databases

ProteinModelPortali P39110.
SMRi P39110. Positions 2-178.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35315. 67 interactions.
DIPi DIP-1256N.
IntActi P39110. 4 interactions.
MINTi MINT-404656.
STRINGi 4932.YMR138W.

Proteomic databases

MaxQBi P39110.
PaxDbi P39110.
PRIDEi P39110.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR138W ; YMR138W ; YMR138W .
GeneIDi 855169.
KEGGi sce:YMR138W.

Organism-specific databases

CYGDi YMR138w.
SGDi S000004746. CIN4.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00750000118672.
HOGENOMi HOG000163691.
KOi K07943.
OMAi EIRCLIL.
OrthoDBi EOG7FNCKB.

Enzyme and pathway databases

BioCyci YEAST:G3O-32831-MONOMER.

Miscellaneous databases

NextBioi 978605.

Gene expression databases

Genevestigatori P39110.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view ]
Pfami PF00025. Arf. 1 hit.
[Graphical view ]
PRINTSi PR00328. SAR1GTPBP.
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51417. ARF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A small GTP-binding protein implicated in yeast microtubule function."
    Stearns T., Clark C.D., Hoyt M.A., Kahn R.A., Botstein D.
    Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Molecular characterisation of GTP1, a Saccharomyces cerevisiae gene encoding a small GTP-binding protein."
    Wolter R., Richter D., Niegemann E., Brendel M.
    Curr. Genet. 26:564-566(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCIN4_YEAST
AccessioniPrimary (citable) accession number: P39110
Secondary accession number(s): D6VZW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 468 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

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