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P39110

- CIN4_YEAST

UniProt

P39110 - CIN4_YEAST

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Protein

GTP-binding protein CIN4

Gene

CIN4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Implicated in yeast microtubule function.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 308GTPBy similarity
Nucleotide bindingi69 – 735GTPBy similarity
Nucleotide bindingi131 – 1344GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: SGD

GO - Biological processi

  1. protein folding Source: SGD
  2. small GTPase mediated signal transduction Source: InterPro
  3. tubulin complex assembly Source: SGD
  4. tubulin complex biogenesis Source: SGD
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32831-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein CIN4
Alternative name(s):
Chromosome instability protein 4
Gene namesi
Name:CIN4
Synonyms:GTP1, UGX1
Ordered Locus Names:YMR138W
ORF Names:YM9375.07
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR138w.
SGDiS000004746. CIN4.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 191191GTP-binding protein CIN4PRO_0000122464Add
BLAST

Proteomic databases

MaxQBiP39110.
PaxDbiP39110.
PRIDEiP39110.

Expressioni

Gene expression databases

GenevestigatoriP39110.

Interactioni

Protein-protein interaction databases

BioGridi35315. 68 interactions.
DIPiDIP-1256N.
IntActiP39110. 4 interactions.
MINTiMINT-404656.
STRINGi4932.YMR138W.

Structurei

3D structure databases

ProteinModelPortaliP39110.
SMRiP39110. Positions 2-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00770000121655.
HOGENOMiHOG000163691.
InParanoidiP39110.
KOiK07943.
OMAiEIRCLIL.
OrthoDBiEOG7FNCKB.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39110-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLLSIIRKQ KLRDKEIRCL ILGLDNSGKS TIVNKLLPKD EQNNDGIMPT
60 70 80 90 100
VGFQIHSLMI KDVTISLWDI GGQRTLRPFW DNYFDKTQAM IWCIDVSLSM
110 120 130 140 150
RFDETLQELK ELINRDENRI GYECAVIVVL NKIDLVEDKS ELHRRCLLVE
160 170 180 190
SELKCLFKPD IRIELVKCSG VTGEGIDNLR DRLVESCHFT Q
Length:191
Mass (Da):22,067
Last modified:February 1, 1995 - v1
Checksum:iCF30AF932A2D2566
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36669 Genomic DNA. Translation: AAA50350.1.
X77086 Genomic DNA. Translation: CAA54358.1.
Z47071 Genomic DNA. Translation: CAA87352.1.
AY558409 Genomic DNA. Translation: AAS56735.1.
BK006946 Genomic DNA. Translation: DAA10035.1.
PIRiS51496.
RefSeqiNP_013858.1. NM_001182640.1.

Genome annotation databases

EnsemblFungiiYMR138W; YMR138W; YMR138W.
GeneIDi855169.
KEGGisce:YMR138W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36669 Genomic DNA. Translation: AAA50350.1 .
X77086 Genomic DNA. Translation: CAA54358.1 .
Z47071 Genomic DNA. Translation: CAA87352.1 .
AY558409 Genomic DNA. Translation: AAS56735.1 .
BK006946 Genomic DNA. Translation: DAA10035.1 .
PIRi S51496.
RefSeqi NP_013858.1. NM_001182640.1.

3D structure databases

ProteinModelPortali P39110.
SMRi P39110. Positions 2-178.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35315. 68 interactions.
DIPi DIP-1256N.
IntActi P39110. 4 interactions.
MINTi MINT-404656.
STRINGi 4932.YMR138W.

Proteomic databases

MaxQBi P39110.
PaxDbi P39110.
PRIDEi P39110.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR138W ; YMR138W ; YMR138W .
GeneIDi 855169.
KEGGi sce:YMR138W.

Organism-specific databases

CYGDi YMR138w.
SGDi S000004746. CIN4.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00770000121655.
HOGENOMi HOG000163691.
InParanoidi P39110.
KOi K07943.
OMAi EIRCLIL.
OrthoDBi EOG7FNCKB.

Enzyme and pathway databases

BioCyci YEAST:G3O-32831-MONOMER.

Miscellaneous databases

NextBioi 978605.

Gene expression databases

Genevestigatori P39110.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view ]
Pfami PF00025. Arf. 1 hit.
[Graphical view ]
PRINTSi PR00328. SAR1GTPBP.
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51417. ARF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A small GTP-binding protein implicated in yeast microtubule function."
    Stearns T., Clark C.D., Hoyt M.A., Kahn R.A., Botstein D.
    Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Molecular characterisation of GTP1, a Saccharomyces cerevisiae gene encoding a small GTP-binding protein."
    Wolter R., Richter D., Niegemann E., Brendel M.
    Curr. Genet. 26:564-566(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCIN4_YEAST
AccessioniPrimary (citable) accession number: P39110
Secondary accession number(s): D6VZW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 26, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 468 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3