P39110 (CIN4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP-binding protein CIN4

Alternative name(s):
Chromosome instability protein 4

Gene names

Name:	CIN4
Synonyms:	GTP1, UGX1
Ordered Locus Names:	YMR138W
ORF Names:	YM9375.07

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Implicated in yeast microtubule function.
Miscellaneous	Present with 468 molecules/cell in log phase SD medium.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from genetic interaction PubMed 2407611. Source: SGD small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro tubulin complex assembly Inferred from genetic interaction PubMed 9215891. Source: SGD
Cellular_component	cytoplasm Inferred from direct assay PubMed 14562095. Source: SGD
Molecular_function	GTP binding Inferred from sequence or structural similarity Ref.2. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 191	191	GTP-binding protein CIN4		PRO_0000122464
Regions
	Nucleotide binding	23 – 30	8	GTP By similarity
	Nucleotide binding	69 – 73	5	GTP By similarity
	Nucleotide binding	131 – 134	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P39110 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: CF30AF932A2D2566	FASTA	191	22,067
	10 20 30 40 50 60 MGLLSIIRKQ KLRDKEIRCL ILGLDNSGKS TIVNKLLPKD EQNNDGIMPT VGFQIHSLMI 70 80 90 100 110 120 KDVTISLWDI GGQRTLRPFW DNYFDKTQAM IWCIDVSLSM RFDETLQELK ELINRDENRI 130 140 150 160 170 180 GYECAVIVVL NKIDLVEDKS ELHRRCLLVE SELKCLFKPD IRIELVKCSG VTGEGIDNLR 190 DRLVESCHFT Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A small GTP-binding protein implicated in yeast microtubule function." Stearns T., Clark C.D., Hoyt M.A., Kahn R.A., Botstein D. Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Molecular characterisation of GTP1, a Saccharomyces cerevisiae gene encoding a small GTP-binding protein." Wolter R., Richter D., Niegemann E., Brendel M. Curr. Genet. 26:564-566(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[4]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[5]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L36669 Genomic DNA. Translation: AAA50350.1. X77086 Genomic DNA. Translation: CAA54358.1. Z47071 Genomic DNA. Translation: CAA87352.1. AY558409 Genomic DNA. Translation: AAS56735.1. BK006946 Genomic DNA. Translation: DAA10035.1.
PIR	S51496.
RefSeq	NP_013858.1. NM_001182640.1.
3D structure databases
ProteinModelPortal	P39110.
SMR	P39110. Positions 2-178.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1256N.
IntAct	P39110. 4 interactions.
MINT	MINT-404656.
STRING	4932.YMR138W.
Proteomic databases
PaxDb	P39110.
PRIDE	P39110.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YMR138W; YMR138W; YMR138W.
GeneID	855169.
KEGG	sce:YMR138W.
Organism-specific databases
CYGD	YMR138w.
SGD	S000004746. CIN4.
Phylogenomic databases
eggNOG	COG1100.
GeneTree	ENSGT00700000105261.
HOGENOM	HOG000163691.
KO	K07943.
OMA	EIRCLIL.
OrthoDB	EOG4DZ54J.
Gene expression databases
Genevestigator	P39110.
GermOnline	YMR138W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR024156. Small_GTPase_ARF. IPR006689. Small_GTPase_ARF/SAR. [Graphical view]
Pfam	PF00025. Arf. 1 hit. [Graphical view]
PRINTS	PR00328. SAR1GTPBP.
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51417. ARF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	978605.

Entry information

Entry name

CIN4_YEAST

Accession

Primary (citable) accession number: P39110
Secondary accession number(s): D6VZW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program