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P39110

- CIN4_YEAST

UniProt

P39110 - CIN4_YEAST

Protein

GTP-binding protein CIN4

Gene

CIN4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Implicated in yeast microtubule function.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi23 – 308GTPBy similarity
    Nucleotide bindingi69 – 735GTPBy similarity
    Nucleotide bindingi131 – 1344GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: SGD

    GO - Biological processi

    1. protein folding Source: SGD
    2. small GTPase mediated signal transduction Source: InterPro
    3. tubulin complex assembly Source: SGD
    4. tubulin complex biogenesis Source: SGD

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32831-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP-binding protein CIN4
    Alternative name(s):
    Chromosome instability protein 4
    Gene namesi
    Name:CIN4
    Synonyms:GTP1, UGX1
    Ordered Locus Names:YMR138W
    ORF Names:YM9375.07
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR138w.
    SGDiS000004746. CIN4.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 191191GTP-binding protein CIN4PRO_0000122464Add
    BLAST

    Proteomic databases

    MaxQBiP39110.
    PaxDbiP39110.
    PRIDEiP39110.

    Expressioni

    Gene expression databases

    GenevestigatoriP39110.

    Interactioni

    Protein-protein interaction databases

    BioGridi35315. 67 interactions.
    DIPiDIP-1256N.
    IntActiP39110. 4 interactions.
    MINTiMINT-404656.
    STRINGi4932.YMR138W.

    Structurei

    3D structure databases

    ProteinModelPortaliP39110.
    SMRiP39110. Positions 2-178.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00750000118672.
    HOGENOMiHOG000163691.
    KOiK07943.
    OMAiEIRCLIL.
    OrthoDBiEOG7FNCKB.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR024156. Small_GTPase_ARF.
    IPR006689. Small_GTPase_ARF/SAR.
    [Graphical view]
    PfamiPF00025. Arf. 1 hit.
    [Graphical view]
    PRINTSiPR00328. SAR1GTPBP.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51417. ARF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39110-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLLSIIRKQ KLRDKEIRCL ILGLDNSGKS TIVNKLLPKD EQNNDGIMPT    50
    VGFQIHSLMI KDVTISLWDI GGQRTLRPFW DNYFDKTQAM IWCIDVSLSM 100
    RFDETLQELK ELINRDENRI GYECAVIVVL NKIDLVEDKS ELHRRCLLVE 150
    SELKCLFKPD IRIELVKCSG VTGEGIDNLR DRLVESCHFT Q 191
    Length:191
    Mass (Da):22,067
    Last modified:February 1, 1995 - v1
    Checksum:iCF30AF932A2D2566
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36669 Genomic DNA. Translation: AAA50350.1.
    X77086 Genomic DNA. Translation: CAA54358.1.
    Z47071 Genomic DNA. Translation: CAA87352.1.
    AY558409 Genomic DNA. Translation: AAS56735.1.
    BK006946 Genomic DNA. Translation: DAA10035.1.
    PIRiS51496.
    RefSeqiNP_013858.1. NM_001182640.1.

    Genome annotation databases

    EnsemblFungiiYMR138W; YMR138W; YMR138W.
    GeneIDi855169.
    KEGGisce:YMR138W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36669 Genomic DNA. Translation: AAA50350.1 .
    X77086 Genomic DNA. Translation: CAA54358.1 .
    Z47071 Genomic DNA. Translation: CAA87352.1 .
    AY558409 Genomic DNA. Translation: AAS56735.1 .
    BK006946 Genomic DNA. Translation: DAA10035.1 .
    PIRi S51496.
    RefSeqi NP_013858.1. NM_001182640.1.

    3D structure databases

    ProteinModelPortali P39110.
    SMRi P39110. Positions 2-178.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35315. 67 interactions.
    DIPi DIP-1256N.
    IntActi P39110. 4 interactions.
    MINTi MINT-404656.
    STRINGi 4932.YMR138W.

    Proteomic databases

    MaxQBi P39110.
    PaxDbi P39110.
    PRIDEi P39110.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR138W ; YMR138W ; YMR138W .
    GeneIDi 855169.
    KEGGi sce:YMR138W.

    Organism-specific databases

    CYGDi YMR138w.
    SGDi S000004746. CIN4.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00750000118672.
    HOGENOMi HOG000163691.
    KOi K07943.
    OMAi EIRCLIL.
    OrthoDBi EOG7FNCKB.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32831-MONOMER.

    Miscellaneous databases

    NextBioi 978605.

    Gene expression databases

    Genevestigatori P39110.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR024156. Small_GTPase_ARF.
    IPR006689. Small_GTPase_ARF/SAR.
    [Graphical view ]
    Pfami PF00025. Arf. 1 hit.
    [Graphical view ]
    PRINTSi PR00328. SAR1GTPBP.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51417. ARF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A small GTP-binding protein implicated in yeast microtubule function."
      Stearns T., Clark C.D., Hoyt M.A., Kahn R.A., Botstein D.
      Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Molecular characterisation of GTP1, a Saccharomyces cerevisiae gene encoding a small GTP-binding protein."
      Wolter R., Richter D., Niegemann E., Brendel M.
      Curr. Genet. 26:564-566(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCIN4_YEAST
    AccessioniPrimary (citable) accession number: P39110
    Secondary accession number(s): D6VZW1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 468 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3