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Protein

GTP-binding protein CIN4

Gene

CIN4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Implicated in yeast microtubule function.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 308GTPBy similarity
Nucleotide bindingi69 – 735GTPBy similarity
Nucleotide bindingi131 – 1344GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. protein folding Source: SGD
  2. small GTPase mediated signal transduction Source: InterPro
  3. tubulin complex assembly Source: SGD
  4. tubulin complex biogenesis Source: SGD
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32831-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein CIN4
Alternative name(s):
Chromosome instability protein 4
Gene namesi
Name:CIN4
Synonyms:GTP1, UGX1
Ordered Locus Names:YMR138W
ORF Names:YM9375.07
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XIII

Organism-specific databases

CYGDiYMR138w.
EuPathDBiFungiDB:YMR138W.
SGDiS000004746. CIN4.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 191191GTP-binding protein CIN4PRO_0000122464Add
BLAST

Proteomic databases

MaxQBiP39110.
PaxDbiP39110.
PRIDEiP39110.

Expressioni

Gene expression databases

GenevestigatoriP39110.

Interactioni

Protein-protein interaction databases

BioGridi35315. 69 interactions.
DIPiDIP-1256N.
IntActiP39110. 4 interactions.
MINTiMINT-404656.
STRINGi4932.YMR138W.

Structurei

3D structure databases

ProteinModelPortaliP39110.
SMRiP39110. Positions 2-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00770000121655.
HOGENOMiHOG000163691.
InParanoidiP39110.
KOiK07943.
OMAiEIRCLIL.
OrthoDBiEOG7FNCKB.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLSIIRKQ KLRDKEIRCL ILGLDNSGKS TIVNKLLPKD EQNNDGIMPT
60 70 80 90 100
VGFQIHSLMI KDVTISLWDI GGQRTLRPFW DNYFDKTQAM IWCIDVSLSM
110 120 130 140 150
RFDETLQELK ELINRDENRI GYECAVIVVL NKIDLVEDKS ELHRRCLLVE
160 170 180 190
SELKCLFKPD IRIELVKCSG VTGEGIDNLR DRLVESCHFT Q
Length:191
Mass (Da):22,067
Last modified:February 1, 1995 - v1
Checksum:iCF30AF932A2D2566
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36669 Genomic DNA. Translation: AAA50350.1.
X77086 Genomic DNA. Translation: CAA54358.1.
Z47071 Genomic DNA. Translation: CAA87352.1.
AY558409 Genomic DNA. Translation: AAS56735.1.
BK006946 Genomic DNA. Translation: DAA10035.1.
PIRiS51496.
RefSeqiNP_013858.1. NM_001182640.1.

Genome annotation databases

EnsemblFungiiYMR138W; YMR138W; YMR138W.
GeneIDi855169.
KEGGisce:YMR138W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36669 Genomic DNA. Translation: AAA50350.1.
X77086 Genomic DNA. Translation: CAA54358.1.
Z47071 Genomic DNA. Translation: CAA87352.1.
AY558409 Genomic DNA. Translation: AAS56735.1.
BK006946 Genomic DNA. Translation: DAA10035.1.
PIRiS51496.
RefSeqiNP_013858.1. NM_001182640.1.

3D structure databases

ProteinModelPortaliP39110.
SMRiP39110. Positions 2-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35315. 69 interactions.
DIPiDIP-1256N.
IntActiP39110. 4 interactions.
MINTiMINT-404656.
STRINGi4932.YMR138W.

Proteomic databases

MaxQBiP39110.
PaxDbiP39110.
PRIDEiP39110.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR138W; YMR138W; YMR138W.
GeneIDi855169.
KEGGisce:YMR138W.

Organism-specific databases

CYGDiYMR138w.
EuPathDBiFungiDB:YMR138W.
SGDiS000004746. CIN4.

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00770000121655.
HOGENOMiHOG000163691.
InParanoidiP39110.
KOiK07943.
OMAiEIRCLIL.
OrthoDBiEOG7FNCKB.

Enzyme and pathway databases

BioCyciYEAST:G3O-32831-MONOMER.

Miscellaneous databases

NextBioi978605.
PROiP39110.

Gene expression databases

GenevestigatoriP39110.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A small GTP-binding protein implicated in yeast microtubule function."
    Stearns T., Clark C.D., Hoyt M.A., Kahn R.A., Botstein D.
    Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Molecular characterisation of GTP1, a Saccharomyces cerevisiae gene encoding a small GTP-binding protein."
    Wolter R., Richter D., Niegemann E., Brendel M.
    Curr. Genet. 26:564-566(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCIN4_YEAST
AccessioniPrimary (citable) accession number: P39110
Secondary accession number(s): D6VZW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 29, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 468 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.