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P39108

- PEX7_YEAST

UniProt

P39108 - PEX7_YEAST

Protein

Peroxisomal targeting signal 2 receptor

Gene

PEX7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import essential for import of 3-oxoacyl-CoA thiolase (a PTS2-containing protein) into peroxisomes. May direct thiolase to peroxisomes by shuttling between the cytosol and peroxisomal membranes.

    GO - Molecular functioni

    1. peroxisome matrix targeting signal-2 binding Source: SGD
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. protein import into peroxisome matrix, docking Source: SGD

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29739-MONOMER.

    Protein family/group databases

    TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal targeting signal 2 receptor
    Short name:
    PTS2 receptor
    Alternative name(s):
    Peroxin-7
    Peroxisome import protein PAS7
    Gene namesi
    Name:PEX7
    Synonyms:PAS7, PEB1
    Ordered Locus Names:YDR142C
    ORF Names:YD2943.01C, YD9302.18C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    CYGDiYDR142c.
    SGDiS000002549. PEX7.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: SGD
    2. peroxisome Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375Peroxisomal targeting signal 2 receptorPRO_0000051120Add
    BLAST

    Proteomic databases

    MaxQBiP39108.
    PaxDbiP39108.
    PeptideAtlasiP39108.

    Expressioni

    Gene expression databases

    GenevestigatoriP39108.

    Interactioni

    Subunit structurei

    Interacts with PEX5.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PEX18P388555EBI-13183,EBI-24803
    PEX21P500916EBI-13183,EBI-23549
    POT1P277963EBI-13183,EBI-19236

    Protein-protein interaction databases

    BioGridi32196. 29 interactions.
    DIPiDIP-1501N.
    IntActiP39108. 10 interactions.
    MINTiMINT-409587.
    STRINGi4932.YDR142C.

    Structurei

    Secondary structure

    1
    375
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 54
    Beta strandi9 – 168
    Beta strandi23 – 308
    Helixi31 – 333
    Beta strandi38 – 458
    Beta strandi51 – 6111
    Beta strandi63 – 686
    Beta strandi75 – 806
    Beta strandi83 – 897
    Beta strandi97 – 1015
    Beta strandi107 – 1126
    Beta strandi114 – 1185
    Beta strandi120 – 1245
    Beta strandi129 – 1324
    Beta strandi140 – 1434
    Helixi148 – 1536
    Helixi158 – 1603
    Beta strandi177 – 1826
    Beta strandi189 – 1946
    Beta strandi197 – 2037
    Beta strandi210 – 2167
    Beta strandi223 – 2286
    Beta strandi235 – 2406
    Beta strandi245 – 2495
    Beta strandi274 – 2785
    Beta strandi281 – 2844
    Beta strandi286 – 2916
    Beta strandi298 – 3036
    Beta strandi308 – 3125
    Turni326 – 3283
    Turni330 – 3334
    Beta strandi334 – 3385
    Beta strandi345 – 3506
    Beta strandi352 – 3554
    Beta strandi358 – 3636
    Beta strandi366 – 3727

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3W15X-ray1.80A1-375[»]
    ProteinModelPortaliP39108.
    SMRiP39108. Positions 1-374.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati58 – 8932WD 1Add
    BLAST
    Repeati102 – 13332WD 2Add
    BLAST
    Repeati172 – 20332WD 3Add
    BLAST
    Repeati218 – 24932WD 4Add
    BLAST
    Repeati281 – 31232WD 5Add
    BLAST
    Repeati340 – 37233WD 6Add
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat peroxin-7 family.Curated
    Contains 6 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG320380.
    GeneTreeiENSGT00750000117690.
    HOGENOMiHOG000204332.
    KOiK13341.
    OMAiFKEHERE.
    OrthoDBiEOG77HDQG.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 4 hits.
    [Graphical view]
    PRINTSiPR00320. GPROTEINBRPT.
    SMARTiSM00320. WD40. 6 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 2 hits.
    PROSITEiPS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39108-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRYHMQGFS GYGVQYSPFF DNRLAVAAGS NFGLVGNGKL FILEIDRSGR    50
    IVEVNSFLTQ DCLFDLAWNE SHENQVLVAQ GDGTLRLFDT TFKEFPIAIF 100
    KEHEREVFSC NWNLVNRQNF LSSSWDGSIK IWSPLRKQSL MTLTPRPLEI 150
    TKMVDPLNAI ILKKKSFTGI SKNRNCVYQA QFSPHDQNLV LSCSGNSYAS 200
    LFDIRLPSGK NQNNFLVHSG LEALTCDFNK YRPYVVATGG VDNAIRIWDI 250
    RMLNKNESAT IKRTVPGQLH NSSCINEIPN AHGLAIRKVT WSPHHSNILM 300
    SASYDMTCRI WRDLSNDGAK ETYKTNSTDA TKGSIFNFTQ HSEFVFGADW 350
    SLWGKPGYVA STAWDGNLFV WNGLG 375
    Length:375
    Mass (Da):42,323
    Last modified:February 1, 1995 - v1
    Checksum:i7D53A42A8ACF23F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X81424 Genomic DNA. Translation: CAA57183.1.
    X83704 Genomic DNA. Translation: CAA58677.1.
    Z54139 Genomic DNA. Translation: CAA90811.1.
    Z48179 Genomic DNA. Translation: CAA88224.1.
    AY557700 Genomic DNA. Translation: AAS56026.1.
    BK006938 Genomic DNA. Translation: DAA11985.1.
    PIRiS50228.
    RefSeqiNP_010426.1. NM_001180449.1.

    Genome annotation databases

    EnsemblFungiiYDR142C; YDR142C; YDR142C.
    GeneIDi851720.
    KEGGisce:YDR142C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X81424 Genomic DNA. Translation: CAA57183.1 .
    X83704 Genomic DNA. Translation: CAA58677.1 .
    Z54139 Genomic DNA. Translation: CAA90811.1 .
    Z48179 Genomic DNA. Translation: CAA88224.1 .
    AY557700 Genomic DNA. Translation: AAS56026.1 .
    BK006938 Genomic DNA. Translation: DAA11985.1 .
    PIRi S50228.
    RefSeqi NP_010426.1. NM_001180449.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3W15 X-ray 1.80 A 1-375 [» ]
    ProteinModelPortali P39108.
    SMRi P39108. Positions 1-374.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32196. 29 interactions.
    DIPi DIP-1501N.
    IntActi P39108. 10 interactions.
    MINTi MINT-409587.
    STRINGi 4932.YDR142C.

    Protein family/group databases

    TCDBi 3.A.20.1.5. the peroxisomal protein importer (ppi) family.

    Proteomic databases

    MaxQBi P39108.
    PaxDbi P39108.
    PeptideAtlasi P39108.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDR142C ; YDR142C ; YDR142C .
    GeneIDi 851720.
    KEGGi sce:YDR142C.

    Organism-specific databases

    CYGDi YDR142c.
    SGDi S000002549. PEX7.

    Phylogenomic databases

    eggNOGi NOG320380.
    GeneTreei ENSGT00750000117690.
    HOGENOMi HOG000204332.
    KOi K13341.
    OMAi FKEHERE.
    OrthoDBi EOG77HDQG.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29739-MONOMER.

    Miscellaneous databases

    NextBioi 969424.
    PROi P39108.

    Gene expression databases

    Genevestigatori P39108.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 4 hits.
    [Graphical view ]
    PRINTSi PR00320. GPROTEINBRPT.
    SMARTi SM00320. WD40. 6 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 2 hits.
    PROSITEi PS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PAS7 encodes a novel yeast member of the WD-40 protein family essential for import of 3-oxoacyl-CoA thiolase, a PTS2-containing protein, into peroxisomes."
      Marzioch M., Erdmann R., Veenhuis M., Kunau W.-H.
      EMBO J. 13:4908-4918(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "PEB1 (PAS7) in Saccharomyces cerevisiae encodes a hydrophilic, intra-peroxisomal protein that is a member of the WD repeat family and is essential for the import of thiolase into peroxisomes."
      Zhang J.W., Lazarow P.B.
      J. Cell Biol. 129:65-80(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: S288c / GRF88.
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPEX7_YEAST
    AccessioniPrimary (citable) accession number: P39108
    Secondary accession number(s): D6VSC5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 589 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3