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Protein

Peroxisomal targeting signal 2 receptor

Gene

PEX7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import essential for import of 3-oxoacyl-CoA thiolase (a PTS2-containing protein) into peroxisomes. May direct thiolase to peroxisomes by shuttling between the cytosol and peroxisomal membranes.

GO - Molecular functioni

  1. peroxisome matrix targeting signal-2 binding Source: SGD

GO - Biological processi

  1. protein import into peroxisome matrix, docking Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29739-MONOMER.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal targeting signal 2 receptor
Short name:
PTS2 receptor
Alternative name(s):
Peroxin-7
Peroxisome import protein PAS7
Gene namesi
Name:PEX7
Synonyms:PAS7, PEB1
Ordered Locus Names:YDR142C
ORF Names:YD2943.01C, YD9302.18C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDR142c.
SGDiS000002549. PEX7.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: SGD
  2. peroxisome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Peroxisomal targeting signal 2 receptorPRO_0000051120Add
BLAST

Proteomic databases

MaxQBiP39108.
PaxDbiP39108.
PeptideAtlasiP39108.

Expressioni

Gene expression databases

GenevestigatoriP39108.

Interactioni

Subunit structurei

Interacts with PEX5.

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX18P388555EBI-13183,EBI-24803
PEX21P500916EBI-13183,EBI-23549
POT1P277963EBI-13183,EBI-19236

Protein-protein interaction databases

BioGridi32196. 30 interactions.
DIPiDIP-1501N.
IntActiP39108. 10 interactions.
MINTiMINT-409587.
STRINGi4932.YDR142C.

Structurei

Secondary structure

1
375
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 54Combined sources
Beta strandi9 – 168Combined sources
Beta strandi23 – 308Combined sources
Helixi31 – 333Combined sources
Beta strandi38 – 458Combined sources
Beta strandi51 – 6111Combined sources
Beta strandi63 – 686Combined sources
Beta strandi75 – 806Combined sources
Beta strandi83 – 897Combined sources
Beta strandi97 – 1015Combined sources
Beta strandi107 – 1126Combined sources
Beta strandi114 – 1185Combined sources
Beta strandi120 – 1245Combined sources
Beta strandi129 – 1324Combined sources
Beta strandi140 – 1434Combined sources
Helixi148 – 1536Combined sources
Helixi158 – 1603Combined sources
Beta strandi177 – 1826Combined sources
Beta strandi189 – 1946Combined sources
Beta strandi197 – 2037Combined sources
Beta strandi210 – 2167Combined sources
Beta strandi223 – 2286Combined sources
Beta strandi235 – 2406Combined sources
Beta strandi245 – 2495Combined sources
Beta strandi274 – 2785Combined sources
Beta strandi281 – 2844Combined sources
Beta strandi286 – 2916Combined sources
Beta strandi298 – 3036Combined sources
Beta strandi308 – 3125Combined sources
Turni326 – 3283Combined sources
Turni330 – 3334Combined sources
Beta strandi334 – 3385Combined sources
Beta strandi345 – 3506Combined sources
Beta strandi352 – 3554Combined sources
Beta strandi358 – 3636Combined sources
Beta strandi366 – 3727Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3W15X-ray1.80A1-375[»]
ProteinModelPortaliP39108.
SMRiP39108. Positions 1-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati58 – 8932WD 1Add
BLAST
Repeati102 – 13332WD 2Add
BLAST
Repeati172 – 20332WD 3Add
BLAST
Repeati218 – 24932WD 4Add
BLAST
Repeati281 – 31232WD 5Add
BLAST
Repeati340 – 37233WD 6Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat peroxin-7 family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG320380.
GeneTreeiENSGT00750000117690.
HOGENOMiHOG000204332.
InParanoidiP39108.
KOiK13341.
OMAiPHHSNIL.
OrthoDBiEOG77HDQG.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39108-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRYHMQGFS GYGVQYSPFF DNRLAVAAGS NFGLVGNGKL FILEIDRSGR
60 70 80 90 100
IVEVNSFLTQ DCLFDLAWNE SHENQVLVAQ GDGTLRLFDT TFKEFPIAIF
110 120 130 140 150
KEHEREVFSC NWNLVNRQNF LSSSWDGSIK IWSPLRKQSL MTLTPRPLEI
160 170 180 190 200
TKMVDPLNAI ILKKKSFTGI SKNRNCVYQA QFSPHDQNLV LSCSGNSYAS
210 220 230 240 250
LFDIRLPSGK NQNNFLVHSG LEALTCDFNK YRPYVVATGG VDNAIRIWDI
260 270 280 290 300
RMLNKNESAT IKRTVPGQLH NSSCINEIPN AHGLAIRKVT WSPHHSNILM
310 320 330 340 350
SASYDMTCRI WRDLSNDGAK ETYKTNSTDA TKGSIFNFTQ HSEFVFGADW
360 370
SLWGKPGYVA STAWDGNLFV WNGLG
Length:375
Mass (Da):42,323
Last modified:February 1, 1995 - v1
Checksum:i7D53A42A8ACF23F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81424 Genomic DNA. Translation: CAA57183.1.
X83704 Genomic DNA. Translation: CAA58677.1.
Z54139 Genomic DNA. Translation: CAA90811.1.
Z48179 Genomic DNA. Translation: CAA88224.1.
AY557700 Genomic DNA. Translation: AAS56026.1.
BK006938 Genomic DNA. Translation: DAA11985.1.
PIRiS50228.
RefSeqiNP_010426.1. NM_001180449.1.

Genome annotation databases

EnsemblFungiiYDR142C; YDR142C; YDR142C.
GeneIDi851720.
KEGGisce:YDR142C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81424 Genomic DNA. Translation: CAA57183.1.
X83704 Genomic DNA. Translation: CAA58677.1.
Z54139 Genomic DNA. Translation: CAA90811.1.
Z48179 Genomic DNA. Translation: CAA88224.1.
AY557700 Genomic DNA. Translation: AAS56026.1.
BK006938 Genomic DNA. Translation: DAA11985.1.
PIRiS50228.
RefSeqiNP_010426.1. NM_001180449.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3W15X-ray1.80A1-375[»]
ProteinModelPortaliP39108.
SMRiP39108. Positions 1-374.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32196. 30 interactions.
DIPiDIP-1501N.
IntActiP39108. 10 interactions.
MINTiMINT-409587.
STRINGi4932.YDR142C.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

MaxQBiP39108.
PaxDbiP39108.
PeptideAtlasiP39108.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR142C; YDR142C; YDR142C.
GeneIDi851720.
KEGGisce:YDR142C.

Organism-specific databases

CYGDiYDR142c.
SGDiS000002549. PEX7.

Phylogenomic databases

eggNOGiNOG320380.
GeneTreeiENSGT00750000117690.
HOGENOMiHOG000204332.
InParanoidiP39108.
KOiK13341.
OMAiPHHSNIL.
OrthoDBiEOG77HDQG.

Enzyme and pathway databases

BioCyciYEAST:G3O-29739-MONOMER.

Miscellaneous databases

NextBioi969424.
PROiP39108.

Gene expression databases

GenevestigatoriP39108.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PAS7 encodes a novel yeast member of the WD-40 protein family essential for import of 3-oxoacyl-CoA thiolase, a PTS2-containing protein, into peroxisomes."
    Marzioch M., Erdmann R., Veenhuis M., Kunau W.-H.
    EMBO J. 13:4908-4918(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "PEB1 (PAS7) in Saccharomyces cerevisiae encodes a hydrophilic, intra-peroxisomal protein that is a member of the WD repeat family and is essential for the import of thiolase into peroxisomes."
    Zhang J.W., Lazarow P.B.
    J. Cell Biol. 129:65-80(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S288c / GRF88.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPEX7_YEAST
AccessioniPrimary (citable) accession number: P39108
Secondary accession number(s): D6VSC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 7, 2015
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 589 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.