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P39108

- PEX7_YEAST

UniProt

P39108 - PEX7_YEAST

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Protein

Peroxisomal targeting signal 2 receptor

Gene
PEX7, PAS7, PEB1, YDR142C, YD2943.01C, YD9302.18C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import essential for import of 3-oxoacyl-CoA thiolase (a PTS2-containing protein) into peroxisomes. May direct thiolase to peroxisomes by shuttling between the cytosol and peroxisomal membranes.

GO - Molecular functioni

  1. peroxisome matrix targeting signal-2 binding Source: SGD
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. protein import into peroxisome matrix, docking Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29739-MONOMER.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal targeting signal 2 receptor
Short name:
PTS2 receptor
Alternative name(s):
Peroxin-7
Peroxisome import protein PAS7
Gene namesi
Name:PEX7
Synonyms:PAS7, PEB1
Ordered Locus Names:YDR142C
ORF Names:YD2943.01C, YD9302.18C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDR142c.
SGDiS000002549. PEX7.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: SGD
  2. peroxisome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Peroxisomal targeting signal 2 receptorPRO_0000051120Add
BLAST

Proteomic databases

MaxQBiP39108.
PaxDbiP39108.
PeptideAtlasiP39108.

Expressioni

Gene expression databases

GenevestigatoriP39108.

Interactioni

Subunit structurei

Interacts with PEX5.

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX18P388555EBI-13183,EBI-24803
PEX21P500916EBI-13183,EBI-23549
POT1P277963EBI-13183,EBI-19236

Protein-protein interaction databases

BioGridi32196. 29 interactions.
DIPiDIP-1501N.
IntActiP39108. 10 interactions.
MINTiMINT-409587.
STRINGi4932.YDR142C.

Structurei

Secondary structure

1
375
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 54
Beta strandi9 – 168
Beta strandi23 – 308
Helixi31 – 333
Beta strandi38 – 458
Beta strandi51 – 6111
Beta strandi63 – 686
Beta strandi75 – 806
Beta strandi83 – 897
Beta strandi97 – 1015
Beta strandi107 – 1126
Beta strandi114 – 1185
Beta strandi120 – 1245
Beta strandi129 – 1324
Beta strandi140 – 1434
Helixi148 – 1536
Helixi158 – 1603
Beta strandi177 – 1826
Beta strandi189 – 1946
Beta strandi197 – 2037
Beta strandi210 – 2167
Beta strandi223 – 2286
Beta strandi235 – 2406
Beta strandi245 – 2495
Beta strandi274 – 2785
Beta strandi281 – 2844
Beta strandi286 – 2916
Beta strandi298 – 3036
Beta strandi308 – 3125
Turni326 – 3283
Turni330 – 3334
Beta strandi334 – 3385
Beta strandi345 – 3506
Beta strandi352 – 3554
Beta strandi358 – 3636
Beta strandi366 – 3727

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3W15X-ray1.80A1-375[»]
ProteinModelPortaliP39108.
SMRiP39108. Positions 1-374.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati58 – 8932WD 1Add
BLAST
Repeati102 – 13332WD 2Add
BLAST
Repeati172 – 20332WD 3Add
BLAST
Repeati218 – 24932WD 4Add
BLAST
Repeati281 – 31232WD 5Add
BLAST
Repeati340 – 37233WD 6Add
BLAST

Sequence similaritiesi

Contains 6 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG320380.
GeneTreeiENSGT00750000117690.
HOGENOMiHOG000204332.
KOiK13341.
OMAiFKEHERE.
OrthoDBiEOG77HDQG.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39108-1 [UniParc]FASTAAdd to Basket

« Hide

MLRYHMQGFS GYGVQYSPFF DNRLAVAAGS NFGLVGNGKL FILEIDRSGR    50
IVEVNSFLTQ DCLFDLAWNE SHENQVLVAQ GDGTLRLFDT TFKEFPIAIF 100
KEHEREVFSC NWNLVNRQNF LSSSWDGSIK IWSPLRKQSL MTLTPRPLEI 150
TKMVDPLNAI ILKKKSFTGI SKNRNCVYQA QFSPHDQNLV LSCSGNSYAS 200
LFDIRLPSGK NQNNFLVHSG LEALTCDFNK YRPYVVATGG VDNAIRIWDI 250
RMLNKNESAT IKRTVPGQLH NSSCINEIPN AHGLAIRKVT WSPHHSNILM 300
SASYDMTCRI WRDLSNDGAK ETYKTNSTDA TKGSIFNFTQ HSEFVFGADW 350
SLWGKPGYVA STAWDGNLFV WNGLG 375
Length:375
Mass (Da):42,323
Last modified:February 1, 1995 - v1
Checksum:i7D53A42A8ACF23F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X81424 Genomic DNA. Translation: CAA57183.1.
X83704 Genomic DNA. Translation: CAA58677.1.
Z54139 Genomic DNA. Translation: CAA90811.1.
Z48179 Genomic DNA. Translation: CAA88224.1.
AY557700 Genomic DNA. Translation: AAS56026.1.
BK006938 Genomic DNA. Translation: DAA11985.1.
PIRiS50228.
RefSeqiNP_010426.1. NM_001180449.1.

Genome annotation databases

EnsemblFungiiYDR142C; YDR142C; YDR142C.
GeneIDi851720.
KEGGisce:YDR142C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X81424 Genomic DNA. Translation: CAA57183.1 .
X83704 Genomic DNA. Translation: CAA58677.1 .
Z54139 Genomic DNA. Translation: CAA90811.1 .
Z48179 Genomic DNA. Translation: CAA88224.1 .
AY557700 Genomic DNA. Translation: AAS56026.1 .
BK006938 Genomic DNA. Translation: DAA11985.1 .
PIRi S50228.
RefSeqi NP_010426.1. NM_001180449.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3W15 X-ray 1.80 A 1-375 [» ]
ProteinModelPortali P39108.
SMRi P39108. Positions 1-374.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32196. 29 interactions.
DIPi DIP-1501N.
IntActi P39108. 10 interactions.
MINTi MINT-409587.
STRINGi 4932.YDR142C.

Protein family/group databases

TCDBi 3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

MaxQBi P39108.
PaxDbi P39108.
PeptideAtlasi P39108.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDR142C ; YDR142C ; YDR142C .
GeneIDi 851720.
KEGGi sce:YDR142C.

Organism-specific databases

CYGDi YDR142c.
SGDi S000002549. PEX7.

Phylogenomic databases

eggNOGi NOG320380.
GeneTreei ENSGT00750000117690.
HOGENOMi HOG000204332.
KOi K13341.
OMAi FKEHERE.
OrthoDBi EOG77HDQG.

Enzyme and pathway databases

BioCyci YEAST:G3O-29739-MONOMER.

Miscellaneous databases

NextBioi 969424.
PROi P39108.

Gene expression databases

Genevestigatori P39108.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 4 hits.
[Graphical view ]
PRINTSi PR00320. GPROTEINBRPT.
SMARTi SM00320. WD40. 6 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 2 hits.
PROSITEi PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "PAS7 encodes a novel yeast member of the WD-40 protein family essential for import of 3-oxoacyl-CoA thiolase, a PTS2-containing protein, into peroxisomes."
    Marzioch M., Erdmann R., Veenhuis M., Kunau W.-H.
    EMBO J. 13:4908-4918(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "PEB1 (PAS7) in Saccharomyces cerevisiae encodes a hydrophilic, intra-peroxisomal protein that is a member of the WD repeat family and is essential for the import of thiolase into peroxisomes."
    Zhang J.W., Lazarow P.B.
    J. Cell Biol. 129:65-80(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S288c / GRF88.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPEX7_YEAST
AccessioniPrimary (citable) accession number: P39108
Secondary accession number(s): D6VSC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 589 molecules/cell in log phase SD medium.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3

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