Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peroxisomal targeting signal 2 receptor

Gene

PEX7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import essential for import of 3-oxoacyl-CoA thiolase (a PTS2-containing protein) into peroxisomes. May direct thiolase to peroxisomes by shuttling between the cytosol and peroxisomal membranes.

GO - Molecular functioni

  • peroxisome matrix targeting signal-2 binding Source: SGD

GO - Biological processi

  • protein import into peroxisome matrix, docking Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29739-MONOMER.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal targeting signal 2 receptor
Short name:
PTS2 receptor
Alternative name(s):
Peroxin-7
Peroxisome import protein PAS7
Gene namesi
Name:PEX7
Synonyms:PAS7, PEB1
Ordered Locus Names:YDR142C
ORF Names:YD2943.01C, YD9302.18C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR142C.
SGDiS000002549. PEX7.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
  • peroxisome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511201 – 375Peroxisomal targeting signal 2 receptorAdd BLAST375

Proteomic databases

MaxQBiP39108.
PRIDEiP39108.

Interactioni

Subunit structurei

Interacts with PEX5.

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX18P388555EBI-13183,EBI-24803
PEX21P500916EBI-13183,EBI-23549
POT1P277963EBI-13183,EBI-19236

Protein-protein interaction databases

BioGridi32196. 30 interactors.
DIPiDIP-1501N.
IntActiP39108. 11 interactors.
MINTiMINT-409587.

Structurei

Secondary structure

1375
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 5Combined sources4
Beta strandi9 – 16Combined sources8
Beta strandi23 – 30Combined sources8
Helixi31 – 33Combined sources3
Beta strandi38 – 45Combined sources8
Beta strandi51 – 61Combined sources11
Beta strandi63 – 68Combined sources6
Beta strandi75 – 80Combined sources6
Beta strandi83 – 89Combined sources7
Beta strandi97 – 101Combined sources5
Beta strandi107 – 112Combined sources6
Beta strandi114 – 118Combined sources5
Beta strandi120 – 124Combined sources5
Beta strandi129 – 132Combined sources4
Beta strandi140 – 143Combined sources4
Helixi148 – 153Combined sources6
Helixi158 – 160Combined sources3
Beta strandi177 – 182Combined sources6
Beta strandi189 – 194Combined sources6
Beta strandi197 – 203Combined sources7
Beta strandi210 – 216Combined sources7
Beta strandi223 – 228Combined sources6
Beta strandi235 – 240Combined sources6
Beta strandi245 – 249Combined sources5
Beta strandi274 – 278Combined sources5
Beta strandi281 – 284Combined sources4
Beta strandi286 – 291Combined sources6
Beta strandi298 – 303Combined sources6
Beta strandi308 – 312Combined sources5
Turni326 – 328Combined sources3
Turni330 – 333Combined sources4
Beta strandi334 – 338Combined sources5
Beta strandi345 – 350Combined sources6
Beta strandi352 – 355Combined sources4
Beta strandi358 – 363Combined sources6
Beta strandi366 – 372Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3W15X-ray1.80A1-375[»]
ProteinModelPortaliP39108.
SMRiP39108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati58 – 89WD 1Add BLAST32
Repeati102 – 133WD 2Add BLAST32
Repeati172 – 203WD 3Add BLAST32
Repeati218 – 249WD 4Add BLAST32
Repeati281 – 312WD 5Add BLAST32
Repeati340 – 372WD 6Add BLAST33

Sequence similaritiesi

Belongs to the WD repeat peroxin-7 family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00860000133878.
HOGENOMiHOG000204332.
InParanoidiP39108.
KOiK13341.
OMAiHARENPV.
OrthoDBiEOG092C2XL8.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39108-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRYHMQGFS GYGVQYSPFF DNRLAVAAGS NFGLVGNGKL FILEIDRSGR
60 70 80 90 100
IVEVNSFLTQ DCLFDLAWNE SHENQVLVAQ GDGTLRLFDT TFKEFPIAIF
110 120 130 140 150
KEHEREVFSC NWNLVNRQNF LSSSWDGSIK IWSPLRKQSL MTLTPRPLEI
160 170 180 190 200
TKMVDPLNAI ILKKKSFTGI SKNRNCVYQA QFSPHDQNLV LSCSGNSYAS
210 220 230 240 250
LFDIRLPSGK NQNNFLVHSG LEALTCDFNK YRPYVVATGG VDNAIRIWDI
260 270 280 290 300
RMLNKNESAT IKRTVPGQLH NSSCINEIPN AHGLAIRKVT WSPHHSNILM
310 320 330 340 350
SASYDMTCRI WRDLSNDGAK ETYKTNSTDA TKGSIFNFTQ HSEFVFGADW
360 370
SLWGKPGYVA STAWDGNLFV WNGLG
Length:375
Mass (Da):42,323
Last modified:February 1, 1995 - v1
Checksum:i7D53A42A8ACF23F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81424 Genomic DNA. Translation: CAA57183.1.
X83704 Genomic DNA. Translation: CAA58677.1.
Z54139 Genomic DNA. Translation: CAA90811.1.
Z48179 Genomic DNA. Translation: CAA88224.1.
AY557700 Genomic DNA. Translation: AAS56026.1.
BK006938 Genomic DNA. Translation: DAA11985.1.
PIRiS50228.
RefSeqiNP_010426.1. NM_001180449.1.

Genome annotation databases

EnsemblFungiiYDR142C; YDR142C; YDR142C.
GeneIDi851720.
KEGGisce:YDR142C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81424 Genomic DNA. Translation: CAA57183.1.
X83704 Genomic DNA. Translation: CAA58677.1.
Z54139 Genomic DNA. Translation: CAA90811.1.
Z48179 Genomic DNA. Translation: CAA88224.1.
AY557700 Genomic DNA. Translation: AAS56026.1.
BK006938 Genomic DNA. Translation: DAA11985.1.
PIRiS50228.
RefSeqiNP_010426.1. NM_001180449.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3W15X-ray1.80A1-375[»]
ProteinModelPortaliP39108.
SMRiP39108.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32196. 30 interactors.
DIPiDIP-1501N.
IntActiP39108. 11 interactors.
MINTiMINT-409587.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

MaxQBiP39108.
PRIDEiP39108.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR142C; YDR142C; YDR142C.
GeneIDi851720.
KEGGisce:YDR142C.

Organism-specific databases

EuPathDBiFungiDB:YDR142C.
SGDiS000002549. PEX7.

Phylogenomic databases

GeneTreeiENSGT00860000133878.
HOGENOMiHOG000204332.
InParanoidiP39108.
KOiK13341.
OMAiHARENPV.
OrthoDBiEOG092C2XL8.

Enzyme and pathway databases

BioCyciYEAST:G3O-29739-MONOMER.

Miscellaneous databases

PROiP39108.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEX7_YEAST
AccessioniPrimary (citable) accession number: P39108
Secondary accession number(s): D6VSC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 589 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.