P39103 (COX14_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase assembly protein COX14

Gene names

Name:	COX14
Ordered Locus Names:	YML129C
ORF Names:	YM4987.06C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	70 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for the synthesis of yeast cytochrome oxidase.
Subcellular location	Mitochondrion membrane; Single-pass membrane protein.
Miscellaneous	Present with 6840 molecules/cell in log phase SD medium. Ref.4

Ontologies

Keywords
Cellular component	Membrane Mitochondrion
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	negative regulation of mitochondrial translation Inferred from physical interaction. Source: SGD
Cellular component	extrinsic to membrane Inferred from direct assay. Source: SGD integral to membrane Inferred from direct assay Ref.1. Source: SGD mitochondrial inner membrane Inferred from direct assay. Source: SGD mitochondrial matrix Inferred from direct assay. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 70	70	Cytochrome c oxidase assembly protein COX14		PRO_0000183930
Regions
	Transmembrane	17 – 38	22	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P39103 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: B26DEAE366707617	FASTA	70	7,959
	10 20 30 40 50 60 MSKYAWYTRV TDTLHRLTVL TLVGGTLYMS GGLAYTLYMN GKKYEQQVTQ QKALEEDNQQ 70 LQSPTAPPTE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of COX14, whose product is required for assembly of yeast cytochrome oxidase." Glerum D.M., Koerner T.J., Tzagoloff A. J. Biol. Chem. 270:15585-15590(1995) [PubMed: 7797555] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 24657 / D273-10B.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed: 9169872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U15040 Genomic DNA. Translation: AAA50449.1. Z50178 Genomic DNA. Translation: CAA90554.1. BK006946 Genomic DNA. Translation: DAA09770.1.
PIR	A57515.
RefSeq	NP_013577.1. NM_001182492.1.
3D structure databases
ProteinModelPortal	P39103.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4151N.
IntAct	P39103. 1 interaction.
MINT	MINT-529474.
STRING	P39103.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YML129C; YML129C; YML129C.
GeneID	854910.
KEGG	sce:YML129C.
NMPDR	fig|4932.3.peg.4613.
Organism-specific databases
CYGD	YML129c.
SGD	S000004598. COX14.
Phylogenomic databases
eggNOG	fuNOG12941.
HOGENOM	HBG203536.
OMA	MSKYAWY.
OrthoDB	EOG4MD197.
Gene expression databases
ArrayExpress	P39103.
Genevestigator	P39103.
GermOnline	YML129C. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	977905.

Entry information

Entry name

COX14_YEAST

Accession

Primary (citable) accession number: P39103
Secondary accession number(s): D6W0F6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	December 14, 2011
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program