Reviewed, UniProtKB/Swiss-Prot P39103 (COX14_YEAST)

Names and origin

Protein names

Recommended name:
    Cytochrome c oxidase assembly protein COX14

Gene names

Name:	COX14
Ordered Locus Names:	YML129C
ORF Names:	YM4987.06C

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	70 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Required for the synthesis of yeast cytochrome oxidase.
Subcellular location	Mitochondrion membrane; Multi-pass membrane protein.
Miscellaneous	Present with 6840 molecules/cell in log phase SD medium. Ref.3

Ontologies

Keywords
Cellular component	Membrane Mitochondrion
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aerobic respiration Ref.1 Inferred from mutant phenotype. Source: SGD negative regulation of translation Inferred from genetic interaction. Source: SGD
Cellular component	extrinsic to membrane Inferred from direct assay. Source: SGD integral to membrane Ref.1 Inferred from direct assay. Source: SGD mitochondrial inner membrane Inferred from direct assay. Source: SGD mitochondrial matrix Inferred from direct assay. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 70	70	Cytochrome c oxidase assembly protein COX14		PRO_0000183930
Regions
	Transmembrane	17 – 38	22	Potential

Sequences

	Sequence		Length	Mass (Da)
	P39103-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: B26DEAE366707617	FASTA	70	7,959
	10 20 30 40 50 60 MSKYAWYTRV TDTLHRLTVL TLVGGTLYMS GGLAYTLYMN GKKYEQQVTQ QKALEEDNQQ 70 LQSPTAPPTE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of COX14, whose product is required for assembly of yeast cytochrome oxidase." Glerum D.M., Koerner T.J., Tzagoloff A. J. Biol. Chem. 270:15585-15590(1995) [PubMed: 7797555] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 24657 / D273-10B.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed: 9169872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U15040 Genomic DNA. Translation: AAA50449.1. Z50178 Genomic DNA. Translation: CAA90554.1.
PIR	A57515.
RefSeq	NP_013577.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4151N.
IntAct	P39103. 2 interactions.
STRING	P39103.
Genome annotation databases
Ensembl	YML129C; YML129C; YML129C; Saccharomyces cerevisiae. [Genome view]
GeneID	854910.
KEGG	sce:YML129C.
NMPDR	fig|4932.3.peg.4613.
Organism-specific databases
CYGD	YML129c.
SGD	S000004598. COX14.
Phylogenomic databases
HOGENOM	HBG203536.
OMA	MSKYAWY.
OrthoDB	EOG9XKWQZ.
Gene expression databases
ArrayExpress	P39103.
Genevestigator	P39103.
GermOnline	YML129C. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	977905.

Entry information

Entry name

COX14_YEAST

Accession

Primary (citable) accession number: P39103

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	December 15, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)