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P39086

- GRIK1_HUMAN

UniProt

P39086 - GRIK1_HUMAN

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Protein

Glutamate receptor ionotropic, kainate 1

Gene

GRIK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei538 – 5381GlutamateBy similarity
Binding sitei753 – 7531GlutamateBy similarity

GO - Molecular functioni

  1. extracellular-glutamate-gated ion channel activity Source: RefGenome
  2. kainate selective glutamate receptor activity Source: UniProtKB

GO - Biological processi

  1. adult behavior Source: Ensembl
  2. behavioral response to pain Source: Ensembl
  3. central nervous system development Source: ProtInc
  4. glutamate receptor signaling pathway Source: ProtInc
  5. ionotropic glutamate receptor signaling pathway Source: GOC
  6. ion transmembrane transport Source: GOC
  7. negative regulation of synaptic transmission, glutamatergic Source: Ensembl
  8. nervous system development Source: ProtInc
  9. positive regulation of gamma-aminobutyric acid secretion Source: Ensembl
  10. positive regulation of synaptic transmission, GABAergic Source: Ensembl
  11. regulation of excitatory postsynaptic membrane potential Source: Ensembl
  12. regulation of inhibitory postsynaptic membrane potential Source: Ensembl
  13. regulation of synaptic transmission, glutamatergic Source: UniProtKB
  14. synaptic transmission Source: Reactome
  15. synaptic transmission, glutamatergic Source: RefGenome
  16. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_21343. Activation of Na-permeable Kainate Receptors.
REACT_21346. Activation of Ca-permeable Kainate Receptor.
SignaLinkiP39086.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, kainate 1
Short name:
GluK1
Alternative name(s):
Excitatory amino acid receptor 3
Short name:
EAA3
Glutamate receptor 5
Short name:
GluR-5
Short name:
GluR5
Gene namesi
Name:GRIK1
Synonyms:GLUR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:4579. GRIK1.

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. dendrite Source: RefGenome
  3. integral component of plasma membrane Source: ProtInc
  4. kainate selective glutamate receptor complex Source: RefGenome
  5. neuronal postsynaptic density Source: Ensembl
  6. plasma membrane Source: Reactome
  7. postsynaptic membrane Source: RefGenome
  8. presynaptic membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28973.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 918888Glutamate receptor ionotropic, kainate 1PRO_0000011541Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi561 – 5611N-linked (GlcNAc...)Sequence Analysis
Modified residuei725 – 7251Phosphoserine; by PKCSequence Analysis
Modified residuei761 – 7611Phosphothreonine; by PKCSequence Analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP39086.
PRIDEiP39086.

PTM databases

PhosphoSiteiP39086.

Expressioni

Tissue specificityi

Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus.

Gene expression databases

BgeeiP39086.
CleanExiHS_GRIK1.
ExpressionAtlasiP39086. baseline and differential.
GenevestigatoriP39086.

Interactioni

Subunit structurei

Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers Probable. The unedited version (Q) assembles into a functional kainate-gated homomeric channel, whereas the edited version (R) is unable to produce channel activity when expressed alone. Both edited and unedited versions can form functional channels with GRIK4 and GRIK5. Interacts with KLHL17 By similarity.By similarityCurated

Protein-protein interaction databases

BioGridi109154. 6 interactions.
STRINGi9606.ENSP00000382791.

Structurei

Secondary structure

1
918
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi449 – 4535
Turni457 – 4593
Beta strandi460 – 4623
Helixi471 – 4744
Beta strandi475 – 4773
Helixi478 – 49013
Beta strandi494 – 4985
Helixi515 – 5217
Beta strandi526 – 5283
Helixi536 – 5394
Beta strandi542 – 5443
Beta strandi548 – 5514
Beta strandi553 – 5597
Helixi686 – 6916
Beta strandi693 – 6986
Helixi704 – 7118
Helixi715 – 72612
Helixi728 – 7314
Beta strandi732 – 7354
Helixi736 – 74510
Beta strandi746 – 7538
Helixi754 – 7618
Beta strandi767 – 7715
Beta strandi777 – 7793
Beta strandi782 – 7843
Helixi790 – 80213
Helixi805 – 81410

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZNSX-ray2.00A445-559[»]
A682-820[»]
2ZNTX-ray1.60A445-559[»]
A682-820[»]
2ZNUX-ray1.80A445-559[»]
A682-820[»]
3FUZX-ray1.65A/B445-559[»]
A/B682-820[»]
3FV1X-ray1.50A/B445-559[»]
A/B682-820[»]
3FV2X-ray1.50A/B445-559[»]
A/B682-820[»]
3FVGX-ray1.50A/B445-559[»]
A/B682-820[»]
3FVKX-ray1.50A/B445-559[»]
A/B682-820[»]
3FVNX-ray1.50A/B445-559[»]
A/B682-820[»]
3FVOX-ray1.50A/B445-559[»]
A/B682-820[»]
4MF3X-ray3.00A/B443-822[»]
ProteinModelPortaliP39086.
SMRiP39086. Positions 35-860.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP39086.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 576546ExtracellularSequence AnalysisAdd
BLAST
Topological domaini598 – 65356CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini675 – 834160ExtracellularSequence AnalysisAdd
BLAST
Topological domaini856 – 91863CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei577 – 59721HelicalSequence AnalysisAdd
BLAST
Transmembranei654 – 67421HelicalSequence AnalysisAdd
BLAST
Transmembranei835 – 85521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni531 – 5333Glutamate bindingBy similarity
Regioni704 – 7052Glutamate bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG316680.
GeneTreeiENSGT00760000118920.
HOGENOMiHOG000234371.
HOVERGENiHBG051839.
InParanoidiP39086.
KOiK05201.
PhylomeDBiP39086.
TreeFamiTF334668.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P39086-1) [UniParc]FASTAAdd to Basket

Also known as: GluR5-1D

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEHGTLLAQP GLWTRDTSWA LLYFLCYILP QTAPQVLRIG GIFETVENEP
60 70 80 90 100
VNVEELAFKF AVTSINRNRT LMPNTTLTYD IQRINLFDSF EASRRACDQL
110 120 130 140 150
ALGVAALFGP SHSSSVSAVQ SICNALEVPH IQTRWKHPSV DNKDLFYINL
160 170 180 190 200
YPDYAAISRA ILDLVLYYNW KTVTVVYEDS TGLIRLQELI KAPSRYNIKI
210 220 230 240 250
KIRQLPSGNK DAKPLLKEMK KGKEFYVIFD CSHETAAEIL KQILFMGMMT
260 270 280 290 300
EYYHYFFTTL DLFALDLELY RYSGVNMTGF RLLNIDNPHV SSIIEKWSME
310 320 330 340 350
RLQAPPRPET GLLDGMMTTE AALMYDAVYM VAIASHRASQ LTVSSLQCHR
360 370 380 390 400
HKPWRLGPRF MNLIKEARWD GLTGHITFNK TNGLRKDFDL DIISLKEEGT
410 420 430 440 450
EKAAGEVSKH LYKVWKKIGI WNSNSGLNMT DSNKDKSSNI TDSLANRTLI
460 470 480 490 500
VTTILEEPYV MYRKSDKPLY GNDRFEGYCL DLLKELSNIL GFIYDVKLVP
510 520 530 540 550
DGKYGAQNDK GEWNGMVKEL IDHRADLAVA PLTITYVREK VIDFSKPFMT
560 570 580 590 600
LGISILYRKP NGTNPGVFSF LNPLSPDIWM YVLLACLGVS CVLFVIARFT
610 620 630 640 650
PYEWYNPHPC NPDSDVVENN FTLLNSFWFG VGALMQQGSE LMPKALSTRI
660 670 680 690 700
VGGIWWFFTL IIISSYTANL AAFLTVERME SPIDSADDLA KQTKIEYGAV
710 720 730 740 750
RDGSTMTFFK KSKISTYEKM WAFMSSRQQT ALVRNSDEGI QRVLTTDYAL
760 770 780 790 800
LMESTSIEYV TQRNCNLTQI GGLIDSKGYG VGTPIGSPYR DKITIAILQL
810 820 830 840 850
QEEGKLHMMK EKWWRGNGCP EEDNKEASAL GVENIGGIFI VLAAGLVLSV
860 870 880 890 900
FVAIGEFIYK SRKNNDIEQA FCFFYGLQCK QTHPTNSTSG TTLSTDLECG
910
KLIREERGIR KQSSVHTV
Length:918
Mass (Da):103,981
Last modified:February 1, 1995 - v1
Checksum:i0EB8DB6356599002
GO
Isoform 2 (identifier: P39086-2) [UniParc]FASTAAdd to Basket

Also known as: EAA3A

The sequence of this isoform differs from the canonical sequence as follows:
     402-416: Missing.
     870-918: AFCFFYGLQC...IRKQSSVHTV → CLSFNAIMEE...RRTQRKETVA

Show »
Length:905
Mass (Da):102,631
Checksum:i6D9350206E5A2E9C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti281 – 2811R → G in AAA95961. (PubMed:8589992)Curated

RNA editingi

Partially edited.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti332 – 3321A → V.1 Publication
Corresponds to variant rs143252117 [ dbSNP | Ensembl ].
VAR_012751
Natural varianti636 – 6361Q → R in RNA edited version.
VAR_000304
Natural varianti757 – 7571I → V.
Corresponds to variant rs363494 [ dbSNP | Ensembl ].
VAR_012041
Natural varianti862 – 8621R → Q.1 Publication
VAR_012752
Natural varianti870 – 8701A → V.
Corresponds to variant rs363503 [ dbSNP | Ensembl ].
VAR_012042
Natural varianti902 – 9021L → S.1 Publication
Corresponds to variant rs363504 [ dbSNP | Ensembl ].
VAR_012043

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei402 – 41615Missing in isoform 2. 2 PublicationsVSP_000127Add
BLAST
Alternative sequencei870 – 91849AFCFF…SVHTV → CLSFNAIMEELGISLKNQKK IKKKSRTKGKSSFTSILTCH QRRTQRKETVA in isoform 2. 2 PublicationsVSP_000128Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19058 mRNA. Translation: AAA52568.1.
U16125 mRNA. Translation: AAA95961.1.
AJ249208 mRNA. Translation: CAC80546.1.
CCDSiCCDS33530.1. [P39086-2]
CCDS42913.1. [P39086-1]
PIRiI58178.
RefSeqiNP_000821.1. NM_000830.3. [P39086-1]
NP_783300.1. NM_175611.2. [P39086-2]
UniGeneiHs.664641.

Genome annotation databases

EnsembliENST00000389125; ENSP00000373777; ENSG00000171189. [P39086-2]
ENST00000399907; ENSP00000382791; ENSG00000171189. [P39086-1]
GeneIDi2897.
KEGGihsa:2897.
UCSCiuc002ynn.3. human. [P39086-2]
uc002yno.1. human. [P39086-1]

Polymorphism databases

DMDMi729597.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19058 mRNA. Translation: AAA52568.1 .
U16125 mRNA. Translation: AAA95961.1 .
AJ249208 mRNA. Translation: CAC80546.1 .
CCDSi CCDS33530.1. [P39086-2 ]
CCDS42913.1. [P39086-1 ]
PIRi I58178.
RefSeqi NP_000821.1. NM_000830.3. [P39086-1 ]
NP_783300.1. NM_175611.2. [P39086-2 ]
UniGenei Hs.664641.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2ZNS X-ray 2.00 A 445-559 [» ]
A 682-820 [» ]
2ZNT X-ray 1.60 A 445-559 [» ]
A 682-820 [» ]
2ZNU X-ray 1.80 A 445-559 [» ]
A 682-820 [» ]
3FUZ X-ray 1.65 A/B 445-559 [» ]
A/B 682-820 [» ]
3FV1 X-ray 1.50 A/B 445-559 [» ]
A/B 682-820 [» ]
3FV2 X-ray 1.50 A/B 445-559 [» ]
A/B 682-820 [» ]
3FVG X-ray 1.50 A/B 445-559 [» ]
A/B 682-820 [» ]
3FVK X-ray 1.50 A/B 445-559 [» ]
A/B 682-820 [» ]
3FVN X-ray 1.50 A/B 445-559 [» ]
A/B 682-820 [» ]
3FVO X-ray 1.50 A/B 445-559 [» ]
A/B 682-820 [» ]
4MF3 X-ray 3.00 A/B 443-822 [» ]
ProteinModelPortali P39086.
SMRi P39086. Positions 35-860.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109154. 6 interactions.
STRINGi 9606.ENSP00000382791.

Chemistry

BindingDBi P39086.
ChEMBLi CHEMBL2109241.
DrugBanki DB00273. Topiramate.
GuidetoPHARMACOLOGYi 450.

PTM databases

PhosphoSitei P39086.

Polymorphism databases

DMDMi 729597.

Proteomic databases

PaxDbi P39086.
PRIDEi P39086.

Protocols and materials databases

DNASUi 2897.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000389125 ; ENSP00000373777 ; ENSG00000171189 . [P39086-2 ]
ENST00000399907 ; ENSP00000382791 ; ENSG00000171189 . [P39086-1 ]
GeneIDi 2897.
KEGGi hsa:2897.
UCSCi uc002ynn.3. human. [P39086-2 ]
uc002yno.1. human. [P39086-1 ]

Organism-specific databases

CTDi 2897.
GeneCardsi GC21M030909.
HGNCi HGNC:4579. GRIK1.
MIMi 138245. gene.
neXtProti NX_P39086.
PharmGKBi PA28973.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG316680.
GeneTreei ENSGT00760000118920.
HOGENOMi HOG000234371.
HOVERGENi HBG051839.
InParanoidi P39086.
KOi K05201.
PhylomeDBi P39086.
TreeFami TF334668.

Enzyme and pathway databases

Reactomei REACT_21343. Activation of Na-permeable Kainate Receptors.
REACT_21346. Activation of Ca-permeable Kainate Receptor.
SignaLinki P39086.

Miscellaneous databases

EvolutionaryTracei P39086.
GeneWikii GRIK1.
GenomeRNAii 2897.
NextBioi 11463.
PROi P39086.
SOURCEi Search...

Gene expression databases

Bgeei P39086.
CleanExi HS_GRIK1.
ExpressionAtlasi P39086. baseline and differential.
Genevestigatori P39086.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view ]
PRINTSi PR00177. NMDARECEPTOR.
SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6."
    Gregor P., O'Hara B.F., Yang X., Uhl G.R.
    NeuroReport 4:1343-1346(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Retina.
  2. "cDNA cloning and functional properties of human glutamate receptor EAA3 (GluR5) in homomeric and heteromeric configuration."
    Korczak B., Nutt S.L., Fletcher E.J., Hoo K.H., Elliott C.E., Rampersad V., McWhinnie E.A., Kamboj R.K.
    Recept. Channels 3:41-49(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Fetal brain.
  3. "Myeloid progenitor cell growth and apoptosis involves known and cell-specific ionotropic glutamate receptors."
    Langer A., Xu D., Kuehcke K., Fehse B., Abdallah S., Lother H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Erythroleukemia.
  4. "RNA editing of human kainate receptor subunits."
    Nutt S.L., Kamboj R.K.
    NeuroReport 5:2625-2629(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA EDITING OF POSITION 636.
    Tissue: Brain.
  5. "Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia."
    Shibata H., Joo A., Fujii Y., Tani A., Makino C., Hirata N., Kikuta R., Ninomiya H., Tashiro N., Fukumaki Y.
    Psychiatr. Genet. 11:139-144(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS VAL-332; GLN-862 AND SER-902.

Entry informationi

Entry nameiGRIK1_HUMAN
AccessioniPrimary (citable) accession number: P39086
Secondary accession number(s): Q13001, Q86SU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate > L-glutamate = quisqualate > CNQX = DNQX > AMPA > dihydrokainate > NMDA.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3