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Protein

T-complex protein 1 subunit zeta

Gene

CCT6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • unfolded protein binding Source: SGD

GO - Biological processi

  • protein folding Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29776-MONOMER.
ReactomeiR-SCE-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-SCE-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit zeta
Short name:
TCP-1-zeta
Alternative name(s):
CCT-zeta
Gene namesi
Name:CCT6
Synonyms:TCP20, TCP6
Ordered Locus Names:YDR188W
ORF Names:YD9395.21
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR188W.
SGDiS000002596. CCT6.

Subcellular locationi

GO - Cellular componenti

  • chaperonin-containing T-complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001283622 – 546T-complex protein 1 subunit zetaAdd BLAST545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei249PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP39079.
PRIDEiP39079.

PTM databases

iPTMnetiP39079.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

GO - Molecular functioni

  • unfolded protein binding Source: SGD

Protein-protein interaction databases

BioGridi32241. 115 interactors.
DIPiDIP-6401N.
IntActiP39079. 29 interactors.
MINTiMINT-615099.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V81X-ray3.80F/N/f/n1-546[»]
4V8RX-ray3.80AZ/Az/BZ/Bz1-546[»]
4V94X-ray3.80F/N/f/n1-546[»]
ProteinModelPortaliP39079.
SMRiP39079.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000074743.
HOGENOMiHOG000226733.
InParanoidiP39079.
KOiK09498.
OMAiYRVKRQM.
OrthoDBiEOG092C2Q7F.

Family and domain databases

CDDicd03342. TCP1_zeta. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012722. Chap_CCT_zeta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PANTHERiPTHR11353:SF21. PTHR11353:SF21. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02347. chap_CCT_zeta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39079-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQLLNPKA ESLRRDAALK VNVTSAEGLQ SVLETNLGPK GTLKMLVDGA
60 70 80 90 100
GNIKLTKDGK VLLTEMQIQS PTAVLIARAA AAQDEITGDG TTTVVCLVGE
110 120 130 140 150
LLRQAHRFIQ EGVHPRIITD GFEIARKESM KFLDEFKISK TNLSNDREFL
160 170 180 190 200
LQVARSSLLT KVDADLTEVL TPIVTDAVLS VYDAQADNLD LHMVEIMQMQ
210 220 230 240 250
HLSPKDTTFI KGLVLDHGGR HPDMPTRVKN AYVLILNVSL EYEKTEVNSG
260 270 280 290 300
FFYSSADQRD KLAASERKFV DAKLKKIIDL KNEVCGMDPD KGFVIINQKG
310 320 330 340 350
IDPMSLDVFA KHNILALRRA KRRNMERLQL VTGGEAQNSV EDLSPQILGF
360 370 380 390 400
SGLVYQETIG EEKFTYVTEN TDPKSCTILI KGSTHYALAQ TKDAVRDGLR
410 420 430 440 450
AVANVLKDKN IIPGAGAFYI ALSRYLRSAN MNKLGAKGKT KTGIEAFAEA
460 470 480 490 500
LLVIPKTLVK NSGFDPLDVL AMVEDELDDA QDSDETRYVG VDLNIGDSCD
510 520 530 540
PTIEGIWDSY RVLRNAITGA TGIASNLLLC DELLRAGRST LKETPQ
Length:546
Mass (Da):59,924
Last modified:February 1, 1995 - v1
Checksum:i7D2A2AB4526D3DB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27698 Genomic DNA. Translation: AAA35140.1.
Z46727 Genomic DNA. Translation: CAA86694.1.
BK006938 Genomic DNA. Translation: DAA12031.1.
PIRiS48086.
RefSeqiNP_010474.3. NM_001180496.3.

Genome annotation databases

EnsemblFungiiYDR188W; YDR188W; YDR188W.
GeneIDi851768.
KEGGisce:YDR188W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27698 Genomic DNA. Translation: AAA35140.1.
Z46727 Genomic DNA. Translation: CAA86694.1.
BK006938 Genomic DNA. Translation: DAA12031.1.
PIRiS48086.
RefSeqiNP_010474.3. NM_001180496.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V81X-ray3.80F/N/f/n1-546[»]
4V8RX-ray3.80AZ/Az/BZ/Bz1-546[»]
4V94X-ray3.80F/N/f/n1-546[»]
ProteinModelPortaliP39079.
SMRiP39079.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32241. 115 interactors.
DIPiDIP-6401N.
IntActiP39079. 29 interactors.
MINTiMINT-615099.

PTM databases

iPTMnetiP39079.

Proteomic databases

MaxQBiP39079.
PRIDEiP39079.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR188W; YDR188W; YDR188W.
GeneIDi851768.
KEGGisce:YDR188W.

Organism-specific databases

EuPathDBiFungiDB:YDR188W.
SGDiS000002596. CCT6.

Phylogenomic databases

GeneTreeiENSGT00550000074743.
HOGENOMiHOG000226733.
InParanoidiP39079.
KOiK09498.
OMAiYRVKRQM.
OrthoDBiEOG092C2Q7F.

Enzyme and pathway databases

BioCyciYEAST:G3O-29776-MONOMER.
ReactomeiR-SCE-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-SCE-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Miscellaneous databases

PROiP39079.

Family and domain databases

CDDicd03342. TCP1_zeta. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012722. Chap_CCT_zeta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PANTHERiPTHR11353:SF21. PTHR11353:SF21. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02347. chap_CCT_zeta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCPZ_YEAST
AccessioniPrimary (citable) accession number: P39079
Secondary accession number(s): D6VSH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.