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Protein

T-complex protein 1 subunit zeta

Gene

CCT6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.

GO - Molecular functioni

GO - Biological processi

  • 'de novo' protein folding Source: GO_Central
  • chaperone-mediated protein folding Source: GO_Central
  • protein folding Source: SGD

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29776-MONOMER
ReactomeiR-SCE-390471 Association of TriC/CCT with target proteins during biosynthesis
R-SCE-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit zeta
Short name:
TCP-1-zeta
Alternative name(s):
CCT-zeta
Gene namesi
Name:CCT6
Synonyms:TCP20, TCP6
Ordered Locus Names:YDR188W
ORF Names:YD9395.21
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR188W
SGDiS000002596 CCT6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001283622 – 546T-complex protein 1 subunit zetaAdd BLAST545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei249PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP39079
PaxDbiP39079
PRIDEiP39079

PTM databases

iPTMnetiP39079

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

GO - Molecular functioni

  • protein binding involved in protein folding Source: GO_Central
  • unfolded protein binding Source: SGD

Protein-protein interaction databases

BioGridi32241, 674 interactors
ComplexPortaliCPX-2156 Chaperonin-containing T-complex
DIPiDIP-6401N
IntActiP39079, 44 interactors
MINTiP39079
STRINGi4932.YDR188W

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V81X-ray3.80F/N/f/n1-546[»]
4V8RX-ray3.80AZ/Az/BZ/Bz1-546[»]
4V94X-ray3.80F/N/f/n1-546[»]
5GW4electron microscopy4.70Z/z1-546[»]
5GW5electron microscopy4.60Z/z1-546[»]
ProteinModelPortaliP39079
SMRiP39079
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000074743
HOGENOMiHOG000226733
InParanoidiP39079
KOiK09498
OMAiMQHKTDT
OrthoDBiEOG092C2Q7F

Family and domain databases

CDDicd03342 TCP1_zeta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012722 Chap_CCT_zeta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02347 chap_CCT_zeta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39079-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQLLNPKA ESLRRDAALK VNVTSAEGLQ SVLETNLGPK GTLKMLVDGA
60 70 80 90 100
GNIKLTKDGK VLLTEMQIQS PTAVLIARAA AAQDEITGDG TTTVVCLVGE
110 120 130 140 150
LLRQAHRFIQ EGVHPRIITD GFEIARKESM KFLDEFKISK TNLSNDREFL
160 170 180 190 200
LQVARSSLLT KVDADLTEVL TPIVTDAVLS VYDAQADNLD LHMVEIMQMQ
210 220 230 240 250
HLSPKDTTFI KGLVLDHGGR HPDMPTRVKN AYVLILNVSL EYEKTEVNSG
260 270 280 290 300
FFYSSADQRD KLAASERKFV DAKLKKIIDL KNEVCGMDPD KGFVIINQKG
310 320 330 340 350
IDPMSLDVFA KHNILALRRA KRRNMERLQL VTGGEAQNSV EDLSPQILGF
360 370 380 390 400
SGLVYQETIG EEKFTYVTEN TDPKSCTILI KGSTHYALAQ TKDAVRDGLR
410 420 430 440 450
AVANVLKDKN IIPGAGAFYI ALSRYLRSAN MNKLGAKGKT KTGIEAFAEA
460 470 480 490 500
LLVIPKTLVK NSGFDPLDVL AMVEDELDDA QDSDETRYVG VDLNIGDSCD
510 520 530 540
PTIEGIWDSY RVLRNAITGA TGIASNLLLC DELLRAGRST LKETPQ
Length:546
Mass (Da):59,924
Last modified:February 1, 1995 - v1
Checksum:i7D2A2AB4526D3DB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27698 Genomic DNA Translation: AAA35140.1
Z46727 Genomic DNA Translation: CAA86694.1
BK006938 Genomic DNA Translation: DAA12031.1
PIRiS48086
RefSeqiNP_010474.3, NM_001180496.3

Genome annotation databases

EnsemblFungiiYDR188W; YDR188W; YDR188W
GeneIDi851768
KEGGisce:YDR188W

Similar proteinsi

Entry informationi

Entry nameiTCPZ_YEAST
AccessioniPrimary (citable) accession number: P39079
Secondary accession number(s): D6VSH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 20, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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