P39069 (KAD1_RAT) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 84.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Adenylate kinase isoenzyme 1 Short name=AK 1 EC=2.7.4.3 Alternative name(s): ATP-AMP transphosphorylase 1 Myokinase | ||
| Gene names |
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| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 194 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. |
| Catalytic activity | ATP + AMP = 2 ADP. |
| Subunit structure | Monomer. |
| Subcellular location | |
| Sequence similarities | Belongs to the adenylate kinase family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 194 | 194 | Adenylate kinase isoenzyme 1 | PRO_0000158914 | |||||
Regions | |||||||||
| Nucleotide binding | 15 – 23 | 9 | ATP By similarity | ||||||
| Nucleotide binding | 94 – 101 | 8 | AMP By similarity | ||||||
Sites | |||||||||
| Binding site | 39 | 1 | AMP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1 | 1 | N-acetylmethionine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 81 | 1 | L → F in BAA97655. Ref.1 | ||||||
| Sequence conflict | 104 | 1 | E → S in BAA02643. Ref.4 | ||||||
| Sequence conflict | 175 | 1 | A → L in BAA02643. Ref.4 | ||||||
| Sequence conflict | 179 | 1 | V → W in BAA02643. Ref.4 | ||||||
| Sequence conflict | 187 | 1 | C → S in BAA97655. Ref.1 | ||||||
| Sequence conflict | 187 | 1 | C → S in BAA02643. Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Rat adenylate kinase isozyme 1." Noma T. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney. |
| [3] | Lubec G., Afjehi-Sadat L., Diao W., Kang S.U. Submitted (JUL-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 10-21; 32-44; 64-77; 84-97; 101-128; 156-167 AND 172-194, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Brain, Hippocampus and Spinal cord. |
| [4] | "Tissue-specific and developmentally regulated expression of the genes encoding adenylate kinase isozymes." Tanabe T., Yamada M., Noma T., Kajii T., Nakazawa A. J. Biochem. 113:200-207(1993) [PubMed: 8468325] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 72-194. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB022701 mRNA. Translation: BAA97655.1. BC089797 mRNA. Translation: AAH89797.1. D13376 mRNA. Translation: BAA02643.1. |
| IPI | IPI00210351. |
| PIR | PQ0534. |
| RefSeq | NP_077325.2. NM_024349.2. |
| UniGene | Rn.79537. |
3D structure databases | |
| ProteinModelPortal | P39069. |
| SMR | P39069. Positions 1-194. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P39069. |
Proteomic databases | |
| PRIDE | P39069. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 24183. |
| KEGG | rno:24183. |
Organism-specific databases | |
| CTD | 203. |
| RGD | 2076. Ak1. |
Phylogenomic databases | |
| HOVERGEN | HBG108060. |
Gene expression databases | |
| Genevestigator | P39069. |
Family and domain databases | |
| InterPro | IPR000850. Adenylate_kin. IPR006267. Adenylate_kin1. [Graphical view] |
| KO | K00939. |
| PANTHER | PTHR23359. Adenylate_kin. 1 hit. |
| Pfam | PF00406. ADK. 1 hit. [Graphical view] |
| PRINTS | PR00094. ADENYLTKNASE. |
| TIGRFAMs | TIGR01360. Aden_kin_iso1. 1 hit. |
| PROSITE | PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 602533. |
Entry information
| Entry name | KAD1_RAT | ||||||||
| Accession | Primary (citable) accession number: P39069 Secondary accession number(s): Q5EBC5, Q9JJN3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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