Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P39069 (KAD1_RAT)

Last modified February 9, 2010. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Adenylate kinase isoenzyme 1
      Short name=AK 1
    EC=2.7.4.3
Alternative name(s):
    ATP-AMP transphosphorylase 1
    Myokinase
Gene names
Name: Ak1
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth.

Catalytic activity

ATP + AMP = 2 ADP.

Subunit structure

Monomer.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the adenylate kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 194194Adenylate kinase isoenzyme 1
PRO_0000158914

Regions

Nucleotide binding15 – 239ATP By similarity
Nucleotide binding94 – 1018AMP By similarity

Sites

Binding site391AMP By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Experimental info

Sequence conflict811L → F in BAA97655. Ref.1
Sequence conflict1041E → S in BAA02643. Ref.4
Sequence conflict1751A → L in BAA02643. Ref.4
Sequence conflict1791V → W in BAA02643. Ref.4
Sequence conflict1871C → S in BAA97655. Ref.1
Sequence conflict1871C → S in BAA02643. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P39069-1 [UniParc].

Last modified January 9, 2007. Version 3.
Checksum: 4D53BCB3EF8B7629

FASTA19421,584
        10         20         30         40         50         60 
MEDKLKKAKI IFVVGGPGSG KGTQCEKIVQ KYGYTHLSTG DLLRAEVSSG SSRGKMLSSI 

        70         80         90        100        110        120 
MEKGELVPLE TVLDMLRDAM LAKVDSSNGF LIDGYPREVK QGEEFERKIA QPTLLLYVDA 

       130        140        150        160        170        180 
GPETMTQRLL KRGETSGRVD DNEETIKKRL ETYYKATEPV ISFYDKRGIV RKVNAEGSVD 

       190 
TVFSQVCTYL DSLK 

« Hide

References

« Hide 'large scale' references
[1]"Rat adenylate kinase isozyme 1."
Noma T.
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[3]Lubec G., Afjehi-Sadat L., Diao W., Kang S.U.
Submitted (JUL-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 10-21; 32-44; 64-77; 84-97; 101-128; 156-167 AND 172-194, MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Brain, Hippocampus and Spinal cord.
[4]"Tissue-specific and developmentally regulated expression of the genes encoding adenylate kinase isozymes."
Tanabe T., Yamada M., Noma T., Kajii T., Nakazawa A.
J. Biochem. 113:200-207(1993) [PubMed: 8468325] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 72-194.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB022701 mRNA. Translation: BAA97655.1.
BC089797 mRNA. Translation: AAH89797.1.
D13376 mRNA. Translation: BAA02643.1.
IPIIPI00210351.
PIRPQ0534.
RefSeqNP_077325.2.
UniGeneRn.105715
Rn.79537

3D structure databases

SMRP39069. Positions 1-194.
ModBaseSearch...

Genome annotation databases

GeneID24183.
KEGGrno:24183.

Organism-specific databases

CTD24183.
RGD2076. Ak1.

Phylogenomic databases

HOVERGENP39069.

Enzyme and pathway databases

BRENDA2.7.4.3. 248.

Gene expression databases

GenevestigatorP39069.

Family and domain databases

InterProIPR000850. Adenylate_kin.
IPR006267. Adenylate_kin1.
[Graphical view]
PANTHERPTHR23359. Adenylate_kin. 1 hit.
PfamPF00406. ADK. 1 hit.
[Graphical view]
PRINTSPR00094. ADENYLTKNASE.
TIGRFAMsTIGR01360. aden_kin_iso1. 1 hit.
PROSITEPS00113. ADENYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio602533.

Entry information

Entry nameKAD1_RAT
AccessionPrimary (citable) accession number: P39069
Secondary accession number(s): Q5EBC5, Q9JJN3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 9, 2007
Last modified: February 9, 2010
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents