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UniProtKB - P39059 (COFA1_HUMAN)

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Protein

Collagen alpha-1(XV) chain

Gene

COL15A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle.1 Publication
Restin potently inhibits angiogenesis.By similarity

GO - Molecular functioni

  • extracellular matrix structural constituent Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  • angiogenesis Source: UniProtKB-KW
  • cell adhesion Source: UniProtKB
  • cell differentiation Source: UniProtKB-KW
  • collagen catabolic process Source: Reactome
  • signal transduction Source: UniProtKB
Complete GO annotation...

Keywordsi

Molecular functionDevelopmental protein
Biological processAngiogenesis, Cell adhesion, Differentiation

Enzyme and pathway databases

ReactomeiR-HSA-1442490. Collagen degradation.
R-HSA-1650814. Collagen biosynthesis and modifying enzymes.
R-HSA-2022090. Assembly of collagen fibrils and other multimeric structures.
R-HSA-8948216. Collagen chain trimerization.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XV) chain
Cleaved into the following 4 chains:
Restin
Alternative name(s):
Endostatin-XV
Related to endostatin
Restin-I
Restin-2
Alternative name(s):
Restin-II
Restin-3
Alternative name(s):
Restin-III
Restin-4
Alternative name(s):
Restin-IV
Gene namesi
Name:COL15A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:2192. COL15A1.

Subcellular locationi

GO - Cellular componenti

  • collagen type XV trimer Source: UniProtKB
  • endoplasmic reticulum lumen Source: Reactome
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: BHF-UCL
  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1306.
OpenTargetsiENSG00000204291.
PharmGKBiPA26708.

Chemistry databases

ChEMBLiCHEMBL2364188.

Polymorphism and mutation databases

DMDMi68839886.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000000578828 – 1388Collagen alpha-1(XV) chainAdd BLAST1361
ChainiPRO_00000057891198 – 1386RestinAdd BLAST189
ChainiPRO_00004230141207 – 1386Restin-2Add BLAST180
ChainiPRO_00004230151213 – 1386Restin-3Add BLAST174
ChainiPRO_00004230161221 – 1386Restin-4Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi265O-linked (GalNAc...) threonine1 Publication1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi324N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi687N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi807N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi814N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1046N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1237 ↔ 13771 Publication
Disulfide bondi1339 ↔ 13691 Publication

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
O-glycosylated; with core 1 or possibly core 8 glycans. An N-terminal peptide contains chondroitin sulfate.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

MaxQBiP39059.
PaxDbiP39059.
PeptideAtlasiP39059.
PRIDEiP39059.

PTM databases

iPTMnetiP39059.
PhosphoSitePlusiP39059.
UniCarbKBiP39059.

Expressioni

Tissue specificityi

Expressed predominantly in internal organs such as adrenal gland, pancreas and kidney.

Gene expression databases

BgeeiENSG00000204291.
CleanExiHS_COL15A1.
ExpressionAtlasiP39059. baseline and differential.
GenevisibleiP39059. HS.

Organism-specific databases

HPAiHPA017913.
HPA017915.

Interactioni

Subunit structurei

Trimer; disulfide-linked.1 Publication

Protein-protein interaction databases

BioGridi107702. 1 interactor.
IntActiP39059. 4 interactors.
STRINGi9606.ENSP00000364140.

Structurei

Secondary structure

11388
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1135 – 1140Combined sources6
Helixi1141 – 1145Combined sources5
Helixi1146 – 1150Combined sources5
Beta strandi1155 – 1159Combined sources5
Turni1160 – 1163Combined sources4
Beta strandi1164 – 1169Combined sources6
Beta strandi1172 – 1175Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3N3FX-ray2.00A/B1133-1186[»]
ProteinModelPortaliP39059.
SMRiP39059.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 249Laminin G-likeAdd BLAST184
Repeati358 – 4081Add BLAST51
Repeati409 – 4592Add BLAST51
Repeati460 – 5093Add BLAST50
Repeati510 – 5554Add BLAST46
Domaini619 – 680Collagen-like 1Add BLAST62
Domaini681 – 731Collagen-like 2Add BLAST51
Domaini823 – 865Collagen-like 3Add BLAST43
Domaini879 – 927Collagen-like 4Add BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni229 – 555Nonhelical region 1 (NC1)Add BLAST327
Regioni358 – 5554 X tandem repeatsAdd BLAST198
Regioni556 – 573Triple-helical region 1 (COL1)Add BLAST18
Regioni574 – 618Nonhelical region 2 (NC2)Add BLAST45
Regioni619 – 732Triple-helical region 2 (COL2)Add BLAST114
Regioni733 – 763Nonhelical region 3 (NC3)Add BLAST31
Regioni764 – 798Triple-helical region 3 (COL3)Add BLAST35
Regioni799 – 822Nonhelical region 4 (NC4)Add BLAST24
Regioni823 – 867Triple-helical region 4 (COL4)Add BLAST45
Regioni868 – 878Nonhelical region 5 (NC5)Add BLAST11
Regioni879 – 949Triple-helical region 5 (COL5)Add BLAST71
Regioni950 – 983Nonhelical region 6 (NC6)Add BLAST34
Regioni984 – 1013Triple-helical region 6 (COL6)Add BLAST30
Regioni1014 – 1027Nonhelical region 7 (NC7)Add BLAST14
Regioni1028 – 1045Triple-helical region 7 (COL7)Add BLAST18
Regioni1046 – 1052Nonhelical region 8 (NC8)7
Regioni1053 – 1107Triple-helical region 8 (COL8)Add BLAST55
Regioni1108 – 1117Nonhelical region 9 (NC9)10
Regioni1118 – 1132Triple-helical region 9 (COL9)Add BLAST15
Regioni1133 – 1388Nonhelical region 10 (NC10)Add BLAST256

Sequence similaritiesi

Belongs to the multiplexin collagen family.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3546. Eukaryota.
ENOG410XQ04. LUCA.
GeneTreeiENSGT00710000106713.
HOGENOMiHOG000231591.
HOVERGENiHBG080337.
InParanoidiP39059.
KOiK08135.
OMAiGVEDGHQ.
OrthoDBiEOG091G01N2.
PhylomeDBiP39059.
TreeFamiTF315821.

Family and domain databases

CDDicd00247. Endostatin-like. 1 hit.
Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR016186. C-type_lectin-like/link.
IPR008160. Collagen.
IPR010515. Collagenase_NC10/endostatin.
IPR013320. ConA-like_dom.
IPR016187. CTDL_fold.
IPR001791. Laminin_G.
PfamiView protein in Pfam
PF01391. Collagen. 4 hits.
PF06482. Endostatin. 1 hit.
SMARTiView protein in SMART
SM00210. TSPN. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF56436. SSF56436. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39059-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRRNNGQC WCLLMLLSVS TPLPAVTQTR GATETASQGH LDLTQLIGVP 
        60         70         80         90        100
LPSSVSFVTG YGGFPAYSFG PGANVGRPAR TLIPSTFFRD FAISVVVKPS 
       110        120        130        140        150
STRGGVLFAI TDAFQKVIYL GLRLSGVEDG HQRIILYYTE PGSHVSQEAA 
       160        170        180        190        200
AFSVPVMTHR WNRFAMIVQG EEVTLLVNCE EHSRIPFQRS SQALAFESSA 
       210        220        230        240        250
GIFMGNAGAT GLERFTGSLQ QLTVHPDPRT PEELCDPEES SASGETSGLQ 
       260        270        280        290        300
EADGVAEILE AVTYTQASPK EAKVEPINTP PTPSSPFEDM ELSGEPVPEG 
       310        320        330        340        350
TLETTNMSII QHSSPKQGSG EILNDTLEGV HSVDGDPITD SGSGAGAFLD 
       360        370        380        390        400
IAEEKNLAAT AAGLAEVPIS TAGEAEASSV PTGGPTLSMS TENPEEGVTP 
       410        420        430        440        450
GPDNEERLAA TAAGEAEALA SMPGEVEASG VAPGELDLSM SAQSLGEEAT 
       460        470        480        490        500
VGPSSEDSLT TAAAATEVSL STFEDEEASG VPTDGLAPLT ATMAPERAVT 
       510        520        530        540        550
SGPGDEEDLA AATTEEPLIT AGGEESGSPP PDGPPLPLPT VAPERWITPA 
       560        570        580        590        600
QREHVGMKGQ AGPKGEKGDA GEELPGPPEP SGPVGPTAGA EAEGSGLGWG 
       610        620        630        640        650
SDVGSGSGDL VGSEQLLRGP PGPPGPPGLP GIPGKPGTDV FMGPPGSPGE 
       660        670        680        690        700
DGPAGEPGPP GPEGQPGVDG ATGLPGMKGE KGARGPNGSV GEKGDPGNRG 
       710        720        730        740        750
LPGPPGKKGQ AGPPGVMGPP GPPGPPGPPG PGCTMGLGFE DTEGSGSTQL 
       760        770        780        790        800
LNEPKLSRPT AAIGLKGEKG DRGPKGERGM DGASIVGPPG PRGPPGHIKV 
       810        820        830        840        850
LSNSLINITH GFMNFSDIPE LVGPPGPDGL PGLPGFPGPR GPKGDTGLPG 
       860        870        880        890        900
FPGLKGEQGE KGEPGAILTE DIPLERLMGK KGEPGMHGAP GPMGPKGPPG 
       910        920        930        940        950
HKGEFGLPGR PGRPGLNGLK GTKGDPGVIM QGPPGLPGPP GPPGPPGAVI 
       960        970        980        990       1000
NIKGAIFPIP VRPHCKMPVD TAHPGSPELI TFHGVKGEKG SWGLPGSKGE 
      1010       1020       1030       1040       1050
KGDQGAQGPP GPPLDLAYLR HFLNNLKGEN GDKGFKGEKG EKGDINGSFL 
      1060       1070       1080       1090       1100
MSGPPGLPGN PGPAGQKGET VVGPQGPPGA PGLPGPPGFG RPGDPGPPGP 
      1110       1120       1130       1140       1150
PGPPGPPAIL GAAVALPGPP GPPGQPGLPG SRNLVTAFSN MDDMLQKAHL 
      1160       1170       1180       1190       1200
VIEGTFIYLR DSTEFFIRVR DGWKKLQLGE LIPIPADSPP PPALSSNPHQ 
      1210       1220       1230       1240       1250
LLPPPNPISS ANYEKPALHL AALNMPFSGD IRADFQCFKQ ARAAGLLSTY 
      1260       1270       1280       1290       1300
RAFLSSHLQD LSTIVRKAER YSLPIVNLKG QVLFNNWDSI FSGHGGQFNM 
      1310       1320       1330       1340       1350
HIPIYSFDGR DIMTDPSWPQ KVIWHGSSPH GVRLVDNYCE AWRTADTAVT 
      1360       1370       1380 
GLASPLSTGK ILDQKAYSCA NRLIVLCIEN SFMTDARK
Length:1,388
Mass (Da):141,720
Last modified:July 5, 2005 - v2
Checksum:iAF54DDCC136C3745
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10C → S in BAA04762 (PubMed:8307960).Curated1
Sequence conflicti49V → D in AAA58429 (PubMed:8106446).Curated1
Sequence conflicti94 – 95SV → RA in AAA58429 (PubMed:8106446).Curated2
Sequence conflicti94 – 95SV → RA in BAA04762 (PubMed:8307960).Curated2
Sequence conflicti150A → P in AAA58429 (PubMed:8106446).Curated1
Sequence conflicti409A → R in AAA58429 (PubMed:8106446).Curated1
Sequence conflicti409A → R in AAC78500 (PubMed:9651385).Curated1
Sequence conflicti1134L → LLGELIPIPADSPPPPALSS N in AAC78500 (PubMed:9651385).Curated1
Sequence conflicti1178 – 1197Missing in AAC78500 (PubMed:9651385).CuratedAdd BLAST20
Sequence conflicti1227F → V in AAC78500 (PubMed:9651385).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033787163R → H. Corresponds to variant dbSNP:rs2075662Ensembl.1
Natural variantiVAR_033788204M → V1 PublicationCorresponds to variant dbSNP:rs2075663Ensembl.1
Natural variantiVAR_033789391T → M. Corresponds to variant dbSNP:rs10988532Ensembl.1
Natural variantiVAR_033790442A → T. Corresponds to variant dbSNP:rs16918128Ensembl.1
Natural variantiVAR_033791446G → R. Corresponds to variant dbSNP:rs35934703Ensembl.1
Natural variantiVAR_048776504G → V. Corresponds to variant dbSNP:rs2297603Ensembl.1
Natural variantiVAR_033792506E → D. Corresponds to variant dbSNP:rs35250850Ensembl.1
Natural variantiVAR_033793531P → R. Corresponds to variant dbSNP:rs35529307Ensembl.1
Natural variantiVAR_061114705P → L. Corresponds to variant dbSNP:rs41308900Ensembl.1
Natural variantiVAR_033794989K → R. Corresponds to variant dbSNP:rs35642150Ensembl.1
Natural variantiVAR_0337951001K → R. Corresponds to variant dbSNP:rs35544077Ensembl.1
Natural variantiVAR_0337961332V → I. Corresponds to variant dbSNP:rs10519Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25286 mRNA. Translation: AAA58429.1.
L25280
, L25281, L25282, L25283, L25284, L25285, AF052956, AF052957, AF052958, AF052959, AF052960, AF052961, AF052962, AF052963, AF052964, AF052965, AF052966, AF052967, AF052968, AF052969, AF052970, AF052971, AF052972, AF052973, AF052974, AF052975 Genomic DNA. Translation: AAC78500.1.
AL136084, AL354923 Genomic DNA. Translation: CAI17044.2.
AL354923, AL136084 Genomic DNA. Translation: CAI12548.2.
D21230 mRNA. Translation: BAA04762.1.
L01697 mRNA. No translation available.
CCDSiCCDS35081.1.
PIRiA53317.
RefSeqiNP_001846.3. NM_001855.4.
XP_011516516.1. XM_011518214.2.
UniGeneiHs.409034.

Genome annotation databases

EnsembliENST00000375001; ENSP00000364140; ENSG00000204291.
GeneIDi1306.
KEGGihsa:1306.
UCSCiuc004azb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCOFA1_HUMAN
AccessioniPrimary (citable) accession number: P39059
Secondary accession number(s): Q5T6J4, Q9UDC5, Q9Y4W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 5, 2005
Last modified: May 10, 2017
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The name restin has also been used for CAP-Gly domain-containing linker protein 1 the product of the CLIP1 gene.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families