UniProtKB - P39059 (COFA1_HUMAN)
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Protein
Collagen alpha-1(XV) chain
Gene
COL15A1
Organism
Homo sapiens (Human)
Status
Functioni
Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle.1 Publication
Restin potently inhibits angiogenesis.By similarity
Caution
The name restin has also been used for CAP-Gly domain-containing linker protein 1 the product of the CLIP1 gene.Curated
GO - Molecular functioni
- structural molecule activity Source: InterPro
GO - Biological processi
- angiogenesis Source: UniProtKB-KW
- cell adhesion Source: UniProtKB-KW
- cell differentiation Source: UniProtKB-KW
- collagen catabolic process Source: Reactome
- signal transduction Source: UniProtKB
Keywordsi
Molecular function | Developmental protein |
Biological process | Angiogenesis, Cell adhesion, Differentiation |
Enzyme and pathway databases
Reactomei | R-HSA-1442490 Collagen degradation R-HSA-1650814 Collagen biosynthesis and modifying enzymes R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures R-HSA-8948216 Collagen chain trimerization |
SIGNORi | P39059 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:COL15A1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000204291.10 |
HGNCi | HGNC:2192 COL15A1 |
MIMi | 120325 gene |
neXtProti | NX_P39059 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 1306 |
OpenTargetsi | ENSG00000204291 |
PharmGKBi | PA26708 |
Chemistry databases
ChEMBLi | CHEMBL2364188 |
Polymorphism and mutation databases
DMDMi | 68839886 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_0000005788 | 28 – 1388 | Collagen alpha-1(XV) chainAdd BLAST | 1361 | |
ChainiPRO_0000005789 | 1198 – 1386 | RestinAdd BLAST | 189 | |
ChainiPRO_0000423014 | 1207 – 1386 | Restin-2Add BLAST | 180 | |
ChainiPRO_0000423015 | 1213 – 1386 | Restin-3Add BLAST | 174 | |
ChainiPRO_0000423016 | 1221 – 1386 | Restin-4Add BLAST | 166 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 265 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 306 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 324 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 687 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 807 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 814 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1046 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1237 ↔ 1377 | 1 Publication | ||
Disulfide bondi | 1339 ↔ 1369 | 1 Publication |
Post-translational modificationi
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
O-glycosylated; with core 1 or possibly core 8 glycans. An N-terminal peptide contains chondroitin sulfate.2 Publications
Keywords - PTMi
Disulfide bond, Glycoprotein, HydroxylationProteomic databases
MaxQBi | P39059 |
PaxDbi | P39059 |
PeptideAtlasi | P39059 |
PRIDEi | P39059 |
PTM databases
GlyConnecti | 727 |
iPTMneti | P39059 |
PhosphoSitePlusi | P39059 |
UniCarbKBi | P39059 |
Expressioni
Tissue specificityi
Expressed predominantly in internal organs such as adrenal gland, pancreas and kidney.
Gene expression databases
Bgeei | ENSG00000204291 |
CleanExi | HS_COL15A1 |
ExpressionAtlasi | P39059 baseline and differential |
Genevisiblei | P39059 HS |
Organism-specific databases
HPAi | HPA017913 HPA017915 |
Interactioni
Subunit structurei
Trimer; disulfide-linked.1 Publication
Protein-protein interaction databases
BioGridi | 1077021 interactor. |
IntActi | P39059 4 interactors. |
STRINGi | 9606.ENSP00000364140 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 1135 – 1140 | Combined sources | 6 | |
Helixi | 1141 – 1145 | Combined sources | 5 | |
Helixi | 1146 – 1150 | Combined sources | 5 | |
Beta strandi | 1155 – 1159 | Combined sources | 5 | |
Turni | 1160 – 1163 | Combined sources | 4 | |
Beta strandi | 1164 – 1169 | Combined sources | 6 | |
Beta strandi | 1172 – 1175 | Combined sources | 4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3N3F | X-ray | 2.00 | A/B | 1133-1186 | [»] | |
ProteinModelPortali | P39059 | |||||
SMRi | P39059 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 66 – 249 | Laminin G-likeAdd BLAST | 184 | |
Repeati | 358 – 408 | 1Add BLAST | 51 | |
Repeati | 409 – 459 | 2Add BLAST | 51 | |
Repeati | 460 – 509 | 3Add BLAST | 50 | |
Repeati | 510 – 555 | 4Add BLAST | 46 | |
Domaini | 619 – 680 | Collagen-like 1Add BLAST | 62 | |
Domaini | 681 – 731 | Collagen-like 2Add BLAST | 51 | |
Domaini | 823 – 865 | Collagen-like 3Add BLAST | 43 | |
Domaini | 879 – 927 | Collagen-like 4Add BLAST | 49 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 229 – 555 | Nonhelical region 1 (NC1)Add BLAST | 327 | |
Regioni | 358 – 555 | 4 X tandem repeatsAdd BLAST | 198 | |
Regioni | 556 – 573 | Triple-helical region 1 (COL1)Add BLAST | 18 | |
Regioni | 574 – 618 | Nonhelical region 2 (NC2)Add BLAST | 45 | |
Regioni | 619 – 732 | Triple-helical region 2 (COL2)Add BLAST | 114 | |
Regioni | 733 – 763 | Nonhelical region 3 (NC3)Add BLAST | 31 | |
Regioni | 764 – 798 | Triple-helical region 3 (COL3)Add BLAST | 35 | |
Regioni | 799 – 822 | Nonhelical region 4 (NC4)Add BLAST | 24 | |
Regioni | 823 – 867 | Triple-helical region 4 (COL4)Add BLAST | 45 | |
Regioni | 868 – 878 | Nonhelical region 5 (NC5)Add BLAST | 11 | |
Regioni | 879 – 949 | Triple-helical region 5 (COL5)Add BLAST | 71 | |
Regioni | 950 – 983 | Nonhelical region 6 (NC6)Add BLAST | 34 | |
Regioni | 984 – 1013 | Triple-helical region 6 (COL6)Add BLAST | 30 | |
Regioni | 1014 – 1027 | Nonhelical region 7 (NC7)Add BLAST | 14 | |
Regioni | 1028 – 1045 | Triple-helical region 7 (COL7)Add BLAST | 18 | |
Regioni | 1046 – 1052 | Nonhelical region 8 (NC8) | 7 | |
Regioni | 1053 – 1107 | Triple-helical region 8 (COL8)Add BLAST | 55 | |
Regioni | 1108 – 1117 | Nonhelical region 9 (NC9) | 10 | |
Regioni | 1118 – 1132 | Triple-helical region 9 (COL9)Add BLAST | 15 | |
Regioni | 1133 – 1388 | Nonhelical region 10 (NC10)Add BLAST | 256 |
Sequence similaritiesi
Belongs to the multiplexin collagen family.Curated
Keywords - Domaini
Collagen, Repeat, SignalPhylogenomic databases
eggNOGi | KOG3546 Eukaryota ENOG410XQ04 LUCA |
GeneTreei | ENSGT00710000106713 |
HOGENOMi | HOG000231591 |
HOVERGENi | HBG080337 |
InParanoidi | P39059 |
KOi | K08135 |
OMAi | GVEDGHQ |
OrthoDBi | EOG091G01N2 |
PhylomeDBi | P39059 |
TreeFami | TF315821 |
Family and domain databases
CDDi | cd00247 Endostatin-like, 1 hit |
Gene3Di | 3.10.100.101 hit |
InterProi | View protein in InterPro IPR016186 C-type_lectin-like/link_sf IPR008160 Collagen IPR010515 Collagenase_NC10/endostatin IPR013320 ConA-like_dom_sf IPR016187 CTDL_fold IPR001791 Laminin_G |
Pfami | View protein in Pfam PF01391 Collagen, 4 hits PF06482 Endostatin, 1 hit |
SMARTi | View protein in SMART SM00210 TSPN, 1 hit |
SUPFAMi | SSF49899 SSF49899, 1 hit SSF56436 SSF56436, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P39059-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPRRNNGQC WCLLMLLSVS TPLPAVTQTR GATETASQGH LDLTQLIGVP
60 70 80 90 100
LPSSVSFVTG YGGFPAYSFG PGANVGRPAR TLIPSTFFRD FAISVVVKPS
110 120 130 140 150
STRGGVLFAI TDAFQKVIYL GLRLSGVEDG HQRIILYYTE PGSHVSQEAA
160 170 180 190 200
AFSVPVMTHR WNRFAMIVQG EEVTLLVNCE EHSRIPFQRS SQALAFESSA
210 220 230 240 250
GIFMGNAGAT GLERFTGSLQ QLTVHPDPRT PEELCDPEES SASGETSGLQ
260 270 280 290 300
EADGVAEILE AVTYTQASPK EAKVEPINTP PTPSSPFEDM ELSGEPVPEG
310 320 330 340 350
TLETTNMSII QHSSPKQGSG EILNDTLEGV HSVDGDPITD SGSGAGAFLD
360 370 380 390 400
IAEEKNLAAT AAGLAEVPIS TAGEAEASSV PTGGPTLSMS TENPEEGVTP
410 420 430 440 450
GPDNEERLAA TAAGEAEALA SMPGEVEASG VAPGELDLSM SAQSLGEEAT
460 470 480 490 500
VGPSSEDSLT TAAAATEVSL STFEDEEASG VPTDGLAPLT ATMAPERAVT
510 520 530 540 550
SGPGDEEDLA AATTEEPLIT AGGEESGSPP PDGPPLPLPT VAPERWITPA
560 570 580 590 600
QREHVGMKGQ AGPKGEKGDA GEELPGPPEP SGPVGPTAGA EAEGSGLGWG
610 620 630 640 650
SDVGSGSGDL VGSEQLLRGP PGPPGPPGLP GIPGKPGTDV FMGPPGSPGE
660 670 680 690 700
DGPAGEPGPP GPEGQPGVDG ATGLPGMKGE KGARGPNGSV GEKGDPGNRG
710 720 730 740 750
LPGPPGKKGQ AGPPGVMGPP GPPGPPGPPG PGCTMGLGFE DTEGSGSTQL
760 770 780 790 800
LNEPKLSRPT AAIGLKGEKG DRGPKGERGM DGASIVGPPG PRGPPGHIKV
810 820 830 840 850
LSNSLINITH GFMNFSDIPE LVGPPGPDGL PGLPGFPGPR GPKGDTGLPG
860 870 880 890 900
FPGLKGEQGE KGEPGAILTE DIPLERLMGK KGEPGMHGAP GPMGPKGPPG
910 920 930 940 950
HKGEFGLPGR PGRPGLNGLK GTKGDPGVIM QGPPGLPGPP GPPGPPGAVI
960 970 980 990 1000
NIKGAIFPIP VRPHCKMPVD TAHPGSPELI TFHGVKGEKG SWGLPGSKGE
1010 1020 1030 1040 1050
KGDQGAQGPP GPPLDLAYLR HFLNNLKGEN GDKGFKGEKG EKGDINGSFL
1060 1070 1080 1090 1100
MSGPPGLPGN PGPAGQKGET VVGPQGPPGA PGLPGPPGFG RPGDPGPPGP
1110 1120 1130 1140 1150
PGPPGPPAIL GAAVALPGPP GPPGQPGLPG SRNLVTAFSN MDDMLQKAHL
1160 1170 1180 1190 1200
VIEGTFIYLR DSTEFFIRVR DGWKKLQLGE LIPIPADSPP PPALSSNPHQ
1210 1220 1230 1240 1250
LLPPPNPISS ANYEKPALHL AALNMPFSGD IRADFQCFKQ ARAAGLLSTY
1260 1270 1280 1290 1300
RAFLSSHLQD LSTIVRKAER YSLPIVNLKG QVLFNNWDSI FSGHGGQFNM
1310 1320 1330 1340 1350
HIPIYSFDGR DIMTDPSWPQ KVIWHGSSPH GVRLVDNYCE AWRTADTAVT
1360 1370 1380
GLASPLSTGK ILDQKAYSCA NRLIVLCIEN SFMTDARK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 | C → S in BAA04762 (PubMed:8307960).Curated | 1 | |
Sequence conflicti | 49 | V → D in AAA58429 (PubMed:8106446).Curated | 1 | |
Sequence conflicti | 94 – 95 | SV → RA in AAA58429 (PubMed:8106446).Curated | 2 | |
Sequence conflicti | 94 – 95 | SV → RA in BAA04762 (PubMed:8307960).Curated | 2 | |
Sequence conflicti | 150 | A → P in AAA58429 (PubMed:8106446).Curated | 1 | |
Sequence conflicti | 409 | A → R in AAA58429 (PubMed:8106446).Curated | 1 | |
Sequence conflicti | 409 | A → R in AAC78500 (PubMed:9651385).Curated | 1 | |
Sequence conflicti | 1134 | L → LLGELIPIPADSPPPPALSS N in AAC78500 (PubMed:9651385).Curated | 1 | |
Sequence conflicti | 1178 – 1197 | Missing in AAC78500 (PubMed:9651385).CuratedAdd BLAST | 20 | |
Sequence conflicti | 1227 | F → V in AAC78500 (PubMed:9651385).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033787 | 163 | R → H. Corresponds to variant dbSNP:rs2075662Ensembl. | 1 | |
Natural variantiVAR_033788 | 204 | M → V1 PublicationCorresponds to variant dbSNP:rs2075663Ensembl. | 1 | |
Natural variantiVAR_033789 | 391 | T → M. Corresponds to variant dbSNP:rs10988532Ensembl. | 1 | |
Natural variantiVAR_033790 | 442 | A → T. Corresponds to variant dbSNP:rs16918128Ensembl. | 1 | |
Natural variantiVAR_033791 | 446 | G → R. Corresponds to variant dbSNP:rs35934703Ensembl. | 1 | |
Natural variantiVAR_048776 | 504 | G → V. Corresponds to variant dbSNP:rs2297603Ensembl. | 1 | |
Natural variantiVAR_033792 | 506 | E → D. Corresponds to variant dbSNP:rs35250850Ensembl. | 1 | |
Natural variantiVAR_033793 | 531 | P → R. Corresponds to variant dbSNP:rs35529307Ensembl. | 1 | |
Natural variantiVAR_061114 | 705 | P → L. Corresponds to variant dbSNP:rs41308900Ensembl. | 1 | |
Natural variantiVAR_033794 | 989 | K → R. Corresponds to variant dbSNP:rs35642150Ensembl. | 1 | |
Natural variantiVAR_033795 | 1001 | K → R. Corresponds to variant dbSNP:rs35544077Ensembl. | 1 | |
Natural variantiVAR_033796 | 1332 | V → I. Corresponds to variant dbSNP:rs10519Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L25286 mRNA Translation: AAA58429.1 L25280 AF052975 Genomic DNA Translation: AAC78500.1 AL136084 Genomic DNA No translation available. AL354923 Genomic DNA No translation available. D21230 mRNA Translation: BAA04762.1 L01697 mRNA No translation available. |
CCDSi | CCDS35081.1 |
PIRi | A53317 |
RefSeqi | NP_001846.3, NM_001855.4 XP_011516516.1, XM_011518214.2 |
UniGenei | Hs.409034 |
Genome annotation databases
Ensembli | ENST00000375001; ENSP00000364140; ENSG00000204291 |
GeneIDi | 1306 |
KEGGi | hsa:1306 |
UCSCi | uc004azb.3 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | COFA1_HUMAN | |
Accessioni | P39059Primary (citable) accession number: P39059 Secondary accession number(s): Q5T6J4, Q9UDC5, Q9Y4W4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | July 5, 2005 | |
Last modified: | April 25, 2018 | |
This is version 162 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |