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P39055

- DYN1_CAEEL

UniProt

P39055 - DYN1_CAEEL

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Protein
Dynamin
Gene
dyn-1, C02C6.1
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.

Catalytic activityi

GTP + H2O = GDP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 478GTP By similarity
Nucleotide bindingi138 – 1425GTP By similarity
Nucleotide bindingi207 – 2104GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: WormBase
  3. protein binding Source: IntAct

GO - Biological processi

  1. GTP catabolic process Source: GOC
  2. embryo development Source: WormBase
  3. embryo development ending in birth or egg hatching Source: WormBase
  4. endocytosis Source: WormBase
  5. locomotion Source: WormBase
  6. phagosome maturation involved in apoptotic cell clearance Source: WormBase
  7. positive regulation of necrotic cell death Source: WormBase
  8. receptor-mediated endocytosis Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Motor protein

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dynamin (EC:3.6.5.5)
Gene namesi
Name:dyn-1
ORF Names:C02C6.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiC02C6.1a; CE07833; WBGene00001130; dyn-1.
C02C6.1b; CE07832; WBGene00001130; dyn-1.

Subcellular locationi

Cytoplasm. Cytoplasmcytoskeleton
Note: Microtubule-associated.

GO - Cellular componenti

  1. apical part of cell Source: WormBase
  2. axon Source: WormBase
  3. cleavage furrow Source: WormBase
  4. cytoplasmic vesicle Source: WormBase
  5. midbody Source: WormBase
  6. phagocytic cup Source: WormBase
  7. phagocytic vesicle Source: WormBase
  8. pseudopodium Source: WormBase
  9. spindle microtubule Source: WormBase
  10. synapse Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 830830Dynamin
PRO_0000206575Add
BLAST

Proteomic databases

PaxDbiP39055.
PRIDEiP39055.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
B0303.7P342584EBI-317945,EBI-322705
gei-18Q7K7J03EBI-317945,EBI-2315822
lst-4Q8I4E24EBI-317945,EBI-4325777
Y37A1B.17G5ECK44EBI-317945,EBI-6533538

Protein-protein interaction databases

BioGridi46538. 4 interactions.
IntActiP39055. 21 interactions.
MINTiMINT-230275.

Structurei

3D structure databases

ProteinModelPortaliP39055.
SMRiP39055. Positions 8-740.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 296267Dynamin-type G
Add
BLAST
Domaini519 – 624106PH
Add
BLAST
Domaini653 – 74492GED
Add
BLAST

Sequence similaritiesi

Contains 1 GED domain.
Contains 1 PH domain.

Phylogenomic databases

eggNOGiCOG0699.
GeneTreeiENSGT00740000115284.
HOGENOMiHOG000161069.
InParanoidiP39055.
KOiK01528.
OMAiSKLGSYP.
OrthoDBiEOG76MK7N.
PhylomeDBiP39055.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR027744. Dynamin.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR003130. GED.
IPR020850. GTPase_effector_domain_GED.
IPR027417. P-loop_NTPase.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF49. PTHR11566:SF49. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: P39055-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSWQNQGMQA LIPVINRVQD AFSQLGTSVS FELPQIAVVG GQSAGKSSVL    50
ENFVGKDFLP RGSGIVTRRP LILQLIQDRN EYAEFLHKKG HRFVDFDAVR 100
KEIEDETDRV TGQNKGISPH PINLRVFSPN VLNLTLIDLP GLTKVPVGDQ 150
PADIEQQIRD MILTFINRET CLILAVTPAN SDLATSDALK LAKEVDPQGL 200
RTIGVLTKLD LMDEGTDARE ILENKLFTLR RGYVGVVNRG QKDIVGRKDI 250
RAALDAERKF FISHPSYRHM ADRLGTSYLQ HTLNQQLTNH IRDTLPTLRD 300
SLQKKMFAME KDVAEYKNYQ PNDPGRKTKA LLQMVTQFNA DIERSIEGSS 350
AKLVSTNELS GGARINRLFH ERFPFEIVKM EIDEKEMRKE IQYAIRNIHG 400
IRVGLFTPDM AFEAIAKKQI TRLKEPSLKC VDLVVNELAN VIRQCADTMA 450
RYPRLRDELE RIVVSHMRER EQIAKQQIGL IVDYELAYMN TNHEDFIGFS 500
NAEAKASQGQ SAKKNLGNQV IRKGWLSLSN VSFVRGSKDN WFVLMSDSLS 550
WYKDDEEKEK KYMLPLDGVK LKDIEGGFMS RNHKFALFYP DGKNIYKDYK 600
QLELGCTNLD EIDAWKASFL RAGVYPEKQK AQEDESQQEM EDTSIDPQLE 650
RQVETIRNLV DSYMRIITKT IKDLVPKAVM HLIVNQTGEF MKDELLAHLY 700
QCGDTDALME ESQIEAQKRE EMLRMYHACK EALRIISEVN MSTLGDQPPP 750
LPMSDYRPHP SGPSPVPRPA PAPPGGRQAP MPPRGGPGAP PPPGMRPPPG 800
APGGGGGMYP PLIPTRPGPG GPPPNMAPPR 830
Length:830
Mass (Da):93,407
Last modified:May 27, 2002 - v3
Checksum:iFF681250E51AB8A5
GO
Isoform b (identifier: P39055-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     817-830: PGPGGPPPNMAPPR → VPTPSNGAPEIPARPQVPKRPF

Note: No experimental confirmation available.

Show »
Length:838
Mass (Da):94,421
Checksum:i78F89B6EA555B689
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei817 – 83014PGPGG…MAPPR → VPTPSNGAPEIPARPQVPKR PF in isoform b.
VSP_001329Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti734 – 7341R → P in AAB72228. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L29031 mRNA. Translation: AAB72228.2.
Z79596 Genomic DNA. Translation: CAB01857.1.
Z79596 Genomic DNA. Translation: CAC42251.1.
PIRiT18860.
RefSeqiNP_001024331.1. NM_001029160.2. [P39055-1]
NP_001024332.1. NM_001029161.2. [P39055-2]
UniGeneiCel.19561.

Genome annotation databases

EnsemblMetazoaiC02C6.1a; C02C6.1a; WBGene00001130. [P39055-1]
GeneIDi181644.
KEGGicel:CELE_C02C6.1.
UCSCiC02C6.1b. c. elegans. [P39055-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L29031 mRNA. Translation: AAB72228.2 .
Z79596 Genomic DNA. Translation: CAB01857.1 .
Z79596 Genomic DNA. Translation: CAC42251.1 .
PIRi T18860.
RefSeqi NP_001024331.1. NM_001029160.2. [P39055-1 ]
NP_001024332.1. NM_001029161.2. [P39055-2 ]
UniGenei Cel.19561.

3D structure databases

ProteinModelPortali P39055.
SMRi P39055. Positions 8-740.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 46538. 4 interactions.
IntActi P39055. 21 interactions.
MINTi MINT-230275.

Proteomic databases

PaxDbi P39055.
PRIDEi P39055.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C02C6.1a ; C02C6.1a ; WBGene00001130 . [P39055-1 ]
GeneIDi 181644.
KEGGi cel:CELE_C02C6.1.
UCSCi C02C6.1b. c. elegans. [P39055-1 ]

Organism-specific databases

CTDi 181644.
WormBasei C02C6.1a ; CE07833 ; WBGene00001130 ; dyn-1.
C02C6.1b ; CE07832 ; WBGene00001130 ; dyn-1.

Phylogenomic databases

eggNOGi COG0699.
GeneTreei ENSGT00740000115284.
HOGENOMi HOG000161069.
InParanoidi P39055.
KOi K01528.
OMAi SKLGSYP.
OrthoDBi EOG76MK7N.
PhylomeDBi P39055.

Miscellaneous databases

NextBioi 914798.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR027744. Dynamin.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR003130. GED.
IPR020850. GTPase_effector_domain_GED.
IPR027417. P-loop_NTPase.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
PANTHERi PTHR11566. PTHR11566. 1 hit.
PTHR11566:SF49. PTHR11566:SF49. 1 hit.
Pfami PF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view ]
PRINTSi PR00195. DYNAMIN.
SMARTi SM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
SM00233. PH. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A dynamin GTPase mutation causes a rapid and reversible temperature-inducible locomotion defect in C. elegans."
    Clark S.G., Shurland D.L., Meyerowitz E.M., Bargmann C.I., van der Bliek A.M.
    Proc. Natl. Acad. Sci. U.S.A. 94:10438-10443(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    Strain: Bristol N2.
  2. van der Bliek A.M.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO C-TERMINUS.
  3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS A AND B).
    Strain: Bristol N2.

Entry informationi

Entry nameiDYN1_CAEEL
AccessioniPrimary (citable) accession number: P39055
Secondary accession number(s): Q93176, Q95QY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 27, 2002
Last modified: September 3, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi