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Protein

Dynamin

Gene

dyn-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.

Catalytic activityi

GTP + H2O = GDP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 478GTPBy similarity
Nucleotide bindingi138 – 1425GTPBy similarity
Nucleotide bindingi207 – 2104GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: WormBase
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • embryo development ending in birth or egg hatching Source: WormBase
  • endocytosis Source: WormBase
  • locomotion Source: WormBase
  • metabolic process Source: GOC
  • phagosome maturation involved in apoptotic cell clearance Source: WormBase
  • positive regulation of necrotic cell death Source: WormBase
  • receptor-mediated endocytosis Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Motor protein

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.5.5. 1045.
ReactomeiREACT_295497. Recycling pathway of L1.
REACT_299641. Lysosome Vesicle Biogenesis.
REACT_327280. Golgi Associated Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynamin (EC:3.6.5.5)
Gene namesi
Name:dyn-1
ORF Names:C02C6.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC02C6.1a; CE07833; WBGene00001130; dyn-1.
C02C6.1b; CE07832; WBGene00001130; dyn-1.

Subcellular locationi

GO - Cellular componenti

  • apical part of cell Source: WormBase
  • axon Source: WormBase
  • cleavage furrow Source: WormBase
  • cytoplasmic vesicle Source: WormBase
  • midbody Source: WormBase
  • periciliary membrane compartment Source: WormBase
  • phagocytic cup Source: WormBase
  • phagocytic vesicle Source: WormBase
  • presynaptic active zone Source: WormBase
  • pseudopodium Source: WormBase
  • spindle microtubule Source: WormBase
  • synapse Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 830830DynaminPRO_0000206575Add
BLAST

Proteomic databases

PaxDbiP39055.
PRIDEiP39055.

Expressioni

Gene expression databases

ExpressionAtlasiP39055. baseline and differential.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
B0303.7P342584EBI-317945,EBI-322705
gei-18Q7K7J03EBI-317945,EBI-2315822
lst-4Q8I4E24EBI-317945,EBI-4325777
Y37A1B.17G5ECK44EBI-317945,EBI-6533538

Protein-protein interaction databases

BioGridi46538. 4 interactions.
IntActiP39055. 21 interactions.
MINTiMINT-230275.
STRINGi6239.C02C6.1b.

Structurei

3D structure databases

ProteinModelPortaliP39055.
SMRiP39055. Positions 8-740.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 296267Dynamin-type GAdd
BLAST
Domaini519 – 624106PHPROSITE-ProRule annotationAdd
BLAST
Domaini653 – 74492GEDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GED domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0699.
GeneTreeiENSGT00760000119213.
HOGENOMiHOG000161069.
InParanoidiP39055.
KOiK01528.
OMAiFTAIGQN.
OrthoDBiEOG76MK7N.
PhylomeDBiP39055.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR027744. Dynamin.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GTPase_effector_domain_GED.
IPR027417. P-loop_NTPase.
IPR011993. PH-like_dom.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF49. PTHR11566:SF49. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: P39055-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSWQNQGMQA LIPVINRVQD AFSQLGTSVS FELPQIAVVG GQSAGKSSVL
60 70 80 90 100
ENFVGKDFLP RGSGIVTRRP LILQLIQDRN EYAEFLHKKG HRFVDFDAVR
110 120 130 140 150
KEIEDETDRV TGQNKGISPH PINLRVFSPN VLNLTLIDLP GLTKVPVGDQ
160 170 180 190 200
PADIEQQIRD MILTFINRET CLILAVTPAN SDLATSDALK LAKEVDPQGL
210 220 230 240 250
RTIGVLTKLD LMDEGTDARE ILENKLFTLR RGYVGVVNRG QKDIVGRKDI
260 270 280 290 300
RAALDAERKF FISHPSYRHM ADRLGTSYLQ HTLNQQLTNH IRDTLPTLRD
310 320 330 340 350
SLQKKMFAME KDVAEYKNYQ PNDPGRKTKA LLQMVTQFNA DIERSIEGSS
360 370 380 390 400
AKLVSTNELS GGARINRLFH ERFPFEIVKM EIDEKEMRKE IQYAIRNIHG
410 420 430 440 450
IRVGLFTPDM AFEAIAKKQI TRLKEPSLKC VDLVVNELAN VIRQCADTMA
460 470 480 490 500
RYPRLRDELE RIVVSHMRER EQIAKQQIGL IVDYELAYMN TNHEDFIGFS
510 520 530 540 550
NAEAKASQGQ SAKKNLGNQV IRKGWLSLSN VSFVRGSKDN WFVLMSDSLS
560 570 580 590 600
WYKDDEEKEK KYMLPLDGVK LKDIEGGFMS RNHKFALFYP DGKNIYKDYK
610 620 630 640 650
QLELGCTNLD EIDAWKASFL RAGVYPEKQK AQEDESQQEM EDTSIDPQLE
660 670 680 690 700
RQVETIRNLV DSYMRIITKT IKDLVPKAVM HLIVNQTGEF MKDELLAHLY
710 720 730 740 750
QCGDTDALME ESQIEAQKRE EMLRMYHACK EALRIISEVN MSTLGDQPPP
760 770 780 790 800
LPMSDYRPHP SGPSPVPRPA PAPPGGRQAP MPPRGGPGAP PPPGMRPPPG
810 820 830
APGGGGGMYP PLIPTRPGPG GPPPNMAPPR
Length:830
Mass (Da):93,407
Last modified:May 27, 2002 - v3
Checksum:iFF681250E51AB8A5
GO
Isoform b (identifier: P39055-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     817-830: PGPGGPPPNMAPPR → VPTPSNGAPEIPARPQVPKRPF

Note: No experimental confirmation available.
Show »
Length:838
Mass (Da):94,421
Checksum:i78F89B6EA555B689
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti734 – 7341R → P in AAB72228 (PubMed:9294229).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei817 – 83014PGPGG…MAPPR → VPTPSNGAPEIPARPQVPKR PF in isoform b. CuratedVSP_001329Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29031 mRNA. Translation: AAB72228.2.
Z79596 Genomic DNA. Translation: CAB01857.1.
Z79596 Genomic DNA. Translation: CAC42251.1.
PIRiT18860.
RefSeqiNP_001024331.1. NM_001029160.2. [P39055-1]
NP_001024332.1. NM_001029161.2. [P39055-2]
UniGeneiCel.19561.

Genome annotation databases

EnsemblMetazoaiC02C6.1a; C02C6.1a; WBGene00001130. [P39055-1]
GeneIDi181644.
KEGGicel:CELE_C02C6.1.
UCSCiC02C6.1b. c. elegans. [P39055-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29031 mRNA. Translation: AAB72228.2.
Z79596 Genomic DNA. Translation: CAB01857.1.
Z79596 Genomic DNA. Translation: CAC42251.1.
PIRiT18860.
RefSeqiNP_001024331.1. NM_001029160.2. [P39055-1]
NP_001024332.1. NM_001029161.2. [P39055-2]
UniGeneiCel.19561.

3D structure databases

ProteinModelPortaliP39055.
SMRiP39055. Positions 8-740.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi46538. 4 interactions.
IntActiP39055. 21 interactions.
MINTiMINT-230275.
STRINGi6239.C02C6.1b.

Proteomic databases

PaxDbiP39055.
PRIDEiP39055.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC02C6.1a; C02C6.1a; WBGene00001130. [P39055-1]
GeneIDi181644.
KEGGicel:CELE_C02C6.1.
UCSCiC02C6.1b. c. elegans. [P39055-1]

Organism-specific databases

CTDi181644.
WormBaseiC02C6.1a; CE07833; WBGene00001130; dyn-1.
C02C6.1b; CE07832; WBGene00001130; dyn-1.

Phylogenomic databases

eggNOGiCOG0699.
GeneTreeiENSGT00760000119213.
HOGENOMiHOG000161069.
InParanoidiP39055.
KOiK01528.
OMAiFTAIGQN.
OrthoDBiEOG76MK7N.
PhylomeDBiP39055.

Enzyme and pathway databases

BRENDAi3.6.5.5. 1045.
ReactomeiREACT_295497. Recycling pathway of L1.
REACT_299641. Lysosome Vesicle Biogenesis.
REACT_327280. Golgi Associated Vesicle Biogenesis.

Miscellaneous databases

NextBioi914798.
PROiP39055.

Gene expression databases

ExpressionAtlasiP39055. baseline and differential.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR027744. Dynamin.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GTPase_effector_domain_GED.
IPR027417. P-loop_NTPase.
IPR011993. PH-like_dom.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF49. PTHR11566:SF49. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A dynamin GTPase mutation causes a rapid and reversible temperature-inducible locomotion defect in C. elegans."
    Clark S.G., Shurland D.L., Meyerowitz E.M., Bargmann C.I., van der Bliek A.M.
    Proc. Natl. Acad. Sci. U.S.A. 94:10438-10443(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    Strain: Bristol N2.
  2. van der Bliek A.M.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO C-TERMINUS.
  3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS A AND B).
    Strain: Bristol N2.

Entry informationi

Entry nameiDYN1_CAEEL
AccessioniPrimary (citable) accession number: P39055
Secondary accession number(s): Q93176, Q95QY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 27, 2002
Last modified: July 22, 2015
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.