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P39055

- DYN1_CAEEL

UniProt

P39055 - DYN1_CAEEL

Protein

Dynamin

Gene

dyn-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 3 (27 May 2002)
      Previous versions | rss
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    Functioni

    Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.

    Catalytic activityi

    GTP + H2O = GDP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi40 – 478GTPBy similarity
    Nucleotide bindingi138 – 1425GTPBy similarity
    Nucleotide bindingi207 – 2104GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: WormBase
    2. GTP binding Source: UniProtKB-KW
    3. protein binding Source: IntAct

    GO - Biological processi

    1. embryo development Source: WormBase
    2. embryo development ending in birth or egg hatching Source: WormBase
    3. endocytosis Source: WormBase
    4. GTP catabolic process Source: GOC
    5. locomotion Source: WormBase
    6. phagosome maturation involved in apoptotic cell clearance Source: WormBase
    7. positive regulation of necrotic cell death Source: WormBase
    8. receptor-mediated endocytosis Source: WormBase

    Keywords - Molecular functioni

    Hydrolase, Motor protein

    Keywords - Biological processi

    Endocytosis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dynamin (EC:3.6.5.5)
    Gene namesi
    Name:dyn-1
    ORF Names:C02C6.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiC02C6.1a; CE07833; WBGene00001130; dyn-1.
    C02C6.1b; CE07832; WBGene00001130; dyn-1.

    Subcellular locationi

    Cytoplasm. Cytoplasmcytoskeleton
    Note: Microtubule-associated.

    GO - Cellular componenti

    1. apical part of cell Source: WormBase
    2. axon Source: WormBase
    3. cleavage furrow Source: WormBase
    4. cytoplasmic vesicle Source: WormBase
    5. midbody Source: WormBase
    6. phagocytic cup Source: WormBase
    7. phagocytic vesicle Source: WormBase
    8. pseudopodium Source: WormBase
    9. spindle microtubule Source: WormBase
    10. synapse Source: WormBase

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 830830DynaminPRO_0000206575Add
    BLAST

    Proteomic databases

    PaxDbiP39055.
    PRIDEiP39055.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    B0303.7P342584EBI-317945,EBI-322705
    gei-18Q7K7J03EBI-317945,EBI-2315822
    lst-4Q8I4E24EBI-317945,EBI-4325777
    Y37A1B.17G5ECK44EBI-317945,EBI-6533538

    Protein-protein interaction databases

    BioGridi46538. 4 interactions.
    IntActiP39055. 21 interactions.
    MINTiMINT-230275.

    Structurei

    3D structure databases

    ProteinModelPortaliP39055.
    SMRiP39055. Positions 8-740.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 296267Dynamin-type GAdd
    BLAST
    Domaini519 – 624106PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini653 – 74492GEDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GED domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0699.
    GeneTreeiENSGT00740000115284.
    HOGENOMiHOG000161069.
    InParanoidiP39055.
    KOiK01528.
    OMAiSKLGSYP.
    OrthoDBiEOG76MK7N.
    PhylomeDBiP39055.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR027744. Dynamin.
    IPR000375. Dynamin_central.
    IPR001401. Dynamin_GTPase.
    IPR019762. Dynamin_GTPase_CS.
    IPR022812. Dynamin_SF.
    IPR003130. GED.
    IPR020850. GTPase_effector_domain_GED.
    IPR027417. P-loop_NTPase.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PANTHERiPTHR11566. PTHR11566. 1 hit.
    PTHR11566:SF49. PTHR11566:SF49. 1 hit.
    PfamiPF01031. Dynamin_M. 1 hit.
    PF00350. Dynamin_N. 1 hit.
    PF02212. GED. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view]
    PRINTSiPR00195. DYNAMIN.
    SMARTiSM00053. DYNc. 1 hit.
    SM00302. GED. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
    PS51718. G_DYNAMIN_2. 1 hit.
    PS51388. GED. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: P39055-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSWQNQGMQA LIPVINRVQD AFSQLGTSVS FELPQIAVVG GQSAGKSSVL    50
    ENFVGKDFLP RGSGIVTRRP LILQLIQDRN EYAEFLHKKG HRFVDFDAVR 100
    KEIEDETDRV TGQNKGISPH PINLRVFSPN VLNLTLIDLP GLTKVPVGDQ 150
    PADIEQQIRD MILTFINRET CLILAVTPAN SDLATSDALK LAKEVDPQGL 200
    RTIGVLTKLD LMDEGTDARE ILENKLFTLR RGYVGVVNRG QKDIVGRKDI 250
    RAALDAERKF FISHPSYRHM ADRLGTSYLQ HTLNQQLTNH IRDTLPTLRD 300
    SLQKKMFAME KDVAEYKNYQ PNDPGRKTKA LLQMVTQFNA DIERSIEGSS 350
    AKLVSTNELS GGARINRLFH ERFPFEIVKM EIDEKEMRKE IQYAIRNIHG 400
    IRVGLFTPDM AFEAIAKKQI TRLKEPSLKC VDLVVNELAN VIRQCADTMA 450
    RYPRLRDELE RIVVSHMRER EQIAKQQIGL IVDYELAYMN TNHEDFIGFS 500
    NAEAKASQGQ SAKKNLGNQV IRKGWLSLSN VSFVRGSKDN WFVLMSDSLS 550
    WYKDDEEKEK KYMLPLDGVK LKDIEGGFMS RNHKFALFYP DGKNIYKDYK 600
    QLELGCTNLD EIDAWKASFL RAGVYPEKQK AQEDESQQEM EDTSIDPQLE 650
    RQVETIRNLV DSYMRIITKT IKDLVPKAVM HLIVNQTGEF MKDELLAHLY 700
    QCGDTDALME ESQIEAQKRE EMLRMYHACK EALRIISEVN MSTLGDQPPP 750
    LPMSDYRPHP SGPSPVPRPA PAPPGGRQAP MPPRGGPGAP PPPGMRPPPG 800
    APGGGGGMYP PLIPTRPGPG GPPPNMAPPR 830
    Length:830
    Mass (Da):93,407
    Last modified:May 27, 2002 - v3
    Checksum:iFF681250E51AB8A5
    GO
    Isoform b (identifier: P39055-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         817-830: PGPGGPPPNMAPPR → VPTPSNGAPEIPARPQVPKRPF

    Note: No experimental confirmation available.

    Show »
    Length:838
    Mass (Da):94,421
    Checksum:i78F89B6EA555B689
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti734 – 7341R → P in AAB72228. (PubMed:9294229)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei817 – 83014PGPGG…MAPPR → VPTPSNGAPEIPARPQVPKR PF in isoform b. CuratedVSP_001329Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L29031 mRNA. Translation: AAB72228.2.
    Z79596 Genomic DNA. Translation: CAB01857.1.
    Z79596 Genomic DNA. Translation: CAC42251.1.
    PIRiT18860.
    RefSeqiNP_001024331.1. NM_001029160.2. [P39055-1]
    NP_001024332.1. NM_001029161.2. [P39055-2]
    UniGeneiCel.19561.

    Genome annotation databases

    EnsemblMetazoaiC02C6.1a; C02C6.1a; WBGene00001130. [P39055-1]
    GeneIDi181644.
    KEGGicel:CELE_C02C6.1.
    UCSCiC02C6.1b. c. elegans. [P39055-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L29031 mRNA. Translation: AAB72228.2 .
    Z79596 Genomic DNA. Translation: CAB01857.1 .
    Z79596 Genomic DNA. Translation: CAC42251.1 .
    PIRi T18860.
    RefSeqi NP_001024331.1. NM_001029160.2. [P39055-1 ]
    NP_001024332.1. NM_001029161.2. [P39055-2 ]
    UniGenei Cel.19561.

    3D structure databases

    ProteinModelPortali P39055.
    SMRi P39055. Positions 8-740.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 46538. 4 interactions.
    IntActi P39055. 21 interactions.
    MINTi MINT-230275.

    Proteomic databases

    PaxDbi P39055.
    PRIDEi P39055.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C02C6.1a ; C02C6.1a ; WBGene00001130 . [P39055-1 ]
    GeneIDi 181644.
    KEGGi cel:CELE_C02C6.1.
    UCSCi C02C6.1b. c. elegans. [P39055-1 ]

    Organism-specific databases

    CTDi 181644.
    WormBasei C02C6.1a ; CE07833 ; WBGene00001130 ; dyn-1.
    C02C6.1b ; CE07832 ; WBGene00001130 ; dyn-1.

    Phylogenomic databases

    eggNOGi COG0699.
    GeneTreei ENSGT00740000115284.
    HOGENOMi HOG000161069.
    InParanoidi P39055.
    KOi K01528.
    OMAi SKLGSYP.
    OrthoDBi EOG76MK7N.
    PhylomeDBi P39055.

    Miscellaneous databases

    NextBioi 914798.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR027744. Dynamin.
    IPR000375. Dynamin_central.
    IPR001401. Dynamin_GTPase.
    IPR019762. Dynamin_GTPase_CS.
    IPR022812. Dynamin_SF.
    IPR003130. GED.
    IPR020850. GTPase_effector_domain_GED.
    IPR027417. P-loop_NTPase.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    PANTHERi PTHR11566. PTHR11566. 1 hit.
    PTHR11566:SF49. PTHR11566:SF49. 1 hit.
    Pfami PF01031. Dynamin_M. 1 hit.
    PF00350. Dynamin_N. 1 hit.
    PF02212. GED. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view ]
    PRINTSi PR00195. DYNAMIN.
    SMARTi SM00053. DYNc. 1 hit.
    SM00302. GED. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00410. G_DYNAMIN_1. 1 hit.
    PS51718. G_DYNAMIN_2. 1 hit.
    PS51388. GED. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A dynamin GTPase mutation causes a rapid and reversible temperature-inducible locomotion defect in C. elegans."
      Clark S.G., Shurland D.L., Meyerowitz E.M., Bargmann C.I., van der Bliek A.M.
      Proc. Natl. Acad. Sci. U.S.A. 94:10438-10443(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
      Strain: Bristol N2.
    2. van der Bliek A.M.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO C-TERMINUS.
    3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS A AND B).
      Strain: Bristol N2.

    Entry informationi

    Entry nameiDYN1_CAEEL
    AccessioniPrimary (citable) accession number: P39055
    Secondary accession number(s): Q93176, Q95QY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: May 27, 2002
    Last modified: October 1, 2014
    This is version 126 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3