Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P39055 (DYN1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dynamin

EC=3.6.5.5
Gene names
Name:dyn-1
ORF Names:C02C6.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length830 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.

Catalytic activity

GTP + H2O = GDP + phosphate.

Subcellular location

Cytoplasm. Cytoplasmcytoskeleton. Note: Microtubule-associated.

Sequence similarities

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

Contains 1 dynamin-type G (guanine nucleotide-binding) domain.

Contains 1 GED domain.

Contains 1 PH domain.

Ontologies

Keywords
   Biological processEndocytosis
   Cellular componentCytoplasm
Cytoskeleton
Microtubule
   Coding sequence diversityAlternative splicing
   LigandGTP-binding
Nucleotide-binding
   Molecular functionHydrolase
Motor protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processGTP catabolic process

Inferred from direct assay PubMed 20016007. Source: GOC

embryo development

Inferred from mutant phenotype PubMed 11483962. Source: WormBase

embryo development ending in birth or egg hatching

Inferred from mutant phenotype PubMed 10588660. Source: WormBase

endocytosis

Inferred from mutant phenotype PubMed 11560892Ref.1. Source: WormBase

locomotion

Inferred from mutant phenotype Ref.1. Source: WormBase

phagosome maturation involved in apoptotic cell clearance

Inferred from mutant phenotype PubMed 21494661. Source: WormBase

positive regulation of necrotic cell death

Inferred from genetic interaction PubMed 22157748. Source: WormBase

receptor-mediated endocytosis

Inferred from mutant phenotype PubMed 10588660. Source: WormBase

   Cellular_componentapical part of cell

Inferred from direct assay PubMed 20016007PubMed 9802908. Source: WormBase

axon

Inferred from direct assay PubMed 9802908. Source: WormBase

cleavage furrow

Inferred from direct assay PubMed 12498685. Source: WormBase

cytoplasmic vesicle

Inferred from direct assay PubMed 12498685. Source: WormBase

midbody

Inferred from direct assay PubMed 12498685. Source: WormBase

phagocytic cup

Inferred from direct assay PubMed 18425118. Source: WormBase

phagocytic vesicle

Inferred from direct assay PubMed 16740477PubMed 18425118. Source: WormBase

pseudopodium

Inferred from direct assay PubMed 16740477. Source: WormBase

spindle microtubule

Inferred from direct assay PubMed 12498685. Source: WormBase

synapse

Inferred from direct assay PubMed 11483962PubMed 9802908. Source: WormBase

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from direct assay PubMed 20016007. Source: WormBase

protein binding

Inferred from physical interaction PubMed 19123269PubMed 19447967PubMed 21148288PubMed 23549480. Source: IntAct

Complete GO annotation...

Binary interactions

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform a (identifier: P39055-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform b (identifier: P39055-2)

The sequence of this isoform differs from the canonical sequence as follows:
     817-830: PGPGGPPPNMAPPR → VPTPSNGAPEIPARPQVPKRPF
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 830830Dynamin
PRO_0000206575

Regions

Domain30 – 296267Dynamin-type G
Domain519 – 624106PH
Domain653 – 74492GED
Nucleotide binding40 – 478GTP By similarity
Nucleotide binding138 – 1425GTP By similarity
Nucleotide binding207 – 2104GTP By similarity

Natural variations

Alternative sequence817 – 83014PGPGG…MAPPR → VPTPSNGAPEIPARPQVPKR PF in isoform b.
VSP_001329

Experimental info

Sequence conflict7341R → P in AAB72228. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform a [UniParc].

Last modified May 27, 2002. Version 3.
Checksum: FF681250E51AB8A5

FASTA83093,407
        10         20         30         40         50         60 
MSWQNQGMQA LIPVINRVQD AFSQLGTSVS FELPQIAVVG GQSAGKSSVL ENFVGKDFLP 

        70         80         90        100        110        120 
RGSGIVTRRP LILQLIQDRN EYAEFLHKKG HRFVDFDAVR KEIEDETDRV TGQNKGISPH 

       130        140        150        160        170        180 
PINLRVFSPN VLNLTLIDLP GLTKVPVGDQ PADIEQQIRD MILTFINRET CLILAVTPAN 

       190        200        210        220        230        240 
SDLATSDALK LAKEVDPQGL RTIGVLTKLD LMDEGTDARE ILENKLFTLR RGYVGVVNRG 

       250        260        270        280        290        300 
QKDIVGRKDI RAALDAERKF FISHPSYRHM ADRLGTSYLQ HTLNQQLTNH IRDTLPTLRD 

       310        320        330        340        350        360 
SLQKKMFAME KDVAEYKNYQ PNDPGRKTKA LLQMVTQFNA DIERSIEGSS AKLVSTNELS 

       370        380        390        400        410        420 
GGARINRLFH ERFPFEIVKM EIDEKEMRKE IQYAIRNIHG IRVGLFTPDM AFEAIAKKQI 

       430        440        450        460        470        480 
TRLKEPSLKC VDLVVNELAN VIRQCADTMA RYPRLRDELE RIVVSHMRER EQIAKQQIGL 

       490        500        510        520        530        540 
IVDYELAYMN TNHEDFIGFS NAEAKASQGQ SAKKNLGNQV IRKGWLSLSN VSFVRGSKDN 

       550        560        570        580        590        600 
WFVLMSDSLS WYKDDEEKEK KYMLPLDGVK LKDIEGGFMS RNHKFALFYP DGKNIYKDYK 

       610        620        630        640        650        660 
QLELGCTNLD EIDAWKASFL RAGVYPEKQK AQEDESQQEM EDTSIDPQLE RQVETIRNLV 

       670        680        690        700        710        720 
DSYMRIITKT IKDLVPKAVM HLIVNQTGEF MKDELLAHLY QCGDTDALME ESQIEAQKRE 

       730        740        750        760        770        780 
EMLRMYHACK EALRIISEVN MSTLGDQPPP LPMSDYRPHP SGPSPVPRPA PAPPGGRQAP 

       790        800        810        820        830 
MPPRGGPGAP PPPGMRPPPG APGGGGGMYP PLIPTRPGPG GPPPNMAPPR 

« Hide

Isoform b [UniParc].

Checksum: 78F89B6EA555B689
Show »

FASTA83894,421

References

« Hide 'large scale' references
[1]"A dynamin GTPase mutation causes a rapid and reversible temperature-inducible locomotion defect in C. elegans."
Clark S.G., Shurland D.L., Meyerowitz E.M., Bargmann C.I., van der Bliek A.M.
Proc. Natl. Acad. Sci. U.S.A. 94:10438-10443(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
Strain: Bristol N2.
[2]van der Bliek A.M.
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO C-TERMINUS.
[3]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS A AND B).
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L29031 mRNA. Translation: AAB72228.2.
Z79596 Genomic DNA. Translation: CAB01857.1.
Z79596 Genomic DNA. Translation: CAC42251.1.
PIRT18860.
RefSeqNP_001024331.1. NM_001029160.2. [P39055-1]
NP_001024332.1. NM_001029161.2. [P39055-2]
UniGeneCel.19561.

3D structure databases

ProteinModelPortalP39055.
SMRP39055. Positions 8-740.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid46538. 4 interactions.
IntActP39055. 21 interactions.
MINTMINT-230275.

Proteomic databases

PaxDbP39055.
PRIDEP39055.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC02C6.1a; C02C6.1a; WBGene00001130. [P39055-1]
GeneID181644.
KEGGcel:CELE_C02C6.1.
UCSCC02C6.1b. c. elegans. [P39055-1]

Organism-specific databases

CTD181644.
WormBaseC02C6.1a; CE07833; WBGene00001130; dyn-1.
C02C6.1b; CE07832; WBGene00001130; dyn-1.

Phylogenomic databases

eggNOGCOG0699.
GeneTreeENSGT00740000115284.
HOGENOMHOG000161069.
InParanoidP39055.
KOK01528.
OMASKLGSYP.
OrthoDBEOG76MK7N.
PhylomeDBP39055.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProIPR027744. Dynamin.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR003130. GED.
IPR020850. GTPase_effector_domain_GED.
IPR027417. P-loop_NTPase.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
[Graphical view]
PANTHERPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF49. PTHR11566:SF49. 1 hit.
PfamPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSPR00195. DYNAMIN.
SMARTSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio914798.

Entry information

Entry nameDYN1_CAEEL
AccessionPrimary (citable) accession number: P39055
Secondary accession number(s): Q93176, Q95QY9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 27, 2002
Last modified: July 9, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase