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P39054

- DYN2_MOUSE

UniProt

P39054 - DYN2_MOUSE

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Protein

Dynamin-2

Gene

Dnm2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis.1 Publication

Catalytic activityi

GTP + H2O = GDP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 458GTPBy similarity
Nucleotide bindingi136 – 1405GTPBy similarity
Nucleotide bindingi205 – 2084GTPBy similarity

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. receptor internalization Source: Ensembl
  2. transferrin transport Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Motor protein

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196550. MHC class II antigen presentation.
REACT_202778. Retrograde neurotrophin signalling.
REACT_209040. Gap junction degradation.
REACT_215995. NOSTRIN mediated eNOS trafficking.
REACT_220352. Formation of annular gap junctions.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynamin-2 (EC:3.6.5.5)
Alternative name(s):
Dynamin UDNM
Gene namesi
Name:Dnm2
Synonyms:Dyn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:109547. Dnm2.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Cell junctionsynapse By similarity. Midbody By similarity
Note: Microtubule-associated. Also found in the postsynaptic density of neuronal cells (By similarity).By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
  3. Golgi apparatus Source: Ensembl
  4. microtubule Source: UniProtKB-KW
  5. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Microtubule, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

Exhibits growth and cytokinesis defects.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 870870Dynamin-2PRO_0000206571Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei299 – 2991N6-acetyllysine1 Publication
Modified residuei598 – 5981N6-acetyllysineBy similarity
Modified residuei764 – 7641Phosphoserine; by CDK1By similarity

Post-translational modificationi

Phosphorylation at Ser-764 by CDK1 is greatly increased upon mitotic entry. It regulates cytokinesis downstream of calcineurin, and does not affect clathrin-mediated endocytosis. Dephosphorylated by Calcineurin/PP2 (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP39054.
PaxDbiP39054.
PRIDEiP39054.

2D gel databases

REPRODUCTION-2DPAGEIPI00131445.

PTM databases

PhosphoSiteiP39054.

Expressioni

Tissue specificityi

Expressed in most tissues during embryonic development, including the peripheral nervous system although no expression is evident in skeletal muscle or heart.1 Publication

Gene expression databases

BgeeiP39054.
CleanExiMM_DNM2.
ExpressionAtlasiP39054. baseline and differential.
GenevestigatoriP39054.

Interactioni

Subunit structurei

Interacts with SHANK1, SHANK2 and NOSTRIN (By similarity). Interacts with SNX9. Interacts with SNX33 (via SH3 domain). Interacts with MYO1E (via SH3 domain) (By similarity). Interacts with MYOF and SH3BP4. Interacts with PSTPIP1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CttnQ605982EBI-642337,EBI-397955
CTTN1Q014062EBI-642337,EBI-2530463From a different organism.

Protein-protein interaction databases

IntActiP39054. 15 interactions.
MINTiMINT-1605893.

Structurei

3D structure databases

ProteinModelPortaliP39054.
SMRiP39054. Positions 5-737.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 294267Dynamin-type GAdd
BLAST
Domaini519 – 625107PHPROSITE-ProRule annotationAdd
BLAST
Domaini653 – 74492GEDPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi747 – 866120Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 GED domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0699.
GeneTreeiENSGT00760000119213.
HOGENOMiHOG000161069.
HOVERGENiHBG107833.
InParanoidiP39054.
KOiK01528.
PhylomeDBiP39054.
TreeFamiTF300362.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR027188. DNM2.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR003130. GED.
IPR020850. GTPase_effector_domain_GED.
IPR027417. P-loop_NTPase.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF23. PTHR11566:SF23. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P39054-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNRGMEELI PLVNKLQDAF SSIGQSCHLD LPQIAVVGGQ SAGKSSVLEN
60 70 80 90 100
FVGRDFLPRG SGIVTRRPLI LQLIFSKTEY AEFLHCKSKK FTDFDEVRQE
110 120 130 140 150
IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP
160 170 180 190 200
DIEYQIKDMI LQFISRESSL ILAVTPANMD LANSDALKLA KEVDPQGLRT
210 220 230 240 250
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIEGKKDIRA
260 270 280 290 300
ALAAERKFFL SHPAYRHMAD RMGTPHLQKT LNQQLTNHIR ESLPTLRSKL
310 320 330 340 350
QSQLLSLEKE VEEYKNFRPD DPTRKTKALL QMVQQFGVDF EKRIEGSGDQ
360 370 380 390 400
VDTLELSGGA RINRIFHERF PFELVKMEFD EKDLRREISY AIKNIHGVRT
410 420 430 440 450
GLFTPDLAFE AIVKKQVVKL KEPCLKCVDL VIQELISTVR QCTSKLSSYP
460 470 480 490 500
RLREETERIV TTYIREREGR TKDQILLLID IEQSYINTNH EDFIGFANAQ
510 520 530 540 550
QRSTQLNKKR AIPNQGEILV IRRGWLTINN ISLMKGGSKE YWFVLTAESL
560 570 580 590 600
SWYKDEEEKE KKYMLPLDNL KIRDVEKGFM SNKHVFAIFN TEQRNVYKDL
610 620 630 640 650
RQIELACDSQ EDVDSWKASF LRAGVYPEKD QAENEDGAQE NTFSMDPQLE
660 670 680 690 700
RQVETIRNLV DSYVAIINKS IRDLMPKTIM HLMINNTKAF IHHELLAYLY
710 720 730 740 750
SSADQSSLME ESAEQAQRRD DMLRMYHALK EALNIIGDIS TSTVSTPVPP
760 770 780 790 800
PVDDTWLQNT SGHSPTPQRR PVSSVHPPGR PPAVRGPTPG PPLIPMPVGA
810 820 830 840 850
TSSFSAPPIP SRPGPQSVFA NNDPFSAPPQ IPSRPARIPP GIPPGVPSRR
860 870
APAAPSRPTI IRPAEPSLLD
Length:870
Mass (Da):98,145
Last modified:July 26, 2002 - v2
Checksum:iE80864AF94B8F778
GO
Isoform 2 (identifier: P39054-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-519: Missing.

Show »
Length:866
Mass (Da):97,733
Checksum:iCA0BEB6FA5E5028D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti297 – 2982RS → HG in AAA40523. (PubMed:9143510)Curated
Sequence conflicti848 – 87023SRRAP…PSLLD → RRPPPLAPARPFF in BAB23745. (PubMed:16141072)CuratedAdd
BLAST

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei516 – 5194Missing in isoform 2. 1 PublicationVSP_001326

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L31398 mRNA. Translation: AAA40523.1.
AK005012 mRNA. Translation: BAB23745.1.
CCDSiCCDS57657.1. [P39054-1]
CCDS57659.1. [P39054-2]
RefSeqiNP_001240822.1. NM_001253893.1. [P39054-1]
NP_001240823.1. NM_001253894.1.
NP_031897.2. NM_007871.2. [P39054-2]
UniGeneiMm.433257.

Genome annotation databases

EnsembliENSMUST00000091087; ENSMUSP00000088616; ENSMUSG00000033335. [P39054-2]
ENSMUST00000172482; ENSMUSP00000133564; ENSMUSG00000033335. [P39054-1]
GeneIDi13430.
KEGGimmu:13430.
UCSCiuc009olk.2. mouse. [P39054-2]
uc029wxt.1. mouse. [P39054-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L31398 mRNA. Translation: AAA40523.1 .
AK005012 mRNA. Translation: BAB23745.1 .
CCDSi CCDS57657.1. [P39054-1 ]
CCDS57659.1. [P39054-2 ]
RefSeqi NP_001240822.1. NM_001253893.1. [P39054-1 ]
NP_001240823.1. NM_001253894.1.
NP_031897.2. NM_007871.2. [P39054-2 ]
UniGenei Mm.433257.

3D structure databases

ProteinModelPortali P39054.
SMRi P39054. Positions 5-737.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P39054. 15 interactions.
MINTi MINT-1605893.

PTM databases

PhosphoSitei P39054.

2D gel databases

REPRODUCTION-2DPAGE IPI00131445.

Proteomic databases

MaxQBi P39054.
PaxDbi P39054.
PRIDEi P39054.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000091087 ; ENSMUSP00000088616 ; ENSMUSG00000033335 . [P39054-2 ]
ENSMUST00000172482 ; ENSMUSP00000133564 ; ENSMUSG00000033335 . [P39054-1 ]
GeneIDi 13430.
KEGGi mmu:13430.
UCSCi uc009olk.2. mouse. [P39054-2 ]
uc029wxt.1. mouse. [P39054-1 ]

Organism-specific databases

CTDi 1785.
MGIi MGI:109547. Dnm2.

Phylogenomic databases

eggNOGi COG0699.
GeneTreei ENSGT00760000119213.
HOGENOMi HOG000161069.
HOVERGENi HBG107833.
InParanoidi P39054.
KOi K01528.
PhylomeDBi P39054.
TreeFami TF300362.

Enzyme and pathway databases

Reactomei REACT_196550. MHC class II antigen presentation.
REACT_202778. Retrograde neurotrophin signalling.
REACT_209040. Gap junction degradation.
REACT_215995. NOSTRIN mediated eNOS trafficking.
REACT_220352. Formation of annular gap junctions.

Miscellaneous databases

ChiTaRSi DNM2. mouse.
NextBioi 283855.
PROi P39054.
SOURCEi Search...

Gene expression databases

Bgeei P39054.
CleanExi MM_DNM2.
ExpressionAtlasi P39054. baseline and differential.
Genevestigatori P39054.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR027188. DNM2.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR003130. GED.
IPR020850. GTPase_effector_domain_GED.
IPR027417. P-loop_NTPase.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
PANTHERi PTHR11566. PTHR11566. 1 hit.
PTHR11566:SF23. PTHR11566:SF23. 1 hit.
Pfami PF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view ]
PRINTSi PR00195. DYNAMIN.
SMARTi SM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
SM00233. PH. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectively."
    Klocke R., Augustin A., Ronsiek M., Stief A., van der Putten H., Jockusch H.
    Genomics 41:290-292(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: NIH Swiss.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Liver.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 45-54; 91-107; 114-142; 207-217; 230-237; 300-309; 370-376 AND 678-688, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  4. "TTP specifically regulates the internalization of the transferrin receptor."
    Tosoni D., Puri C., Confalonieri S., Salcini A.E., De Camilli P., Tacchetti C., Di Fiore P.P.
    Cell 123:875-888(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SH3BP4.
  5. Cited for: INTERACTION WITH MYOF.
  6. "Isoform and splice-variant specific functions of dynamin-2 revealed by analysis of conditional knock-out cells."
    Liu Y.W., Surka M.C., Schroeter T., Lukiyanchuk V., Schmid S.L.
    Mol. Biol. Cell 19:5347-5359(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  7. Cited for: TISSUE SPECIFICITY.
  8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-299, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiDYN2_MOUSE
AccessioniPrimary (citable) accession number: P39054
Secondary accession number(s): Q9DBE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 26, 2002
Last modified: October 29, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3