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P39053

- DYN1_MOUSE

UniProt

P39053 - DYN1_MOUSE

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Protein
Dynamin-1
Gene
Dnm1, Dnm, Kiaa4093
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis By similarity.

Catalytic activityi

GTP + H2O = GDP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 458GTP By similarity
Nucleotide bindingi136 – 1405GTP By similarity
Nucleotide bindingi205 – 2084GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: InterPro
  3. protein binding Source: UniProtKB
  4. protein kinase binding Source: ParkinsonsUK-UCL

GO - Biological processi

  1. endosome organization Source: Ensembl
  2. receptor internalization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Motor protein

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196550. MHC class II antigen presentation.
REACT_202778. Retrograde neurotrophin signalling.
REACT_209040. Gap junction degradation.
REACT_220352. Formation of annular gap junctions.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynamin-1 (EC:3.6.5.5)
Gene namesi
Name:Dnm1
Synonyms:Dnm, Kiaa4093
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:107384. Dnm1.

Subcellular locationi

Cytoplasm. Cytoplasmcytoskeleton
Note: Microtubule-associated.1 Publication

GO - Cellular componenti

  1. membrane coat Source: MGI
  2. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 867867Dynamin-1
PRO_0000206564Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei80 – 801Phosphotyrosine1 Publication
Modified residuei125 – 1251Nitrated tyrosine; alternate1 Publication
Modified residuei125 – 1251Phosphotyrosine; alternate1 Publication
Modified residuei347 – 3471Phosphoserine By similarity
Modified residuei354 – 3541Phosphotyrosine1 Publication
Modified residuei512 – 5121Phosphoserine By similarity
Modified residuei774 – 7741Phosphoserine By similarity
Modified residuei778 – 7781Phosphoserine By similarity
Modified residuei822 – 8221Phosphoserine By similarity

Post-translational modificationi

Phosphorylated in response to EGF stimulation in cells expressing truncated EGFR.1 Publication

Keywords - PTMi

Nitration, Phosphoprotein

Proteomic databases

MaxQBiP39053.
PaxDbiP39053.
PRIDEiP39053.

PTM databases

PhosphoSiteiP39053.

Expressioni

Gene expression databases

ArrayExpressiP39053.
BgeeiP39053.
CleanExiMM_DNM1.
GenevestigatoriP39053.

Interactioni

Subunit structurei

Binds SH3GL1, SH3GL2 and SH3GL3 By similarity. Interacts with SNX9 By similarity. Interacts with PHOCN. Interacts with MYO1E (via SH3 domain). Interacts with SNX33 (via SH3 domain) By similarity. Interacts with CAV1 and SH3GLB1. Interacts with PACSIN1, PACSIN2 and PACSIN3.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0073EBI-397785,EBI-5323863From a different organism.
Pfn2Q9JJV2-12EBI-397785,EBI-990256

Protein-protein interaction databases

BioGridi199257. 13 interactions.
IntActiP39053. 20 interactions.
MINTiMINT-86537.

Structurei

3D structure databases

ProteinModelPortaliP39053.
SMRiP39053. Positions 6-746.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 294267Dynamin-type G
Add
BLAST
Domaini515 – 625111PH
Add
BLAST
Domaini659 – 75092GED
Add
BLAST

Sequence similaritiesi

Contains 1 GED domain.
Contains 1 PH domain.

Phylogenomic databases

eggNOGiCOG0699.
GeneTreeiENSGT00740000115253.
HOVERGENiHBG107833.
KOiK01528.
OMAiQYPHLRE.
OrthoDBiEOG76MK7N.
PhylomeDBiP39053.
TreeFamiTF300362.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR027741. DNM1.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR003130. GED.
IPR020850. GTPase_effector_domain_GED.
IPR027417. P-loop_NTPase.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF32. PTHR11566:SF32. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P39053-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGNRGMEDLI PLVNRLQDAF SAIGQNADLD LPQIAVVGGQ SAGKSSVLEN    50
FVGRDFLPRG SGIVTRRPLV LQLVNSTTEY AEFLHCKGKK FTDFEEVRLE 100
IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLVDLPGM TKVPVGDQPP 150
DIEFQIRDML MQFVTKENCL ILAVSPANSD LANSDALKIA KEVDPQGQRT 200
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIDGKKDITA 250
ALAAERKFFL SHPSYRHLAD RMGTPYLQKV LNQQLTNHIR DTLPGLRNKL 300
QSQLLSIEKE VDEYKNFRPD DPARKTKALL QMVQQFAVDF EKRIEGSGDQ 350
IDTYELSGGA RINRIFHERF PFELVKMEFD EKELRREISY AIKNIHGIRT 400
GLFTPDMAFE TIVKKQVKKI REPCLKCVDM VISELISTVR QCTKKLQQYP 450
RLREEMERIV TTHIREREGR TKEQVMLLID IELAYMNTNH EDFIGFANAQ 500
QRSNQMNKKK TSGNQDEILV IRKGWLTINN IGIMKGGSKE YWFVLTAENL 550
SWYKDDEEKE KKYMLSVDNL KLRDVEKGFM SSKHIFALFN TEQRNVYKDY 600
RQLELACETQ EEVDSWKASF LRAGVYPERV GDKEKASETE ENGSDSFMHS 650
MDPQLERQVE TIRNLVDSYM AIVNKTVRDL MPKTIMHLMI NNTKEFIFSE 700
LLANLYSCGD QNTLMEESAE QAQRRDEMLR MYHALKEALS IIGDINTTTV 750
STPMPPPVDD SWLQVQSVPA GRRSPTSSPT PQRRAPAVPP ARPGSRGPAP 800
GPPPAGSALG GAPPVPSRPG ASPDPFGPPP QVPSRPNRAP PGVPSLGAWR 850
LNSPQGKHEN RAGKARL 867
Length:867
Mass (Da):97,803
Last modified:June 20, 2003 - v2
Checksum:iF48EC3DF5F39A08B
GO
Isoform 2 (identifier: P39053-2) [UniParc]FASTAAdd to Basket

Also known as: BreDnm19

The sequence of this isoform differs from the canonical sequence as follows:
     516-519: Missing.
     846-867: LGAWRLNSPQGKHENRAGKARL → RKAQPHLRDLQPPDQRRLPS

Show »
Length:861
Mass (Da):97,281
Checksum:i81F22599EA77FB3F
GO
Isoform 3 (identifier: P39053-3) [UniParc]FASTAAdd to Basket

Also known as: BraDnm8

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: MAFETIVKKQ...LISTVRQCTK → LAFEATVKKQ...LTSTIRKCSE
     845-867: SLGAWRLNSPQGKHENRAGKARL → RITISDP

Show »
Length:851
Mass (Da):95,927
Checksum:i5D9294C5D1015A88
GO
Isoform 4 (identifier: P39053-4) [UniParc]FASTAAdd to Basket

Also known as: BraDnm2

The sequence of this isoform differs from the canonical sequence as follows:
     846-867: LGAWRLNSPQGKHENRAGKARL → RSGQASPSRPESPRPPFDL

Show »
Length:864
Mass (Da):97,424
Checksum:i4E27474E413CCEE7
GO
Isoform 5 (identifier: P39053-5) [UniParc]FASTAAdd to Basket

Also known as: BreDnm15

The sequence of this isoform differs from the canonical sequence as follows:
     845-867: SLGAWRLNSPQGKHENRAGKARL → RITISDP

Show »
Length:851
Mass (Da):96,057
Checksum:i5FE0938290E39F51
GO
Isoform 6 (identifier: P39053-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-519: Missing.
     846-867: LGAWRLNSPQGKHENRAGKARL → RKGPASPTRPAAPRPTEAPLLDL

Note: No experimental confirmation available. Contains a phosphoserine at position 847.

Show »
Length:864
Mass (Da):97,284
Checksum:i12CA402BCCCF2936
GO

Sequence cautioni

The sequence BAD90284.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei407 – 44438MAFET…RQCTK → LAFEATVKKQVQKLKEPSIK CVDMVVSELTSTIRKCSE in isoform 3.
VSP_007643Add
BLAST
Alternative sequencei516 – 5194Missing in isoform 2 and isoform 6.
VSP_007644
Alternative sequencei845 – 86723SLGAW…GKARL → RITISDP in isoform 3 and isoform 5.
VSP_007645Add
BLAST
Alternative sequencei846 – 86722LGAWR…GKARL → RKAQPHLRDLQPPDQRRLPS in isoform 2.
VSP_007646Add
BLAST
Alternative sequencei846 – 86722LGAWR…GKARL → RSGQASPSRPESPRPPFDL in isoform 4.
VSP_007647Add
BLAST
Alternative sequencei846 – 86722LGAWR…GKARL → RKGPASPTRPAAPRPTEAPL LDL in isoform 6.
VSP_024845Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti135 – 1351V → A in AAA37318. 1 Publication
Sequence conflicti450 – 4501P → R in AAA37318. 1 Publication
Sequence conflicti531 – 5311I → S in AAA37318. 1 Publication
Sequence conflicti573 – 5731R → H in BAE25726. 1 Publication
Sequence conflicti600 – 6001Y → N in AAA37318. 1 Publication
Sequence conflicti703 – 7031A → V in AAH58623. 1 Publication
Sequence conflicti722 – 7221A → R in AAA37319. 1 Publication
Sequence conflicti722 – 7221A → R in AAA37323. 1 Publication
Sequence conflicti722 – 7221A → R in AAA37324. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L29457 mRNA. Translation: AAA37319.1.
L31395 mRNA. Translation: AAA37318.1.
L31396 mRNA. Translation: AAA37323.1.
L31397 mRNA. Translation: AAA37324.1.
AK011651 mRNA. Translation: BAB27759.1.
AK144142 mRNA. Translation: BAE25726.1.
AK220483 mRNA. Translation: BAD90284.1. Different initiation.
AL808027 Genomic DNA. Translation: CAM15852.1.
AL808027 Genomic DNA. Translation: CAM15853.1.
AL808027 Genomic DNA. Translation: CAM15855.1.
AL808027 Genomic DNA. Translation: CAM15857.1.
BC034679 mRNA. Translation: AAH34679.1.
BC058623 mRNA. Translation: AAH58623.1.
AF170568 Genomic DNA. Translation: AAF24220.1.
CCDSiCCDS38102.1. [P39053-6]
RefSeqiNP_034195.2. NM_010065.2. [P39053-6]
UniGeneiMm.44736.

Genome annotation databases

EnsembliENSMUST00000078352; ENSMUSP00000077461; ENSMUSG00000026825. [P39053-3]
ENSMUST00000091089; ENSMUSP00000088618; ENSMUSG00000026825. [P39053-6]
ENSMUST00000113350; ENSMUSP00000108977; ENSMUSG00000026825. [P39053-5]
ENSMUST00000113352; ENSMUSP00000108979; ENSMUSG00000026825. [P39053-5]
ENSMUST00000113365; ENSMUSP00000108992; ENSMUSG00000026825. [P39053-4]
ENSMUST00000139624; ENSMUSP00000122679; ENSMUSG00000026825. [P39053-1]
GeneIDi13429.
KEGGimmu:13429.
UCSCiuc008jfc.1. mouse. [P39053-6]
uc008jfd.2. mouse. [P39053-3]
uc029twn.1. mouse. [P39053-5]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L29457 mRNA. Translation: AAA37319.1 .
L31395 mRNA. Translation: AAA37318.1 .
L31396 mRNA. Translation: AAA37323.1 .
L31397 mRNA. Translation: AAA37324.1 .
AK011651 mRNA. Translation: BAB27759.1 .
AK144142 mRNA. Translation: BAE25726.1 .
AK220483 mRNA. Translation: BAD90284.1 . Different initiation.
AL808027 Genomic DNA. Translation: CAM15852.1 .
AL808027 Genomic DNA. Translation: CAM15853.1 .
AL808027 Genomic DNA. Translation: CAM15855.1 .
AL808027 Genomic DNA. Translation: CAM15857.1 .
BC034679 mRNA. Translation: AAH34679.1 .
BC058623 mRNA. Translation: AAH58623.1 .
AF170568 Genomic DNA. Translation: AAF24220.1 .
CCDSi CCDS38102.1. [P39053-6 ]
RefSeqi NP_034195.2. NM_010065.2. [P39053-6 ]
UniGenei Mm.44736.

3D structure databases

ProteinModelPortali P39053.
SMRi P39053. Positions 6-746.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199257. 13 interactions.
IntActi P39053. 20 interactions.
MINTi MINT-86537.

PTM databases

PhosphoSitei P39053.

Proteomic databases

MaxQBi P39053.
PaxDbi P39053.
PRIDEi P39053.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000078352 ; ENSMUSP00000077461 ; ENSMUSG00000026825 . [P39053-3 ]
ENSMUST00000091089 ; ENSMUSP00000088618 ; ENSMUSG00000026825 . [P39053-6 ]
ENSMUST00000113350 ; ENSMUSP00000108977 ; ENSMUSG00000026825 . [P39053-5 ]
ENSMUST00000113352 ; ENSMUSP00000108979 ; ENSMUSG00000026825 . [P39053-5 ]
ENSMUST00000113365 ; ENSMUSP00000108992 ; ENSMUSG00000026825 . [P39053-4 ]
ENSMUST00000139624 ; ENSMUSP00000122679 ; ENSMUSG00000026825 . [P39053-1 ]
GeneIDi 13429.
KEGGi mmu:13429.
UCSCi uc008jfc.1. mouse. [P39053-6 ]
uc008jfd.2. mouse. [P39053-3 ]
uc029twn.1. mouse. [P39053-5 ]

Organism-specific databases

CTDi 1759.
MGIi MGI:107384. Dnm1.
Rougei Search...

Phylogenomic databases

eggNOGi COG0699.
GeneTreei ENSGT00740000115253.
HOVERGENi HBG107833.
KOi K01528.
OMAi QYPHLRE.
OrthoDBi EOG76MK7N.
PhylomeDBi P39053.
TreeFami TF300362.

Enzyme and pathway databases

Reactomei REACT_196550. MHC class II antigen presentation.
REACT_202778. Retrograde neurotrophin signalling.
REACT_209040. Gap junction degradation.
REACT_220352. Formation of annular gap junctions.

Miscellaneous databases

ChiTaRSi DNM1. mouse.
NextBioi 283851.
PROi P39053.
SOURCEi Search...

Gene expression databases

ArrayExpressi P39053.
Bgeei P39053.
CleanExi MM_DNM1.
Genevestigatori P39053.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR027741. DNM1.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR003130. GED.
IPR020850. GTPase_effector_domain_GED.
IPR027417. P-loop_NTPase.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
PANTHERi PTHR11566. PTHR11566. 1 hit.
PTHR11566:SF32. PTHR11566:SF32. 1 hit.
Pfami PF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view ]
PRINTSi PR00195. DYNAMIN.
SMARTi SM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
SM00233. PH. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectively."
    Klocke R., Augustin A., Ronsiek M., Stief A., van der Putten H., Jockusch H.
    Genomics 41:290-292(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5).
    Strain: NIH Swiss.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
    Strain: C57BL/6J.
    Tissue: Colon and Embryo.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
    Strain: C57BL/6.
    Tissue: Brain and Retina.
  6. "Characterization of the mouse dynamin I gene promoter and identification of sequences that direct expression in neuronal cells."
    Yoo J., Lee S.S., Jeong M.J., Lee K.I., Kwon B.M., Kim S.H., Park Y.M., Han M.Y.
    Biochem. J. 351:661-668(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-32.
  7. Lubec G., Klug S., Kang S.U., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Strain: C57BL/6 and OF1.
    Tissue: Brain and Hippocampus.
  8. "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis."
    Modregger J., Ritter B., Witter B., Paulsson M., Plomann M.
    J. Cell Sci. 113:4511-4521(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PACSIN1; PACSIN2 AND PACSIN3, SUBCELLULAR LOCATION.
  9. "The endocytosis-linked protein dynamin associates with caveolin-1 and is tyrosine phosphorylated in response to the activation of a noninternalizing epidermal growth factor receptor mutant."
    Kim Y.N., Bertics P.J.
    Endocrinology 143:1726-1731(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CAV1, PHOSPHORYLATION.
  10. "Characterization of endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1."
    Modregger J., Schmidt A.A., Ritter B., Huttner W.B., Plomann M.
    J. Biol. Chem. 278:4160-4167(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SH3GLB1.
  11. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-125, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  13. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-80; TYR-125 AND TYR-354, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  14. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-847 (ISOFORM 6), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiDYN1_MOUSE
AccessioniPrimary (citable) accession number: P39053
Secondary accession number(s): A2AN50
, A2AN51, A2AN54, A2AN55, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 20, 2003
Last modified: September 3, 2014
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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