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P39053

- DYN1_MOUSE

UniProt

P39053 - DYN1_MOUSE

Protein

Dynamin-1

Gene

Dnm1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 143 (01 Oct 2014)
      Sequence version 2 (20 Jun 2003)
      Previous versions | rss
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    Functioni

    Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis By similarity.By similarity

    Catalytic activityi

    GTP + H2O = GDP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi38 – 458GTPBy similarity
    Nucleotide bindingi136 – 1405GTPBy similarity
    Nucleotide bindingi205 – 2084GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB
    4. protein kinase binding Source: ParkinsonsUK-UCL

    GO - Biological processi

    1. endosome organization Source: Ensembl
    2. receptor internalization Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Motor protein

    Keywords - Biological processi

    Endocytosis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_196550. MHC class II antigen presentation.
    REACT_202778. Retrograde neurotrophin signalling.
    REACT_209040. Gap junction degradation.
    REACT_220352. Formation of annular gap junctions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dynamin-1 (EC:3.6.5.5)
    Gene namesi
    Name:Dnm1
    Synonyms:Dnm, Kiaa4093
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:107384. Dnm1.

    Subcellular locationi

    Cytoplasm 1 Publication. Cytoplasmcytoskeleton 1 Publication
    Note: Microtubule-associated.

    GO - Cellular componenti

    1. membrane coat Source: MGI
    2. microtubule Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 867867Dynamin-1PRO_0000206564Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei80 – 801Phosphotyrosine2 Publications
    Modified residuei125 – 1251Nitrated tyrosine; alternate1 Publication
    Modified residuei125 – 1251Phosphotyrosine; alternate2 Publications
    Modified residuei347 – 3471PhosphoserineBy similarity
    Modified residuei354 – 3541Phosphotyrosine2 Publications
    Modified residuei512 – 5121PhosphoserineBy similarity
    Modified residuei774 – 7741PhosphoserineBy similarity
    Modified residuei778 – 7781PhosphoserineBy similarity
    Modified residuei822 – 8221PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated in response to EGF stimulation in cells expressing truncated EGFR.2 Publications

    Keywords - PTMi

    Nitration, Phosphoprotein

    Proteomic databases

    MaxQBiP39053.
    PaxDbiP39053.
    PRIDEiP39053.

    PTM databases

    PhosphoSiteiP39053.

    Expressioni

    Gene expression databases

    ArrayExpressiP39053.
    BgeeiP39053.
    CleanExiMM_DNM1.
    GenevestigatoriP39053.

    Interactioni

    Subunit structurei

    Binds SH3GL1, SH3GL2 and SH3GL3 By similarity. Interacts with SNX9 By similarity. Interacts with PHOCN. Interacts with MYO1E (via SH3 domain). Interacts with SNX33 (via SH3 domain) By similarity. Interacts with CAV1 and SH3GLB1. Interacts with PACSIN1, PACSIN2 and PACSIN3. Interacts with UNC119; leading to a decrease of DNM1 GTPase activity.By similarity4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LRRK2Q5S0073EBI-397785,EBI-5323863From a different organism.
    Pfn2Q9JJV2-12EBI-397785,EBI-990256

    Protein-protein interaction databases

    BioGridi199257. 13 interactions.
    IntActiP39053. 20 interactions.
    MINTiMINT-86537.

    Structurei

    3D structure databases

    ProteinModelPortaliP39053.
    SMRiP39053. Positions 6-746.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 294267Dynamin-type GAdd
    BLAST
    Domaini515 – 625111PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini659 – 75092GEDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GED domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0699.
    GeneTreeiENSGT00740000115253.
    HOVERGENiHBG107833.
    KOiK01528.
    OMAiQYPHLRE.
    OrthoDBiEOG76MK7N.
    PhylomeDBiP39053.
    TreeFamiTF300362.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR027741. DNM1.
    IPR000375. Dynamin_central.
    IPR001401. Dynamin_GTPase.
    IPR019762. Dynamin_GTPase_CS.
    IPR022812. Dynamin_SF.
    IPR003130. GED.
    IPR020850. GTPase_effector_domain_GED.
    IPR027417. P-loop_NTPase.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PANTHERiPTHR11566. PTHR11566. 1 hit.
    PTHR11566:SF32. PTHR11566:SF32. 1 hit.
    PfamiPF01031. Dynamin_M. 1 hit.
    PF00350. Dynamin_N. 1 hit.
    PF02212. GED. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view]
    PRINTSiPR00195. DYNAMIN.
    SMARTiSM00053. DYNc. 1 hit.
    SM00302. GED. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
    PS51718. G_DYNAMIN_2. 1 hit.
    PS51388. GED. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P39053-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGNRGMEDLI PLVNRLQDAF SAIGQNADLD LPQIAVVGGQ SAGKSSVLEN    50
    FVGRDFLPRG SGIVTRRPLV LQLVNSTTEY AEFLHCKGKK FTDFEEVRLE 100
    IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLVDLPGM TKVPVGDQPP 150
    DIEFQIRDML MQFVTKENCL ILAVSPANSD LANSDALKIA KEVDPQGQRT 200
    IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIDGKKDITA 250
    ALAAERKFFL SHPSYRHLAD RMGTPYLQKV LNQQLTNHIR DTLPGLRNKL 300
    QSQLLSIEKE VDEYKNFRPD DPARKTKALL QMVQQFAVDF EKRIEGSGDQ 350
    IDTYELSGGA RINRIFHERF PFELVKMEFD EKELRREISY AIKNIHGIRT 400
    GLFTPDMAFE TIVKKQVKKI REPCLKCVDM VISELISTVR QCTKKLQQYP 450
    RLREEMERIV TTHIREREGR TKEQVMLLID IELAYMNTNH EDFIGFANAQ 500
    QRSNQMNKKK TSGNQDEILV IRKGWLTINN IGIMKGGSKE YWFVLTAENL 550
    SWYKDDEEKE KKYMLSVDNL KLRDVEKGFM SSKHIFALFN TEQRNVYKDY 600
    RQLELACETQ EEVDSWKASF LRAGVYPERV GDKEKASETE ENGSDSFMHS 650
    MDPQLERQVE TIRNLVDSYM AIVNKTVRDL MPKTIMHLMI NNTKEFIFSE 700
    LLANLYSCGD QNTLMEESAE QAQRRDEMLR MYHALKEALS IIGDINTTTV 750
    STPMPPPVDD SWLQVQSVPA GRRSPTSSPT PQRRAPAVPP ARPGSRGPAP 800
    GPPPAGSALG GAPPVPSRPG ASPDPFGPPP QVPSRPNRAP PGVPSLGAWR 850
    LNSPQGKHEN RAGKARL 867
    Length:867
    Mass (Da):97,803
    Last modified:June 20, 2003 - v2
    Checksum:iF48EC3DF5F39A08B
    GO
    Isoform 2 (identifier: P39053-2) [UniParc]FASTAAdd to Basket

    Also known as: BreDnm19

    The sequence of this isoform differs from the canonical sequence as follows:
         516-519: Missing.
         846-867: LGAWRLNSPQGKHENRAGKARL → RKAQPHLRDLQPPDQRRLPS

    Show »
    Length:861
    Mass (Da):97,281
    Checksum:i81F22599EA77FB3F
    GO
    Isoform 3 (identifier: P39053-3) [UniParc]FASTAAdd to Basket

    Also known as: BraDnm8

    The sequence of this isoform differs from the canonical sequence as follows:
         407-444: MAFETIVKKQ...LISTVRQCTK → LAFEATVKKQ...LTSTIRKCSE
         845-867: SLGAWRLNSPQGKHENRAGKARL → RITISDP

    Show »
    Length:851
    Mass (Da):95,927
    Checksum:i5D9294C5D1015A88
    GO
    Isoform 4 (identifier: P39053-4) [UniParc]FASTAAdd to Basket

    Also known as: BraDnm2

    The sequence of this isoform differs from the canonical sequence as follows:
         846-867: LGAWRLNSPQGKHENRAGKARL → RSGQASPSRPESPRPPFDL

    Show »
    Length:864
    Mass (Da):97,424
    Checksum:i4E27474E413CCEE7
    GO
    Isoform 5 (identifier: P39053-5) [UniParc]FASTAAdd to Basket

    Also known as: BreDnm15

    The sequence of this isoform differs from the canonical sequence as follows:
         845-867: SLGAWRLNSPQGKHENRAGKARL → RITISDP

    Show »
    Length:851
    Mass (Da):96,057
    Checksum:i5FE0938290E39F51
    GO
    Isoform 6 (identifier: P39053-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         516-519: Missing.
         846-867: LGAWRLNSPQGKHENRAGKARL → RKGPASPTRPAAPRPTEAPLLDL

    Note: No experimental confirmation available. Contains a phosphoserine at position 847.

    Show »
    Length:864
    Mass (Da):97,284
    Checksum:i12CA402BCCCF2936
    GO

    Sequence cautioni

    The sequence BAD90284.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti135 – 1351V → A in AAA37318. (PubMed:9143510)Curated
    Sequence conflicti450 – 4501P → R in AAA37318. (PubMed:9143510)Curated
    Sequence conflicti531 – 5311I → S in AAA37318. (PubMed:9143510)Curated
    Sequence conflicti573 – 5731R → H in BAE25726. (PubMed:16141072)Curated
    Sequence conflicti600 – 6001Y → N in AAA37318. (PubMed:9143510)Curated
    Sequence conflicti703 – 7031A → V in AAH58623. (PubMed:15489334)Curated
    Sequence conflicti722 – 7221A → R in AAA37319. (PubMed:9143510)Curated
    Sequence conflicti722 – 7221A → R in AAA37323. (PubMed:9143510)Curated
    Sequence conflicti722 – 7221A → R in AAA37324. (PubMed:9143510)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei407 – 44438MAFET…RQCTK → LAFEATVKKQVQKLKEPSIK CVDMVVSELTSTIRKCSE in isoform 3. 2 PublicationsVSP_007643Add
    BLAST
    Alternative sequencei516 – 5194Missing in isoform 2 and isoform 6. 2 PublicationsVSP_007644
    Alternative sequencei845 – 86723SLGAW…GKARL → RITISDP in isoform 3 and isoform 5. 3 PublicationsVSP_007645Add
    BLAST
    Alternative sequencei846 – 86722LGAWR…GKARL → RKAQPHLRDLQPPDQRRLPS in isoform 2. 1 PublicationVSP_007646Add
    BLAST
    Alternative sequencei846 – 86722LGAWR…GKARL → RSGQASPSRPESPRPPFDL in isoform 4. 1 PublicationVSP_007647Add
    BLAST
    Alternative sequencei846 – 86722LGAWR…GKARL → RKGPASPTRPAAPRPTEAPL LDL in isoform 6. 1 PublicationVSP_024845Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L29457 mRNA. Translation: AAA37319.1.
    L31395 mRNA. Translation: AAA37318.1.
    L31396 mRNA. Translation: AAA37323.1.
    L31397 mRNA. Translation: AAA37324.1.
    AK011651 mRNA. Translation: BAB27759.1.
    AK144142 mRNA. Translation: BAE25726.1.
    AK220483 mRNA. Translation: BAD90284.1. Different initiation.
    AL808027 Genomic DNA. Translation: CAM15852.1.
    AL808027 Genomic DNA. Translation: CAM15853.1.
    AL808027 Genomic DNA. Translation: CAM15855.1.
    AL808027 Genomic DNA. Translation: CAM15857.1.
    BC034679 mRNA. Translation: AAH34679.1.
    BC058623 mRNA. Translation: AAH58623.1.
    AF170568 Genomic DNA. Translation: AAF24220.1.
    CCDSiCCDS38102.1. [P39053-6]
    RefSeqiNP_034195.2. NM_010065.2. [P39053-6]
    UniGeneiMm.44736.

    Genome annotation databases

    EnsembliENSMUST00000078352; ENSMUSP00000077461; ENSMUSG00000026825. [P39053-3]
    ENSMUST00000091089; ENSMUSP00000088618; ENSMUSG00000026825. [P39053-6]
    ENSMUST00000113350; ENSMUSP00000108977; ENSMUSG00000026825. [P39053-5]
    ENSMUST00000113352; ENSMUSP00000108979; ENSMUSG00000026825. [P39053-5]
    ENSMUST00000113365; ENSMUSP00000108992; ENSMUSG00000026825. [P39053-4]
    ENSMUST00000139624; ENSMUSP00000122679; ENSMUSG00000026825. [P39053-1]
    GeneIDi13429.
    KEGGimmu:13429.
    UCSCiuc008jfc.1. mouse. [P39053-6]
    uc008jfd.2. mouse. [P39053-3]
    uc029twn.1. mouse. [P39053-5]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L29457 mRNA. Translation: AAA37319.1 .
    L31395 mRNA. Translation: AAA37318.1 .
    L31396 mRNA. Translation: AAA37323.1 .
    L31397 mRNA. Translation: AAA37324.1 .
    AK011651 mRNA. Translation: BAB27759.1 .
    AK144142 mRNA. Translation: BAE25726.1 .
    AK220483 mRNA. Translation: BAD90284.1 . Different initiation.
    AL808027 Genomic DNA. Translation: CAM15852.1 .
    AL808027 Genomic DNA. Translation: CAM15853.1 .
    AL808027 Genomic DNA. Translation: CAM15855.1 .
    AL808027 Genomic DNA. Translation: CAM15857.1 .
    BC034679 mRNA. Translation: AAH34679.1 .
    BC058623 mRNA. Translation: AAH58623.1 .
    AF170568 Genomic DNA. Translation: AAF24220.1 .
    CCDSi CCDS38102.1. [P39053-6 ]
    RefSeqi NP_034195.2. NM_010065.2. [P39053-6 ]
    UniGenei Mm.44736.

    3D structure databases

    ProteinModelPortali P39053.
    SMRi P39053. Positions 6-746.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199257. 13 interactions.
    IntActi P39053. 20 interactions.
    MINTi MINT-86537.

    PTM databases

    PhosphoSitei P39053.

    Proteomic databases

    MaxQBi P39053.
    PaxDbi P39053.
    PRIDEi P39053.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000078352 ; ENSMUSP00000077461 ; ENSMUSG00000026825 . [P39053-3 ]
    ENSMUST00000091089 ; ENSMUSP00000088618 ; ENSMUSG00000026825 . [P39053-6 ]
    ENSMUST00000113350 ; ENSMUSP00000108977 ; ENSMUSG00000026825 . [P39053-5 ]
    ENSMUST00000113352 ; ENSMUSP00000108979 ; ENSMUSG00000026825 . [P39053-5 ]
    ENSMUST00000113365 ; ENSMUSP00000108992 ; ENSMUSG00000026825 . [P39053-4 ]
    ENSMUST00000139624 ; ENSMUSP00000122679 ; ENSMUSG00000026825 . [P39053-1 ]
    GeneIDi 13429.
    KEGGi mmu:13429.
    UCSCi uc008jfc.1. mouse. [P39053-6 ]
    uc008jfd.2. mouse. [P39053-3 ]
    uc029twn.1. mouse. [P39053-5 ]

    Organism-specific databases

    CTDi 1759.
    MGIi MGI:107384. Dnm1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG0699.
    GeneTreei ENSGT00740000115253.
    HOVERGENi HBG107833.
    KOi K01528.
    OMAi QYPHLRE.
    OrthoDBi EOG76MK7N.
    PhylomeDBi P39053.
    TreeFami TF300362.

    Enzyme and pathway databases

    Reactomei REACT_196550. MHC class II antigen presentation.
    REACT_202778. Retrograde neurotrophin signalling.
    REACT_209040. Gap junction degradation.
    REACT_220352. Formation of annular gap junctions.

    Miscellaneous databases

    ChiTaRSi DNM1. mouse.
    NextBioi 283851.
    PROi P39053.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P39053.
    Bgeei P39053.
    CleanExi MM_DNM1.
    Genevestigatori P39053.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR027741. DNM1.
    IPR000375. Dynamin_central.
    IPR001401. Dynamin_GTPase.
    IPR019762. Dynamin_GTPase_CS.
    IPR022812. Dynamin_SF.
    IPR003130. GED.
    IPR020850. GTPase_effector_domain_GED.
    IPR027417. P-loop_NTPase.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    PANTHERi PTHR11566. PTHR11566. 1 hit.
    PTHR11566:SF32. PTHR11566:SF32. 1 hit.
    Pfami PF01031. Dynamin_M. 1 hit.
    PF00350. Dynamin_N. 1 hit.
    PF02212. GED. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view ]
    PRINTSi PR00195. DYNAMIN.
    SMARTi SM00053. DYNc. 1 hit.
    SM00302. GED. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00410. G_DYNAMIN_1. 1 hit.
    PS51718. G_DYNAMIN_2. 1 hit.
    PS51388. GED. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectively."
      Klocke R., Augustin A., Ronsiek M., Stief A., van der Putten H., Jockusch H.
      Genomics 41:290-292(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5).
      Strain: NIH Swiss.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
      Strain: C57BL/6J.
      Tissue: Colon and Embryo.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
      Strain: C57BL/6.
      Tissue: Brain and Retina.
    6. "Characterization of the mouse dynamin I gene promoter and identification of sequences that direct expression in neuronal cells."
      Yoo J., Lee S.S., Jeong M.J., Lee K.I., Kwon B.M., Kim S.H., Park Y.M., Han M.Y.
      Biochem. J. 351:661-668(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-32.
    7. Lubec G., Klug S., Kang S.U., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Strain: C57BL/6 and OF1.
      Tissue: Brain and Hippocampus.
    8. "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis."
      Modregger J., Ritter B., Witter B., Paulsson M., Plomann M.
      J. Cell Sci. 113:4511-4521(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PACSIN1; PACSIN2 AND PACSIN3, SUBCELLULAR LOCATION.
    9. "The endocytosis-linked protein dynamin associates with caveolin-1 and is tyrosine phosphorylated in response to the activation of a noninternalizing epidermal growth factor receptor mutant."
      Kim Y.N., Bertics P.J.
      Endocrinology 143:1726-1731(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CAV1, PHOSPHORYLATION.
    10. "Characterization of endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1."
      Modregger J., Schmidt A.A., Ritter B., Huttner W.B., Plomann M.
      J. Biol. Chem. 278:4160-4167(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SH3GLB1.
    11. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-125, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    13. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
      J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-80; TYR-125 AND TYR-354, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    14. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-847 (ISOFORM 6), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    15. "UNC119 inhibits dynamin and dynamin-dependent endocytic processes."
      Karim Z., Vepachedu R., Gorska M., Alam R.
      Cell. Signal. 22:128-137(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UNC119.

    Entry informationi

    Entry nameiDYN1_MOUSE
    AccessioniPrimary (citable) accession number: P39053
    Secondary accession number(s): A2AN50
    , A2AN51, A2AN54, A2AN55, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: June 20, 2003
    Last modified: October 1, 2014
    This is version 143 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3