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Protein

Dynamin-1

Gene

Dnm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis (By similarity).By similarity

Catalytic activityi

GTP + H2O = GDP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 45GTPBy similarity8
Nucleotide bindingi136 – 140GTPBy similarity5
Nucleotide bindingi205 – 208GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW
  • identical protein binding Source: MGI
  • microtubule binding Source: GO_Central
  • poly(A) RNA binding Source: MGI
  • protein dimerization activity Source: MGI
  • protein kinase binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • clathrin-dependent endocytosis Source: InterPro
  • dynamin family protein polymerization involved in mitochondrial fission Source: GO_Central
  • endocytosis Source: MGI
  • endosome organization Source: MGI
  • G-protein coupled receptor internalization Source: Ensembl
  • membrane fusion Source: GO_Central
  • mitochondrial fission Source: GO_Central
  • positive regulation of synaptic vesicle recycling Source: Ensembl
  • protein tetramerization Source: MGI
  • receptor internalization Source: GO_Central
  • receptor-mediated endocytosis Source: MGI
  • sensory perception of sound Source: MGI
  • synaptic transmission, GABAergic Source: MGI
  • toxin transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Motor protein

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-166016. Toll Like Receptor 4 (TLR4) Cascade.
R-MMU-190873. Gap junction degradation.
R-MMU-196025. Formation of annular gap junctions.
R-MMU-2132295. MHC class II antigen presentation.
R-MMU-437239. Recycling pathway of L1.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynamin-1 (EC:3.6.5.5)
Gene namesi
Name:Dnm1
Synonyms:Dnm, Kiaa4093
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:107384. Dnm1.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cytoplasmcytoskeleton 1 Publication

  • Note: Microtubule-associated.

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • Golgi apparatus Source: Ensembl
  • membrane coat Source: MGI
  • microtubule Source: UniProtKB-KW
  • mitochondrial membrane Source: GO_Central
  • myelin sheath Source: UniProtKB
  • photoreceptor inner segment Source: MGI
  • plasma membrane Source: Ensembl
  • synaptic vesicle Source: Ensembl
  • varicosity Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002065641 – 867Dynamin-1Add BLAST867

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei80PhosphotyrosineCombined sources1
Modified residuei125Nitrated tyrosine; alternateCombined sources1
Modified residuei125Phosphotyrosine; alternateCombined sources1
Modified residuei306PhosphoserineCombined sources1
Modified residuei347PhosphoserineBy similarity1
Modified residuei354PhosphotyrosineCombined sources1
Modified residuei512PhosphoserineCombined sources1
Modified residuei774PhosphoserineBy similarity1
Modified residuei778PhosphoserineBy similarity1
Modified residuei796Omega-N-methylarginineCombined sources1
Modified residuei822PhosphoserineBy similarity1
Isoform 6 (identifier: P39053-6)
Modified residuei847PhosphoserineCombined sources1
Isoform 4 (identifier: P39053-4)
Modified residuei851PhosphoserineCombined sources1
Modified residuei857PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated in response to EGF stimulation in cells expressing truncated EGFR.1 Publication

Keywords - PTMi

Methylation, Nitration, Phosphoprotein

Proteomic databases

MaxQBiP39053.
PaxDbiP39053.
PeptideAtlasiP39053.
PRIDEiP39053.

PTM databases

iPTMnetiP39053.
PhosphoSitePlusiP39053.
SwissPalmiP39053.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026825.
CleanExiMM_DNM1.
ExpressionAtlasiP39053. baseline and differential.
GenevisibleiP39053. MM.

Interactioni

Subunit structurei

Binds SH3GL1, SH3GL2 and SH3GL3 (By similarity). Interacts with SNX9 (By similarity). Interacts with PHOCN. Interacts with MYO1E (via SH3 domain). Interacts with SNX33 (via SH3 domain) (By similarity). Interacts with CAV1 and SH3GLB1. Interacts with PACSIN1, PACSIN2 and PACSIN3. Interacts with UNC119; leading to a decrease of DNM1 GTPase activity. Interacts with DIAPH1 (By similarity).By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AmphQ7TQF73EBI-397785,EBI-775139
LRRK2Q5S0073EBI-397785,EBI-5323863From a different organism.
Pfn2Q9JJV2-12EBI-397785,EBI-990256

GO - Molecular functioni

  • identical protein binding Source: MGI
  • microtubule binding Source: GO_Central
  • protein dimerization activity Source: MGI
  • protein kinase binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi199257. 21 interactors.
IntActiP39053. 27 interactors.
MINTiMINT-86537.
STRINGi10090.ENSMUSP00000088618.

Structurei

3D structure databases

ProteinModelPortaliP39053.
SMRiP39053.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 294Dynamin-type GAdd BLAST267
Domaini515 – 625PHPROSITE-ProRule annotationAdd BLAST111
Domaini659 – 750GEDPROSITE-ProRule annotationAdd BLAST92

Sequence similaritiesi

Contains 1 GED domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
GeneTreeiENSGT00760000119213.
HOVERGENiHBG107833.
InParanoidiP39053.
KOiK01528.
OMAiNGDESAN.
OrthoDBiEOG091G0EIQ.
PhylomeDBiP39053.
TreeFamiTF300362.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR027741. DNM1.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF32. PTHR11566:SF32. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P39053-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNRGMEDLI PLVNRLQDAF SAIGQNADLD LPQIAVVGGQ SAGKSSVLEN
60 70 80 90 100
FVGRDFLPRG SGIVTRRPLV LQLVNSTTEY AEFLHCKGKK FTDFEEVRLE
110 120 130 140 150
IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLVDLPGM TKVPVGDQPP
160 170 180 190 200
DIEFQIRDML MQFVTKENCL ILAVSPANSD LANSDALKIA KEVDPQGQRT
210 220 230 240 250
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIDGKKDITA
260 270 280 290 300
ALAAERKFFL SHPSYRHLAD RMGTPYLQKV LNQQLTNHIR DTLPGLRNKL
310 320 330 340 350
QSQLLSIEKE VDEYKNFRPD DPARKTKALL QMVQQFAVDF EKRIEGSGDQ
360 370 380 390 400
IDTYELSGGA RINRIFHERF PFELVKMEFD EKELRREISY AIKNIHGIRT
410 420 430 440 450
GLFTPDMAFE TIVKKQVKKI REPCLKCVDM VISELISTVR QCTKKLQQYP
460 470 480 490 500
RLREEMERIV TTHIREREGR TKEQVMLLID IELAYMNTNH EDFIGFANAQ
510 520 530 540 550
QRSNQMNKKK TSGNQDEILV IRKGWLTINN IGIMKGGSKE YWFVLTAENL
560 570 580 590 600
SWYKDDEEKE KKYMLSVDNL KLRDVEKGFM SSKHIFALFN TEQRNVYKDY
610 620 630 640 650
RQLELACETQ EEVDSWKASF LRAGVYPERV GDKEKASETE ENGSDSFMHS
660 670 680 690 700
MDPQLERQVE TIRNLVDSYM AIVNKTVRDL MPKTIMHLMI NNTKEFIFSE
710 720 730 740 750
LLANLYSCGD QNTLMEESAE QAQRRDEMLR MYHALKEALS IIGDINTTTV
760 770 780 790 800
STPMPPPVDD SWLQVQSVPA GRRSPTSSPT PQRRAPAVPP ARPGSRGPAP
810 820 830 840 850
GPPPAGSALG GAPPVPSRPG ASPDPFGPPP QVPSRPNRAP PGVPSLGAWR
860
LNSPQGKHEN RAGKARL
Length:867
Mass (Da):97,803
Last modified:June 20, 2003 - v2
Checksum:iF48EC3DF5F39A08B
GO
Isoform 3 (identifier: P39053-3) [UniParc]FASTAAdd to basket
Also known as: BraDnm8

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: MAFETIVKKQ...LISTVRQCTK → LAFEATVKKQ...LTSTIRKCSE
     845-867: SLGAWRLNSPQGKHENRAGKARL → RITISDP

Show »
Length:851
Mass (Da):95,927
Checksum:i5D9294C5D1015A88
GO
Isoform 4 (identifier: P39053-4) [UniParc]FASTAAdd to basket
Also known as: BraDnm2

The sequence of this isoform differs from the canonical sequence as follows:
     846-867: LGAWRLNSPQGKHENRAGKARL → RSGQASPSRPESPRPPFDL

Show »
Length:864
Mass (Da):97,424
Checksum:i4E27474E413CCEE7
GO
Isoform 5 (identifier: P39053-5) [UniParc]FASTAAdd to basket
Also known as: BreDnm15

The sequence of this isoform differs from the canonical sequence as follows:
     845-867: SLGAWRLNSPQGKHENRAGKARL → RITISDP

Show »
Length:851
Mass (Da):96,057
Checksum:i5FE0938290E39F51
GO
Isoform 6 (identifier: P39053-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-519: Missing.
     846-867: LGAWRLNSPQGKHENRAGKARL → RKGPASPTRPAAPRPTEAPLLDL

Note: PubMed:9143510 (AAA37324) sequence has a frameshift in position 844.Combined sources
Show »
Length:864
Mass (Da):97,284
Checksum:i12CA402BCCCF2936
GO

Sequence cautioni

The sequence BAD90284 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135V → A in AAA37318 (PubMed:9143510).Curated1
Sequence conflicti450P → R in AAA37318 (PubMed:9143510).Curated1
Sequence conflicti531I → S in AAA37318 (PubMed:9143510).Curated1
Sequence conflicti573R → H in BAE25726 (PubMed:16141072).Curated1
Sequence conflicti600Y → N in AAA37318 (PubMed:9143510).Curated1
Sequence conflicti703A → V in AAH58623 (PubMed:15489334).Curated1
Sequence conflicti722A → R in AAA37319 (PubMed:9143510).Curated1
Sequence conflicti722A → R in AAA37323 (PubMed:9143510).Curated1
Sequence conflicti722A → R in AAA37324 (PubMed:9143510).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007643407 – 444MAFET…RQCTK → LAFEATVKKQVQKLKEPSIK CVDMVVSELTSTIRKCSE in isoform 3. 2 PublicationsAdd BLAST38
Alternative sequenceiVSP_007644516 – 519Missing in isoform 6. 2 Publications4
Alternative sequenceiVSP_007645845 – 867SLGAW…GKARL → RITISDP in isoform 3 and isoform 5. 3 PublicationsAdd BLAST23
Alternative sequenceiVSP_007647846 – 867LGAWR…GKARL → RSGQASPSRPESPRPPFDL in isoform 4. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_024845846 – 867LGAWR…GKARL → RKGPASPTRPAAPRPTEAPL LDL in isoform 6. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29457 mRNA. Translation: AAA37319.1.
L31395 mRNA. Translation: AAA37318.1.
L31396 mRNA. Translation: AAA37323.1.
L31397 mRNA. Translation: AAA37324.1. Frameshift.
AK011651 mRNA. Translation: BAB27759.1.
AK144142 mRNA. Translation: BAE25726.1.
AK220483 mRNA. Translation: BAD90284.1. Different initiation.
AL808027 Genomic DNA. Translation: CAM15852.1.
AL808027 Genomic DNA. Translation: CAM15853.1.
AL808027 Genomic DNA. Translation: CAM15855.1.
AL808027 Genomic DNA. Translation: CAM15857.1.
BC034679 mRNA. Translation: AAH34679.1.
BC058623 mRNA. Translation: AAH58623.1.
AF170568 Genomic DNA. Translation: AAF24220.1.
CCDSiCCDS38102.1. [P39053-6]
CCDS79772.1. [P39053-3]
RefSeqiNP_001288666.1. NM_001301737.1. [P39053-3]
NP_034195.2. NM_010065.3. [P39053-6]
XP_006497718.2. XM_006497655.2. [P39053-4]
XP_006497721.2. XM_006497658.3. [P39053-3]
XP_006497722.2. XM_006497659.3. [P39053-3]
XP_006497723.2. XM_006497660.2. [P39053-3]
XP_006497724.2. XM_006497661.2. [P39053-5]
XP_017170817.1. XM_017315328.1. [P39053-5]
UniGeneiMm.44736.

Genome annotation databases

EnsembliENSMUST00000078352; ENSMUSP00000077461; ENSMUSG00000026825. [P39053-3]
ENSMUST00000091089; ENSMUSP00000088618; ENSMUSG00000026825. [P39053-6]
ENSMUST00000113350; ENSMUSP00000108977; ENSMUSG00000026825. [P39053-5]
ENSMUST00000113352; ENSMUSP00000108979; ENSMUSG00000026825. [P39053-5]
ENSMUST00000113365; ENSMUSP00000108992; ENSMUSG00000026825. [P39053-4]
ENSMUST00000139624; ENSMUSP00000122679; ENSMUSG00000026825. [P39053-1]
ENSMUST00000202578; ENSMUSP00000143955; ENSMUSG00000026825. [P39053-3]
GeneIDi13429.
KEGGimmu:13429.
UCSCiuc008jfc.2. mouse. [P39053-6]
uc008jfd.3. mouse. [P39053-3]
uc029twn.1. mouse. [P39053-5]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29457 mRNA. Translation: AAA37319.1.
L31395 mRNA. Translation: AAA37318.1.
L31396 mRNA. Translation: AAA37323.1.
L31397 mRNA. Translation: AAA37324.1. Frameshift.
AK011651 mRNA. Translation: BAB27759.1.
AK144142 mRNA. Translation: BAE25726.1.
AK220483 mRNA. Translation: BAD90284.1. Different initiation.
AL808027 Genomic DNA. Translation: CAM15852.1.
AL808027 Genomic DNA. Translation: CAM15853.1.
AL808027 Genomic DNA. Translation: CAM15855.1.
AL808027 Genomic DNA. Translation: CAM15857.1.
BC034679 mRNA. Translation: AAH34679.1.
BC058623 mRNA. Translation: AAH58623.1.
AF170568 Genomic DNA. Translation: AAF24220.1.
CCDSiCCDS38102.1. [P39053-6]
CCDS79772.1. [P39053-3]
RefSeqiNP_001288666.1. NM_001301737.1. [P39053-3]
NP_034195.2. NM_010065.3. [P39053-6]
XP_006497718.2. XM_006497655.2. [P39053-4]
XP_006497721.2. XM_006497658.3. [P39053-3]
XP_006497722.2. XM_006497659.3. [P39053-3]
XP_006497723.2. XM_006497660.2. [P39053-3]
XP_006497724.2. XM_006497661.2. [P39053-5]
XP_017170817.1. XM_017315328.1. [P39053-5]
UniGeneiMm.44736.

3D structure databases

ProteinModelPortaliP39053.
SMRiP39053.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199257. 21 interactors.
IntActiP39053. 27 interactors.
MINTiMINT-86537.
STRINGi10090.ENSMUSP00000088618.

PTM databases

iPTMnetiP39053.
PhosphoSitePlusiP39053.
SwissPalmiP39053.

Proteomic databases

MaxQBiP39053.
PaxDbiP39053.
PeptideAtlasiP39053.
PRIDEiP39053.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078352; ENSMUSP00000077461; ENSMUSG00000026825. [P39053-3]
ENSMUST00000091089; ENSMUSP00000088618; ENSMUSG00000026825. [P39053-6]
ENSMUST00000113350; ENSMUSP00000108977; ENSMUSG00000026825. [P39053-5]
ENSMUST00000113352; ENSMUSP00000108979; ENSMUSG00000026825. [P39053-5]
ENSMUST00000113365; ENSMUSP00000108992; ENSMUSG00000026825. [P39053-4]
ENSMUST00000139624; ENSMUSP00000122679; ENSMUSG00000026825. [P39053-1]
ENSMUST00000202578; ENSMUSP00000143955; ENSMUSG00000026825. [P39053-3]
GeneIDi13429.
KEGGimmu:13429.
UCSCiuc008jfc.2. mouse. [P39053-6]
uc008jfd.3. mouse. [P39053-3]
uc029twn.1. mouse. [P39053-5]

Organism-specific databases

CTDi1759.
MGIiMGI:107384. Dnm1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
GeneTreeiENSGT00760000119213.
HOVERGENiHBG107833.
InParanoidiP39053.
KOiK01528.
OMAiNGDESAN.
OrthoDBiEOG091G0EIQ.
PhylomeDBiP39053.
TreeFamiTF300362.

Enzyme and pathway databases

ReactomeiR-MMU-166016. Toll Like Receptor 4 (TLR4) Cascade.
R-MMU-190873. Gap junction degradation.
R-MMU-196025. Formation of annular gap junctions.
R-MMU-2132295. MHC class II antigen presentation.
R-MMU-437239. Recycling pathway of L1.

Miscellaneous databases

ChiTaRSiDnm1. mouse.
PROiP39053.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026825.
CleanExiMM_DNM1.
ExpressionAtlasiP39053. baseline and differential.
GenevisibleiP39053. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR027741. DNM1.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF32. PTHR11566:SF32. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDYN1_MOUSE
AccessioniPrimary (citable) accession number: P39053
Secondary accession number(s): A2AN50
, A2AN51, A2AN54, A2AN55, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 20, 2003
Last modified: November 2, 2016
This is version 166 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.