P39053 (DYN1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dynamin-1
EC=3.6.5.5

Gene names

Name:	Dnm1
Synonyms:	Dnm, Kiaa4093

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	867 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis By similarity.
Catalytic activity	GTP + H2O = GDP + phosphate.
Subunit structure	Binds SH3GL1, SH3GL2 and SH3GL3 By similarity. Interacts with SNX9 By similarity. Interacts with PHOCN By similarity. Interacts with CAV1 and SH3GLB1. Ref.8 Ref.9
Subcellular location	Cytoplasm. Cytoplasm › cytoskeleton. Note: Microtubule-associated.
Post-translational modification	Phosphorylated in response to EGF stimulation in cells expressing truncated EGFR. Ref.8 Ref.11 Ref.12 Ref.13
Sequence similarities	Belongs to the dynamin family. Contains 1 GED domain. Contains 1 PH domain.
Sequence caution	The sequence BAD90284.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Endocytosis
Cellular component	Cytoplasm Cytoskeleton Microtubule
Coding sequence diversity	Alternative splicing
Ligand	GTP-binding Nucleotide-binding
Molecular function	Hydrolase Motor protein
PTM	Nitration Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular component	membrane coat Inferred from direct assay. Source: MGI microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction Ref.8. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Pfn2	Q9JJV2-1	2	EBI-397785,EBI-990256

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P39053-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Phosphorylated on Ser-847.

Isoform 2 (identifier: P39053-2)

Also known as: BreDnm19;

The sequence of this isoform differs from the canonical sequence as follows:
     516-519: Missing.
     846-867: LGAWRLNSPQGKHENRAGKARL → RKAQPHLRDLQPPDQRRLPS

Isoform 3 (identifier: P39053-3)

Also known as: BraDnm8;

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: MAFETIVKKQ...LISTVRQCTK → LAFEATVKKQ...LTSTIRKCSE
     845-867: SLGAWRLNSPQGKHENRAGKARL → RITISDP

Isoform 4 (identifier: P39053-4)

Also known as: BraDnm2;

The sequence of this isoform differs from the canonical sequence as follows:
     846-867: LGAWRLNSPQGKHENRAGKARL → RSGQASPSRPESPRPPFDL

Isoform 5 (identifier: P39053-5)

Also known as: BreDnm15;

The sequence of this isoform differs from the canonical sequence as follows:
     845-867: SLGAWRLNSPQGKHENRAGKARL → RITISDP

Isoform 6 (identifier: P39053-6)

The sequence of this isoform differs from the canonical sequence as follows:
     516-519: Missing.
     846-867: LGAWRLNSPQGKHENRAGKARL → RKGPASPTRPAAPRPTEAPLLDL

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 867	867	Dynamin-1		PRO_0000206564
Regions
	Domain	515 – 625	111	PH
	Domain	659 – 750	92	GED
	Nucleotide binding	38 – 45	8	GTP By similarity
	Nucleotide binding	136 – 140	5	GTP By similarity
	Nucleotide binding	205 – 208	4	GTP By similarity
Amino acid modifications
	Modified residue	80	1	Phosphotyrosine Ref.11
	Modified residue	125	1	Nitrated tyrosine Ref.10
	Modified residue	125	1	Phosphotyrosine Ref.11
	Modified residue	354	1	Phosphotyrosine Ref.11
	Modified residue	774	1	Phosphoserine By similarity
	Modified residue	776	1	Phosphothreonine By similarity
	Modified residue	778	1	Phosphoserine Ref.12
Natural variations
	Alternative sequence	407 – 444	38	MAFET…RQCTK → LAFEATVKKQVQKLKEPSIK CVDMVVSELTSTIRKCSE in isoform 3.		VSP_007643
	Alternative sequence	516 – 519	4	Missing in isoform 2 and isoform 6.		VSP_007644
	Alternative sequence	845 – 867	23	SLGAW…GKARL → RITISDP in isoform 3 and isoform 5.		VSP_007645
	Alternative sequence	846 – 867	22	LGAWR…GKARL → RKAQPHLRDLQPPDQRRLPS in isoform 2.		VSP_007646
	Alternative sequence	846 – 867	22	LGAWR…GKARL → RSGQASPSRPESPRPPFDL in isoform 4.		VSP_007647
	Alternative sequence	846 – 867	22	LGAWR…GKARL → RKGPASPTRPAAPRPTEAPL LDL in isoform 6.		VSP_024845
Experimental info
	Sequence conflict	135	1	V → A in AAA37318. Ref.1
	Sequence conflict	450	1	P → R in AAA37318. Ref.1
	Sequence conflict	531	1	I → S in AAA37318. Ref.1
	Sequence conflict	573	1	R → H in BAE25726. Ref.2
	Sequence conflict	600	1	Y → N in AAA37318. Ref.1
	Sequence conflict	703	1	A → V in AAH58623. Ref.5
	Sequence conflict	722	1	A → R in AAA37319. Ref.1
	Sequence conflict	722	1	A → R in AAA37323. Ref.1
	Sequence conflict	722	1	A → R in AAA37324. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 20, 2003. Version 2. Checksum: F48EC3DF5F39A08B	FASTA	867	97,803
	10 20 30 40 50 60 MGNRGMEDLI PLVNRLQDAF SAIGQNADLD LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 70 80 90 100 110 120 SGIVTRRPLV LQLVNSTTEY AEFLHCKGKK FTDFEEVRLE IEAETDRVTG TNKGISPVPI 130 140 150 160 170 180 NLRVYSPHVL NLTLVDLPGM TKVPVGDQPP DIEFQIRDML MQFVTKENCL ILAVSPANSD 190 200 210 220 230 240 LANSDALKIA KEVDPQGQRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK 250 260 270 280 290 300 DIDGKKDITA ALAAERKFFL SHPSYRHLAD RMGTPYLQKV LNQQLTNHIR DTLPGLRNKL 310 320 330 340 350 360 QSQLLSIEKE VDEYKNFRPD DPARKTKALL QMVQQFAVDF EKRIEGSGDQ IDTYELSGGA 370 380 390 400 410 420 RINRIFHERF PFELVKMEFD EKELRREISY AIKNIHGIRT GLFTPDMAFE TIVKKQVKKI 430 440 450 460 470 480 REPCLKCVDM VISELISTVR QCTKKLQQYP RLREEMERIV TTHIREREGR TKEQVMLLID 490 500 510 520 530 540 IELAYMNTNH EDFIGFANAQ QRSNQMNKKK TSGNQDEILV IRKGWLTINN IGIMKGGSKE 550 560 570 580 590 600 YWFVLTAENL SWYKDDEEKE KKYMLSVDNL KLRDVEKGFM SSKHIFALFN TEQRNVYKDY 610 620 630 640 650 660 RQLELACETQ EEVDSWKASF LRAGVYPERV GDKEKASETE ENGSDSFMHS MDPQLERQVE 670 680 690 700 710 720 TIRNLVDSYM AIVNKTVRDL MPKTIMHLMI NNTKEFIFSE LLANLYSCGD QNTLMEESAE 730 740 750 760 770 780 QAQRRDEMLR MYHALKEALS IIGDINTTTV STPMPPPVDD SWLQVQSVPA GRRSPTSSPT 790 800 810 820 830 840 PQRRAPAVPP ARPGSRGPAP GPPPAGSALG GAPPVPSRPG ASPDPFGPPP QVPSRPNRAP 850 860 PGVPSLGAWR LNSPQGKHEN RAGKARL
	Isoform 2 (BreDnm19) [UniParc]. Checksum: 81F22599EA77FB3F	FASTA	861	97,281
	10 20 30 40 50 60 MGNRGMEDLI PLVNRLQDAF SAIGQNADLD LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 70 80 90 100 110 120 SGIVTRRPLV LQLVNSTTEY AEFLHCKGKK FTDFEEVRLE IEAETDRVTG TNKGISPVPI 130 140 150 160 170 180 NLRVYSPHVL NLTLVDLPGM TKVPVGDQPP DIEFQIRDML MQFVTKENCL ILAVSPANSD 190 200 210 220 230 240 LANSDALKIA KEVDPQGQRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK 250 260 270 280 290 300 DIDGKKDITA ALAAERKFFL SHPSYRHLAD RMGTPYLQKV LNQQLTNHIR DTLPGLRNKL 310 320 330 340 350 360 QSQLLSIEKE VDEYKNFRPD DPARKTKALL QMVQQFAVDF EKRIEGSGDQ IDTYELSGGA 370 380 390 400 410 420 RINRIFHERF PFELVKMEFD EKELRREISY AIKNIHGIRT GLFTPDMAFE TIVKKQVKKI 430 440 450 460 470 480 REPCLKCVDM VISELISTVR QCTKKLQQYP RLREEMERIV TTHIREREGR TKEQVMLLID 490 500 510 520 530 540 IELAYMNTNH EDFIGFANAQ QRSNQMNKKK TSGNQVIRKG WLTINNIGIM KGGSKEYWFV 550 560 570 580 590 600 LTAENLSWYK DDEEKEKKYM LSVDNLKLRD VEKGFMSSKH IFALFNTEQR NVYKDYRQLE 610 620 630 640 650 660 LACETQEEVD SWKASFLRAG VYPERVGDKE KASETEENGS DSFMHSMDPQ LERQVETIRN 670 680 690 700 710 720 LVDSYMAIVN KTVRDLMPKT IMHLMINNTK EFIFSELLAN LYSCGDQNTL MEESAEQAQR 730 740 750 760 770 780 RDEMLRMYHA LKEALSIIGD INTTTVSTPM PPPVDDSWLQ VQSVPAGRRS PTSSPTPQRR 790 800 810 820 830 840 APAVPPARPG SRGPAPGPPP AGSALGGAPP VPSRPGASPD PFGPPPQVPS RPNRAPPGVP 850 860 SRKAQPHLRD LQPPDQRRLP S
	Isoform 3 (BraDnm8) [UniParc]. Checksum: 5D9294C5D1015A88	FASTA	851	95,927
	10 20 30 40 50 60 MGNRGMEDLI PLVNRLQDAF SAIGQNADLD LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 70 80 90 100 110 120 SGIVTRRPLV LQLVNSTTEY AEFLHCKGKK FTDFEEVRLE IEAETDRVTG TNKGISPVPI 130 140 150 160 170 180 NLRVYSPHVL NLTLVDLPGM TKVPVGDQPP DIEFQIRDML MQFVTKENCL ILAVSPANSD 190 200 210 220 230 240 LANSDALKIA KEVDPQGQRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK 250 260 270 280 290 300 DIDGKKDITA ALAAERKFFL SHPSYRHLAD RMGTPYLQKV LNQQLTNHIR DTLPGLRNKL 310 320 330 340 350 360 QSQLLSIEKE VDEYKNFRPD DPARKTKALL QMVQQFAVDF EKRIEGSGDQ IDTYELSGGA 370 380 390 400 410 420 RINRIFHERF PFELVKMEFD EKELRREISY AIKNIHGIRT GLFTPDLAFE ATVKKQVQKL 430 440 450 460 470 480 KEPSIKCVDM VVSELTSTIR KCSEKLQQYP RLREEMERIV TTHIREREGR TKEQVMLLID 490 500 510 520 530 540 IELAYMNTNH EDFIGFANAQ QRSNQMNKKK TSGNQDEILV IRKGWLTINN IGIMKGGSKE 550 560 570 580 590 600 YWFVLTAENL SWYKDDEEKE KKYMLSVDNL KLRDVEKGFM SSKHIFALFN TEQRNVYKDY 610 620 630 640 650 660 RQLELACETQ EEVDSWKASF LRAGVYPERV GDKEKASETE ENGSDSFMHS MDPQLERQVE 670 680 690 700 710 720 TIRNLVDSYM AIVNKTVRDL MPKTIMHLMI NNTKEFIFSE LLANLYSCGD QNTLMEESAE 730 740 750 760 770 780 QAQRRDEMLR MYHALKEALS IIGDINTTTV STPMPPPVDD SWLQVQSVPA GRRSPTSSPT 790 800 810 820 830 840 PQRRAPAVPP ARPGSRGPAP GPPPAGSALG GAPPVPSRPG ASPDPFGPPP QVPSRPNRAP 850 PGVPRITISD P
	Isoform 4 (BraDnm2) [UniParc]. Checksum: 4E27474E413CCEE7	FASTA	864	97,424
	10 20 30 40 50 60 MGNRGMEDLI PLVNRLQDAF SAIGQNADLD LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 70 80 90 100 110 120 SGIVTRRPLV LQLVNSTTEY AEFLHCKGKK FTDFEEVRLE IEAETDRVTG TNKGISPVPI 130 140 150 160 170 180 NLRVYSPHVL NLTLVDLPGM TKVPVGDQPP DIEFQIRDML MQFVTKENCL ILAVSPANSD 190 200 210 220 230 240 LANSDALKIA KEVDPQGQRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK 250 260 270 280 290 300 DIDGKKDITA ALAAERKFFL SHPSYRHLAD RMGTPYLQKV LNQQLTNHIR DTLPGLRNKL 310 320 330 340 350 360 QSQLLSIEKE VDEYKNFRPD DPARKTKALL QMVQQFAVDF EKRIEGSGDQ IDTYELSGGA 370 380 390 400 410 420 RINRIFHERF PFELVKMEFD EKELRREISY AIKNIHGIRT GLFTPDMAFE TIVKKQVKKI 430 440 450 460 470 480 REPCLKCVDM VISELISTVR QCTKKLQQYP RLREEMERIV TTHIREREGR TKEQVMLLID 490 500 510 520 530 540 IELAYMNTNH EDFIGFANAQ QRSNQMNKKK TSGNQDEILV IRKGWLTINN IGIMKGGSKE 550 560 570 580 590 600 YWFVLTAENL SWYKDDEEKE KKYMLSVDNL KLRDVEKGFM SSKHIFALFN TEQRNVYKDY 610 620 630 640 650 660 RQLELACETQ EEVDSWKASF LRAGVYPERV GDKEKASETE ENGSDSFMHS MDPQLERQVE 670 680 690 700 710 720 TIRNLVDSYM AIVNKTVRDL MPKTIMHLMI NNTKEFIFSE LLANLYSCGD QNTLMEESAE 730 740 750 760 770 780 QAQRRDEMLR MYHALKEALS IIGDINTTTV STPMPPPVDD SWLQVQSVPA GRRSPTSSPT 790 800 810 820 830 840 PQRRAPAVPP ARPGSRGPAP GPPPAGSALG GAPPVPSRPG ASPDPFGPPP QVPSRPNRAP 850 860 PGVPSRSGQA SPSRPESPRP PFDL
	Isoform 5 (BreDnm15) [UniParc]. Checksum: 5FE0938290E39F51	FASTA	851	96,057
	10 20 30 40 50 60 MGNRGMEDLI PLVNRLQDAF SAIGQNADLD LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 70 80 90 100 110 120 SGIVTRRPLV LQLVNSTTEY AEFLHCKGKK FTDFEEVRLE IEAETDRVTG TNKGISPVPI 130 140 150 160 170 180 NLRVYSPHVL NLTLVDLPGM TKVPVGDQPP DIEFQIRDML MQFVTKENCL ILAVSPANSD 190 200 210 220 230 240 LANSDALKIA KEVDPQGQRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK 250 260 270 280 290 300 DIDGKKDITA ALAAERKFFL SHPSYRHLAD RMGTPYLQKV LNQQLTNHIR DTLPGLRNKL 310 320 330 340 350 360 QSQLLSIEKE VDEYKNFRPD DPARKTKALL QMVQQFAVDF EKRIEGSGDQ IDTYELSGGA 370 380 390 400 410 420 RINRIFHERF PFELVKMEFD EKELRREISY AIKNIHGIRT GLFTPDMAFE TIVKKQVKKI 430 440 450 460 470 480 REPCLKCVDM VISELISTVR QCTKKLQQYP RLREEMERIV TTHIREREGR TKEQVMLLID 490 500 510 520 530 540 IELAYMNTNH EDFIGFANAQ QRSNQMNKKK TSGNQDEILV IRKGWLTINN IGIMKGGSKE 550 560 570 580 590 600 YWFVLTAENL SWYKDDEEKE KKYMLSVDNL KLRDVEKGFM SSKHIFALFN TEQRNVYKDY 610 620 630 640 650 660 RQLELACETQ EEVDSWKASF LRAGVYPERV GDKEKASETE ENGSDSFMHS MDPQLERQVE 670 680 690 700 710 720 TIRNLVDSYM AIVNKTVRDL MPKTIMHLMI NNTKEFIFSE LLANLYSCGD QNTLMEESAE 730 740 750 760 770 780 QAQRRDEMLR MYHALKEALS IIGDINTTTV STPMPPPVDD SWLQVQSVPA GRRSPTSSPT 790 800 810 820 830 840 PQRRAPAVPP ARPGSRGPAP GPPPAGSALG GAPPVPSRPG ASPDPFGPPP QVPSRPNRAP 850 PGVPRITISD P
	Isoform 6 [UniParc]. Checksum: 12CA402BCCCF2936	FASTA	864	97,284
	10 20 30 40 50 60 MGNRGMEDLI PLVNRLQDAF SAIGQNADLD LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 70 80 90 100 110 120 SGIVTRRPLV LQLVNSTTEY AEFLHCKGKK FTDFEEVRLE IEAETDRVTG TNKGISPVPI 130 140 150 160 170 180 NLRVYSPHVL NLTLVDLPGM TKVPVGDQPP DIEFQIRDML MQFVTKENCL ILAVSPANSD 190 200 210 220 230 240 LANSDALKIA KEVDPQGQRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK 250 260 270 280 290 300 DIDGKKDITA ALAAERKFFL SHPSYRHLAD RMGTPYLQKV LNQQLTNHIR DTLPGLRNKL 310 320 330 340 350 360 QSQLLSIEKE VDEYKNFRPD DPARKTKALL QMVQQFAVDF EKRIEGSGDQ IDTYELSGGA 370 380 390 400 410 420 RINRIFHERF PFELVKMEFD EKELRREISY AIKNIHGIRT GLFTPDMAFE TIVKKQVKKI 430 440 450 460 470 480 REPCLKCVDM VISELISTVR QCTKKLQQYP RLREEMERIV TTHIREREGR TKEQVMLLID 490 500 510 520 530 540 IELAYMNTNH EDFIGFANAQ QRSNQMNKKK TSGNQVIRKG WLTINNIGIM KGGSKEYWFV 550 560 570 580 590 600 LTAENLSWYK DDEEKEKKYM LSVDNLKLRD VEKGFMSSKH IFALFNTEQR NVYKDYRQLE 610 620 630 640 650 660 LACETQEEVD SWKASFLRAG VYPERVGDKE KASETEENGS DSFMHSMDPQ LERQVETIRN 670 680 690 700 710 720 LVDSYMAIVN KTVRDLMPKT IMHLMINNTK EFIFSELLAN LYSCGDQNTL MEESAEQAQR 730 740 750 760 770 780 RDEMLRMYHA LKEALSIIGD INTTTVSTPM PPPVDDSWLQ VQSVPAGRRS PTSSPTPQRR 790 800 810 820 830 840 APAVPPARPG SRGPAPGPPP AGSALGGAPP VPSRPGASPD PFGPPPQVPS RPNRAPPGVP 850 860 SRKGPASPTR PAAPRPTEAP LLDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectively." Klocke R., Augustin A., Ronsiek M., Stief A., van der Putten H., Jockusch H. Genomics 41:290-292(1997) [PubMed: 9143510] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5). Strain: NIH Swiss. Tissue: Brain.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Strain: C57BL/6J. Tissue: Colon and Embryo.
[3]	"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H. Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[4]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5). Strain: C57BL/6. Tissue: Brain and Retina.
[6]	"Characterization of the mouse dynamin I gene promoter and identification of sequences that direct expression in neuronal cells." Yoo J., Lee S.S., Jeong M.J., Lee K.I., Kwon B.M., Kim S.H., Park Y.M., Han M.Y. Biochem. J. 351:661-668(2000) [PubMed: 11042120] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-32.
[7]	Lubec G., Klug S., Kang S.U., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 5-54; 67-87; 91-107; 114-188; 207-217; 230-237; 247-266; 280-290; 300-309; 328-361; 370-376; 400-414; 511-535; 563-571; 584-594; 664-675 AND 684-694. Strain: C57BL/6 and OF1. Tissue: Brain and Hippocampus.
[8]	"The endocytosis-linked protein dynamin associates with caveolin-1 and is tyrosine phosphorylated in response to the activation of a noninternalizing epidermal growth factor receptor mutant." Kim Y.N., Bertics P.J. Endocrinology 143:1726-1731(2002) [PubMed: 11956154] [Abstract] Cited for: INTERACTION WITH CAV1, PHOSPHORYLATION.
[9]	"Characterization of endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1." Modregger J., Schmidt A.A., Ritter B., Huttner W.B., Plomann M. J. Biol. Chem. 278:4160-4167(2003) [PubMed: 12456676] [Abstract] Cited for: INTERACTION WITH SH3GLB1.
[10]	"Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease." Sacksteder C.A., Qian W.-J., Knyushko T.V., Wang H., Chin M.H., Lacan G., Melega W.P., Camp D.G. II, Smith R.D., Smith D.J., Squier T.C., Bigelow D.J. Biochemistry 45:8009-8022(2006) [PubMed: 16800626] [Abstract] Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-125, MASS SPECTROMETRY. Tissue: Brain.
[11]	"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P. J. Proteome Res. 7:311-318(2008) [PubMed: 18034455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-80; TYR-125 AND TYR-354, MASS SPECTROMETRY. Tissue: Brain.
[12]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed: 19367708] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-778, MASS SPECTROMETRY. Tissue: Melanoma.
[13]	"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry." Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J. Mol. Cell. Proteomics 8:904-912(2009) [PubMed: 19131326] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-847 (ISOFORM 6), MASS SPECTROMETRY. Tissue: Embryonic fibroblast.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L29457 mRNA. Translation: AAA37319.1. L31395 mRNA. Translation: AAA37318.1. L31396 mRNA. Translation: AAA37323.1. L31397 mRNA. Translation: AAA37324.1. AK011651 mRNA. Translation: BAB27759.1. AK144142 mRNA. Translation: BAE25726.1. AK220483 mRNA. Translation: BAD90284.1. Different initiation. AL808027 Genomic DNA. Translation: CAM15852.1. AL808027 Genomic DNA. Translation: CAM15853.1. AL808027 Genomic DNA. Translation: CAM15855.1. AL808027 Genomic DNA. Translation: CAM15857.1. BC034679 mRNA. Translation: AAH34679.1. BC058623 mRNA. Translation: AAH58623.1. AF170568 Genomic DNA. Translation: AAF24220.1.
IPI	IPI00272878. IPI00331291. IPI00331293. IPI00465648. IPI00753037. IPI00845595.
RefSeq	NP_034195.2. NM_010065.2.
UniGene	Mm.44736.
3D structure databases
ProteinModelPortal	P39053.
SMR	P39053. Positions 6-746.
ModBase	Search...
Protein-protein interaction databases
IntAct	P39053. 12 interactions.
MINT	MINT-86537.
STRING	P39053.
PTM databases
PhosphoSite	P39053.
Proteomic databases
PRIDE	P39053.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000078352; ENSMUSP00000077461; ENSMUSG00000026825. ENSMUST00000091089; ENSMUSP00000088618; ENSMUSG00000026825. ENSMUST00000113350; ENSMUSP00000108977; ENSMUSG00000026825. ENSMUST00000113352; ENSMUSP00000108979; ENSMUSG00000026825. ENSMUST00000113354; ENSMUSP00000108981; ENSMUSG00000026825. ENSMUST00000113365; ENSMUSP00000108992; ENSMUSG00000026825. ENSMUST00000139624; ENSMUSP00000122679; ENSMUSG00000026825.
GeneID	13429.
KEGG	mmu:13429.
UCSC	uc008jfc.1. mouse. uc008jfd.1. mouse.
Organism-specific databases
CTD	1759.
MGI	MGI:107384. Dnm1.
Rouge	Search...
Phylogenomic databases
eggNOG	roNOG10695.
GeneTree	ENSGT00600000084144.
HOVERGEN	HBG107833.
OMA	DMILTFI.
OrthoDB	EOG49GKG1.
PhylomeDB	P39053.
Gene expression databases
ArrayExpress	P39053.
Bgee	P39053.
CleanEx	MM_DNM1.
Genevestigator	P39053.
GermOnline	ENSMUSG00000026825. Mus musculus.
Family and domain databases
InterPro	IPR022812. Dynamin. IPR000375. Dynamin_central. IPR001401. Dynamin_GTPase. IPR019762. Dynamin_GTPase_CS. IPR003130. GED. IPR020850. GTPase_effector_domain_GED. IPR011993. PH_type. IPR001849. Pleckstrin_homology. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 2 hits.
KO	K01528.
Pfam	PF01031. Dynamin_M. 1 hit. PF00350. Dynamin_N. 1 hit. PF02212. GED. 1 hit. PF00169. PH. 1 hit. [Graphical view]
PRINTS	PR00195. DYNAMIN.
SMART	SM00053. DYNc. 1 hit. SM00302. GED. 1 hit. SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS00410. DYNAMIN. 1 hit. PS51388. GED. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	283851.
SOURCE	Search...

Entry information

Entry name

DYN1_MOUSE

Accession

Primary (citable) accession number: P39053
Secondary accession number(s): A2AN50 , A2AN51, A2AN54, A2AN55, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	June 20, 2003
Last modified:	January 25, 2012
This is version 117 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program