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Protein

Dynamin-2

Gene

Dnm2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (PubMed:21210813). Plays an important role in vesicular trafficking processes, in particular endocytosis (PubMed:19995918). Involved in cytokinesis (PubMed:21195118). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity).By similarity3 Publications

Catalytic activityi

GTP + H2O = GDP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 469GTPBy similarity
Nucleotide bindingi205 – 2117GTPBy similarity
Nucleotide bindingi236 – 2394GTPBy similarity

GO - Molecular functioni

  • D2 dopamine receptor binding Source: RGD
  • GTPase activity Source: RGD
  • GTP binding Source: RGD
  • nitric-oxide synthase binding Source: RGD
  • phosphatidylinositol 3-kinase regulatory subunit binding Source: RGD
  • protein complex binding Source: RGD
  • protein kinase binding Source: RGD
  • SH3 domain binding Source: RGD
  • WW domain binding Source: RGD

GO - Biological processi

  • aorta development Source: Ensembl
  • cellular response to carbon monoxide Source: RGD
  • cellular response to dopamine Source: RGD
  • cellular response to nitric oxide Source: RGD
  • cellular response to X-ray Source: RGD
  • cilium morphogenesis Source: RGD
  • coronary vasculature development Source: Ensembl
  • endocytosis Source: RGD
  • Golgi to plasma membrane transport Source: RGD
  • G-protein coupled receptor internalization Source: RGD
  • macropinocytosis Source: RGD
  • negative regulation of membrane tubulation Source: Ensembl
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: RGD
  • neuron projection morphogenesis Source: UniProtKB
  • positive regulation of endocytosis Source: RGD
  • positive regulation of lamellipodium assembly Source: RGD
  • positive regulation of nitric oxide biosynthetic process Source: RGD
  • positive regulation of phagocytosis Source: RGD
  • positive regulation of sodium:potassium-exchanging ATPase activity Source: RGD
  • positive regulation of substrate adhesion-dependent cell spreading Source: RGD
  • receptor-mediated endocytosis Source: UniProtKB
  • regulation of axon extension Source: UniProtKB
  • regulation of Golgi organization Source: RGD
  • regulation of Rac protein signal transduction Source: RGD
  • response to cocaine Source: RGD
  • response to light stimulus Source: RGD
  • spermatogenesis Source: RGD
  • transferrin transport Source: Ensembl
  • ventricular septum development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Motor protein

Keywords - Biological processi

Endocytosis, Phagocytosis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.5.5. 5301.
ReactomeiR-RNO-190873. Gap junction degradation.
R-RNO-196025. Formation of annular gap junctions.
R-RNO-203641. NOSTRIN mediated eNOS trafficking.
R-RNO-2132295. MHC class II antigen presentation.
R-RNO-432720. Lysosome Vesicle Biogenesis.
R-RNO-432722. Golgi Associated Vesicle Biogenesis.
R-RNO-437239. Recycling pathway of L1.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynamin-2 (EC:3.6.5.5)
Gene namesi
Name:Dnm2
Synonyms:Dyn2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi2513. Dnm2.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB
  • centrosome Source: RGD
  • clathrin-coated endocytic vesicle Source: RGD
  • coated pit Source: UniProtKB
  • cytoplasm Source: RGD
  • cytosol Source: Ensembl
  • endosome Source: RGD
  • extracellular exosome Source: Ensembl
  • focal adhesion Source: Ensembl
  • Golgi apparatus Source: RGD
  • Golgi membrane Source: RGD
  • lamellipodium Source: RGD
  • microtubule Source: UniProtKB-KW
  • midbody Source: UniProtKB-SubCell
  • nucleus Source: RGD
  • perinuclear region of cytoplasm Source: RGD
  • phagocytic cup Source: RGD
  • photoreceptor inner segment Source: Ensembl
  • plasma membrane Source: RGD
  • postsynaptic density Source: UniProtKB-SubCell
  • postsynaptic membrane Source: UniProtKB
  • protein complex Source: RGD
  • ruffle membrane Source: RGD
  • trans-Golgi network Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Coated pit, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi231 – 2311Y → F: Strongly reduced phosphorylation. Decreases receptor-mediated endocytosis. 1 Publication
Mutagenesisi597 – 5971Y → F: Strongly reduced phosphorylation. Decreases receptor-mediated endocytosis. 1 Publication
Mutagenesisi764 – 7641S → A: Reduces proline-rich domain phosphorylation by 80%. 1 Publication
Mutagenesisi764 – 7641S → E: Abolishes midbody localization and shows increased multinucleation. 1 Publication

Chemistry

ChEMBLiCHEMBL2311233.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 870870Dynamin-2PRO_0000206572Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei231 – 2311Phosphotyrosine1 Publication
Modified residuei299 – 2991N6-acetyllysineBy similarity
Modified residuei597 – 5971Phosphotyrosine1 Publication
Modified residuei598 – 5981N6-acetyllysineBy similarity
Modified residuei755 – 7551PhosphothreonineBy similarity
Modified residuei764 – 7641Phosphoserine; by CDK11 Publication

Post-translational modificationi

Phosphorylation at Ser-764 by CDK1 is greatly increased upon mitotic entry. It regulates cytokinesis downstream of calcineurin, and does not affect clathrin-mediated endocytosis. Dephosphorylated by calcineurin/PP2. Phosphorylated on tyrosine residues after activation of SRC (PubMed:19995918).2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP39052.
PRIDEiP39052.

PTM databases

iPTMnetiP39052.
PhosphoSiteiP39052.

Expressioni

Tissue specificityi

Ubiquitously expressed. Brain expression is restricted to glial cells and fibroblasts. Highest levels in the testis.1 Publication

Gene expression databases

ExpressionAtlasiP39052. baseline.
GenevisibleiP39052. RN.

Interactioni

Subunit structurei

Interacts with MYOF, SHANK1, SHANK2 and NOSTRIN (By similarity). Interacts with SNX9. Interacts with SNX33 (via SH3 domain) (By similarity). Interacts with SH3BP4 (PubMed:16325581). Interacts with MYO1E (via SH3 domain) (PubMed:17257598). Interacts with PSTPIP1 (By similarity). Interacts with CTTN and ACTN1 (PubMed:21210813). Interacts with CTNND2 (By similarity). May interact with PIK3C3 (By similarity). May be a component of a complex composed of RAB5A (in GDP-bound form), DYN2 and PIK3C3 (By similarity).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AmphO088382EBI-349613,EBI-80080
SH3BP4Q9P0V35EBI-349613,EBI-1049513From a different organism.
SH3KBP1Q96B974EBI-349613,EBI-346595From a different organism.
SORBS1Q9BX665EBI-349613,EBI-433642From a different organism.

GO - Molecular functioni

  • D2 dopamine receptor binding Source: RGD
  • nitric-oxide synthase binding Source: RGD
  • phosphatidylinositol 3-kinase regulatory subunit binding Source: RGD
  • protein complex binding Source: RGD
  • protein kinase binding Source: RGD
  • SH3 domain binding Source: RGD
  • WW domain binding Source: RGD

Protein-protein interaction databases

BioGridi247779. 4 interactions.
DIPiDIP-33275N.
IntActiP39052. 14 interactions.
MINTiMINT-1175378.
STRINGi10116.ENSRNOP00000060296.

Chemistry

BindingDBiP39052.

Structurei

3D structure databases

ProteinModelPortaliP39052.
SMRiP39052. Positions 6-304, 520-625.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 294267Dynamin-type GAdd
BLAST
Domaini519 – 625107PHPROSITE-ProRule annotationAdd
BLAST
Domaini653 – 74492GEDPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi747 – 866120Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 GED domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
GeneTreeiENSGT00760000119213.
HOGENOMiHOG000161069.
HOVERGENiHBG107833.
InParanoidiP39052.
KOiK01528.
OrthoDBiEOG76MK7N.
PhylomeDBiP39052.
TreeFamiTF300362.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR027188. DNM2.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF23. PTHR11566:SF23. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P39052-1) [UniParc]FASTAAdd to basket

Also known as: ba, IIBA

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNRGMEELI PLVNKLQDAF SSIGQSCHLD LPQIAVVGGQ SAGKSSVLEN
60 70 80 90 100
FVGRDFLPRG SGIVTRRPLI LQLIFSKTEY AEFLHCKSKK FTDFDEVRQE
110 120 130 140 150
IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP
160 170 180 190 200
DIEYQIKDMI LQFISRESSL ILAVTPANMD LANSDALKLA KEVDPQGLRT
210 220 230 240 250
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIEGRKDIRA
260 270 280 290 300
ALAAERKFFL SHPAYRHMAD RMGTPHLQKT LNQQLTNHIR ESLPTLRSKL
310 320 330 340 350
QSQLLSLEKE VEEYKNFRPD DPTRKTKALL QMVQQFGVDF EKRIEGSGDQ
360 370 380 390 400
VDTLELSGGA RINRIFHERF PFELVKMEFD EKDLRREISY AIKNIHGVRT
410 420 430 440 450
GLFTPDLAFE AIVKKQVVKL KEPCLKCVDL VIQELISTVR QCTSKLSSYP
460 470 480 490 500
RLREETERIV TTYIREREGR TKDQILLLID IEQSYINTNH EDFIGFANAQ
510 520 530 540 550
QRSTQLNKKR AIPNQGEILV IRRGWLTINN ISLMKGGSKE YWFVLTAESL
560 570 580 590 600
SWYKDEEEKE KKYMLPLDNL KIRDVEKGFM SNKHVFAIFN TEQRNVYKDL
610 620 630 640 650
RQIELACDSQ EDVDSWKASF LRAGVYPEKD QAENEDGAQE NTFSMDPQLE
660 670 680 690 700
RQVETIRNLV DSYVAIINKS IRDLMPKTIM HLMINNTKAF IHHELLAYLY
710 720 730 740 750
SSADQSSLME ESAEQAQRRD DMLRMYHALK EALNIIGDIS TSTVSTPVPP
760 770 780 790 800
PVDDTWLQNT SSHSPTPQRR PVSSVHPPGR PPAVRGPTPG PPLIPMPVGA
810 820 830 840 850
TSSFSAPPIP SRPGPQNVFA NNDPFSAPPQ IPSRPARIPP GIPPGVPSRR
860 870
APAAPSRPTI IRPAEPSLLD
Length:870
Mass (Da):98,230
Last modified:February 1, 1995 - v1
Checksum:i3802DBAFA3ABBE98
GO
Isoform 2 (identifier: P39052-2) [UniParc]FASTAAdd to basket

Also known as: aa

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: LAFEAIVKKQ...LISTVRQCTS → MAFEAIVKKQ...LATVIKKCAE

Note: Sequestered to clathrin-coated pits and vesicles at the plasma membrane and the Golgi apparatus.
Show »
Length:870
Mass (Da):98,159
Checksum:iF06960A8E93126A6
GO
Isoform 3 (identifier: P39052-3) [UniParc]FASTAAdd to basket

Also known as: bb, IIC

The sequence of this isoform differs from the canonical sequence as follows:
     516-519: Missing.

Show »
Length:866
Mass (Da):97,818
Checksum:i0B3D9DB3C7A14827
GO
Isoform 4 (identifier: P39052-4) [UniParc]FASTAAdd to basket

Also known as: ab

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: LAFEAIVKKQ...LISTVRQCTS → MAFEAIVKKQ...LATVIKKCAE
     516-519: Missing.

Note: Localized to numerous punctate spots on the plasma membrane.
Show »
Length:866
Mass (Da):97,747
Checksum:iF1A7058D5B951106
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti298 – 2981S → T in AAA16746 (PubMed:8290576).Curated
Sequence conflicti389 – 3891S → T in AAA16746 (PubMed:8290576).Curated
Sequence conflicti487 – 4871N → K in AAA16746 (PubMed:8290576).Curated
Sequence conflicti637 – 6371G → E in AAA16746 (PubMed:8290576).Curated
Sequence conflicti719 – 7191Missing in AAA16746 (PubMed:8290576).Curated
Sequence conflicti786 – 7916GPTPGP → PHTGA in AAA16746 (PubMed:8290576).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei407 – 44438LAFEA…RQCTS → MAFEAIVKKQLVKLKEPSLK CVDLVVSELATVIKKCAE in isoform 2 and isoform 4. 1 PublicationVSP_001327Add
BLAST
Alternative sequencei516 – 5194Missing in isoform 3 and isoform 4. 2 PublicationsVSP_001328

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25605 mRNA. Translation: AAA19736.1.
L24562 mRNA. Translation: AAA16746.1.
PIRiA36878.
A53165.
B53165.
RefSeqiNP_037331.1. NM_013199.1. [P39052-1]
XP_006242670.1. XM_006242608.2. [P39052-2]
XP_006242674.1. XM_006242612.2. [P39052-4]
XP_006242675.1. XM_006242613.2. [P39052-3]
UniGeneiRn.11231.

Genome annotation databases

EnsembliENSRNOT00000010947; ENSRNOP00000010948; ENSRNOG00000007649. [P39052-1]
GeneIDi25751.
KEGGirno:25751.
UCSCiRGD:2513. rat. [P39052-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25605 mRNA. Translation: AAA19736.1.
L24562 mRNA. Translation: AAA16746.1.
PIRiA36878.
A53165.
B53165.
RefSeqiNP_037331.1. NM_013199.1. [P39052-1]
XP_006242670.1. XM_006242608.2. [P39052-2]
XP_006242674.1. XM_006242612.2. [P39052-4]
XP_006242675.1. XM_006242613.2. [P39052-3]
UniGeneiRn.11231.

3D structure databases

ProteinModelPortaliP39052.
SMRiP39052. Positions 6-304, 520-625.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247779. 4 interactions.
DIPiDIP-33275N.
IntActiP39052. 14 interactions.
MINTiMINT-1175378.
STRINGi10116.ENSRNOP00000060296.

Chemistry

BindingDBiP39052.
ChEMBLiCHEMBL2311233.

PTM databases

iPTMnetiP39052.
PhosphoSiteiP39052.

Proteomic databases

PaxDbiP39052.
PRIDEiP39052.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010947; ENSRNOP00000010948; ENSRNOG00000007649. [P39052-1]
GeneIDi25751.
KEGGirno:25751.
UCSCiRGD:2513. rat. [P39052-1]

Organism-specific databases

CTDi1785.
RGDi2513. Dnm2.

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
GeneTreeiENSGT00760000119213.
HOGENOMiHOG000161069.
HOVERGENiHBG107833.
InParanoidiP39052.
KOiK01528.
OrthoDBiEOG76MK7N.
PhylomeDBiP39052.
TreeFamiTF300362.

Enzyme and pathway databases

BRENDAi3.6.5.5. 5301.
ReactomeiR-RNO-190873. Gap junction degradation.
R-RNO-196025. Formation of annular gap junctions.
R-RNO-203641. NOSTRIN mediated eNOS trafficking.
R-RNO-2132295. MHC class II antigen presentation.
R-RNO-432720. Lysosome Vesicle Biogenesis.
R-RNO-432722. Golgi Associated Vesicle Biogenesis.
R-RNO-437239. Recycling pathway of L1.

Miscellaneous databases

NextBioi607943.
PROiP39052.

Gene expression databases

ExpressionAtlasiP39052. baseline.
GenevisibleiP39052. RN.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR027188. DNM2.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF23. PTHR11566:SF23. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Differential expression and regulation of multiple dynamins."
    Sontag J.-M., Fykse E.M., Ushkaryov Y., Liu J.-P., Robinson P.J., Suedhof T.C.
    J. Biol. Chem. 269:4547-4554(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
    Tissue: Brain.
  2. "Identification of dynamin 2, an isoform ubiquitously expressed in rat tissues."
    Cook T.A., Urrutia R., McNiven M.A.
    Proc. Natl. Acad. Sci. U.S.A. 91:644-648(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Strain: Sprague-Dawley.
  3. "Differential distribution of dynamin isoforms in mammalian cells."
    Cao H., Garcia F., McNiven M.A.
    Mol. Biol. Cell 9:2595-2609(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. "TTP specifically regulates the internalization of the transferrin receptor."
    Tosoni D., Puri C., Confalonieri S., Salcini A.E., De Camilli P., Tacchetti C., Di Fiore P.P.
    Cell 123:875-888(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SH3BP4.
  5. "Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis."
    Krendel M., Osterweil E.K., Mooseker M.S.
    FEBS Lett. 581:644-650(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MYO1E.
  6. "SRC-mediated phosphorylation of dynamin and cortactin regulates the 'constitutive' endocytosis of transferrin."
    Cao H., Chen J., Krueger E.W., McNiven M.A.
    Mol. Cell. Biol. 30:781-792(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION AT TYR-231 AND TYR-597, MUTAGENESIS OF TYR-231 AND TYR-597.
  7. Cited for: PHOSPHORYLATION AT SER-764 BY CDK1, MUTAGENESIS OF SER-764, FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Lung.
  8. "Growth cone morphology and spreading are regulated by a dynamin-cortactin complex at point contacts in hippocampal neurons."
    Kurklinsky S., Chen J., McNiven M.A.
    J. Neurochem. 117:48-60(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CTTN AND ACTN1.

Entry informationi

Entry nameiDYN2_RAT
AccessioniPrimary (citable) accession number: P39052
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 11, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.