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Protein

Zinc carboxypeptidase

Gene
N/A
Organism
Saccharothrix mutabilis subsp. capreolus (Streptomyces capreolus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Carboxypeptidase that possesses the specificities of both mammalian Cpase A and B. Thus shows broad substrate specificity, being able to cleave Cbz-Gly-Leu, Cbz-Gly-Val, Cbz-Gly-Phe, Cbz-Gly-Lys and Bz-Gly-Arg in vitro.By similarity

Catalytic activityi

Release of a C-terminal amino acid from a polypeptide, with broad specificity.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi183 – 1831Zinc; catalyticBy similarity
Metal bindingi186 – 1861Zinc; catalyticBy similarity
Metal bindingi315 – 3151Zinc; catalyticBy similarity
Active sitei388 – 3881Proton donor/acceptorBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.17.18. 5989.

Protein family/group databases

MEROPSiM14.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc carboxypeptidaseBy similarity (EC:3.4.17.-By similarity)
OrganismiSaccharothrix mutabilis subsp. capreolus (Streptomyces capreolus)
Taxonomic identifieri66854 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPseudonocardialesPseudonocardiaceaeSaccharothrix

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Propeptidei34 – 11481Activation peptideSequence analysisPRO_0000004413Add
BLAST
Chaini115 – 434320Zinc carboxypeptidasePRO_0000004414Add
BLAST

Keywords - PTMi

Zymogen

Structurei

3D structure databases

ProteinModelPortaliP39041.
SMRiP39041. Positions 115-434.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR000834. Peptidase_M14.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39041-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPKRRRLMA AALGACVALV LPLHAGSAQP STAKTPERTV FEVTASTPEA
60 70 80 90 100
RTRVARTGVD VLGQDGDKLT VVAEPRQQWA LRATGLRVEN LGDYDAQLQA
110 120 130 140 150
LGKVDFTDPQ VGTQDFPSGY TGYHNFQETV TELNQTVTDH PNLVRLSSVG
160 170 180 190 200
KSYQGRDLWM LKLSDNPAVD ENEPEVLFTC NMHAREHLTV EMCLRIIKQY
210 220 230 240 250
TDGYATNPTI KNLVDSREIW IIPMVNPDGV EYDIATGSFR SWRKNRQPNS
260 270 280 290 300
TAVGTDPNRN WGYQWGCCGG SSSSGSSETT AARRRSPPRR SPHPHFVNTR
310 320 330 340 350
VVGGVQQIKT HIDWHTYSEL ILWPYGYTYN DTAPGLDAQQ ASAFSTLGRR
360 370 380 390 400
MASLNGTRRQ QSSDLYITDG TINDWLWGVH KIWSYTFEMY PKSSSPGFYP
410 420 430
RDTVIATQTQ RNDSAVELFL SYSDCVPRII GRTC
Length:434
Mass (Da):48,477
Last modified:February 1, 1995 - v1
Checksum:i5C010AAB636EAC88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00619 Unassigned DNA. Translation: AAA73397.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00619 Unassigned DNA. Translation: AAA73397.1.

3D structure databases

ProteinModelPortaliP39041.
SMRiP39041. Positions 115-434.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM14.007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi3.4.17.18. 5989.

Family and domain databases

InterProiIPR000834. Peptidase_M14.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBPS_STRMP
AccessioniPrimary (citable) accession number: P39041
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 20, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.