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Protein

Cadherin-4

Gene

Cdh4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: MGI
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: MGI
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: MGI
  • positive regulation of axon extension Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-4
Alternative name(s):
Retinal cadherin
Short name:
R-CAD
Short name:
R-cadherin
Gene namesi
Name:Cdh4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:99218. Cdh4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini167 – 731565ExtracellularSequence analysisAdd
BLAST
Transmembranei732 – 75322HelicalSequence analysisAdd
BLAST
Topological domaini754 – 913160CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Propeptidei21 – 166146Sequence analysisPRO_0000003751Add
BLAST
Chaini167 – 913747Cadherin-4PRO_0000003752Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence analysis
Glycosylationi280 – 2801N-linked (GlcNAc...)Sequence analysis
Glycosylationi409 – 4091N-linked (GlcNAc...)Sequence analysis
Glycosylationi554 – 5541N-linked (GlcNAc...)Sequence analysis
Glycosylationi629 – 6291N-linked (GlcNAc...)Sequence analysis
Glycosylationi658 – 6581N-linked (GlcNAc...)Sequence analysis
Glycosylationi699 – 6991N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

MaxQBiP39038.
PaxDbiP39038.
PRIDEiP39038.
TopDownProteomicsiP39038.

PTM databases

iPTMnetiP39038.
PhosphoSiteiP39038.

Expressioni

Tissue specificityi

Distributed widely in mouse tissues with high levels present in brain, skeletal muscle and thymus.

Gene expression databases

BgeeiP39038.
CleanExiMM_CDH4.
ExpressionAtlasiP39038. baseline and differential.
GenevisibleiP39038. MM.

Interactioni

Protein-protein interaction databases

BioGridi198639. 1 interaction.
IntActiP39038. 1 interaction.
STRINGi10090.ENSMUSP00000000314.

Structurei

3D structure databases

ProteinModelPortaliP39038.
SMRiP39038. Positions 31-708, 825-910.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini167 – 274108Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini275 – 389115Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini390 – 504115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini505 – 610106Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini611 – 721111Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi870 – 88516Ser-richAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiP39038.
KOiK06797.
OMAiDHVLNKA.
OrthoDBiEOG7RJPQM.
PhylomeDBiP39038.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 7 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39038-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTGSVLPLL LLGLSGALRA HREDLTVREA CKAGFSEEGY TALISPNVLE
60 70 80 90 100
GEKLLKVEFS SCVGTKGMQY ETNSLDFKVG ADGTVFATRE LKIPSEQVAF
110 120 130 140 150
TVTARERQSA EQWAAMVRLL VAQTSSAHSE HKKGQTVALD PSQPPNDTLL
160 170 180 190 200
PWPQHQSSGG LRRQKRDWVI PPINVPENSR GPFPQQLVRI RSDKDNDIPI
210 220 230 240 250
RYSITGVGAD QPPMEVFNID SMSGRMYVTR PMDREERASY HLRAHAVDMN
260 270 280 290 300
GNKVENPIDL YIYVIDMNDN RPEFINQVYN GSVDEGSKPG TYVMTVTAND
310 320 330 340 350
ADDSTTANGM VRYRIVTQTP QSPSQNMFTI NSETGDIVTV AAGLDREKVQ
360 370 380 390 400
QYTVIVQATD MEGNLNYGLS NTATAIITVT DVNDNPPEFT TSTFAGEVPE
410 420 430 440 450
NRIETVVANL TVMDRDQPHS PNWNAVYRII SGDPSGHFSV RTDPVTNEGM
460 470 480 490 500
VTVVKAVDYE LNRAFMLTVM VSNQAPLASG IQMSFQSTAG VTISVTDVNE
510 520 530 540 550
APYFPSNHKL IRLEEGVPAG TALTTFSAVD PDRFMQQAVR YSKLSDPANW
560 570 580 590 600
LHINTSNGQI TTAAILDRES LYTKNNVYEA TFLAADNGIP PASGTGTLQI
610 620 630 640 650
YLIDINDNAP QLLPKEAQIC ERPGLNAINI TAADADMDPN IGPYVFELPF
660 670 680 690 700
IPTTVRKNWT ITRLNGDYAQ LSLRILYLEA GVYDVPIIVT DSGNPPLSNT
710 720 730 740 750
SVIKVKVCPC DENGDCTTVG AVAAAGLGTG AIVAILICIV ILLIMVLLFV
760 770 780 790 800
VWMKRREKER HTKQLLIDPE DDVRDNILKY DEEGGGEEDQ DYDLSQLQQP
810 820 830 840 850
EAMEHVLSKT PGVRRVDERP VGAEPQYPVR PVVPHPGDIG DFINEGLRAA
860 870 880 890 900
DNDPTAPPYD SLLVFDYEGS GSTAGSVSSL NSSSSGDQDY DYLNDWGPRF
910
KKLADMYGGG EED
Length:913
Mass (Da):100,030
Last modified:February 1, 1995 - v1
Checksum:i1245A8CE8C338481
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69966 mRNA. Translation: CAA49589.1.
D14888 mRNA. Translation: BAA03605.1.
CCDSiCCDS17164.1.
PIRiA47543.
RefSeqiNP_033997.1. NM_009867.3.
UniGeneiMm.184711.

Genome annotation databases

EnsembliENSMUST00000000314; ENSMUSP00000000314; ENSMUSG00000000305.
GeneIDi12561.
KEGGimmu:12561.
UCSCiuc008ohv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69966 mRNA. Translation: CAA49589.1.
D14888 mRNA. Translation: BAA03605.1.
CCDSiCCDS17164.1.
PIRiA47543.
RefSeqiNP_033997.1. NM_009867.3.
UniGeneiMm.184711.

3D structure databases

ProteinModelPortaliP39038.
SMRiP39038. Positions 31-708, 825-910.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198639. 1 interaction.
IntActiP39038. 1 interaction.
STRINGi10090.ENSMUSP00000000314.

PTM databases

iPTMnetiP39038.
PhosphoSiteiP39038.

Proteomic databases

MaxQBiP39038.
PaxDbiP39038.
PRIDEiP39038.
TopDownProteomicsiP39038.

Protocols and materials databases

DNASUi12561.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000314; ENSMUSP00000000314; ENSMUSG00000000305.
GeneIDi12561.
KEGGimmu:12561.
UCSCiuc008ohv.2. mouse.

Organism-specific databases

CTDi1002.
MGIiMGI:99218. Cdh4.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiP39038.
KOiK06797.
OMAiDHVLNKA.
OrthoDBiEOG7RJPQM.
PhylomeDBiP39038.
TreeFamiTF316817.

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Miscellaneous databases

PROiP39038.
SOURCEiSearch...

Gene expression databases

BgeeiP39038.
CleanExiMM_CDH4.
ExpressionAtlasiP39038. baseline and differential.
GenevisibleiP39038. MM.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 7 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of mouse pancreatic islet R-cadherin: differential expression in endocrine and exocrine tissue."
    Hutton J.C., Christofori G., Chi W.Y., Edman U., Guest P.C., Hanahan D., Kelly R.B.
    Mol. Endocrinol. 7:1151-1160(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreatic islet.
  2. "Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene."
    Matsunami H., Miyatani S., Inoue T., Copeland N.G., Gilbert D., Jenkins N.A., Takeichi M.
    J. Cell Sci. 106:401-409(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCADH4_MOUSE
AccessioniPrimary (citable) accession number: P39038
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 8, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.