Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alpha-S2-casein

Gene

CSN1S2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Important role in the capacity of milk to transport calcium phosphate.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Milk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-S2-casein
Gene namesi
Name:CSN1S2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 8

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515By similarityAdd
BLAST
Chaini16 – 235220Alpha-S2-caseinPRO_0000004464Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231PhosphoserineBy similarity
Modified residuei24 – 241PhosphoserineBy similarity
Modified residuei25 – 251PhosphoserineBy similarity
Modified residuei28 – 281PhosphoserineBy similarity
Modified residuei47 – 471PhosphoserineBy similarity
Modified residuei72 – 721PhosphoserineBy similarity
Modified residuei73 – 731PhosphoserineBy similarity
Modified residuei74 – 741PhosphoserineBy similarity
Modified residuei77 – 771PhosphoserineBy similarity
Modified residuei168 – 1681PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP39036.
PeptideAtlasiP39036.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

GenevisibleiP39036. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009878.

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JE87. Eukaryota.
ENOG4111369. LUCA.
GeneTreeiENSGT00530000065240.
HOGENOMiHOG000111307.
HOVERGENiHBG005244.
InParanoidiP39036.
OMAiVMNPWDQ.
OrthoDBiEOG091G0QMQ.
TreeFamiTF339561.

Family and domain databases

InterProiIPR011175. Alpha-s2_casein.
IPR001588. Casein.
IPR031305. Casein_CS.
[Graphical view]
PfamiPF00363. Casein. 2 hits.
[Graphical view]
PIRSFiPIRSF002371. Alpha-s2-casein. 1 hit.
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39036-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFFIFTCLL AVAFAKHEME HVSSSEESIN ISQEKYKQEK NVINHPSKED
60 70 80 90 100
ICATSCEEAV RNIKEVGYAS SSSSEESVDI PAENVKVTVE DKHYLKQLEK
110 120 130 140 150
ISQFYQKFPQ YLQALYQAQI VMNPWDQTKT SAYPFIPTVI QSGEELSTSE
160 170 180 190 200
EPVSSSQEEN TKTVDMESME EFTKKTELTE EEKNRIKFLN KIKQYYQKFT
210 220 230
WPQYIKTVHQ KQKAMKPWNH IKTNSYQIIP NLRYF
Length:235
Mass (Da):27,570
Last modified:February 1, 1995 - v1
Checksum:iC903B760D184C14C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54975 mRNA. Translation: CAA38719.1.
RefSeqiNP_001004030.1. NM_001004030.1.
XP_005656642.1. XM_005656585.1.
UniGeneiSsc.68851.
Ssc.71410.

Genome annotation databases

EnsembliENSSSCT00000010144; ENSSSCP00000009878; ENSSSCG00000009263.
GeneIDi445515.
KEGGissc:445515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54975 mRNA. Translation: CAA38719.1.
RefSeqiNP_001004030.1. NM_001004030.1.
XP_005656642.1. XM_005656585.1.
UniGeneiSsc.68851.
Ssc.71410.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009878.

Proteomic databases

PaxDbiP39036.
PeptideAtlasiP39036.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000010144; ENSSSCP00000009878; ENSSSCG00000009263.
GeneIDi445515.
KEGGissc:445515.

Organism-specific databases

CTDi100327035.

Phylogenomic databases

eggNOGiENOG410JE87. Eukaryota.
ENOG4111369. LUCA.
GeneTreeiENSGT00530000065240.
HOGENOMiHOG000111307.
HOVERGENiHBG005244.
InParanoidiP39036.
OMAiVMNPWDQ.
OrthoDBiEOG091G0QMQ.
TreeFamiTF339561.

Gene expression databases

GenevisibleiP39036. SS.

Family and domain databases

InterProiIPR011175. Alpha-s2_casein.
IPR001588. Casein.
IPR031305. Casein_CS.
[Graphical view]
PfamiPF00363. Casein. 2 hits.
[Graphical view]
PIRSFiPIRSF002371. Alpha-s2-casein. 1 hit.
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCASA2_PIG
AccessioniPrimary (citable) accession number: P39036
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.