Reviewed,
UniProtKB/Swiss-Prot P39023 (RL3_HUMAN)
Last modified
June 16, 2009.
Version 97.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 60S ribosomal protein L3 Alternative name(s): HIV-1 TAR RNA-binding protein B Short name=TARBP-B | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 403 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | The L3 protein is a component of the large subunit of cytoplasmic ribosomes. |
| Subcellular location | |
| Sequence similarities | Belongs to the ribosomal protein L3P family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Coding sequence diversity | Polymorphism |
| Molecular function | Ribonucleoprotein Ribosomal protein |
| PTM | Phosphoprotein |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | translational elongation Inferred from Experiment. Source: Reactome |
| Cellular component | cytosolic large ribosomal subunit Traceable author statement. Source: ProtInc nucleolusInferred from direct assay. Source: HPA |
| Molecular function | RNA binding Traceable author statement. Source: ProtInc protein bindingInferred from physical interaction. Source: IntAct structural constituent of ribosomeTraceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| CDC42BPB | Q9Y5S2 | 1 | EBI-1056348,EBI-1043430 | |
| CNBP | P62633 | 1 | EBI-1056348,EBI-1047529 | |
| EIF6 | P56537 | 1 | EBI-1056348,EBI-372243 | |
| LYAR | Q9NX58 | 1 | EBI-1056348,EBI-713507 | |
| NDRG1 | Q92597 | 1 | EBI-1056348,EBI-716486 | |
| PSTPIP1 | O43586 | 1 | EBI-1056348,EBI-1050964 | |
| SMNDC1 | O75940 | 1 | EBI-1056348,EBI-1052641 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.10 | ||||||
| Chain | 2 – 403 | 402 | 60S ribosomal protein L3 | PRO_0000077227 | |||||
Amino acid modifications | |||||||||
| Modified residue | 7 | 1 | Phosphoserine Ref.13 | ||||||
| Modified residue | 13 | 1 | Phosphoserine Ref.14 | ||||||
| Modified residue | 307 | 1 | Phosphotyrosine Ref.11 Ref.12 | ||||||
Natural variations | |||||||||
| Natural variant | 78 | 1 | I → T: dbSNP rs11548004. | VAR_052040 | |||||
Experimental info | |||||||||
| Sequence conflict | 22 | 1 | S → T in AAA91344. Ref.8 | ||||||
| Sequence conflict | 260 | 1 | A → V in AAA91344. Ref.8 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Complete coding sequence of human ribosomal protein L3 mRNA." Leffers H. Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients." Shichijo S., Itoh K. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon adenocarcinoma. |
| [3] | "A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
| [5] | "The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. Wright H.Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Colon, Lung, Muscle, Ovary, PNS, Skin and Uterus. |
| [7] | Still I.H. Submitted (MAR-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-403. |
| [8] | "Molecular cloning and characterization of a TAR-binding nuclear factor from T cells." Reddy T.R., Suhasini M., Rappaport J., Looney D.J., Kraus G., Wong-Staal F. AIDS Res. Hum. Retroviruses 11:663-669(1995) [PubMed: 7576925] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-277. |
| [9] | "A map of 75 human ribosomal protein genes." Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C. Genome Res. 8:509-523(1998) [PubMed: 9582194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 328-398. |
| [10] | "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing." Odintsova T.I., Muller E.C., Ivanov A.V., Egorov T.A., Bienert R., Vladimirov S.N., Kostka S., Otto A., Wittmann-Liebold B., Karpova G.G. J. Protein Chem. 22:249-258(2003) [PubMed: 12962325] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-13, MASS SPECTROMETRY. |
| [11] | "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-307, MASS SPECTROMETRY. |
| [12] | "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. Comb M.J.Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-307, MASS SPECTROMETRY. |
| [13] | "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, MASS SPECTROMETRY. |
| [14] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, MASS SPECTROMETRY. |
| [15] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X73460 mRNA. Translation: CAA51839.1. AB062291 mRNA. Translation: BAB93474.1. CR456566 mRNA. Translation: CAG30452.1. AK315693 mRNA. Translation: BAG38056.1. AL022326 Genomic DNA. Translation: CAA18450.1. BC002408 mRNA. Translation: AAH02408.1. BC006483 mRNA. Translation: AAH06483.1. BC008003 mRNA. Translation: AAH08003.1. BC012146 mRNA. Translation: AAH12146.1. BC012786 mRNA. Translation: AAH12786.1. BC013674 mRNA. Translation: AAH13674.1. BC014017 mRNA. Translation: AAH14017.1. BC015032 mRNA. Translation: AAH15032.1. BC015767 mRNA. Translation: AAH15767.1. BC063662 mRNA. Translation: AAH63662.1. BC088373 mRNA. Translation: AAH88373.1. BC107711 mRNA. Translation: AAI07712.1. M90054 mRNA. Translation: AAA60291.1. L22453 mRNA. Translation: AAA91344.1. AB007166 Genomic DNA. Translation: BAA25828.1. | |
| IPI | IPI00550021. |
| PIR | S34195. |
| RefSeq | NP_000958.1. |
| UniGene | Hs.119598 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P39023. 23 interactions. |
PTM databases | |
| PhosphoSite | P39023. |
2-D gel databases | |
| SWISS-2DPAGE | P39023. |
Proteomic databases | |
| PRIDE | P39023. |
Genome annotation databases | |
| Ensembl | ENSG00000100316. Homo sapiens. [Contig view] |
| GeneID | 6122. |
| KEGG | hsa:6122. |
Organism-specific databases | |
| GeneCards | GC22M038033. GC22M038038. |
| H-InvDB | HIX0016489. HIX0059255. |
| HGNC | HGNC:10332. RPL3. |
| HPA | HPA003365. |
| MIM | 604163. gene. |
| PharmGKB | PA30960. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P39023. |
| HOVERGEN | P39023. |
| OMA | P39023. WGTKKLP. |
Enzyme and pathway databases | |
| Reactome | REACT_1762. 3' -UTR-mediated translational regulation. REACT_6167. Influenza Infection. REACT_71. Gene Expression. |
Gene expression databases | |
| CleanEx | HS_RPL3. |
| GermOnline | ENSG00000100316. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000597. Ribosomal_L3. IPR019926. Ribosomal_L3_CS. [Graphical view] |
| Pfam | PF00297. Ribosomal_L3. 1 hit. [Graphical view] |
| PROSITE | PS00474. RIBOSOMAL_L3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 23777. |
| SOURCE | Search... |
Entry information
| Entry name | RL3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P39023 Secondary accession number(s): B2RDV9, Q15548, Q5I0G0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 22 Human chromosome 22: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| Ribosomal proteins Ribosomal proteins families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


