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Protein

60S ribosomal protein L3

Gene

RPL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The L3 protein is a component of the large subunit of cytoplasmic ribosomes.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L3
Alternative name(s):
HIV-1 TAR RNA-binding protein B
Short name:
TARBP-B
Large ribosomal subunit protein uL31 Publication
Gene namesi
Name:RPL3
ORF Names:OK/SW-cl.32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100316.15
HGNCiHGNC:10332 RPL3
MIMi604163 gene
neXtProtiNX_P39023

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6122
OpenTargetsiENSG00000100316
PharmGKBiPA34713

Chemistry databases

DrugBankiDB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
DB07374 Anisomycin
DB04865 Omacetaxine mepesuccinate
DB08437 Puromycin

Polymorphism and mutation databases

BioMutaiRPL3
DMDMi730565

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000772272 – 40360S ribosomal protein L3Add BLAST402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineCombined sources1
Cross-linki39Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei136N6-acetyllysineBy similarity1
Cross-linki224Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki226Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei286N6-acetyllysine; alternateBy similarity1
Cross-linki286Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei294N6-acetyllysine; alternateCombined sources1
Cross-linki294Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Modified residuei304PhosphoserineCombined sources1
Modified residuei366N6-acetyllysine; alternateCombined sources1
Cross-linki366Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei373N6-acetyllysineBy similarity1
Cross-linki386Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki393Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki399Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP39023
MaxQBiP39023
PaxDbiP39023
PeptideAtlasiP39023
PRIDEiP39023
TopDownProteomicsiP39023

2D gel databases

SWISS-2DPAGEP39023

PTM databases

iPTMnetiP39023
PhosphoSitePlusiP39023
SwissPalmiP39023

Expressioni

Gene expression databases

BgeeiENSG00000100316
CleanExiHS_RPL3
ExpressionAtlasiP39023 baseline and differential
GenevisibleiP39023 HS

Organism-specific databases

HPAiHPA003365

Interactioni

Subunit structurei

Component of the large ribosomal subunit (Probable). Interacts with METTL18 (PubMed:23349634). Interacts with DHX33 (PubMed:26100019).1 Publication2 Publications

Protein-protein interaction databases

BioGridi112042, 189 interactors
CORUMiP39023
IntActiP39023, 48 interactors
MINTiP39023
STRINGi9606.ENSP00000346001

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LB1-403[»]
4V6Xelectron microscopy5.00CB1-403[»]
5AJ0electron microscopy3.50AB1-403[»]
5LKSelectron microscopy3.60LB1-403[»]
5T2Celectron microscopy3.60E1-403[»]
6EK0electron microscopy2.90LB1-403[»]
ProteinModelPortaliP39023
SMRiP39023
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0746 Eukaryota
COG0087 LUCA
GeneTreeiENSGT00390000017606
HOGENOMiHOG000107319
HOVERGENiHBG001864
InParanoidiP39023
KOiK02925
OMAiHQRTEYN
OrthoDBiEOG091G086T
PhylomeDBiP39023
TreeFamiTF300555

Family and domain databases

InterProiView protein in InterPro
IPR000597 Ribosomal_L3
IPR019926 Ribosomal_L3_CS
IPR009000 Transl_B-barrel_sf
PfamiView protein in Pfam
PF00297 Ribosomal_L3, 1 hit
SUPFAMiSSF50447 SSF50447, 1 hit
PROSITEiView protein in PROSITE
PS00474 RIBOSOMAL_L3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39023-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHRKFSAPR HGSLGFLPRK RSSRHRGKVK SFPKDDPSKP VHLTAFLGYK
60 70 80 90 100
AGMTHIVREV DRPGSKVNKK EVVEAVTIVE TPPMVVVGIV GYVETPRGLR
110 120 130 140 150
TFKTVFAEHI SDECKRRFYK NWHKSKKKAF TKYCKKWQDE DGKKQLEKDF
160 170 180 190 200
SSMKKYCQVI RVIAHTQMRL LPLRQKKAHL MEIQVNGGTV AEKLDWARER
210 220 230 240 250
LEQQVPVNQV FGQDEMIDVI GVTKGKGYKG VTSRWHTKKL PRKTHRGLRK
260 270 280 290 300
VACIGAWHPA RVAFSVARAG QKGYHHRTEI NKKIYKIGQG YLIKDGKLIK
310 320 330 340 350
NNASTDYDLS DKSINPLGGF VHYGEVTNDF VMLKGCVVGT KKRVLTLRKS
360 370 380 390 400
LLVQTKRRAL EKIDLKFIDT TSKFGHGRFQ TMEEKKAFMG PLKKDRIAKE

EGA
Length:403
Mass (Da):46,109
Last modified:January 23, 2007 - v2
Checksum:iA607CEE75CF62148
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22S → T in AAA91344 (PubMed:7576925).Curated1
Sequence conflicti260A → V in AAA91344 (PubMed:7576925).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06922011H → R Rare variant found in a Diamond-Blackfan anemia patient; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73460 mRNA Translation: CAA51839.1
AB062291 mRNA Translation: BAB93474.1
CR456566 mRNA Translation: CAG30452.1
AK315693 mRNA Translation: BAG38056.1
AL022326 Genomic DNA No translation available.
BC002408 mRNA Translation: AAH02408.1
BC006483 mRNA Translation: AAH06483.1
BC008003 mRNA Translation: AAH08003.1
BC012146 mRNA Translation: AAH12146.1
BC012786 mRNA Translation: AAH12786.1
BC013674 mRNA Translation: AAH13674.1
BC014017 mRNA Translation: AAH14017.1
BC015032 mRNA Translation: AAH15032.1
BC015767 mRNA Translation: AAH15767.1
BC063662 mRNA Translation: AAH63662.1
BC088373 mRNA Translation: AAH88373.1
BC107711 mRNA Translation: AAI07712.1
M90054 mRNA Translation: AAA60291.1
L22453 mRNA Translation: AAA91344.1
AB007166 Genomic DNA Translation: BAA25828.1
CCDSiCCDS13988.1
PIRiS34195
RefSeqiNP_000958.1, NM_000967.3
UniGeneiHs.119598

Genome annotation databases

EnsembliENST00000216146; ENSP00000346001; ENSG00000100316
GeneIDi6122
KEGGihsa:6122
UCSCiuc003axi.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRL3_HUMAN
AccessioniPrimary (citable) accession number: P39023
Secondary accession number(s): B2RDV9, Q15548, Q5I0G0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 191 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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